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Aliases for CKMT1B Gene

Aliases for CKMT1B Gene

  • Creatine Kinase, Mitochondrial 1B 2 3
  • Creatine Kinase, Mitochondrial 1 (Ubiquitous) 2 3
  • Acidic-Type Mitochondrial Creatine Kinase 3 4
  • Ubiquitous Mitochondrial Creatine Kinase 3 4
  • EC 2.7.3.2 4 63
  • Mia-CK 3 4
  • U-MtCK 3 4
  • CKMT1 3 6
  • CKMT 3 4
  • Creatine Kinase U-Type, Mitochondrial 3
  • CKMT1A CKMT1B 4
  • EC 2.7.3 63
  • UMTCK 3

External Ids for CKMT1B Gene

Previous Symbols for CKMT1B Gene

  • CKMT
  • CKMT1

Summaries for CKMT1B Gene

Entrez Gene Summary for CKMT1B Gene

  • Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKMT1B Gene

CKMT1B (Creatine Kinase, Mitochondrial 1B) is a Protein Coding gene. Diseases associated with CKMT1B include prostate rhabdomyosarcoma. Among its related pathways are Metabolism and Arginine and proline metabolism. An important paralog of this gene is CKB.

UniProtKB/Swiss-Prot for CKMT1B Gene

  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Gene Wiki entry for CKMT1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKMT1B Gene

Genomics for CKMT1B Gene

Genomic Location for CKMT1B Gene

Start:
43,593,054 bp from pter
End:
43,604,901 bp from pter
Size:
11,848 bases
Orientation:
Plus strand

Genomic View for CKMT1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKMT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKMT1B Gene

Regulatory Elements for CKMT1B Gene

Transcription factor binding sites by QIAGEN in the CKMT1B gene promoter:

Proteins for CKMT1B Gene

  • Protein details for CKMT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12532-KCRU_HUMAN
    Recommended name:
    Creatine kinase U-type, mitochondrial
    Protein Accession:
    P12532
    Secondary Accessions:
    • B4DIT8
    • B7ZA09
    • Q0VAM3
    • Q32NF6
    • Q53FC4

    Protein attributes for CKMT1B Gene

    Size:
    417 amino acids
    Molecular mass:
    47037 Da
    Quaternary structure:
    • Exists as an octamer composed of four MTCK homodimers.
    Miscellaneous:
    • Mitochondrial creatine kinase binds cardiolipin

    Three dimensional structures from OCA and Proteopedia for CKMT1B Gene

    Alternative splice isoforms for CKMT1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKMT1B Gene

Proteomics data for CKMT1B Gene at MOPED

Post-translational modifications for CKMT1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CKMT1B Gene

Domains for CKMT1B Gene

Graphical View of Domain Structure for InterPro Entry

P12532

UniProtKB/Swiss-Prot:

KCRU_HUMAN
Domain:
  • Contains 1 phosphagen kinase C-terminal domain.:
    • P12532
  • Contains 1 phosphagen kinase N-terminal domain.:
    • P12532
Family:
  • Belongs to the ATP:guanido phosphotransferase family.:
    • P12532
genes like me logo Genes that share domains with CKMT1B: view

No data available for Gene Families for CKMT1B Gene

Function for CKMT1B Gene

Molecular function for CKMT1B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + creatine = ADP + phosphocreatine.
UniProtKB/Swiss-Prot Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Enzyme Numbers (IUBMB) for CKMT1B Gene

Gene Ontology (GO) - Molecular Function for CKMT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004111 creatine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with CKMT1B: view
genes like me logo Genes that share phenotypes with CKMT1B: view

Animal Models for CKMT1B Gene

MGI Knock Outs for CKMT1B:

miRNA for CKMT1B Gene

miRTarBase miRNAs that target CKMT1B

No data available for Transcription Factor Targeting and HOMER Transcription for CKMT1B Gene

Localization for CKMT1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKMT1B Gene

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKMT1B Gene COMPARTMENTS Subcellular localization image for CKMT1B gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CKMT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 2914937
GO:0005743 mitochondrial inner membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CKMT1B: view

Pathways for CKMT1B Gene

genes like me logo Genes that share pathways with CKMT1B: view

Pathways by source for CKMT1B Gene

1 BioSystems pathway for CKMT1B Gene
2 KEGG pathways for CKMT1B Gene

Gene Ontology (GO) - Biological Process for CKMT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006600 creatine metabolic process TAS --
GO:0016310 phosphorylation IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CKMT1B: view

Compounds for CKMT1B Gene

(5) Novoseek inferred chemical compound relationships for CKMT1B Gene

Compound -log(P) Hits PubMed IDs
cyclocreatine 87.9 1
cardiolipin 70.7 1
creatinine 68.3 29
phosphocreatine 59.7 5
atp 30.1 2
genes like me logo Genes that share compounds with CKMT1B: view

Transcripts for CKMT1B Gene

Unigene Clusters for CKMT1B Gene

Creatine kinase, mitochondrial 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKMT1B Gene

No ASD Table

Relevant External Links for CKMT1B Gene

GeneLoc Exon Structure for
CKMT1B
ECgene alternative splicing isoforms for
CKMT1B

Expression for CKMT1B Gene

mRNA expression in normal human tissues for CKMT1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKMT1B Gene

This gene is overexpressed in Brain - Cerebellum (12.6) and Brain - Cerebellar Hemisphere (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKMT1B Gene

SOURCE GeneReport for Unigene cluster for CKMT1B Gene Hs.741420

genes like me logo Genes that share expressions with CKMT1B: view

No data available for mRNA Expression by UniProt/SwissProt for CKMT1B Gene

Orthologs for CKMT1B Gene

This gene was present in the common ancestor of animals.

Orthologs for CKMT1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
LOC100608872 35
  • 99.44 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CKMT1 36
  • 98 (a)
OneToMany
CKMT1B 35
  • 92.96 (n)
  • 98.3 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 98 (a)
OneToMany
CKMT1B 35
  • 94.16 (n)
  • 98.32 (a)
mouse
(Mus musculus)
Mammalia Ckmt1 35
  • 92.01 (n)
  • 96.88 (a)
Ckmt1 16
Ckmt1 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ckmt1b 35
  • 91.69 (n)
  • 96.88 (a)
chicken
(Gallus gallus)
Aves CKMT1A 35
  • 77.22 (n)
  • 88.49 (a)
CKMT1A 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia ckmt1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ckmt1b 35
  • 73.78 (n)
  • 84.17 (a)
MGC76150 35
zebrafish
(Danio rerio)
Actinopterygii ckmt1 35
  • 72.6 (n)
  • 81.49 (a)
ckmt1 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Argk 36
  • 27 (a)
ManyToMany
CG30274 36
  • 20 (a)
ManyToMany
CG4546 36
  • 29 (a)
ManyToMany
CG5144 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F11G11.13 36
  • 36 (a)
ManyToMany
F32B5.1 36
  • 34 (a)
ManyToMany
F44G3.2 36
  • 38 (a)
ManyToMany
F46H5.3 36
  • 39 (a)
ManyToMany
W10C8.5 36
  • 37 (a)
ManyToMany
ZC434.8 36
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
CSA.4059 36
  • 64 (a)
ManyToMany
Species with no ortholog for CKMT1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKMT1B Gene

ENSEMBL:
Gene Tree for CKMT1B (if available)
TreeFam:
Gene Tree for CKMT1B (if available)

Paralogs for CKMT1B Gene

Paralogs for CKMT1B Gene

Selected SIMAP similar genes for CKMT1B Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with CKMT1B: view

Variants for CKMT1B Gene

Sequence variations from dbSNP and Humsavar for CKMT1B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2467425 -- 43,597,498(+) CAGCA(C/T)GTAAG intron-variant
rs2614796 -- 43,598,407(+) TTGGA(A/G)AGGAG intron-variant
rs3890552 -- 43,597,536(+) AACTA(C/T)AAACA intron-variant
rs10518820 -- 43,596,778(+) AGGCT(G/T)TTGAC intron-variant
rs28475234 -- 43,596,990(+) AAAGT(A/T)TCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CKMT1B Gene

Variant ID Type Subtype PubMed ID
nsv437799 CNV Loss 16327808
nsv832988 CNV Loss 17160897
nsv428304 CNV Loss 18775914
dgv741e1 CNV Complex 17122850
dgv742e1 CNV Complex 17122850
nsv524910 CNV Loss 19592680
dgv2370n71 CNV Gain 21882294
dgv2371n71 CNV Gain 21882294
dgv2372n71 CNV Gain 21882294
nsv509569 CNV Insertion 20534489
nsv904151 CNV Gain 21882294
dgv2373n71 CNV Loss 21882294
nsv904153 CNV Gain+Loss 21882294
esv24113 CNV Gain+Loss 19812545
nsv1514 CNV Loss 18451855
esv2421427 CNV Deletion 20811451
nsv9249 CNV Gain+Loss 18304495
esv33424 CNV Loss 17666407
dgv2374n71 CNV Loss 21882294
dgv743e1 CNV Complex 17122850
esv2749626 CNV Deletion 23290073

Relevant External Links for CKMT1B Gene

HapMap Linkage Disequilibrium report
CKMT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKMT1B Gene

Disorders for CKMT1B Gene

(1) MalaCards Diseases for CKMT1B Gene

Search for CKMT1B Gene in MalaCards »

(2) University of Copenhagen DISEASES for CKMT1B Gene

Relevant External Links for CKMT1B

Genetic Association Database (GAD)
CKMT1B
Human Genome Epidemiology (HuGE) Navigator
CKMT1B
genes like me logo Genes that share disorders with CKMT1B: view

No data available for UniProtKB/Swiss-Prot for CKMT1B Gene

Publications for CKMT1B Gene

  1. Crystal structure of human ubiquitous mitochondrial creatine kinase. (PMID: 10737943) Eder M. … Schlattner U. (Proteins 2000) 3 4 23
  2. A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance. (PMID: 11768757) Schlattner U. … Wallimann T. (J. Bioenerg. Biomembr. 2000) 3 23
  3. Expression of the mitochondrial creatine kinase genes. (PMID: 7808456) Payne R.M. … Strauss A.W. (Mol. Cell. Biochem. 1994) 3 23
  4. The ubiquitous mitochondrial creatine kinase gene maps to a conserved region on human chromosome 15q15 and mouse chromosome 2 bands F1-F3. (PMID: 7896282) Steeghs K. … Wieringa B. (Genomics 1994) 3 23
  5. Regulation of creatine kinase isoenzymes in human placenta during early, mid-, and late gestation. (PMID: 8923416) Thomure M.F. … Payne R.M. (J. Soc. Gynecol. Investig. 1996) 3 23

Products for CKMT1B Gene

  • antibodies-online proteins for CKMT1B
  • antibodies-online antibodies for CKMT1B
  • antibodies-online kits for CKMT1B

Sources for CKMT1B Gene

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