Aliases for EXOSC6 Gene
Aliases for EXOSC6 Gene
External Ids for EXOSC6 Gene
- HGNC: 19055
- Entrez Gene: 118460
- Ensembl: ENSG00000223496
- OMIM: 606490
- UniProtKB: Q5RKV6
Previous GeneCards Identifiers for EXOSC6 Gene
- GC16M070061
- GC16M068841
- GC16M070284
- GC16M056117
Summaries for EXOSC6 Gene
-
This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]
GeneCards Summary for EXOSC6 Gene
EXOSC6 (Exosome Component 6) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Gene Expression. Gene Ontology (GO) annotations related to this gene include exoribonuclease activity. An important paralog of this gene is EXOSC4.
UniProtKB/Swiss-Prot for EXOSC6 Gene
-
Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Additional gene information for EXOSC6 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC6 Gene
Genomics for EXOSC6 Gene
GeneHancer (GH) Regulatory Elements for EXOSC6 Gene
- Top Transcription factor binding sites by QIAGEN in the EXOSC6 gene promoter:
Regulatory Element Products
Genomic Locations for EXOSC6 Gene
- chr16:70,246,778-70,251,930
- (GRCh38/hg38)
- Size:
- 5,153 bases
- Orientation:
- Minus strand
- chr16:70,284,134-70,285,833
- (GRCh37/hg19)
Genomic View for EXOSC6 Gene
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC


RefSeq DNA sequence for EXOSC6 Gene
Proteins for EXOSC6 Gene
-
Protein details for EXOSC6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5RKV6-EXOS6_HUMAN
- Recommended name:
- Exosome complex component MTR3
- Protein Accession:
- Q5RKV6
Protein attributes for EXOSC6 Gene
- Size:
- 272 amino acids
- Molecular mass:
- 28235 Da
- Quaternary structure:
-
- Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure.
Protein Expression for EXOSC6 Gene
Post-translational modifications for EXOSC6 Gene
Other Protein References for EXOSC6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for EXOSC6
-
Abcam antibodies for EXOSC6
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- GeneTex EXOSC6 antibody for EXOSC6
-
Santa Cruz Biotechnology (SCBT) Antibodies for EXOSC6
Protein Products
-
OriGene Purified Proteins for EXOSC6
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-
Abcam proteins for EXOSC6
Assay Products
No data available for DME Specific Peptides for EXOSC6 Gene
Domains & Families for EXOSC6 Gene
Gene Families for EXOSC6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for EXOSC6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for EXOSC6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5RKV6- Family:
-
- Belongs to the RNase PH family.
Function for EXOSC6 Gene
Molecular function for EXOSC6 Gene
- UniProtKB/Swiss-Prot Function:
- Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Phenotypes From GWAS Catalog for EXOSC6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA,IEA | 22681889 |
GO:0004532 | NOT exoribonuclease activity | IDA | 17174896 |
Phenotypes for EXOSC6 Gene
- GenomeRNAi human phenotypes for EXOSC6:
Animal Model Products
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-
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CRISPR Products
-
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-
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miRNA for EXOSC6 Gene
- miRTarBase miRNAs that target EXOSC6
-
- hsa-mir-92a-3p (MIRT049776)
- hsa-mir-5692a (MIRT543624)
- hsa-mir-889-3p (MIRT643536)
- hsa-mir-652-5p (MIRT643537)
- hsa-mir-548as-3p (MIRT643538)
- hsa-mir-4266 (MIRT661880)
- hsa-mir-7160-5p (MIRT661881)
- hsa-mir-6884-5p (MIRT661882)
- hsa-mir-485-5p (MIRT661883)
- hsa-mir-4649-3p (MIRT661884)
- hsa-mir-665 (MIRT661885)
- hsa-mir-4768-3p (MIRT661886)
- hsa-mir-5690 (MIRT661887)
- hsa-mir-4478 (MIRT661888)
- hsa-mir-4419b (MIRT661889)
- hsa-mir-3929 (MIRT661890)
- hsa-mir-4779 (MIRT661891)
- hsa-mir-374c-3p (MIRT661892)
- hsa-mir-4684-5p (MIRT683707)
- hsa-mir-4717-3p (MIRT683708)
- hsa-mir-3675-3p (MIRT683709)
- hsa-mir-942-3p (MIRT683710)
- hsa-mir-6771-3p (MIRT683711)
- hsa-mir-548c-3p (MIRT683712)
- hsa-mir-4738-3p (MIRT709007)
- hsa-mir-6827-3p (MIRT709008)
- hsa-mir-340-3p (MIRT709009)
- hsa-mir-3163 (MIRT709010)
- hsa-mir-129-5p (MIRT783485)
- hsa-mir-599 (MIRT787975)
- hsa-mir-6823-5p (MIRT788967)
miRNA Products
- Search ViGene Biosciences for EXOSC6
Inhibitory RNA Products
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- Overview of 60 available EXOSC6 gene related products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EXOSC6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for EXOSC6
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOSC6 Gene
Localization for EXOSC6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EXOSC6 Gene
- Cytoplasm. Nucleus, nucleolus. Nucleus.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000176 | nuclear exosome (RNase complex) | IBA | -- |
GO:0000177 | cytoplasmic exosome (RNase complex) | IBA | -- |
GO:0000178 | exosome (RNase complex) | IEA,IDA | 20531389 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for EXOSC6 Gene
Pathways & Interactions for EXOSC6 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
2 | Deadenylation-dependent mRNA decay |
.46
|
|
3 | rRNA processing in the nucleus and cytosol |
.89
|
|
4 | PERK regulates gene expression | ||
5 | Gene Expression |
.48
|
Pathways by source for EXOSC6 Gene
14 Reactome pathways for EXOSC6 Gene
1 KEGG pathway for EXOSC6 Gene
1 GeneGo (Thomson Reuters) pathway for EXOSC6 Gene
Interacting Proteins for EXOSC6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006364 | rRNA processing | TAS | -- |
GO:0016075 | rRNA catabolic process | IBA | -- |
GO:0031125 | rRNA 3-end processing | IBA | -- |
GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 | IBA | -- |
GO:0034475 | U4 snRNA 3-end processing | IBA | -- |
No data available for SIGNOR curated interactions for EXOSC6 Gene
Transcripts for EXOSC6 Gene
mRNA/cDNA for EXOSC6 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (96) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EXOSC6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC6
- genomics-online: gRNA clones - Search results for 60 available EXOSC6 gene related products
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- Applied Biological Materials CRISPR for EXOSC6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC6
- GenScript: Design CRISPR guide RNA sequences for EXOSC6
miRNA Products
- Search ViGene Biosciences for EXOSC6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EXOSC6
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- genomics-online: shRNA clones - Search results for 60 available EXOSC6 gene related products
- Overview of 60 available EXOSC6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EXOSC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EXOSC6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for EXOSC6 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOSC6 Gene
NURSA nuclear receptor signaling pathways regulating expression of EXOSC6 Gene:
EXOSC6SOURCE GeneReport for Unigene cluster for EXOSC6 Gene:
Hs.660633Primer Products
-
OriGene qPCR primer pairs for EXOSC6
-
OriGene qPCR primer pairs and template standards for EXOSC6
- genomics-online: primer clones - Search results for 60 available EXOSC6 gene related products
- Overview of 60 available EXOSC6 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOSC6 Gene
Orthologs for EXOSC6 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | EXOSC6 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | EXOSC6 33 |
|
||
mouse (Mus musculus) |
Mammalia | Exosc6 33 16 |
|
||
rat (Rattus norvegicus) |
Mammalia | Exosc6 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | EXOSC6 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rarg 33 |
|
||
Str.64 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6653 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | exosc6 33 34 |
|
||
idibd1130 33 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011906 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Mtr3 34 |
|
OneToOne | |
worm (Caenorhabditis elegans) |
Secernentea | exos-4.2 34 |
|
OneToOne | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SKI6 34 |
|
OneToMany | |
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G27490 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os08g0116800 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU08026 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC211.08c 33 |
|
- Species where no ortholog for EXOSC6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EXOSC6 Gene
Pseudogenes.org Pseudogenes for EXOSC6 Gene
Variants for EXOSC6 Gene
SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11537663 | likely-benign, Charcot-Marie-Tooth, Type 2 | 70,252,647(-) | T/A | upstream_transcript_variant | |
rs116553521 | likely-benign, Charcot-Marie-Tooth, Type 2 | 70,252,470(-) | T/G | upstream_transcript_variant | |
rs140814462 | uncertain-significance, benign, Charcot-Marie-Tooth, Type 2, Charcot-Marie-Tooth disease, type 2 | 70,253,289(-) | C/A/T | upstream_transcript_variant | |
rs141837805 | uncertain-significance, Charcot-Marie-Tooth, Type 2 | 70,252,397(-) | C/T | upstream_transcript_variant | |
rs145581652 | uncertain-significance, benign, Charcot-Marie-Tooth, Type 2, Charcot-Marie-Tooth disease, type 2 | 70,253,741(-) | C/T | upstream_transcript_variant |
Additional Variant Information for EXOSC6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EXOSC6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC6 Gene
Disorders for EXOSC6 Gene
Additional Disease Information for EXOSC6
No disorders were found for EXOSC6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOSC6 Gene
Publications for EXOSC6 Gene
- Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. (PMID: 12419256) Raijmakers R … Pruijn GJ (Journal of molecular biology 2002) 2 3 4 58
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PMID: 11719186) Chen CY … Karin M (Cell 2001) 2 3 4 58
- The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. (PMID: 21255825) Basu U … Alt FW (Cell 2011) 3 4 58
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals RH … Pruijn GJ (The EMBO journal 2010) 3 4 58
- Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PMID: 17174896) Liu Q … Lima CD (Cell 2006) 3 4 58
Products for EXOSC6 Gene
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- Invitrogen Antibodies for EXOSC6
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 30 available EXOSC6 Antibodies ranked by validation data
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- GeneTex EXOSC6 antibody for EXOSC6
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- ViGene Biosciences adenoviral particle packaged cDNA for EXOSC6 gene
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Sources for EXOSC6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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