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Aliases for TAGAP Gene

Aliases for TAGAP Gene

  • T-Cell Activation RhoGTPase Activating Protein 2 3 5
  • TAGAP1 3 4
  • T-Cell Activation Rho GTPase-Activating Protein 3
  • T-Cell Activation GTPase Activating Protein 2
  • T-Cell Activation GTPase-Activating Protein 4
  • ARHGAP47 3
  • FKSG15 3
  • IDDM21 3

External Ids for TAGAP Gene

Previous GeneCards Identifiers for TAGAP Gene

  • GC06M158897
  • GC06M159329
  • GC06M159365
  • GC06M159426
  • GC06M159375
  • GC06M159457
  • GC06M156926

Summaries for TAGAP Gene

Entrez Gene Summary for TAGAP Gene

  • This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for TAGAP Gene

TAGAP (T-Cell Activation RhoGTPase Activating Protein) is a Protein Coding gene. Diseases associated with TAGAP include Diabetes Mellitus, Insulin-Dependent, 21 and Auditory Agnosia. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGAP20.

UniProtKB/Swiss-Prot for TAGAP Gene

  • May function as a GTPase-activating protein and may play important roles during T-cell activation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGAP Gene

Genomics for TAGAP Gene

Regulatory Elements for TAGAP Gene

Enhancers for TAGAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G159098 1.7 FANTOM5 Ensembl ENCODE dbSUPER 41.3 -53.9 -53903 1.8 HDAC1 BMI1 ZBTB40 TCF12 RELB ETV6 IKZF2 CREM ZNF362 JUNB TAGAP RSPH3 SYTL3 DYNLT1 ENSG00000224478 ENSG00000226032
GH06G159060 1.5 FANTOM5 Ensembl ENCODE dbSUPER 26.4 -17.9 -17865 4.8 SCRT1 PKNOX1 SCRT2 MAX ZNF548 CREM SPI1 TAGAP SYTL3 DYNLT1 ENSG00000226032
GH06G159103 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.4 -62.0 -61952 6.5 HDGF PKNOX1 ATF1 FOXA2 WRNIP1 ELK1 ZNF143 FOS NFYC REST TAGAP RSPH3 EZR ENSG00000224478 ENSG00000226032
GH06G159093 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.5 -49.8 -49809 2.8 CTCF EBF1 RELA POLR2A FOXK2 ELK1 EED RELB IKZF2 CREM TAGAP RSPH3 DYNLT1 ENSG00000224478 ENSG00000226032
GH06G159100 1.1 FANTOM5 ENCODE dbSUPER 26.9 -55.0 -55016 0.2 ZNF362 ZMYM3 KDM1A MYC TAGAP RSPH3 ENSG00000224478 ENSG00000226032
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAGAP on UCSC Golden Path with GeneCards custom track

Promoters for TAGAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000206185 852 1801 TBP PKNOX1 MXI1 TAF1 SIN3A MAX ZBTB40 POLR2A EED RELB

Genomic Location for TAGAP Gene

Chromosome:
6
Start:
159,034,468 bp from pter
End:
159,045,152 bp from pter
Size:
10,685 bases
Orientation:
Minus strand

Genomic View for TAGAP Gene

Genes around TAGAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGAP Gene

Proteins for TAGAP Gene

  • Protein details for TAGAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N103-TAGAP_HUMAN
    Recommended name:
    T-cell activation Rho GTPase-activating protein
    Protein Accession:
    Q8N103
    Secondary Accessions:
    • Q2NKM8
    • Q8NI40
    • Q96KZ2
    • Q96QA2

    Protein attributes for TAGAP Gene

    Size:
    731 amino acids
    Molecular mass:
    80703 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAGAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAGAP Gene

Post-translational modifications for TAGAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAGAP Gene

No data available for DME Specific Peptides for TAGAP Gene

Domains & Families for TAGAP Gene

Gene Families for TAGAP Gene

Protein Domains for TAGAP Gene

Suggested Antigen Peptide Sequences for TAGAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TAGAP: view

No data available for UniProtKB/Swiss-Prot for TAGAP Gene

Function for TAGAP Gene

Molecular function for TAGAP Gene

UniProtKB/Swiss-Prot Function:
May function as a GTPase-activating protein and may play important roles during T-cell activation.

Gene Ontology (GO) - Molecular Function for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with TAGAP: view
genes like me logo Genes that share phenotypes with TAGAP: view

Animal Models for TAGAP Gene

MGI Knock Outs for TAGAP:

Animal Model Products

CRISPR Products

miRNA for TAGAP Gene

miRTarBase miRNAs that target TAGAP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAGAP Gene

Localization for TAGAP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAGAP gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TAGAP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAGAP Gene

Pathways & Interactions for TAGAP Gene

genes like me logo Genes that share pathways with TAGAP: view

Pathways by source for TAGAP Gene

Interacting Proteins for TAGAP Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356033%0d%0a9606.ENSP00000400175%0d%0a9606.ENSP00000351132%0d%0a9606.ENSP00000339467%0d%0a9606.ENSP00000308576%0d%0a9606.ENSP00000249071%0d%0a
Selected Interacting proteins: ENSP00000356033 Q8N103-TAGAP_HUMAN for TAGAP Gene via STRING IID

Gene Ontology (GO) - Biological Process for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with TAGAP: view

No data available for SIGNOR curated interactions for TAGAP Gene

Transcripts for TAGAP Gene

Unigene Clusters for TAGAP Gene

T-cell activation RhoGTPase activating protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for TAGAP Gene

GeneLoc Exon Structure for
TAGAP
ECgene alternative splicing isoforms for
TAGAP

Expression for TAGAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAGAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGAP Gene

This gene is overexpressed in Whole Blood (x27.2) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for TAGAP Gene

This gene is overexpressed in Heart (30.8), Peripheral blood mononuclear cells (21.3), Blymphocyte (6.6), and Platelet (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAGAP Gene



Protein tissue co-expression partners for TAGAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAGAP Gene:

TAGAP

SOURCE GeneReport for Unigene cluster for TAGAP Gene:

Hs.529984

Evidence on tissue expression from TISSUES for TAGAP Gene

  • Lung(4.2)
  • Spleen(4.2)
  • Liver(4.1)
  • Blood(3.8)
genes like me logo Genes that share expression patterns with TAGAP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGAP Gene

Orthologs for TAGAP Gene

This gene was present in the common ancestor of animals.

Orthologs for TAGAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGAP 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia TAGAP 34 35
  • 79.35 (n)
mouse
(Mus musculus)
Mammalia Tagap 34 16 35
  • 75.94 (n)
Tagap1 35
  • 53 (a)
OneToMany
1700006A11Rik 35
  • 22 (a)
OneToMany
Gm1527 35
  • 15 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tagap 34
  • 75.94 (n)
cow
(Bos Taurus)
Mammalia TAGAP 34 35
  • 73.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAGAP 35
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAGAP 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAGAP 34 35
  • 59.21 (n)
lizard
(Anolis carolinensis)
Reptilia TAGAP 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tagap 34
  • 54.29 (n)
zebrafish
(Danio rerio)
Actinopterygii tagapb 34 35
  • 46.09 (n)
tagapa 35
  • 28 (a)
OneToMany
arhgap20 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-2 35
  • 8 (a)
OneToMany
Species where no ortholog for TAGAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGAP Gene

ENSEMBL:
Gene Tree for TAGAP (if available)
TreeFam:
Gene Tree for TAGAP (if available)

Paralogs for TAGAP Gene

Paralogs for TAGAP Gene

(1) SIMAP similar genes for TAGAP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAGAP: view

Variants for TAGAP Gene

Sequence variations from dbSNP and Humsavar for TAGAP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000412339 -- 159,045,152(+) TATGT(C/T)TTTTT intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1000491823 -- 159,040,954(+) TGGCC(C/T)TTCAT intron-variant, nc-transcript-variant
rs1000953049 -- 159,041,152(+) GCAGA(A/G)TGCAT intron-variant
rs1000992306 -- 159,046,119(+) TGCTA(A/G)GCTTA intron-variant, upstream-variant-2KB
rs1001366129 -- 159,047,123(+) GACGG(A/G)CTTTT intron-variant, upstream-variant-2KB

Variation tolerance for TAGAP Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAGAP Gene

Human Gene Mutation Database (HGMD)
TAGAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAGAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAGAP Gene

Disorders for TAGAP Gene

MalaCards: The human disease database

(5) MalaCards diseases for TAGAP Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent, 21
  • type 1 diabetes mellitus 21
auditory agnosia
celiac disease
  • celiac sprue
anus disease
  • anal disease
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards
Search TAGAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAGAP

Genetic Association Database (GAD)
TAGAP
Human Genome Epidemiology (HuGE) Navigator
TAGAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAGAP
genes like me logo Genes that share disorders with TAGAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAGAP Gene

Publications for TAGAP Gene

  1. Newly identified genetic risk variants for celiac disease related to the immune response. (PMID: 18311140) Hunt K.A. … van Heel D.A. (Nat. Genet. 2008) 2 3 46 64
  2. A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. (PMID: 21298027) Festen E.A. … Rioux J.D. (PLoS Genet. 2011) 3 46 64
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  4. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PMID: 22190364) Patsopoulos N.A. … de Bakker P.I. (Ann. Neurol. 2011) 3 46 64
  5. Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort. (PMID: 19693089) Amundsen S.S. … Sollid L.M. (Genes Immun. 2010) 3 46 64

Products for TAGAP Gene

Sources for TAGAP Gene

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