Aliases for EXOSC6 Gene
Aliases for EXOSC6 Gene
External Ids for EXOSC6 Gene
- HGNC: 19055
- Entrez Gene: 118460
- Ensembl: ENSG00000223496
- OMIM: 606490
- UniProtKB: Q5RKV6
Previous GeneCards Identifiers for EXOSC6 Gene
- GC16M070061
- GC16M068841
- GC16M070284
- GC16M056117
Summaries for EXOSC6 Gene
-
This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]
GeneCards Summary for EXOSC6 Gene
EXOSC6 (Exosome Component 6) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Deadenylation-dependent mRNA decay. GO annotations related to this gene include poly(A) RNA binding and exoribonuclease activity. An important paralog of this gene is EXOSC4.
UniProtKB/Swiss-Prot for EXOSC6 Gene
-
Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC6 Gene
Genomics for EXOSC6 Gene
Regulatory Elements for EXOSC6 Gene
Enhancers for EXOSC6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around EXOSC6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the EXOSC6 gene promoter:
Regulatory Element Products
Genomic Location for EXOSC6 Gene
- Chromosome:
- 16
- Start:
- 70,246,778 bp from pter
- End:
- 70,251,930 bp from pter
- Size:
- 5,153 bases
- Orientation:
- Minus strand
Genomic View for EXOSC6 Gene
Genes around EXOSC6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
EXOSC6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EXOSC6 Gene
Proteins for EXOSC6 Gene
-
Protein details for EXOSC6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5RKV6-EXOS6_HUMAN
- Recommended name:
- Exosome complex component MTR3
- Protein Accession:
- Q5RKV6
Protein attributes for EXOSC6 Gene
- Size:
- 272 amino acids
- Molecular mass:
- 28235 Da
- Quaternary structure:
-
- Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure.
Protein Expression for EXOSC6 Gene
Post-translational modifications for EXOSC6 Gene
Other Protein References for EXOSC6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for EXOSC6
-
Abcam antibodies for EXOSC6
- Invitrogen Antibodies for EXOSC6
- antibodies-online Antibodies for EXOSC6: See all 28
- GeneTex EXOSC6 antibody for EXOSC6
-
Santa Cruz Biotechnology (SCBT) Antibodies for EXOSC6
Protein Products
-
OriGene Purified Proteins for EXOSC6
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOSC6
- Origene Custom Protein Services for EXOSC6
- Novus Biologicals proteins for EXOSC6
- antibodies-online Proteins for EXOSC6: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EXOSC6
-
Abcam proteins for EXOSC6
Assay Products
No data available for DME Specific Peptides for EXOSC6 Gene
Domains & Families for EXOSC6 Gene
Gene Families for EXOSC6 Gene
- HGNC:
Protein Domains for EXOSC6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for EXOSC6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5RKV6- Family:
-
- Belongs to the RNase PH family.
Function for EXOSC6 Gene
Molecular function for EXOSC6 Gene
- UniProtKB/Swiss-Prot Function:
- Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA,IEA | 22681889 |
| GO:0004532 | NOT exoribonuclease activity | IDA | 17174896 |
Phenotypes for EXOSC6 Gene
- GenomeRNAi human phenotypes for EXOSC6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EXOSC6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EXOSC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC6 gene
- Search ViGene Biosciences for EXOSC6
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC6
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC6
- GenScript: Design CRISPR guide RNA sequences for EXOSC6
miRNA for EXOSC6 Gene
- miRTarBase miRNAs that target EXOSC6
-
- hsa-mir-92a-3p (MIRT049776)
- hsa-mir-5692a (MIRT543624)
- hsa-mir-889-3p (MIRT643536)
- hsa-mir-652-5p (MIRT643537)
- hsa-mir-548as-3p (MIRT643538)
- hsa-mir-4266 (MIRT661880)
- hsa-mir-7160-5p (MIRT661881)
- hsa-mir-6884-5p (MIRT661882)
- hsa-mir-485-5p (MIRT661883)
- hsa-mir-4649-3p (MIRT661884)
- hsa-mir-665 (MIRT661885)
- hsa-mir-4768-3p (MIRT661886)
- hsa-mir-5690 (MIRT661887)
- hsa-mir-4478 (MIRT661888)
- hsa-mir-4419b (MIRT661889)
- hsa-mir-3929 (MIRT661890)
- hsa-mir-4779 (MIRT661891)
- hsa-mir-374c-3p (MIRT661892)
- hsa-mir-4684-5p (MIRT683707)
- hsa-mir-4717-3p (MIRT683708)
- hsa-mir-3675-3p (MIRT683709)
- hsa-mir-942-3p (MIRT683710)
- hsa-mir-6771-3p (MIRT683711)
- hsa-mir-548c-3p (MIRT683712)
- hsa-mir-4738-3p (MIRT709007)
- hsa-mir-6827-3p (MIRT709008)
- hsa-mir-340-3p (MIRT709009)
- hsa-mir-3163 (MIRT709010)
miRNA Products
- Search ViGene Biosciences for EXOSC6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for EXOSC6
- Browse OriGene Inhibitory RNA Products For EXOSC6
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC6 gene
Clone Products
-
OriGene ORF clones in human for EXOSC6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder custom plasmid, inducible vectors for EXOSC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for EXOSC6
-
ViGene Biosciences adenoviral particle packaged cDNA for EXOSC6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EXOSC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC6 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOSC6 Gene
Localization for EXOSC6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EXOSC6 Gene
- Cytoplasm. Nucleus, nucleolus. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000176 | nuclear exosome (RNase complex) | IBA | -- |
| GO:0000177 | cytoplasmic exosome (RNase complex) | IBA | -- |
| GO:0000178 | exosome (RNase complex) | IDA,IEA | 20531389 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for EXOSC6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | Deadenylation-dependent mRNA decay |
.47
|
|
| 3 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 4 | PERK regulates gene expression | ||
| 5 | Gene Expression |
.48
|
|
Pathways by source for EXOSC6 Gene
14 Reactome pathways for EXOSC6 Gene
1 KEGG pathway for EXOSC6 Gene
1 GeneGo (Thomson Reuters) pathway for EXOSC6 Gene
Interacting Proteins for EXOSC6 Gene
Selected Interacting proteins:
ENSP00000398597
Q5RKV6-EXOS6_HUMAN
for EXOSC6 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006364 | rRNA processing | TAS | -- |
| GO:0016075 | rRNA catabolic process | IBA | -- |
| GO:0031125 | rRNA 3-end processing | IBA | -- |
| GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 | IBA | -- |
| GO:0034475 | U4 snRNA 3-end processing | IBA | -- |
No data available for SIGNOR curated interactions for EXOSC6 Gene
Transcripts for EXOSC6 Gene
mRNA/cDNA for EXOSC6 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (96) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EXOSC6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC6
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC6
- GenScript: Design CRISPR guide RNA sequences for EXOSC6
miRNA Products
- Search ViGene Biosciences for EXOSC6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for EXOSC6
- Browse OriGene Inhibitory RNA Products For EXOSC6
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC6 gene
Clone Products
-
OriGene ORF clones in human for EXOSC6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EXOSC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for EXOSC6 Gene
This gene is overexpressed in Breast (32.6) and Peripheral blood mononuclear cells (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOSC6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EXOSC6 Gene:
EXOSC6SOURCE GeneReport for Unigene cluster for EXOSC6 Gene:
Hs.660633Primer Products
-
OriGene qPCR primer pairs for EXOSC6
-
OriGene qPCR primer pairs and template standards for EXOSC6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOSC6 Gene
Orthologs for EXOSC6 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EXOSC6 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EXOSC6 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Exosc6 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Exosc6 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EXOSC6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rarg 34 |
|
||
| Str.64 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6653 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | exosc6 35 34 |
|
OneToOne | |
| idibd1130 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011906 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mtr3 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | exos-4.2 35 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SKI6 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G27490 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os08g0116800 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU08026 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC211.08c 34 |
|
- Species where no ortholog for EXOSC6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EXOSC6 Gene
Pseudogenes.org Pseudogenes for EXOSC6 Gene
Variants for EXOSC6 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11537663 | Likely benign | 70,252,647(+) | AAGAT(A/T)CAAAT | nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs116553521 | Likely benign | 70,252,470(+) | AGCCG(G/T)TATCT | nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs149377346 | Likely benign | 70,252,837(+) | ACCAC(C/T)TTTAC | nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| rs150625194 | Likely benign | 70,252,508(+) | AATGC(A/G)GGGTT | nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs35744709 | Likely benign | 70,252,728(-) | TGTAA(A/T)GAACT | nc-transcript-variant, upstream-variant-2KB, reference, missense |
Gene Damage Index Score:
4.33;
63.12% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EXOSC6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EXOSC6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC6 Gene
Disorders for EXOSC6 Gene
Relevant External Links for EXOSC6
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- EXOSC6
No disorders were found for EXOSC6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOSC6 Gene
Publications for EXOSC6 Gene
- Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. (PMID: 12419256) Raijmakers R. … Pruijn G.J.M. (J. Mol. Biol. 2002) 2 3 4 64
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PMID: 11719186) Chen C.-Y. … Karin M. (Cell 2001) 2 3 4 64
- The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. (PMID: 21255825) Basu U. … Alt F.W. (Cell 2011) 3 4 64
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals R.H. … Pruijn G.J. (EMBO J. 2010) 3 4 64
- Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PMID: 17174896) Liu Q. … Lima C.D. (Cell 2006) 3 4 64
Products for EXOSC6 Gene
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- OriGene qPCR primer pairs and template standards for EXOSC6
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- Novus Biologicals Antibodies for EXOSC6
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- Abcam proteins for EXOSC6
- Search for Assays for EXOSC6 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for EXOSC6: See all 28
- Search antibodies-online for kits
- antibodies-online Proteins for EXOSC6: See all 7
- Search antibodies-online for peptides
- GeneTex EXOSC6 antibody for EXOSC6
- Search GeneTex for Proteins for EXOSC6
- ViGene Biosciences adenoviral particle packaged cDNA for EXOSC6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EXOSC6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EXOSC6 gene
- Search ViGene Biosciences for EXOSC6
- Santa Cruz Biotechnology (SCBT) Antibodies for EXOSC6
- Search Santa Cruz Biotechnology (SCBT) for EXOSC6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC6
- Horizon Cell Lines for EXOSC6
- Cyagen custom Knockout/knockin (KOKI) mouse models for EXOSC6
- VectorBuilder custom plasmid, inducible vectors for EXOSC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for EXOSC6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
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