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Aliases for MMP21 Gene

Aliases for MMP21 Gene

  • Matrix Metallopeptidase 21 2 3 5
  • Matrix Metalloproteinase 21 2 3
  • MMP-21 3 4
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • HTX7 3

External Ids for MMP21 Gene

Previous GeneCards Identifiers for MMP21 Gene

  • GC10M126430
  • GC10M126658
  • GC10M127496
  • GC10M127029
  • GC10M127445
  • GC10M121144

Summaries for MMP21 Gene

Entrez Gene Summary for MMP21 Gene

  • This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]

GeneCards Summary for MMP21 Gene

MMP21 (Matrix Metallopeptidase 21) is a Protein Coding gene. Diseases associated with MMP21 include dextrocardia with situs inversus and visceral heterotaxy. Among its related pathways are Matrix Metalloproteinases and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP19.

UniProtKB/Swiss-Prot for MMP21 Gene

  • May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin.

Tocris Summary for MMP21 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP21 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP21 Gene

Genomics for MMP21 Gene

Regulatory Elements for MMP21 Gene

Genomic Location for MMP21 Gene

Chromosome:
10
Start:
125,764,939 bp from pter
End:
125,785,224 bp from pter
Size:
20,286 bases
Orientation:
Minus strand

Genomic View for MMP21 Gene

Genes around MMP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP21 Gene

Proteins for MMP21 Gene

  • Protein details for MMP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N119-MMP21_HUMAN
    Recommended name:
    Matrix metalloproteinase-21
    Protein Accession:
    Q8N119
    Secondary Accessions:
    • Q5VZP9
    • Q8NG02

    Protein attributes for MMP21 Gene

    Size:
    569 amino acids
    Molecular mass:
    65043 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP21 Gene

Proteomics data for MMP21 Gene at MOPED

Selected DME Specific Peptides for MMP21 Gene

Post-translational modifications for MMP21 Gene

Other Protein References for MMP21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for MMP21

Domains & Families for MMP21 Gene

Gene Families for MMP21 Gene

Suggested Antigen Peptide Sequences for MMP21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N119

UniProtKB/Swiss-Prot:

MMP21_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP21: view

Function for MMP21 Gene

Molecular function for MMP21 Gene

UniProtKB/Swiss-Prot Function:
May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin.

Enzyme Numbers (IUBMB) for MMP21 Gene

Gene Ontology (GO) - Molecular Function for MMP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
genes like me logo Genes that share ontologies with MMP21: view
genes like me logo Genes that share phenotypes with MMP21: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP21

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MMP21 Gene

Localization for MMP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP21 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP21 Gene COMPARTMENTS Subcellular localization image for MMP21 gene
Compartment Confidence
extracellular 4
mitochondrion 2
cytosol 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for MMP21 Gene

Pathways & Interactions for MMP21 Gene

genes like me logo Genes that share pathways with MMP21: view

Pathways by source for MMP21 Gene

Interacting Proteins for MMP21 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357798%0d%0a9606.ENSP00000218388%0d%0a9606.ENSP00000262768%0d%0a9606.ENSP00000266085%0d%0a9606.ENSP00000287814%0d%0a
Selected Interacting proteins: ENSP00000357798 for MMP21 Gene via STRING

Gene Ontology (GO) - Biological Process for MMP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with MMP21: view

No data available for SIGNOR curated interactions for MMP21 Gene

Drugs & Compounds for MMP21 Gene

(2) Drugs for MMP21 Gene - From: HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
calcium Nutra 0

(4) Additional Compounds for MMP21 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4

(5) Tocris Compounds for MMP21 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
Marimastat Broad spectrum MMP inhibitor 154039-60-8
ONO 4817 Broad spectrum MMP inhibitor 223472-31-9
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP21: view

Transcripts for MMP21 Gene

mRNA/cDNA for MMP21 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP21 Gene

Matrix metallopeptidase 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP21 Gene

No ASD Table

Relevant External Links for MMP21 Gene

GeneLoc Exon Structure for
MMP21
ECgene alternative splicing isoforms for
MMP21

Expression for MMP21 Gene

mRNA expression in normal human tissues for MMP21 Gene

mRNA differential expression in normal tissues according to GTEx for MMP21 Gene

This gene is overexpressed in Ovary (x4.5).

Protein differential expression in normal tissues from HIPED for MMP21 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP21 Gene



SOURCE GeneReport for Unigene cluster for MMP21 Gene Hs.314141

mRNA Expression by UniProt/SwissProt for MMP21 Gene

Q8N119-MMP21_HUMAN
Tissue specificity: Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
genes like me logo Genes that share expression patterns with MMP21: view

Protein tissue co-expression partners for MMP21 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MMP21 Gene

Orthologs for MMP21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP21 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MMP21 35
  • 82.69 (n)
  • 80.29 (a)
MMP21 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp21 35
  • 78.78 (n)
  • 78.55 (a)
Mmp21 16
Mmp21 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP21 35
  • 99.36 (n)
  • 99.12 (a)
MMP21 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp21 35
  • 77.96 (n)
  • 75.89 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP21 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP21 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp21 35
  • 62.7 (n)
  • 60 (a)
Str.5461 35
African clawed frog
(Xenopus laevis)
Amphibia mmp21-A 35
zebrafish
(Danio rerio)
Actinopterygii LOC100003089 35
  • 58.79 (n)
  • 53.69 (a)
MMP21 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 36
  • 21 (a)
ManyToMany
H19M22.3 36
  • 20 (a)
ManyToMany
zmp-1 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for MMP21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP21 Gene

ENSEMBL:
Gene Tree for MMP21 (if available)
TreeFam:
Gene Tree for MMP21 (if available)

Paralogs for MMP21 Gene

Paralogs for MMP21 Gene

genes like me logo Genes that share paralogs with MMP21: view

Variants for MMP21 Gene

Sequence variations from dbSNP and Humsavar for MMP21 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10901425 - 125,773,956(+) CGGCC(A/G)CGGAC reference, missense
rs28381282 - 125,774,244(-) GCGGG(A/C)GAACG reference, missense
rs28381284 - 125,774,184(-) CCGGC(A/C)GCGCT reference, missense
rs28381302 - 125,770,525(-) TGGAG(A/G)GGTGA reference, missense
rs28381319 - 125,767,581(-) CACGG(C/T)GTTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MMP21 Gene

Variant ID Type Subtype PubMed ID
nsv832017 CNV Loss 17160897
dgv837n71 CNV Gain 21882294
nsv428241 CNV Loss 18775914
dgv324e1 CNV Complex 17122850

Variation tolerance for MMP21 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP21 Gene

HapMap Linkage Disequilibrium report
MMP21
Human Gene Mutation Database (HGMD)
MMP21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP21 Gene

Disorders for MMP21 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MMP21 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
dextrocardia with situs inversus
  • situs inversus
visceral heterotaxy
  • heterotaxia
- elite association - COSMIC cancer census association via MalaCards
Search MMP21 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP21

Genetic Association Database (GAD)
MMP21
Human Genome Epidemiology (HuGE) Navigator
MMP21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP21
genes like me logo Genes that share disorders with MMP21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP21 Gene

Publications for MMP21 Gene

  1. Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer. (PMID: 12490321) Ahokas K. … Saarialho-Kere U. (Gene 2002) 3 4 23 67
  2. MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture. (PMID: 16984259) Skoog T. … Saarialho-Kere U. (Exp. Dermatol. 2006) 3 23
  3. The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer. (PMID: 15015597) Shagisultanova E.I. … Malkhosyan S.R. (Anticancer Res. 2004) 3 23
  4. Matrix metalloproteinase-21 is expressed epithelially during development and in cancer and is up-regulated by transforming growth factor-beta1 in keratinocytes. (PMID: 14691307) Ahokas K. … Saarialho-Kere U. (Lab. Invest. 2003) 3 23
  5. Clinical potential of matrix metalloprotease inhibitors in cancer therapy. (PMID: 10852638) Heath E.I. … Grochow L.B. (Drugs 2000) 25 26

Products for MMP21 Gene

Sources for MMP21 Gene

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