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Aliases for DIS3L Gene

Aliases for DIS3L Gene

  • DIS3 Like Exosome 3'-5' Exoribonuclease 2
  • DIS3 Like Exosome 3-5 Exoribonuclease 2 3 5
  • DIS3L1 3 4
  • DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2
  • DIS3 Mitotic Control Homolog-Like 3
  • EC 3.1.13.- 4
  • EC 3.1.13 63
  • KIAA1955 4

External Ids for DIS3L Gene

Previous GeneCards Identifiers for DIS3L Gene

  • GC15P064373
  • GC15P066585
  • GC15P043422

Summaries for DIS3L Gene

GeneCards Summary for DIS3L Gene

DIS3L (DIS3 Like Exosome 3'-5' Exoribonuclease) is a Protein Coding gene. Diseases associated with DIS3L include perlman syndrome. Among its related pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and 3-5-exoribonuclease activity. An important paralog of this gene is DIS3L2.

UniProtKB/Swiss-Prot for DIS3L Gene

  • Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Gene Wiki entry for DIS3L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIS3L Gene

Genomics for DIS3L Gene

Regulatory Elements for DIS3L Gene

Enhancers for DIS3L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DIS3L on UCSC Golden Path with GeneCards custom track

Promoters for DIS3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DIS3L on UCSC Golden Path with GeneCards custom track

Genomic Location for DIS3L Gene

Chromosome:
15
Start:
66,293,217 bp from pter
End:
66,333,898 bp from pter
Size:
40,682 bases
Orientation:
Plus strand

Genomic View for DIS3L Gene

Genes around DIS3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIS3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIS3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIS3L Gene

Proteins for DIS3L Gene

  • Protein details for DIS3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF46-DI3L1_HUMAN
    Recommended name:
    DIS3-like exonuclease 1
    Protein Accession:
    Q8TF46
    Secondary Accessions:
    • Q8N1N8
    • Q8WTU9
    • Q96CM7

    Protein attributes for DIS3L Gene

    Size:
    1054 amino acids
    Molecular mass:
    120787 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
    SequenceCaution:
    • Sequence=BAB85541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DIS3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DIS3L Gene

Proteomics data for DIS3L Gene at MOPED

Post-translational modifications for DIS3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DIS3L Gene

Gene Families for DIS3L Gene

Protein Domains for DIS3L Gene

Suggested Antigen Peptide Sequences for DIS3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF46

UniProtKB/Swiss-Prot:

DI3L1_HUMAN :
  • Belongs to the RNR ribonuclease family.
Family:
  • Belongs to the RNR ribonuclease family.
genes like me logo Genes that share domains with DIS3L: view

Function for DIS3L Gene

Molecular function for DIS3L Gene

UniProtKB/Swiss-Prot Function:
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Enzyme Numbers (IUBMB) for DIS3L Gene

Gene Ontology (GO) - Molecular Function for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with DIS3L: view

Phenotypes for DIS3L Gene

genes like me logo Genes that share phenotypes with DIS3L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DIS3L

miRNA for DIS3L Gene

miRTarBase miRNAs that target DIS3L

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIS3L Gene

Localization for DIS3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIS3L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIS3L Gene COMPARTMENTS Subcellular localization image for DIS3L gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) IBA --
genes like me logo Genes that share ontologies with DIS3L: view

Pathways & Interactions for DIS3L Gene

SuperPathways for DIS3L Gene

Superpath Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with DIS3L: view

Pathways by source for DIS3L Gene

1 KEGG pathway for DIS3L Gene

Gene Ontology (GO) - Biological Process for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0016075 rRNA catabolic process IEA,IMP 20368444
genes like me logo Genes that share ontologies with DIS3L: view

No data available for SIGNOR curated interactions for DIS3L Gene

Drugs & Compounds for DIS3L Gene

No Compound Related Data Available

Transcripts for DIS3L Gene

Unigene Clusters for DIS3L Gene

DIS3 mitotic control homolog (S. cerevisiae)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIS3L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - -
SP2: -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - -
SP9:
SP10: -
SP11:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for DIS3L Gene

GeneLoc Exon Structure for
DIS3L
ECgene alternative splicing isoforms for
DIS3L

Expression for DIS3L Gene

mRNA expression in normal human tissues for DIS3L Gene

Protein differential expression in normal tissues from HIPED for DIS3L Gene

This gene is overexpressed in Heart (22.7), Peripheral blood mononuclear cells (12.0), and Lymph node (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIS3L Gene



SOURCE GeneReport for Unigene cluster for DIS3L Gene Hs.446251

genes like me logo Genes that share expression patterns with DIS3L: view

Protein tissue co-expression partners for DIS3L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DIS3L Gene

Orthologs for DIS3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIS3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DIS3L 35
  • 88.66 (n)
  • 91.96 (a)
DIS3L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DIS3L 35
  • 89.73 (n)
  • 92.87 (a)
DIS3L 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dis3l 35
  • 86.6 (n)
  • 91.9 (a)
Dis3l 16
Dis3l 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DIS3L 35
  • 99.46 (n)
  • 99.72 (a)
DIS3L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dis3l 35
  • 85.96 (n)
  • 91.56 (a)
oppossum
(Monodelphis domestica)
Mammalia DIS3L 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DIS3L 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIS3L 35
  • 75.14 (n)
  • 79.67 (a)
DIS3L 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DIS3L 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dis3l 35
  • 67.01 (n)
  • 70.46 (a)
Str.941 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3437 35
zebrafish
(Danio rerio)
Actinopterygii dis3l 35
  • 62.74 (n)
  • 65.02 (a)
dis3l 36
  • 63 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIS3 36
  • 32 (a)
OneToMany
Species with no ortholog for DIS3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DIS3L Gene

ENSEMBL:
Gene Tree for DIS3L (if available)
TreeFam:
Gene Tree for DIS3L (if available)

Paralogs for DIS3L Gene

Paralogs for DIS3L Gene

(2) SIMAP similar genes for DIS3L Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with DIS3L: view

Variants for DIS3L Gene

Sequence variations from dbSNP and Humsavar for DIS3L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34668776 - 66,322,912(+) CTTAC(A/G)TTGAT reference, missense
rs3803412 - 66,326,004(-) TCTCA(C/T)CCAAG reference, missense
rs17258507 - 66,329,008(+) TGCGA(A/G)CGACC reference, missense
rs5813390 -- 66,299,561(+) AAAAA(-/A)GGGAT intron-variant
rs5813391 -- 66,329,913(+) GTCTC(-/A)AAAAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DIS3L Gene

Variant ID Type Subtype PubMed ID
nsv833045 CNV Gain 17160897

Variation tolerance for DIS3L Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIS3L Gene

HapMap Linkage Disequilibrium report
DIS3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIS3L Gene

Disorders for DIS3L Gene

MalaCards: The human disease database

(1) MalaCards diseases for DIS3L Gene - From: DISEASES

Disorder Aliases PubMed IDs
perlman syndrome
  • nephroblastomatosis - fetal ascites - macrosomia - wilms tumor
- elite association - COSMIC cancer census association via MalaCards
Search DIS3L in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIS3L

Genetic Association Database (GAD)
DIS3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIS3L
genes like me logo Genes that share disorders with DIS3L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIS3L Gene

Publications for DIS3L Gene

  1. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PMID: 20531386) Tomecki R. … Jensen T.H. (EMBO J. 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 3

Products for DIS3L Gene

Sources for DIS3L Gene

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