Aliases for CLCN6 Gene
External Ids for CLCN6 Gene
Previous GeneCards Identifiers for CLCN6 Gene
This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
GeneCards Summary for CLCN6 Gene
CLCN6 (Chloride Channel, Voltage-Sensitive 6) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated chloride channel activity and antiporter activity. An important paralog of this gene is CLCN7.
UniProtKB/Swiss-Prot for CLCN6 Gene
Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter