Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCD Gene

Aliases for DCD Gene

  • Dermcidin 2 3 3 5
  • Preproteolysin 2 3 4
  • Diffusible Survival/Evasion Peptide 2 3
  • Proteolysis Inducing Factor 2 3
  • Survival Promoting Peptide 2 3
  • AIDD 3 4
  • DSEP 3 4
  • EC 3.4.-.- 4
  • DCD-1 3
  • HCAP 3
  • PIF 3

External Ids for DCD Gene

Previous GeneCards Identifiers for DCD Gene

  • GC12P049932
  • GC12M055152
  • GC12M054755
  • GC12M053324
  • GC12M055038
  • GC12M052076

Summaries for DCD Gene

Entrez Gene Summary for DCD Gene

  • This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for DCD Gene

DCD (Dermcidin) is a Protein Coding gene. Diseases associated with DCD include Skin Conditions and Angiomyoma. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for DCD Gene

  • DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).

  • Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

Gene Wiki entry for DCD Gene

Additional gene information for DCD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCD Gene

Genomics for DCD Gene

GeneHancer (GH) Regulatory Elements for DCD Gene

Promoters and enhancers for DCD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I054976 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.5 -333.1 -333105 9.9 HDGF PKNOX1 FOXA2 SMAD1 IRF4 ZNF766 GATA2 ZNF207 ZNF143 ATF7 TESPA1 NEUROD4 DCD GC12M054982 GC12P054960
GH12I054634 Promoter 0.5 EPDnew 0.4 +13.6 13578 0.1 LACRT DCD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCD gene promoter:

Genomic Locations for DCD Gene

Genomic Locations for DCD Gene
chr12:54,644,591-54,648,493
(GRCh38/hg38)
Size:
3,903 bases
Orientation:
Minus strand
chr12:55,038,375-55,042,277
(GRCh37/hg19)

Genomic View for DCD Gene

Genes around DCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCD Gene

Proteins for DCD Gene

  • Protein details for DCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P81605-DCD_HUMAN
    Recommended name:
    Dermcidin
    Protein Accession:
    P81605
    Secondary Accessions:
    • A5JHP2
    • A5JHP3
    • P58461
    • Q53YJ2

    Protein attributes for DCD Gene

    Size:
    110 amino acids
    Molecular mass:
    11284 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DCD Gene

    Alternative splice isoforms for DCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCD Gene

Post-translational modifications for DCD Gene

No Post-translational modifications

Other Protein References for DCD Gene

No data available for DME Specific Peptides for DCD Gene

Domains & Families for DCD Gene

Gene Families for DCD Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for DCD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCD: view

No data available for UniProtKB/Swiss-Prot for DCD Gene

Function for DCD Gene

Molecular function for DCD Gene

UniProtKB/Swiss-Prot Function:
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).
UniProtKB/Swiss-Prot Function:
Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

Enzyme Numbers (IUBMB) for DCD Gene

Phenotypes From GWAS Catalog for DCD Gene

Gene Ontology (GO) - Molecular Function for DCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DCD: view
genes like me logo Genes that share phenotypes with DCD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCD Gene

Localization for DCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCD Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCD gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0031012 extracellular matrix IDA 23979707
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with DCD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCD Gene

Pathways & Interactions for DCD Gene

genes like me logo Genes that share pathways with DCD: view

Pathways by source for DCD Gene

3 Reactome pathways for DCD Gene

Gene Ontology (GO) - Biological Process for DCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0019730 antimicrobial humoral response TAS --
GO:0031640 killing of cells of other organism IEA --
GO:0042742 defense response to bacterium IEA --
GO:0050832 defense response to fungus IEA --
genes like me logo Genes that share ontologies with DCD: view

No data available for SIGNOR curated interactions for DCD Gene

Drugs & Compounds for DCD Gene

(7) Drugs for DCD Gene - From: DrugBank, ClinicalTrials, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2430
Basiliximab Approved, Investigational Pharma 140
Manganese Approved Nutra 37
Antibodies Pharma 7224
Antibodies, Monoclonal Pharma 4660
genes like me logo Genes that share compounds with DCD: view

Transcripts for DCD Gene

mRNA/cDNA for DCD Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCD Gene

Dermcidin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCD Gene

No ASD Table

Relevant External Links for DCD Gene

GeneLoc Exon Structure for
DCD
ECgene alternative splicing isoforms for
DCD

Expression for DCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCD Gene

mRNA differential expression in normal tissues according to GTEx for DCD Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x29.6) and Skin - Not Sun Exposed (Suprapubic) (x21.8).

Protein differential expression in normal tissues from HIPED for DCD Gene

This gene is overexpressed in Brain (19.2), Pancreatic juice (12.4), and Serum (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCD Gene



NURSA nuclear receptor signaling pathways regulating expression of DCD Gene:

DCD

SOURCE GeneReport for Unigene cluster for DCD Gene:

Hs.350570

mRNA Expression by UniProt/SwissProt for DCD Gene:

P81605-DCD_HUMAN
Tissue specificity: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.

Evidence on tissue expression from TISSUES for DCD Gene

  • Skin(4.7)
  • Liver(4.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with DCD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCD Gene

Orthologs for DCD Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCD 33 34
  • 99.7 (n)
Species where no ortholog for DCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCD Gene

ENSEMBL:
Gene Tree for DCD (if available)
TreeFam:
Gene Tree for DCD (if available)

Paralogs for DCD Gene

No data available for Paralogs for DCD Gene

Variants for DCD Gene

Sequence variations from dbSNP and Humsavar for DCD Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1002139151 -- 54,648,505(-) T/G upstream_transcript_variant
rs1002144556 -- 54,648,389(-) T/C 5_prime_UTR_variant
rs1002426888 -- 54,650,123(-) G/A upstream_transcript_variant
rs1002646146 -- 54,644,262(-) C/T downstream_transcript_variant
rs1002789379 -- 54,644,818(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCD Gene

Variant ID Type Subtype PubMed ID
nsv832421 CNV gain 17160897

Variation tolerance for DCD Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCD Gene

Disorders for DCD Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCD Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
angiomyoma
  • vascular leiomyoma
- elite association - COSMIC cancer census association via MalaCards
Search DCD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DCD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCD Gene

Publications for DCD Gene

  1. Dermcidin: a novel human antibiotic peptide secreted by sweat glands. (PMID: 11694882) Schittek B … Garbe C (Nature immunology 2001) 2 3 4 22 58
  2. Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles. (PMID: 20510021) Jung HH … Kim JI (BMB reports 2010) 3 4 22 58
  3. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. (PMID: 17448443) Lee Motoyama JP … Suzuki K (Biochemical and biophysical research communications 2007) 3 4 22 58
  4. Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits. (PMID: 19670153) Schleinitz D … Stumvoll M (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2010) 3 44 58
  5. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. (PMID: 19833888) Simonis-Bik AM … 't Hart LM (Diabetes 2010) 3 44 58

Products for DCD Gene

Sources for DCD Gene

Content
Loading form....