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Aliases for FOXP4 Gene

Aliases for FOXP4 Gene

  • Forkhead Box P4 2 3 5
  • Fork Head-Related Protein-Like A 3 4
  • Fork Head-Related Protein Like A 3
  • Winged-Helix Repressor FOXP4 3
  • HFKHLA 3
  • FKHLA 4

External Ids for FOXP4 Gene

Previous GeneCards Identifiers for FOXP4 Gene

  • GC06P041515
  • GC06P041561
  • GC06P041622
  • GC06P041232

Summaries for FOXP4 Gene

Entrez Gene Summary for FOXP4 Gene

  • This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXP4 Gene

FOXP4 (Forkhead Box P4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is FOXP3.

UniProtKB/Swiss-Prot for FOXP4 Gene

  • Transcriptional repressor that represses lung-specific expression.

Gene Wiki entry for FOXP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXP4 Gene

Genomics for FOXP4 Gene

Regulatory Elements for FOXP4 Gene

Promoters for FOXP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXP4 Gene

Chromosome:
6
Start:
41,546,426 bp from pter
End:
41,602,384 bp from pter
Size:
55,959 bases
Orientation:
Plus strand

Genomic View for FOXP4 Gene

Genes around FOXP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXP4 Gene

Proteins for FOXP4 Gene

  • Protein details for FOXP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVH2-FOXP4_HUMAN
    Recommended name:
    Forkhead box protein P4
    Protein Accession:
    Q8IVH2
    Secondary Accessions:
    • Q5W098
    • Q7Z7F8
    • Q8IW55
    • Q96E19

    Protein attributes for FOXP4 Gene

    Size:
    680 amino acids
    Molecular mass:
    73488 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding (By similarity).

    Alternative splice isoforms for FOXP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXP4 Gene

Proteomics data for FOXP4 Gene at MOPED

Post-translational modifications for FOXP4 Gene

  • Ubiquitination at Lys 175 and Lys 532
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for FOXP4 Gene

Domains & Families for FOXP4 Gene

Gene Families for FOXP4 Gene

Protein Domains for FOXP4 Gene

Suggested Antigen Peptide Sequences for FOXP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVH2

UniProtKB/Swiss-Prot:

FOXP4_HUMAN :
  • The leucine-zipper is required for dimerization and transcriptional repression.
  • Contains 1 C2H2-type zinc finger.
Domain:
  • The leucine-zipper is required for dimerization and transcriptional repression.
  • Contains 1 fork-head DNA-binding domain.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with FOXP4: view

Function for FOXP4 Gene

Molecular function for FOXP4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that represses lung-specific expression.

Gene Ontology (GO) - Molecular Function for FOXP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25027557
genes like me logo Genes that share ontologies with FOXP4: view
genes like me logo Genes that share phenotypes with FOXP4: view

Animal Models for FOXP4 Gene

MGI Knock Outs for FOXP4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXP4 Gene

Localization for FOXP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXP4 Gene COMPARTMENTS Subcellular localization image for FOXP4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FOXP4 Gene

Pathways & Interactions for FOXP4 Gene

SuperPathways for FOXP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXP4: view

No data available for Pathways by source and SIGNOR curated interactions for FOXP4 Gene

Drugs & Compounds for FOXP4 Gene

No Compound Related Data Available

Transcripts for FOXP4 Gene

Unigene Clusters for FOXP4 Gene

Forkhead box P4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2:
SP3:

Relevant External Links for FOXP4 Gene

GeneLoc Exon Structure for
FOXP4
ECgene alternative splicing isoforms for
FOXP4

Expression for FOXP4 Gene

mRNA expression in normal human tissues for FOXP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOXP4 Gene

This gene is overexpressed in Lung (41.4), Prostate (15.3), and Fetal Brain (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXP4 Gene



SOURCE GeneReport for Unigene cluster for FOXP4 Gene Hs.131436

genes like me logo Genes that share expression patterns with FOXP4: view

Protein tissue co-expression partners for FOXP4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOXP4 Gene

Orthologs for FOXP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXP4 35
  • 97.36 (n)
  • 97.26 (a)
FOXP4 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXP4 36
  • 78 (a)
OneToOne
FOXP4 35
  • 90.96 (n)
  • 95.58 (a)
dog
(Canis familiaris)
Mammalia FOXP4 35
  • 91.06 (n)
  • 94.66 (a)
FOXP4 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxp4 16
Foxp4 35
  • 88.24 (n)
  • 93.59 (a)
Foxp4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXP4 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXP4 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxp4 35
  • 90.13 (n)
  • 97.11 (a)
chicken
(Gallus gallus)
Aves LOC100858652 35
  • 79.04 (n)
  • 82.84 (a)
FOXP4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXP4 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxp4 35
  • 68.65 (n)
  • 77.21 (a)
zebrafish
(Danio rerio)
Actinopterygii foxp4 36
  • 71 (a)
OneToOne
foxp4 35
  • 71.88 (n)
  • 75.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta FoxP 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fkh-7 36
  • 24 (a)
ManyToMany
fkh-8 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for FOXP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXP4 Gene

ENSEMBL:
Gene Tree for FOXP4 (if available)
TreeFam:
Gene Tree for FOXP4 (if available)

Paralogs for FOXP4 Gene

(7) SIMAP similar genes for FOXP4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FOXP4: view

Variants for FOXP4 Gene

Sequence variations from dbSNP and Humsavar for FOXP4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036219 A breast cancer sample
rs927772 -- 41,600,717(-) CCTCA(C/T)GTTGC utr-variant-3-prime
rs912883 -- 41,584,302(-) AAGGT(A/G)GGCCT intron-variant
rs913074 -- 41,570,807(+) TGAAG(C/T)GGGGA intron-variant
rs913075 -- 41,601,168(+) TGTGC(A/G)TGCAC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOXP4 Gene

Variant ID Type Subtype PubMed ID
esv28388 CNV Loss 19812545
nsv885830 CNV Loss 21882294
esv2678648 CNV Deletion 23128226
nsv819316 CNV Gain 19587683

Variation tolerance for FOXP4 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXP4 Gene

HapMap Linkage Disequilibrium report
FOXP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXP4 Gene

Disorders for FOXP4 Gene

Relevant External Links for FOXP4

Genetic Association Database (GAD)
FOXP4
Human Genome Epidemiology (HuGE) Navigator
FOXP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXP4

No disorders were found for FOXP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXP4 Gene

Publications for FOXP4 Gene

  1. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. (PMID: 20676098) Takata R. … Nakagawa H. (Nat. Genet. 2010) 3 48 67
  2. Transcriptional Regulation by FOXP1, FOXP2, and FOXP4 Dimerization. (PMID: 25027557) Sin C. … Crawford D.A. (J. Mol. Neurosci. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel. (PMID: 25472883) Dhamija N. … Mitra D. (FEBS J. 2015) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for FOXP4 Gene

Sources for FOXP4 Gene

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