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Aliases for AGAP1 Gene

Aliases for AGAP1 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1 2 3
  • GTP-Binding And GTPase-Activating Protein 1 3 4
  • Centaurin, Gamma 2 2 3
  • Cnt-G2 3 4
  • CENTG2 3 4
  • AGAP-1 3 4
  • GGAP1 3 4
  • Arf GAP With GTP-Binding Protein-Like, ANK Repeat And PH Domains 1 3
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 1 3
  • Centaurin-Gamma-2 4
  • KIAA1099 4

External Ids for AGAP1 Gene

Previous HGNC Symbols for AGAP1 Gene

  • CENTG2

Previous GeneCards Identifiers for AGAP1 Gene

  • GC02P236068
  • GC02P236402
  • GC02P228413

Summaries for AGAP1 Gene

Entrez Gene Summary for AGAP1 Gene

  • This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for AGAP1 Gene

AGAP1 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include GTP binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for AGAP1 Gene

  • GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.

Gene Wiki entry for AGAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP1 Gene

Genomics for AGAP1 Gene

Regulatory Elements for AGAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGAP1 Gene

235,494,089 bp from pter
236,131,800 bp from pter
637,712 bases
Plus strand

Genomic View for AGAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP1 Gene

Proteins for AGAP1 Gene

  • Protein details for AGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RTX7
    • Q541S5
    • Q6P9D7
    • Q9NV93

    Protein attributes for AGAP1 Gene

    857 amino acids
    Molecular mass:
    94470 Da
    Quaternary structure:
    • Homodimer. Interacts with several subunits of the AP-3 protein complex: AP3M1, AP3S1 and AP3S2. Interacts with GUCY1A3 and GUCY1B3.
    • Sequence=AAH60814.1; Type=Miscellaneous discrepancy; Note=A 4-nucleotides insertion of unknown origin disrupts the reading frame.; Evidence={ECO:0000305}; Sequence=BAA83051.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91862.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AGAP1 Gene


neXtProt entry for AGAP1 Gene

Proteomics data for AGAP1 Gene at MOPED

Post-translational modifications for AGAP1 Gene

Antibody Products

No data available for DME Specific Peptides for AGAP1 Gene

Domains for AGAP1 Gene

Gene Families for AGAP1 Gene

  • ANKRD :Ankyrin repeat domain containing
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for AGAP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UPQ3
  • The PH domain mediates AP-3 binding
  • Contains 1 Arf-GAP domain.
  • Contains 1 PH domain.
  • Belongs to the centaurin gamma-like family.
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with AGAP1: view

Function for AGAP1 Gene

Molecular function for AGAP1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity stimulated by phosphatidylinositol 3,4,5-trisphosphate (PIP3) and, to a lesser extent, by phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidic acid potentiates PIP2 stimulation
UniProtKB/Swiss-Prot Function:
GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.

Gene Ontology (GO) - Molecular Function for AGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
GO:0005543 phospholipid binding IDA 18954304
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with AGAP1: view

Phenotypes for AGAP1 Gene

genes like me logo Genes that share phenotypes with AGAP1: view

Animal Model Products

miRNA for AGAP1 Gene

miRTarBase miRNAs that target AGAP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGAP1 Gene

Localization for AGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGAP1 Gene

Cytoplasm. Note=Associates with the endocytic compartment.

Subcellular locations from

Jensen Localization Image for AGAP1 Gene COMPARTMENTS Subcellular localization image for AGAP1 gene
Compartment Confidence
cytosol 3
nucleus 3
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with AGAP1: view

Pathways for AGAP1 Gene

SuperPathways for AGAP1 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with AGAP1: view

Pathways by source for AGAP1 Gene

1 KEGG pathway for AGAP1 Gene

Gene Ontology (GO) - Biological Process for AGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP1: view

Compounds for AGAP1 Gene

(13) HMDB Compounds for AGAP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
  • Dipalmitoylphosphatidic acid
  • PA(16:0/18:1n7)
Not Available
  • PA(16:0/18:1n9)
Not Available
  • PA(34:2)
Not Available
genes like me logo Genes that share compounds with AGAP1: view

Transcripts for AGAP1 Gene

Unigene Clusters for AGAP1 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - -
SP2: - -

Relevant External Links for AGAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGAP1 Gene

mRNA expression in normal human tissues for AGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for AGAP1 Gene

This gene is overexpressed in Urine (33.0), Fetal Brain (13.0), and Brain (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGAP1 Gene

SOURCE GeneReport for Unigene cluster for AGAP1 Gene Hs.435039

mRNA Expression by UniProt/SwissProt for AGAP1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with AGAP1: view

Expression partners for AGAP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AGAP1 Gene

Orthologs for AGAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia AGAP1 35
  • 92.14 (n)
  • 98.13 (a)
AGAP1 36
  • 98 (a)
(Mus musculus)
Mammalia Agap1 35
  • 89.73 (n)
  • 97.55 (a)
Agap1 16
Agap1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Agap1 35
  • 87.89 (n)
  • 96.11 (a)
(Bos Taurus)
Mammalia AGAP1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
(Pan troglodytes)
Mammalia AGAP1 36
  • 99 (a)
(Gallus gallus)
Aves AGAP1 35
  • 84.99 (n)
  • 96.62 (a)
-- 36
  • 96 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
-- 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia agap1 35
  • 77.76 (n)
  • 91.29 (a)
(Danio rerio)
Actinopterygii agap1 35
  • 78.16 (n)
  • 89.86 (a)
agap1 36
  • 89 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009160 35
  • 58.7 (n)
  • 57.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 35
  • 55.98 (n)
  • 53.99 (a)
cenG1A 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea cnt-2 35
  • 51.55 (n)
  • 47.93 (a)
cnt-2 36
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13853 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for AGAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGAP1 Gene

Gene Tree for AGAP1 (if available)
Gene Tree for AGAP1 (if available)

Paralogs for AGAP1 Gene Pseudogenes for AGAP1 Gene

genes like me logo Genes that share paralogs with AGAP1: view

Variants for AGAP1 Gene

Sequence variations from dbSNP and Humsavar for AGAP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs16795 -- 235,514,783(+) CCAGG(A/C)CTGGA intron-variant
rs717518 -- 235,601,057(-) tactg(G/T)ggcag intron-variant
rs722502 -- 236,075,472(-) TACGA(A/T)GTCCA intron-variant
rs731651 -- 236,064,969(+) TTCTT(C/T)CCAAA intron-variant
rs746554 -- 235,512,968(+) CTCTG(G/T)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP1 Gene

Variant ID Type Subtype PubMed ID
nsv527654 CNV Gain 19592680
nsv876029 CNV Gain 21882294
nsv834575 CNV Gain 17160897
esv1000874 CNV Insertion 20482838
esv2424821 CNV Deletion 19546169
esv25019 CNV Loss 19812545
esv2721687 CNV Deletion 23290073
esv2721688 CNV Deletion 23290073
nsv213603 CNV Loss 16902084
esv2721689 CNV Deletion 23290073
esv1723837 CNV Insertion 17803354
esv2721690 CNV Deletion 23290073
esv2721691 CNV Deletion 23290073
nsv876030 CNV Gain 21882294
nsv460141 CNV Loss 19166990
esv2721692 CNV Deletion 23290073
nsv876031 CNV Gain 21882294
nsv821919 CNV Gain 20364138
esv24255 CNV Loss 19812545
esv2721693 CNV Deletion 23290073
esv2721697 CNV Deletion 23290073
esv2661531 CNV Deletion 23128226
esv2721698 CNV Deletion 23290073
esv2670324 CNV Deletion 23128226
esv2721699 CNV Deletion 23290073
esv22988 CNV Loss 19812545
esv2647729 CNV Insertion 19546169
esv2721700 CNV Deletion 23290073
esv2675448 CNV Deletion 23128226
esv275222 CNV Loss 21479260
nsv876032 CNV Gain 21882294
nsv522224 CNV Gain 19592680
esv2521379 CNV Deletion 19546169
esv259545 OTHER Complex 20981092
esv259715 OTHER Complex 20981092
esv1341911 CNV Insertion 17803354
nsv214308 CNV Insertion 16902084
esv2751845 CNV Gain 17911159
nsv876033 CNV Gain 21882294
nsv524185 CNV Loss 19592680
esv2659699 CNV Deletion 23128226
esv33938 CNV Loss 17666407
dgv4456n71 CNV Loss 21882294
nsv821922 CNV Gain 20364138
nsv876036 CNV Loss 21882294

Relevant External Links for AGAP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP1 Gene

Disorders for AGAP1 Gene

Relevant External Links for AGAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for AGAP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AGAP1 Gene

Publications for AGAP1 Gene

  1. AGAP1, an endosome-associated, phosphoinositide-dependent ADP- ribosylation factor GTPase-activating protein that affects actin cytoskeleton. (PMID: 12388557) Nie Z. … Randazzo P.A. (J. Biol. Chem. 2002) 3 4 23
  2. AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. (PMID: 15381706) Meurer S. … Gross S. (J. Biol. Chem. 2004) 3 4 23
  3. Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene. (PMID: 15892143) Wassink T.H. … Sheffield V.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005) 3 4 23
  4. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. (PMID: 16079295) Nie Z. … Randazzo P.A. (J. Cell Sci. 2005) 3 4 23
  5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4

Products for AGAP1 Gene

Sources for AGAP1 Gene

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