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Aliases for ARHGAP33 Gene

Aliases for ARHGAP33 Gene

  • Rho GTPase Activating Protein 33 2 3 5
  • Rho-Type GTPase-Activating Protein 33 3 4
  • Tc10/CDC42 GTPase-Activating Protein 3 4
  • Sorting Nexin 26 2 3
  • Sorting Nexin-26 3 4
  • SNX26 3 4
  • TCGAP 3 4
  • Neurite Outgrowth Multiadaptor RhoGAP Protein 3
  • NOMA-GAP 3

External Ids for ARHGAP33 Gene

Previous HGNC Symbols for ARHGAP33 Gene

  • SNX26

Previous GeneCards Identifiers for ARHGAP33 Gene

  • GC19P036266
  • GC19P032771
  • GC19P035811
  • GC19P035834

Summaries for ARHGAP33 Gene

Entrez Gene Summary for ARHGAP33 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for ARHGAP33 Gene

ARHGAP33 (Rho GTPase Activating Protein 33) is a Protein Coding gene. Diseases associated with ARHGAP33 include noma. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity and phosphatidylinositol binding. An important paralog of this gene is ARHGAP31.

UniProtKB/Swiss-Prot for ARHGAP33 Gene

  • May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).

Gene Wiki entry for ARHGAP33 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP33 Gene

Genomics for ARHGAP33 Gene

Regulatory Elements for ARHGAP33 Gene

Promoters for ARHGAP33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP33 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP33 Gene

Chromosome:
19
Start:
35,774,532 bp from pter
End:
35,788,822 bp from pter
Size:
14,291 bases
Orientation:
Plus strand

Genomic View for ARHGAP33 Gene

Genes around ARHGAP33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP33 Gene

Proteins for ARHGAP33 Gene

  • Protein details for ARHGAP33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14559-RHG33_HUMAN
    Recommended name:
    Rho GTPase-activating protein 33
    Protein Accession:
    O14559
    Secondary Accessions:
    • O14552
    • O14560
    • Q6ZSP6
    • Q96CP3
    • Q9NT23

    Protein attributes for ARHGAP33 Gene

    Size:
    1287 amino acids
    Molecular mass:
    137213 Da
    Quaternary structure:
    • Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain (By similarity). Interacts with NEK6.
    SequenceCaution:
    • Sequence=AAB81198.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP33 Gene

Proteomics data for ARHGAP33 Gene at MOPED

Post-translational modifications for ARHGAP33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP33 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ARHGAP33

No data available for DME Specific Peptides for ARHGAP33 Gene

Domains & Families for ARHGAP33 Gene

Gene Families for ARHGAP33 Gene

Protein Domains for ARHGAP33 Gene

Suggested Antigen Peptide Sequences for ARHGAP33 Gene

Graphical View of Domain Structure for InterPro Entry

O14559

UniProtKB/Swiss-Prot:

RHG33_HUMAN :
  • Belongs to the PX domain-containing GAP family.
Domain:
  • Belongs to the PX domain-containing GAP family.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGAP33: view

Function for ARHGAP33 Gene

Molecular function for ARHGAP33 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGAP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with ARHGAP33: view
genes like me logo Genes that share phenotypes with ARHGAP33: view

Animal Models for ARHGAP33 Gene

MGI Knock Outs for ARHGAP33:

Animal Model Products

CRISPR Products

miRNA for ARHGAP33 Gene

miRTarBase miRNAs that target ARHGAP33

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP33 Gene

Localization for ARHGAP33 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP33 Gene COMPARTMENTS Subcellular localization image for ARHGAP33 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP33 Gene

Pathways & Interactions for ARHGAP33 Gene

genes like me logo Genes that share pathways with ARHGAP33: view

Pathways by source for ARHGAP33 Gene

1 GeneTex pathway for ARHGAP33 Gene
1 BioSystems pathway for ARHGAP33 Gene
3 Reactome pathways for ARHGAP33 Gene

SIGNOR curated interactions for ARHGAP33 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ARHGAP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0015031 protein transport IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP33: view

Drugs & Compounds for ARHGAP33 Gene

No Compound Related Data Available

Transcripts for ARHGAP33 Gene

Unigene Clusters for ARHGAP33 Gene

Rho GTPase activating protein 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7: -
SP8: -
SP9:

ExUns: 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARHGAP33 Gene

GeneLoc Exon Structure for
ARHGAP33
ECgene alternative splicing isoforms for
ARHGAP33

Expression for ARHGAP33 Gene

mRNA expression in normal human tissues for ARHGAP33 Gene

Protein differential expression in normal tissues from HIPED for ARHGAP33 Gene

This gene is overexpressed in Fetal Brain (34.8) and Heart (34.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGAP33 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP33 Gene Hs.515364

genes like me logo Genes that share expression patterns with ARHGAP33: view

Protein tissue co-expression partners for ARHGAP33 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGAP33 Gene

Orthologs for ARHGAP33 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP33 35
  • 89.1 (n)
  • 93.24 (a)
ARHGAP33 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP33 35
  • 89.21 (n)
  • 93.73 (a)
-- 36
  • 76 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Arhgap33 35
  • 86.28 (n)
  • 92.14 (a)
Arhgap33 16
Arhgap33 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap33 35
  • 84.5 (n)
  • 89.42 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP33 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP33 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP33 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ARHGAP33 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arhgap33 36
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 36
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ARHGAP33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP33 Gene

ENSEMBL:
Gene Tree for ARHGAP33 (if available)
TreeFam:
Gene Tree for ARHGAP33 (if available)

Paralogs for ARHGAP33 Gene

Paralogs for ARHGAP33 Gene

(10) SIMAP similar genes for ARHGAP33 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARHGAP33 Gene

genes like me logo Genes that share paralogs with ARHGAP33: view

Variants for ARHGAP33 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP33 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs231222 -- 35,783,586(+) ggagc(C/T)gcagg intron-variant, upstream-variant-2KB
rs231223 -- 35,782,328(+) GCGAG(C/G)CCCTC intron-variant
rs231224 -- 35,781,512(+) gccct(C/G)atagg intron-variant
rs231225 -- 35,776,616(+) GACTG(C/G)GCTGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs231226 -- 35,776,875(+) ccagg(C/T)gcagc intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP33 Gene

Variant ID Type Subtype PubMed ID
dgv3852n71 CNV Loss 21882294
dgv3853n71 CNV Loss 21882294
nsv911636 CNV Loss 21882294
nsv911637 CNV Loss 21882294
nsv911638 CNV Loss 21882294

Variation tolerance for ARHGAP33 Gene

Residual Variation Intolerance Score: 4.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP33 Gene

HapMap Linkage Disequilibrium report
ARHGAP33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP33 Gene

Disorders for ARHGAP33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP33 Gene - From: GeneCards

Disorder Aliases PubMed IDs
noma
  • cancrum oris
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP33

Human Genome Epidemiology (HuGE) Navigator
ARHGAP33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP33
genes like me logo Genes that share disorders with ARHGAP33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP33 Gene

Publications for ARHGAP33 Gene

  1. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G. … Kobarg J. (J. Proteome Res. 2010) 3 4 67
  2. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. (PMID: 12297274) Peck J. … Burbelo P.D. (FEBS Lett. 2002) 2 3
  3. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3

Products for ARHGAP33 Gene

Sources for ARHGAP33 Gene

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