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Aliases for FOXP4 Gene

Aliases for FOXP4 Gene

  • Forkhead Box P4 2 3 5
  • Fork Head-Related Protein Like A 3
  • Fork Head-Related Protein-Like A 4
  • Winged-Helix Repressor FOXP4 3
  • Forkhead Box Protein P4 3
  • HFKHLA 3
  • FKHLA 4

External Ids for FOXP4 Gene

Previous GeneCards Identifiers for FOXP4 Gene

  • GC06P041515
  • GC06P041561
  • GC06P041622
  • GC06P041232

Summaries for FOXP4 Gene

Entrez Gene Summary for FOXP4 Gene

  • This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXP4 Gene

FOXP4 (Forkhead Box P4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXP2.

UniProtKB/Swiss-Prot for FOXP4 Gene

  • Transcriptional repressor that represses lung-specific expression.

Gene Wiki entry for FOXP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXP4 Gene

Genomics for FOXP4 Gene

Regulatory Elements for FOXP4 Gene

Enhancers for FOXP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G041576 2 FANTOM5 Ensembl ENCODE dbSUPER 23.1 +31.7 31719 3.1 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC FOXP4 FOXP4-AS1 FRS3 GC06M041544 GC06P041549 GC06P041550
GH06G041568 1.4 ENCODE dbSUPER 25.1 +23.3 23254 2.7 HDGF FOXA2 MLX ZFP64 ARID4B DMAP1 YBX1 YY1 SLC30A9 ZNF766 FOXP4 FOXP4-AS1 UBR2 MDFI GC06M041544 GC06P041549 GC06P041550
GH06G041580 1.4 Ensembl ENCODE dbSUPER 22.8 +37.8 37847 7.2 FOXA2 ZFP64 SIN3A FEZF1 ZNF48 YY1 GLIS2 GATA2 FOS ZNF263 FOXP4 FOXP4-AS1 ENSG00000124593 GC06M041544 GC06P041550 GC06P041549
GH06G041560 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +15.3 15311 3.1 FOXA2 RAD21 ZBTB40 ETS1 ZNF335 ZNF121 RELB PCBP1 ETV6 IKZF2 FOXP4 MDFI CCND3 NFYA TAF8 TFEB GC06P041550 GC06P041549 GC06M041544
GH06G041544 1.4 ENCODE dbSUPER 12.1 +0.8 847 4.7 HDGF CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOXP4 FOXP4-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXP4 on UCSC Golden Path with GeneCards custom track

Promoters for FOXP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196847 374 2401 HDGF CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 ZNF143

Genomic Location for FOXP4 Gene

Chromosome:
6
Start:
41,546,426 bp from pter
End:
41,602,384 bp from pter
Size:
55,959 bases
Orientation:
Plus strand

Genomic View for FOXP4 Gene

Genes around FOXP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXP4 Gene

Proteins for FOXP4 Gene

  • Protein details for FOXP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVH2-FOXP4_HUMAN
    Recommended name:
    Forkhead box protein P4
    Protein Accession:
    Q8IVH2
    Secondary Accessions:
    • Q5W098
    • Q7Z7F8
    • Q8IW55
    • Q96E19

    Protein attributes for FOXP4 Gene

    Size:
    680 amino acids
    Molecular mass:
    73488 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding (By similarity).

    Alternative splice isoforms for FOXP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXP4 Gene

Post-translational modifications for FOXP4 Gene

  • Ubiquitination at Lys175 and isoforms=2, 3532
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for FOXP4
  • Santa Cruz Biotechnology (SCBT) Antibodies for FOXP4

No data available for DME Specific Peptides for FOXP4 Gene

Domains & Families for FOXP4 Gene

Gene Families for FOXP4 Gene

Protein Domains for FOXP4 Gene

Suggested Antigen Peptide Sequences for FOXP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVH2

UniProtKB/Swiss-Prot:

FOXP4_HUMAN :
  • The leucine-zipper is required for dimerization and transcriptional repression.
Domain:
  • The leucine-zipper is required for dimerization and transcriptional repression.
genes like me logo Genes that share domains with FOXP4: view

Function for FOXP4 Gene

Molecular function for FOXP4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that represses lung-specific expression.

Gene Ontology (GO) - Molecular Function for FOXP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25027557
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXP4: view
genes like me logo Genes that share phenotypes with FOXP4: view

Animal Models for FOXP4 Gene

MGI Knock Outs for FOXP4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXP4 Gene

Localization for FOXP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXP4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXP4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FOXP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with FOXP4: view

Pathways & Interactions for FOXP4 Gene

SuperPathways for FOXP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOXP4: view

No data available for Pathways by source and SIGNOR curated interactions for FOXP4 Gene

Transcripts for FOXP4 Gene

Unigene Clusters for FOXP4 Gene

Forkhead box P4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2:
SP3:

Relevant External Links for FOXP4 Gene

GeneLoc Exon Structure for
FOXP4
ECgene alternative splicing isoforms for
FOXP4

Expression for FOXP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOXP4 Gene

This gene is overexpressed in Lung (41.4), Prostate (15.3), and Fetal Brain (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXP4 Gene



Protein tissue co-expression partners for FOXP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXP4 Gene:

FOXP4

SOURCE GeneReport for Unigene cluster for FOXP4 Gene:

Hs.131436

Evidence on tissue expression from TISSUES for FOXP4 Gene

  • Lung(4.4)
  • Liver(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with FOXP4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXP4 Gene

Orthologs for FOXP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXP4 34 35
  • 97.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FOXP4 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXP4 34 35
  • 91.06 (n)
cow
(Bos Taurus)
Mammalia FOXP4 34 35
  • 90.96 (n)
rat
(Rattus norvegicus)
Mammalia Foxp4 34
  • 90.13 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXP4 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxp4 34 16 35
  • 88.24 (n)
chicken
(Gallus gallus)
Aves LOC100858652 34
  • 79.04 (n)
FOXP4 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXP4 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxp4 34
  • 68.65 (n)
zebrafish
(Danio rerio)
Actinopterygii foxp4 34 35
  • 71.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta FoxP 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fkh-7 35
  • 24 (a)
ManyToMany
fkh-8 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for FOXP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXP4 Gene

ENSEMBL:
Gene Tree for FOXP4 (if available)
TreeFam:
Gene Tree for FOXP4 (if available)

Paralogs for FOXP4 Gene

(7) SIMAP similar genes for FOXP4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FOXP4: view

Variants for FOXP4 Gene

Sequence variations from dbSNP and Humsavar for FOXP4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs867245225 A breast cancer sample 41,590,303(+) AGAAC(A/G)CCGAC downstream-variant-500B, reference, missense
rs1000052567 -- 41,548,275(+) GCCGG(A/G)AATAG intron-variant, upstream-variant-2KB
rs1000122350 -- 41,547,124(+) CGGGC(C/G)GGAGC intron-variant, upstream-variant-2KB
rs1000145342 -- 41,586,663(+) TCATC(A/G)ATCAT intron-variant
rs1000161301 -- 41,570,118(+) CACAC(A/G)CAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXP4 Gene

Variant ID Type Subtype PubMed ID
esv2678648 CNV deletion 23128226
esv28388 CNV loss 19812545
esv3608791 CNV loss 21293372
nsv1073551 CNV deletion 25765185
nsv1144141 CNV deletion 24896259
nsv819316 CNV gain 19587683

Variation tolerance for FOXP4 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXP4 Gene

Human Gene Mutation Database (HGMD)
FOXP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXP4 Gene

Disorders for FOXP4 Gene

Relevant External Links for FOXP4

Genetic Association Database (GAD)
FOXP4
Human Genome Epidemiology (HuGE) Navigator
FOXP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXP4

No disorders were found for FOXP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXP4 Gene

Publications for FOXP4 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. (PMID: 20676098) Takata R. … Nakagawa H. (Nat. Genet. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Overexpression of long non-coding RNA MFI2 promotes cell proliferation and suppresses apoptosis in human osteosarcoma. (PMID: 27513470) Yin Z. … Li M. (Oncol. Rep. 2016) 3 64
  5. Identification of differentially methylated regions in new genes associated with knee osteoarthritis. (PMID: 26484395) Bonin C.A. … Westendorf J.J. (Gene 2016) 3 64

Products for FOXP4 Gene

Sources for FOXP4 Gene

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