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Aliases for OSR2 Gene

Aliases for OSR2 Gene

  • Odd-Skipped Related Transciption Factor 2 2 3 5
  • Odd-Skipped Related 2 (Drosophila) 2

External Ids for OSR2 Gene

Previous GeneCards Identifiers for OSR2 Gene

  • GC08P098965
  • GC08P100030
  • GC08P099625
  • GC08P099913
  • GC08P099908
  • GC08P100025
  • GC08P095159
  • GC08P099956
  • GC08P098944

Summaries for OSR2 Gene

Entrez Gene Summary for OSR2 Gene

  • OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSR2 Gene

OSR2 (Odd-Skipped Related Transciption Factor 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is OSR1.

Gene Wiki entry for OSR2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSR2 Gene

Genomics for OSR2 Gene

Regulatory Elements for OSR2 Gene

Enhancers for OSR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OSR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OSR2 Gene

98,938,104 bp from pter
98,952,110 bp from pter
14,007 bases
Plus strand

Genomic View for OSR2 Gene

Genes around OSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSR2 Gene

Proteins for OSR2 Gene

  • Protein details for OSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein odd-skipped-related 2
    Protein Accession:
    Secondary Accessions:
    • A8K626
    • B4E3B7
    • Q96AM6
    • Q96LB6
    • Q96LB7

    Protein attributes for OSR2 Gene

    312 amino acids
    Molecular mass:
    35513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSR2 Gene


neXtProt entry for OSR2 Gene

Proteomics data for OSR2 Gene at MOPED

Post-translational modifications for OSR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OSR2 Gene

Domains & Families for OSR2 Gene

Gene Families for OSR2 Gene

Protein Domains for OSR2 Gene

Suggested Antigen Peptide Sequences for OSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Odd C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
  • Belongs to the Odd C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with OSR2: view

Function for OSR2 Gene

Gene Ontology (GO) - Molecular Function for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with OSR2: view
genes like me logo Genes that share phenotypes with OSR2: view

Animal Models for OSR2 Gene

MGI Knock Outs for OSR2:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OSR2 Gene

Localization for OSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSR2 Gene

Subcellular locations from

Jensen Localization Image for OSR2 Gene COMPARTMENTS Subcellular localization image for OSR2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for OSR2 Gene

Pathways & Interactions for OSR2 Gene

SuperPathways for OSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001823 mesonephros development IEA,ISS --
GO:0002062 chondrocyte differentiation IEA,ISS --
GO:0010628 positive regulation of gene expression IEA,ISS --
GO:0030154 cell differentiation IEA,ISS --
GO:0030501 positive regulation of bone mineralization IEA,ISS --
genes like me logo Genes that share ontologies with OSR2: view

No data available for Pathways by source and SIGNOR curated interactions for OSR2 Gene

Drugs & Compounds for OSR2 Gene

No Compound Related Data Available

Transcripts for OSR2 Gene

Unigene Clusters for OSR2 Gene

Odd-skipped related 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OSR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -

Relevant External Links for OSR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSR2 Gene

mRNA expression in normal human tissues for OSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSR2 Gene

This gene is overexpressed in Uterus (x7.3), Fallopian Tube (x6.9), Cervix - Ectocervix (x6.6), and Cervix - Endocervix (x5.4).

Protein differential expression in normal tissues from HIPED for OSR2 Gene

This gene is overexpressed in Plasma (47.7) and Adipocyte (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OSR2 Gene

SOURCE GeneReport for Unigene cluster for OSR2 Gene Hs.253247

genes like me logo Genes that share expression patterns with OSR2: view

Protein tissue co-expression partners for OSR2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for OSR2 Gene

Orthologs for OSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OSR2 35
  • 93.12 (n)
  • 98.02 (a)
OSR2 36
  • 92 (a)
(Canis familiaris)
Mammalia OSR2 35
  • 95.62 (n)
  • 98.72 (a)
OSR2 36
  • 99 (a)
(Mus musculus)
Mammalia Osr2 35
  • 92.52 (n)
  • 97.64 (a)
Osr2 16
Osr2 36
  • 92 (a)
(Pan troglodytes)
Mammalia OSR2 35
  • 99.54 (n)
  • 99.54 (a)
OSR2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Osr2 35
  • 92.52 (n)
  • 98.82 (a)
(Gallus gallus)
Aves OSR2 35
  • 82.75 (n)
  • 92.16 (a)
OSR2 36
  • 93 (a)
(Anolis carolinensis)
Reptilia OSR2 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osr2 35
  • 82.69 (n)
  • 95.83 (a)
Str.10705 35
(Danio rerio)
Actinopterygii osr2 35
  • 75.16 (n)
  • 79.72 (a)
osr2 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta bowl 37
  • 82 (a)
odd 37
  • 78 (a)
sob 37
  • 87 (a)
bowl 36
  • 22 (a)
drm 36
  • 51 (a)
odd 36
  • 31 (a)
sob 36
  • 28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta ODR1 35
  • 74.64 (n)
  • 89.86 (a)
(Caenorhabditis elegans)
Secernentea odd-1 37
  • 60 (a)
odd-2 37
  • 81 (a)
odd-1 36
  • 35 (a)
odd-2 36
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10104 35
Species with no ortholog for OSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSR2 Gene

Gene Tree for OSR2 (if available)
Gene Tree for OSR2 (if available)

Paralogs for OSR2 Gene

Paralogs for OSR2 Gene

(449) SIMAP similar genes for OSR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSR2: view

Variants for OSR2 Gene

Sequence variations from dbSNP and Humsavar for OSR2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2290032 -- 98,945,886(-) GAGAT(A/T)AATGA intron-variant
rs727011 -- 98,951,777(-) GATGC(A/G)ACCCC utr-variant-3-prime
rs111991210 -- 98,948,836(+) ATTTT(G/T)AGGGC intron-variant
rs143167020 -- 98,946,344(+) GGATC(G/T)CTGCA intron-variant, upstream-variant-2KB
rs143429157 -- 98,950,410(+) GGTTT(C/T)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSR2 Gene

Variant ID Type Subtype PubMed ID
nsv6327 CNV Loss 18451855

Variation tolerance for OSR2 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OSR2 Gene

Disorders for OSR2 Gene

Relevant External Links for OSR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OSR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSR2 Gene

Publications for OSR2 Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48 67
  2. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. (PMID: 15175245) Lan Y. … Jiang R. (Development 2004) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Functional evidence implicating FOXL2 in non-syndromic premature ovarian failure and in the regulation of the transcription factor OSR2. (PMID: 19429596) Laissue P. … Veitia R.A. (J. Med. Genet. 2009) 23

Products for OSR2 Gene

Sources for OSR2 Gene