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Aliases for CKS1B Gene

Aliases for CKS1B Gene

  • CDC28 Protein Kinase Regulatory Subunit 1B 2 3
  • CKS1 3 4 6
  • CDC28 Protein Kinase 1B 2 3
  • CKS-1 3 4
  • NB4 Apoptosis/Differentiation Related Protein 3
  • Cyclin-Dependent Kinases Regulatory Subunit 1 3
  • Cell Division Control Protein CKS1 3
  • CDC2-Associated Protein CKS1 3
  • CDC28 Protein Kinase 1 3
  • PNAS-143 3
  • PNAS-16 3
  • PNAS-18 3
  • Ckshs1 3

External Ids for CKS1B Gene

Summaries for CKS1B Gene

Entrez Gene Summary for CKS1B Gene

  • CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

GeneCards Summary for CKS1B Gene

CKS1B (CDC28 Protein Kinase Regulatory Subunit 1B) is a Protein Coding gene. Diseases associated with CKS1B include mantle cell lymphoma. Among its related pathways are Pathways in cancer and Cell Cycle, Mitotic. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CKS2.

UniProtKB/Swiss-Prot for CKS1B Gene

  • Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function

Gene Wiki entry for CKS1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKS1B Gene

Genomics for CKS1B Gene

Genomic Location for CKS1B Gene

Start:
154,974,642 bp from pter
End:
154,979,249 bp from pter
Size:
4,608 bases
Orientation:
Plus strand

Genomic View for CKS1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKS1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKS1B Gene

Regulatory Elements for CKS1B Gene

Proteins for CKS1B Gene

  • Protein details for CKS1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61024-CKS1_HUMAN
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 1
    Protein Accession:
    P61024
    Secondary Accessions:
    • P33551

    Protein attributes for CKS1B Gene

    Size:
    79 amino acids
    Molecular mass:
    9660 Da
    Quaternary structure:
    • Forms a homohexamer that can probably bind six kinase subunits

    Three dimensional structures from OCA and Proteopedia for CKS1B Gene

neXtProt entry for CKS1B Gene

Proteomics data for CKS1B Gene at MOPED

Post-translational modifications for CKS1B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys4

Other Protein References for CKS1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CKS1B Gene

Domains for CKS1B Gene

Protein Domains for CKS1B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P61024

UniProtKB/Swiss-Prot:

CKS1_HUMAN
Family:
  • Belongs to the CKS family.:
    • P61024
genes like me logo Genes that share domains with CKS1B: view

No data available for Gene Families for CKS1B Gene

Function for CKS1B Gene

Molecular function for CKS1B Gene

UniProtKB/Swiss-Prot Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function

Gene Ontology (GO) - Molecular Function for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12813041
GO:0016301 kinase activity --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
genes like me logo Genes that share ontologies with CKS1B: view
genes like me logo Genes that share phenotypes with CKS1B: view

Animal Models for CKS1B Gene

MGI Knock Outs for CKS1B:

miRNA for CKS1B Gene

miRTarBase miRNAs that target CKS1B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CKS1B Gene

Localization for CKS1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKS1B Gene COMPARTMENTS Subcellular localization image for CKS1B gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CKS1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CKS1B Gene

Pathways for CKS1B Gene

genes like me logo Genes that share pathways with CKS1B: view

Pathways by source for CKS1B Gene

Gene Ontology (GO) - Biological Process for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8601310
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0007049 cell cycle --
GO:0008283 cell proliferation TAS 2227411
genes like me logo Genes that share ontologies with CKS1B: view

Compounds for CKS1B Gene

(1) Drugbank Compounds for CKS1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Meta Vanadate
target

(2) Novoseek inferred chemical compound relationships for CKS1B Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 2
hydrogen 0 3
genes like me logo Genes that share compounds with CKS1B: view

Transcripts for CKS1B Gene

Unigene Clusters for CKS1B Gene

CDC28 protein kinase regulatory subunit 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKS1B Gene

No ASD Table

Relevant External Links for CKS1B Gene

GeneLoc Exon Structure for
CKS1B
ECgene alternative splicing isoforms for
CKS1B

Expression for CKS1B Gene

mRNA expression in normal human tissues for CKS1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CKS1B Gene

SOURCE GeneReport for Unigene cluster for CKS1B Gene Hs.374378

genes like me logo Genes that share expressions with CKS1B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CKS1B Gene

Orthologs for CKS1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CKS1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKS1B 35
  • 100 (n)
  • 100 (a)
CKS1B 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CKS1B 35
  • 96.2 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia CKS1B 35
  • 94.94 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Cks1b 35
  • 93.25 (n)
  • 100 (a)
Cks1b 16
Cks1b 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CKS1B 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cks1b 35
  • 92.83 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves CKS1B 35
  • 81.01 (n)
  • 97.47 (a)
CKS1B 36
  • 97 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 95 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.3190 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cks1b 35
  • 79.65 (n)
  • 93.51 (a)
Str.7452 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1323 35
zebrafish
(Danio rerio)
Actinopterygii cks1b 35
  • 79.73 (n)
  • 93.24 (a)
cks1b 36
  • 87 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003796 35
  • 66.2 (n)
  • 73.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cks85A 35
  • 67.61 (n)
  • 71.83 (a)
Cks85A 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cks-1 35
  • 65.8 (n)
  • 63.64 (a)
cks-1 36
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKS1 36
  • 26 (a)
OneToMany
CKS1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for CKS1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKS1B Gene

ENSEMBL:
Gene Tree for CKS1B (if available)
TreeFam:
Gene Tree for CKS1B (if available)

Paralogs for CKS1B Gene

Paralogs for CKS1B Gene

Selected SIMAP similar genes for CKS1B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CKS1B Gene

genes like me logo Genes that share paralogs with CKS1B: view

Variants for CKS1B Gene

Sequence variations from dbSNP and Humsavar for CKS1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6910 -- 154,978,937(+) TTCTT(A/G)AGTAG utr-variant-3-prime, nc-transcript-variant
rs35548854 -- 154,976,940(+) CTTAT(-/C)CCTTG intron-variant
rs41264271 -- 154,978,250(+) TTTTT(A/T)AAAAA intron-variant
rs72997365 -- 154,977,039(+) TTTTT(A/C)AGAGA intron-variant
rs76459669 -- 154,979,287(+) CTCAG(G/T)GTGAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CKS1B Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872453 CNV Loss 21882294
nsv872454 CNV Loss 21882294

Relevant External Links for CKS1B Gene

HapMap Linkage Disequilibrium report
CKS1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKS1B Gene

Disorders for CKS1B Gene

(1) MalaCards Diseases for CKS1B Gene

Search for CKS1B Gene in MalaCards »

(1) University of Copenhagen DISEASES for CKS1B Gene

(11) Novoseek inferred disease relationships for CKS1B Gene

Disease -log(P) Hits PubMed IDs
aggressiveness 48.3 1
carcinoma medullary 46.2 1
carcinoma 22.8 1
carcinoma squamous cell 20.9 3
tumors 20.3 19

Relevant External Links for CKS1B

Genetic Association Database (GAD)
CKS1B
Human Genome Epidemiology (HuGE) Navigator
CKS1B
genes like me logo Genes that share disorders with CKS1B: view

No data available for UniProtKB/Swiss-Prot for CKS1B Gene

Publications for CKS1B Gene

  1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PMID: 2227411) Richardson H.E. … Reed S.I. (Genes Dev. 1990) 2 3 4 23
  2. Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. (PMID: 7791211) Arvai A.S. … Tainer J.A. (J. Mol. Biol. 1995) 3 4 23
  3. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. (PMID: 8601310) Bourne Y. … Tainer J.A. (Cell 1996) 3 4 23
  4. Three different binding sites of Cks1 are required for p27-ubiquitin ligation. (PMID: 12140288) Sitry D. … Hershko A. (J. Biol. Chem. 2002) 3 23
  5. Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family. (PMID: 12473461) Seeliger M.A. … Itzhaki L.S. (J. Mol. Biol. 2003) 3 23

Products for CKS1B Gene

Sources for CKS1B Gene

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