Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGAP33 Gene

Aliases for ARHGAP33 Gene

  • Rho GTPase Activating Protein 33 2 3 5
  • Rho-Type GTPase-Activating Protein 33 3 4
  • Tc10/CDC42 GTPase-Activating Protein 3 4
  • Sorting Nexin 26 2 3
  • SNX26 3 4
  • TCGAP 3 4
  • Neurite Outgrowth Multiadaptor RhoGAP Protein 3
  • Rho GTPase-Activating Protein 33 3
  • Sorting Nexin-26 4
  • NOMA-GAP 3

External Ids for ARHGAP33 Gene

Previous HGNC Symbols for ARHGAP33 Gene

  • SNX26

Previous GeneCards Identifiers for ARHGAP33 Gene

  • GC19P036266
  • GC19P032771
  • GC19P035811
  • GC19P035834
  • GC19P035992
  • GC19P036015
  • GC19P036177
  • GC19P036255
  • GC19P036422

Summaries for ARHGAP33 Gene

Entrez Gene Summary for ARHGAP33 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for ARHGAP33 Gene

ARHGAP33 (Rho GTPase Activating Protein 33) is a Protein Coding gene. Diseases associated with ARHGAP33 include Noma. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol binding. An important paralog of this gene is ARHGAP32.

UniProtKB/Swiss-Prot for ARHGAP33 Gene

  • May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).

Gene Wiki entry for ARHGAP33 Gene

Additional gene information for ARHGAP33 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP33 Gene

Genomics for ARHGAP33 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP33 Gene

Promoters and enhancers for ARHGAP33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035774 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.1 1092 1.6 PKNOX1 CLOCK ATF1 ARID4B SIN3A GLIS2 ELK1 ZNF207 ZNF143 FOS ARHGAP33 ENSG00000267049 ZNF461 ZNF529 LOC100134317 U2AF1L4 LINC01534 ZNF30 RBM42 ZNF792
GH19I035246 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33 -525.9 -525907 3.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 LSR RBM42 KMT2B ZNF599 TMEM147-AS1 HAUS5 ZNF792 ZNF30 ZNF302 KIAA0355
GH19I035508 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 31.6 -264.7 -264667 2.5 SMAD1 MLX ARID4B SIN3A ZNF2 ZBTB7B IRF4 SLC30A9 ZNF143 KLF13 DMKN ZFP82 CLIP3 ARHGAP33 TMEM147-AS1 LINC00665 ZNF566 PROSER3 KMT2B ZNF599
GH19I036572 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.2 +799.0 798976 3 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF529 ZNF529-AS1 ZNF790-AS1 ZNF567 ZFP82 ZNF527 ZNF585A LINC01534 ZNF793 ZNF383
GH19I035897 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.3 +129.5 129526 13 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZFP41 NFKBID TYROBP HCST ENSG00000280194 ZNF567 ZNF566 ZNF790 ZNF529 TMEM147-AS1 ZNF260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP33 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARHGAP33 Gene

Genomic Locations for ARHGAP33 Gene
chr19:35,774,532-35,788,822
(GRCh38/hg38)
Size:
14,291 bases
Orientation:
Plus strand
chr19:36,265,434-36,279,724
(GRCh37/hg19)

Genomic View for ARHGAP33 Gene

Genes around ARHGAP33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP33 Gene

Proteins for ARHGAP33 Gene

  • Protein details for ARHGAP33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14559-RHG33_HUMAN
    Recommended name:
    Rho GTPase-activating protein 33
    Protein Accession:
    O14559
    Secondary Accessions:
    • O14552
    • O14560
    • Q6ZSP6
    • Q96CP3
    • Q9NT23

    Protein attributes for ARHGAP33 Gene

    Size:
    1287 amino acids
    Molecular mass:
    137213 Da
    Quaternary structure:
    • Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain (By similarity). Interacts with NEK6.
    SequenceCaution:
    • Sequence=AAB81198.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP33 Gene

Post-translational modifications for ARHGAP33 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ARHGAP33 Gene

Domains & Families for ARHGAP33 Gene

Gene Families for ARHGAP33 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARHGAP33 Gene

Graphical View of Domain Structure for InterPro Entry

O14559

UniProtKB/Swiss-Prot:

RHG33_HUMAN :
  • Belongs to the PX domain-containing GAP family.
Domain:
  • Belongs to the PX domain-containing GAP family.
genes like me logo Genes that share domains with ARHGAP33: view

Function for ARHGAP33 Gene

Molecular function for ARHGAP33 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).

Phenotypes From GWAS Catalog for ARHGAP33 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 16777849
GO:0019901 protein kinase binding IPI 20873783
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with ARHGAP33: view
genes like me logo Genes that share phenotypes with ARHGAP33: view

Animal Models for ARHGAP33 Gene

MGI Knock Outs for ARHGAP33:

Animal Model Products

miRNA for ARHGAP33 Gene

miRTarBase miRNAs that target ARHGAP33

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP33 Gene

Localization for ARHGAP33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP33 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
plasma membrane 3
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005938 cell cortex IBA --
GO:0015629 actin cytoskeleton IBA --
genes like me logo Genes that share ontologies with ARHGAP33: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP33 Gene

Pathways & Interactions for ARHGAP33 Gene

genes like me logo Genes that share pathways with ARHGAP33: view

Pathways by source for ARHGAP33 Gene

1 GeneTex pathway for ARHGAP33 Gene
1 BioSystems pathway for ARHGAP33 Gene
3 Reactome pathways for ARHGAP33 Gene

SIGNOR curated interactions for ARHGAP33 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ARHGAP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IBA --
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGAP33: view

Drugs & Compounds for ARHGAP33 Gene

No Compound Related Data Available

Transcripts for ARHGAP33 Gene

Unigene Clusters for ARHGAP33 Gene

Rho GTPase activating protein 33:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7: -
SP8: -
SP9:

ExUns: 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARHGAP33 Gene

GeneLoc Exon Structure for
ARHGAP33
ECgene alternative splicing isoforms for
ARHGAP33

Expression for ARHGAP33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP33 Gene

Protein differential expression in normal tissues from HIPED for ARHGAP33 Gene

This gene is overexpressed in Fetal Brain (34.8) and Heart (34.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGAP33 Gene



Protein tissue co-expression partners for ARHGAP33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP33 Gene:

ARHGAP33

SOURCE GeneReport for Unigene cluster for ARHGAP33 Gene:

Hs.515364

Evidence on tissue expression from TISSUES for ARHGAP33 Gene

  • Nervous system(4.7)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ARHGAP33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP33 Gene

Orthologs for ARHGAP33 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP33 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
OneToMany
ARHGAP33 33
  • 89.21 (n)
-- 34
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP33 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP33 33 34
  • 89.1 (n)
mouse
(Mus musculus)
Mammalia Arhgap33 33 16 34
  • 86.28 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap33 33
  • 84.5 (n)
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP33 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP33 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ARHGAP33 34
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arhgap33 34
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 34
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToMany
Species where no ortholog for ARHGAP33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP33 Gene

ENSEMBL:
Gene Tree for ARHGAP33 (if available)
TreeFam:
Gene Tree for ARHGAP33 (if available)

Paralogs for ARHGAP33 Gene

Paralogs for ARHGAP33 Gene

(10) SIMAP similar genes for ARHGAP33 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARHGAP33 Gene

genes like me logo Genes that share paralogs with ARHGAP33: view

Variants for ARHGAP33 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP33 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs780247702 likely-benign, not specified 35,780,821(+) T/A/C genic_upstream_transcript_variant, intron_variant
rs1000340213 -- 35,783,492(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000361674 -- 35,777,196(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000367743 -- 35,773,960(+) C/A upstream_transcript_variant
rs1000943872 -- 35,782,309(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP33 Gene

Variant ID Type Subtype PubMed ID
nsv1152678 CNV duplication 26484159
nsv579423 CNV loss 21841781
nsv953286 CNV deletion 24416366

Variation tolerance for ARHGAP33 Gene

Residual Variation Intolerance Score: 4.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP33 Gene

Human Gene Mutation Database (HGMD)
ARHGAP33
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP33 Gene

Disorders for ARHGAP33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP33 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
noma
  • cancrum oris
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP33

genes like me logo Genes that share disorders with ARHGAP33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP33 Gene

Publications for ARHGAP33 Gene

  1. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G … Kobarg J (Journal of proteome research 2010) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. (PMID: 12297274) Peck J … Burbelo PD (FEBS letters 2002) 2 3 58

Products for ARHGAP33 Gene

Sources for ARHGAP33 Gene

Content
Loading form....