Aliases for DIS3L Gene
External Ids for DIS3L Gene
Previous GeneCards Identifiers for DIS3L Gene
GeneCards Summary for DIS3L Gene
DIS3L (DIS3 Like Exosome 3'-5' Exoribonuclease) is a Protein Coding gene. Diseases associated with DIS3L include perlman syndrome. Among its related pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and 3-5-exoribonuclease activity. An important paralog of this gene is DIS3L2.
UniProtKB/Swiss-Prot for DIS3L Gene
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.