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Aliases for RLN3 Gene

Aliases for RLN3 Gene

  • Relaxin 3 2 3
  • Prorelaxin H3 2 3 4
  • RXN3 3 4 6
  • Insulin-Like Peptide INSL7 3 4
  • Insulin-Like Peptide 7 3 4
  • Insl7 3 4
  • ZINS4 3 4
  • H3 3 6
  • Relaxin 3 (H3) 2
  • Insulin-Like 7 3
  • Relaxin-3 3

External Ids for RLN3 Gene

Summaries for RLN3 Gene

Entrez Gene Summary for RLN3 Gene

  • Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes. [provided by RefSeq, Jul 2008]

GeneCards Summary for RLN3 Gene

RLN3 (Relaxin 3) is a Protein Coding gene. Diseases associated with RLN3 include tick infestation. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include hormone activity and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for RLN3 Gene

  • May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142)

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RLN3 Gene

Genomics for RLN3 Gene

Genomic Location for RLN3 Gene

Start:
14,028,148 bp from pter
End:
14,031,042 bp from pter
Size:
2,895 bases
Orientation:
Plus strand

Genomic View for RLN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RLN3 Gene

Regulatory Elements for RLN3 Gene

Proteins for RLN3 Gene

  • Protein details for RLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXF3-REL3_HUMAN
    Recommended name:
    Relaxin-3
    Protein Accession:
    Q8WXF3
    Secondary Accessions:
    • Q6UXW5

    Protein attributes for RLN3 Gene

    Size:
    142 amino acids
    Molecular mass:
    15451 Da
    Quaternary structure:
    • Heterodimer of a B chain and an A chain linked by two disulfide bonds
    SequenceCaution:
    • Sequence=AAQ88548.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RLN3 Gene

neXtProt entry for RLN3 Gene

Proteomics data for RLN3 Gene at MOPED

Post-translational modifications for RLN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RLN3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RLN3 Gene

Domains for RLN3 Gene

Gene Families for RLN3 Gene

HGNC:

Protein Domains for RLN3 Gene

UniProtKB/Swiss-Prot:

REL3_HUMAN
Family:
  • Belongs to the insulin family.:
    • Q8WXF3
genes like me logo Genes that share domains with RLN3: view

Function for RLN3 Gene

Molecular function for RLN3 Gene

UniProtKB/Swiss-Prot Function: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142)

Gene Ontology (GO) - Molecular Function for RLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 24802387
genes like me logo Genes that share ontologies with RLN3: view
genes like me logo Genes that share phenotypes with RLN3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RLN3 Gene

Localization for RLN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RLN3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RLN3 Gene COMPARTMENTS Subcellular localization image for RLN3 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with RLN3: view

Compounds for RLN3 Gene

(1) Novoseek inferred chemical compound relationships for RLN3 Gene

Compound -log(P) Hits PubMed IDs
adenylate 17.5 1
genes like me logo Genes that share compounds with RLN3: view

Transcripts for RLN3 Gene

mRNA/cDNA for RLN3 Gene

Unigene Clusters for RLN3 Gene

Relaxin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RLN3 Gene

No ASD Table

Relevant External Links for RLN3 Gene

GeneLoc Exon Structure for
RLN3
ECgene alternative splicing isoforms for
RLN3

Expression for RLN3 Gene

mRNA expression in normal human tissues for RLN3 Gene

mRNA differential expression in normal tissues according to GTEx for RLN3 Gene

This gene is overexpressed in Whole Blood (18.5) and Testis (9.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RLN3 Gene

SOURCE GeneReport for Unigene cluster for RLN3 Gene Hs.352155

genes like me logo Genes that share expressions with RLN3: view

Orthologs for RLN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RLN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RLN3 36
  • 98.59 (n)
  • 97.89 (a)
RLN3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RLN3 36
  • 79.75 (n)
  • 77.78 (a)
RLN3 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RLN3 36
  • 81.03 (n)
  • 81.3 (a)
mouse
(Mus musculus)
Mammalia Rln3 36
  • 76.77 (n)
  • 79.55 (a)
Rln3 16
Rln3 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rln3 36
  • 76.26 (n)
  • 77.27 (a)
lizard
(Anolis carolinensis)
Reptilia RLN3 37
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rln1 37
  • 32 (a)
OneToMany
rln3a 37
  • 36 (a)
OneToMany
Species with no ortholog for RLN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RLN3 Gene

ENSEMBL:
Gene Tree for RLN3 (if available)
TreeFam:
Gene Tree for RLN3 (if available)

Paralogs for RLN3 Gene

No data available for Paralogs for RLN3 Gene

Variants for RLN3 Gene

Sequence variations from dbSNP and Humsavar for RLN3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1982631 -- 14,028,597(-) CCATG(A/G)ATGGC intron-variant
rs1982632 -- 14,028,192(-) GGAGA(C/T)GCTTT upstream-variant-2KB
rs7247578 -- 14,027,335(+) gccac(C/T)gcgcc upstream-variant-2KB
rs7249702 -- 14,027,400(+) tttga(A/G)aacca upstream-variant-2KB
rs7259906 -- 14,029,348(+) tcatg(C/T)gctac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RLN3 Gene

Variant ID Type Subtype PubMed ID
nsv911102 CNV Loss 21882294
dgv3739n71 CNV Loss 21882294
dgv3741n71 CNV Loss 21882294
nsv833761 CNV Loss 17160897

Relevant External Links for RLN3 Gene

HapMap Linkage Disequilibrium report
RLN3

Disorders for RLN3 Gene

(1) MalaCards Diseases for RLN3 Gene

Search for RLN3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RLN3 Gene

Relevant External Links for RLN3

Genetic Association Database (GAD)
RLN3
Human Genome Epidemiology (HuGE) Navigator
RLN3
genes like me logo Genes that share disorders with RLN3: view

No data available for UniProtKB/Swiss-Prot for RLN3 Gene

Publications for RLN3 Gene

  1. H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. (PMID: 12506116) Sudo S. … Hsueh A.J.W. (J. Biol. Chem. 2003) 3 4 23
  2. Production of recombinant human relaxin 3 in AtT20 cells. (PMID: 12686464) Kizawa H. … Fujino M. (Regul. Pept. 2003) 3 4 23
  3. Identification of relaxin-3/INSL7 as a ligand for GPCR142. (PMID: 14522967) Liu C. … Lovenberg T.W. (J. Biol. Chem. 2003) 3 4 23
  4. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135. (PMID: 14522968) Liu C. … Lovenberg T.W. (J. Biol. Chem. 2003) 3 4 23
  5. Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. (PMID: 16365033) Rosengren K.J. … Craik D.J. (J. Biol. Chem. 2006) 3 4 23

Products for RLN3 Gene

Sources for RLN3 Gene

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