Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSR2 Gene

Aliases for OSR2 Gene

  • Odd-Skipped Related Transciption Factor 2 2 3
  • Odd-Skipped Related 2 (Drosophila) 2

External Ids for OSR2 Gene

Previous GeneCards Identifiers for OSR2 Gene

  • GC08P098965
  • GC08P100030
  • GC08P099625
  • GC08P099913
  • GC08P099908
  • GC08P100025
  • GC08P095159
  • GC08P099956

Summaries for OSR2 Gene

Entrez Gene Summary for OSR2 Gene

  • OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSR2 Gene

OSR2 (Odd-Skipped Related Transciption Factor 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZNF664.

Gene Wiki entry for OSR2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSR2 Gene

Genomics for OSR2 Gene

Regulatory Elements for OSR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSR2 Gene

Start:
98,944,403 bp from pter
End:
98,952,110 bp from pter
Size:
7,708 bases
Orientation:
Plus strand

Genomic View for OSR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSR2 Gene

Proteins for OSR2 Gene

  • Protein details for OSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2R0-OSR2_HUMAN
    Recommended name:
    Protein odd-skipped-related 2
    Protein Accession:
    Q8N2R0
    Secondary Accessions:
    • A8K626
    • B4E3B7
    • Q96AM6
    • Q96LB6
    • Q96LB7

    Protein attributes for OSR2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSR2 Gene

Proteomics data for OSR2 Gene at MOPED

Post-translational modifications for OSR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for OSR2 Gene

Domains for OSR2 Gene

Gene Families for OSR2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for OSR2 Gene

Suggested Antigen Peptide Sequences for OSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2R0

UniProtKB/Swiss-Prot:

OSR2_HUMAN :
  • Q8N2R0
Family:
  • Belongs to the Odd C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with OSR2: view

Function for OSR2 Gene

Gene Ontology (GO) - Molecular Function for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OSR2: view
genes like me logo Genes that share phenotypes with OSR2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OSR2 Gene

Localization for OSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSR2 Gene COMPARTMENTS Subcellular localization image for OSR2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with OSR2: view

Pathways for OSR2 Gene

SuperPathways for OSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001656 metanephros development ISS --
GO:0001823 mesonephros development ISS --
GO:0002062 chondrocyte differentiation ISS --
GO:0008284 positive regulation of cell proliferation ISS --
genes like me logo Genes that share ontologies with OSR2: view

No data available for Pathways by source for OSR2 Gene

Transcripts for OSR2 Gene

Unigene Clusters for OSR2 Gene

Odd-skipped related 2 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for OSR2 Gene

GeneLoc Exon Structure for
OSR2
ECgene alternative splicing isoforms for
OSR2

Expression for OSR2 Gene

mRNA expression in normal human tissues for OSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSR2 Gene

This gene is overexpressed in Uterus (7.3), Fallopian Tube (6.9), Cervix - Ectocervix (6.6), and Cervix - Endocervix (5.4).

Protein differential expression in normal tissues for OSR2 Gene

This gene is overexpressed in Plasma (47.7) and Adipocyte (21.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OSR2 Gene

SOURCE GeneReport for Unigene cluster for OSR2 Gene Hs.253247

genes like me logo Genes that share expressions with OSR2: view

Expression partners for OSR2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for OSR2 Gene

Orthologs for OSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OSR2 35
  • 93.12 (n)
  • 98.02 (a)
OSR2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSR2 35
  • 95.62 (n)
  • 98.72 (a)
OSR2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osr2 35
  • 92.52 (n)
  • 97.64 (a)
Osr2 16
Osr2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OSR2 35
  • 99.54 (n)
  • 99.54 (a)
OSR2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osr2 35
  • 92.52 (n)
  • 98.82 (a)
chicken
(Gallus gallus)
Aves OSR2 35
  • 82.75 (n)
  • 92.16 (a)
OSR2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSR2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia osr2 35
  • 82.69 (n)
  • 95.83 (a)
Str.10705 35
zebrafish
(Danio rerio)
Actinopterygii osr2 35
  • 75.16 (n)
  • 79.72 (a)
osr2 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bowl 37
  • 82 (a)
odd 37
  • 78 (a)
sob 37
  • 87 (a)
bowl 36
  • 22 (a)
ManyToMany
drm 36
  • 51 (a)
ManyToMany
odd 36
  • 31 (a)
ManyToMany
sob 36
  • 28 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ODR1 35
  • 74.64 (n)
  • 89.86 (a)
worm
(Caenorhabditis elegans)
Secernentea odd-1 37
  • 60 (a)
odd-2 37
  • 81 (a)
odd-1 36
  • 35 (a)
ManyToMany
odd-2 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10104 35
Species with no ortholog for OSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSR2 Gene

ENSEMBL:
Gene Tree for OSR2 (if available)
TreeFam:
Gene Tree for OSR2 (if available)

Paralogs for OSR2 Gene

Paralogs for OSR2 Gene

Selected SIMAP similar genes for OSR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OSR2: view

Variants for OSR2 Gene

Sequence variations from dbSNP and Humsavar for OSR2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs727011 -- 98,951,777(-) GATGC(A/G)ACCCC utr-variant-3-prime
rs2290032 -- 98,945,886(-) GAGAT(A/T)AATGA intron-variant
rs7814088 -- 98,948,048(+) GAACC(A/G)TCTGG intron-variant, upstream-variant-2KB
rs34358261 -- 98,945,487(+) CCTGT(-/TGT)TAGCC intron-variant
rs34833078 -- 98,950,318(+) CACTT(-/A)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSR2 Gene

Variant ID Type Subtype PubMed ID
nsv6327 CNV Loss 18451855

Relevant External Links for OSR2 Gene

HapMap Linkage Disequilibrium report
OSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSR2 Gene

Disorders for OSR2 Gene

(2) University of Copenhagen DISEASES for OSR2 Gene

Relevant External Links for OSR2

Genetic Association Database (GAD)
OSR2
Human Genome Epidemiology (HuGE) Navigator
OSR2
genes like me logo Genes that share disorders with OSR2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for OSR2 Gene

Publications for OSR2 Gene

  1. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. (PMID: 15175245) Lan Y. … Jiang R. (Development 2004) 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for OSR2 Gene

Sources for OSR2 Gene

Back to Top

Content