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Aliases for GALNT15 Gene

Aliases for GALNT15 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 15 2 3
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 2 2 3
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 15 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 2 3 4
  • Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 2 3 4
  • Protein-UDP Acetylgalactosaminyltransferase-Like Protein 2 3 4
  • Polypeptide GalNAc Transferase-Like Protein 2 3 4
  • Polypeptide GalNAc Transferase 15 2 3
  • Pp-GaNTase-Like Protein 2 3 4
  • GalNAc-T-Like Protein 2 3 4
  • GALNACT15 3 6
  • GALNTL2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 7 3
  • Pregnancy-Induced Hypertension Syndrome-Related Protein 5 3
  • Polypeptide N-Acetylgalactosaminyltransferase 13 3
  • UDP-GalNAc Transferase T15 3
  • Pp-GalNAc-T15 3
  • EC 2.4.1.41 4
  • GALNT13 3
  • GALNT7 3
  • PIH5 3

External Ids for GALNT15 Gene

Previous Symbols for GALNT15 Gene

  • GALNTL2

Summaries for GALNT15 Gene

GeneCards Summary for GALNT15 Gene

GALNT15 (Polypeptide N-Acetylgalactosaminyltransferase 15) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT15 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate

Gene Wiki entry for GALNT15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT15 Gene

Genomics for GALNT15 Gene

Genomic Location for GALNT15 Gene

Start:
16,174,579 bp from pter
End:
16,244,524 bp from pter
Size:
69,946 bases
Orientation:
Plus strand

Genomic View for GALNT15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT15 Gene

No data available for Regulatory Elements for GALNT15 Gene

Proteins for GALNT15 Gene

  • Protein details for GALNT15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3T1-GLT15_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 15
    Protein Accession:
    Q8N3T1
    Secondary Accessions:
    • A6NMN1
    • B2R638
    • F1LIP6
    • Q86T60
    • Q96C46
    • Q96DJ5

    Protein attributes for GALNT15 Gene

    Size:
    639 amino acids
    Molecular mass:
    73063 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD89983.1; Type=Frameshift; Positions=169, 192, 206, 222, 270; Evidence={ECO:0000305};

neXtProt entry for GALNT15 Gene

Proteomics data for GALNT15 Gene at MOPED

Post-translational modifications for GALNT15 Gene

  • Glycosylation at Asn107 and Asn574

Other Protein References for GALNT15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GALNT15 Gene

Domains for GALNT15 Gene

Gene Families for GALNT15 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Suggested Antigen Peptide Sequences for GALNT15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N3T1

UniProtKB/Swiss-Prot:

GLT15_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q8N3T1
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.:
    • Q8N3T1
  • Contains 1 ricin B-type lectin domain.:
    • Q8N3T1
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q8N3T1
genes like me logo Genes that share domains with GALNT15: view

Function for GALNT15 Gene

Molecular function for GALNT15 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate

Enzyme Numbers (IUBMB) for GALNT15 Gene

Gene Ontology (GO) - Molecular Function for GALNT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT15: view

Phenotypes for GALNT15 Gene

GenomeRNAi human phenotypes for GALNT15:
genes like me logo Genes that share phenotypes with GALNT15: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GALNT15 Gene

Localization for GALNT15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT15 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for GALNT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with GALNT15: view

No data available for Subcellular locations from COMPARTMENTS for GALNT15 Gene

Pathways for GALNT15 Gene

genes like me logo Genes that share pathways with GALNT15: view

Pathways by source for GALNT15 Gene

UniProtKB/Swiss-Prot Q8N3T1-GLT15_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for GALNT15 Gene

Gene Ontology (GO) - Biological Process for GALNT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GALNT15: view

Transcripts for GALNT15 Gene

Unigene Clusters for GALNT15 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - - - -
SP3:
SP4:
SP5: - - - - - - - - - - - - -
SP6:

Relevant External Links for GALNT15 Gene

GeneLoc Exon Structure for
GALNT15
ECgene alternative splicing isoforms for
GALNT15

Expression for GALNT15 Gene

mRNA expression in normal human tissues for GALNT15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT15 Gene

This gene is overexpressed in Adipose - Subcutaneous (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GALNT15 Gene

SOURCE GeneReport for Unigene cluster for GALNT15 Gene Hs.411308

mRNA Expression by UniProt/SwissProt for GALNT15 Gene

Q8N3T1-GLT15_HUMAN
Tissue specificity: Widely expressed. Highly expressed in small intestine, placenta, spleen, cerebral cortex and ovary. Expressed at intermediate level in uterus, mammary gland, stomach, cerebellum and whole brain. Weakly expressed in fetal brain, bone marrow, thyroid gland, thymus, heart, skeletal muscle, lung, liver, colon, pancreas, kidney and testis. Not expressed in leukocyte. Expressed in both normal and osteoarthritic cartilage. Expressed at low level in chondrocytes in all zones of both normal and osteoarthritic cartilage.
genes like me logo Genes that share expressions with GALNT15: view

Orthologs for GALNT15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GALNT15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNTL2 35
  • 99.17 (n)
  • 99.06 (a)
GALNTL2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT15 36
  • 74 (a)
OneToOne
GALNTL2 35
  • 79.04 (n)
  • 74.09 (a)
dog
(Canis familiaris)
Mammalia GALNT15 35
  • 87.75 (n)
  • 86.59 (a)
GALNT15 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt15 35
  • 82.42 (n)
  • 78.02 (a)
Galnt15 16
Galnt15 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT15 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT15 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt15 35
  • 79.02 (n)
  • 75.39 (a)
chicken
(Gallus gallus)
Aves GALNT15 36
  • 59 (a)
OneToOne
GALNTL2 35
  • 66.82 (n)
  • 59.15 (a)
lizard
(Anolis carolinensis)
Reptilia GALNT15 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt15 35
  • 57 (n)
  • 51.33 (a)
Species with no ortholog for GALNT15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GALNT15 Gene

ENSEMBL:
Gene Tree for GALNT15 (if available)
TreeFam:
Gene Tree for GALNT15 (if available)

Paralogs for GALNT15 Gene

genes like me logo Genes that share paralogs with GALNT15: view

Variants for GALNT15 Gene

Sequence variations from dbSNP and Humsavar for GALNT15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14210 -- 16,227,559(+) TGAAC(G/T)TAAAG utr-variant-3-prime, intron-variant
rs14576 -- 16,227,479(+) CAGAT(A/C)AATGC synonymous-codon, reference, intron-variant
rs15767 -- 16,227,467(+) TGGCG(A/T)TTTGA synonymous-codon, reference, intron-variant
rs712873 -- 16,243,187(-) AAGCC(C/T)TGGGA intron-variant
rs842242 -- 16,237,875(-) ATTGC(C/G)TAAAC intron-variant

Relevant External Links for GALNT15 Gene

HapMap Linkage Disequilibrium report
GALNT15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GALNT15 Gene

Disorders for GALNT15 Gene

No disorders were found for GALNT15 Gene.

No data available for UniProtKB/Swiss-Prot for GALNT15 Gene

Publications for GALNT15 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  3. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc- T15. (PMID: 15147861) Cheng L. … Narimatsu H. (FEBS Lett. 2004) 2 3 4
  4. Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. (PMID: 11597177) Kumar S. … Lark M.W. (Osteoarthritis Cartilage 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GALNT15 Gene

Sources for GALNT15 Gene

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