Aliases for CATSPER1 Gene
External Ids for CATSPER1 Gene
Previous GeneCards Identifiers for CATSPER1 Gene
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]
GeneCards Summary for CATSPER1 Gene
CATSPER1 (Cation Channel Sperm Associated 1) is a Protein Coding gene. Diseases associated with CATSPER1 include spermatogenic failure 7 and non-syndromic male infertility due to sperm motility disorder. Among its related pathways are Reproduction and Sweet Taste Signaling. GO annotations related to this gene include ion channel activity and calcium activated cation channel activity. An important paralog of this gene is CACNA1A.
UniProtKB/Swiss-Prot for CATSPER1 Gene
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.