Aliases for ADCYAP1R1 Gene
External Ids for ADCYAP1R1 Gene
Previous GeneCards Identifiers for ADCYAP1R1 Gene
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
GeneCards Summary for ADCYAP1R1 Gene
ADCYAP1R1 (Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type I) is a Protein Coding gene. Diseases associated with ADCYAP1R1 include post-traumatic stress disorder. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include receptor activity and ADP-ribosylation factor binding. An important paralog of this gene is VIPR2.
UniProtKB/Swiss-Prot for ADCYAP1R1 Gene
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock, emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human PAC1 receptor gene has been localized to chromosome 7p14.