Aliases for SLC26A8 Gene
External Ids for SLC26A8 Gene
Previous GeneCards Identifiers for SLC26A8 Gene
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]
GeneCards Summary for SLC26A8 Gene
SLC26A8 (Solute Carrier Family 26 (Anion Exchanger), Member 8) is a Protein Coding gene. Diseases associated with SLC26A8 include spermatogenic failure 3 and non-syndromic male infertility due to sperm motility disorder. Among its related pathways are Tenofovir/Adefovir Pathway, Pharmacokinetics. GO annotations related to this gene include chloride channel activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A2.
UniProtKB/Swiss-Prot for SLC26A8 Gene
Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.