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Aliases for FCRL3 Gene

Aliases for FCRL3 Gene

  • Fc Receptor-Like 3 2 3
  • FCRH3 3 4 6
  • Immune Receptor Translocation-Associated Protein 3 3 4
  • SH2 Domain-Containing Phosphatase Anchor Protein 2 3 4
  • Fc Receptor Homolog 3 3 4
  • IFGP Family Protein 3 3 4
  • FcR-Like Protein 3 3 4
  • HIFGP3 3 4
  • IFGP3 3 4
  • IRTA3 3 4
  • SPAP2 3 4
  • Immunoglobulin Superfamily Receptor Translocation Associated Protein 3 3
  • Fc Receptor-Like Protein 3 3
  • CD307c Antigen 4
  • CD307c 3
  • FcRL3 4

External Ids for FCRL3 Gene

Previous GeneCards Identifiers for FCRL3 Gene

  • GC01M154460
  • GC01M155912
  • GC01M129005

Summaries for FCRL3 Gene

Entrez Gene Summary for FCRL3 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCRL3 Gene

FCRL3 (Fc Receptor-Like 3) is a Protein Coding gene. Diseases associated with FCRL3 include autoimmune pancreatitis and juvenile rheumatoid arthritis. An important paralog of this gene is FCRL2.

Gene Wiki entry for FCRL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL3 Gene

Genomics for FCRL3 Gene

Regulatory Elements for FCRL3 Gene

Transcription factor binding sites by QIAGEN in the FCRL3 gene promoter:

Genomic Location for FCRL3 Gene

Start:
157,674,321 bp from pter
End:
157,700,985 bp from pter
Size:
26,665 bases
Orientation:
Minus strand

Genomic View for FCRL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL3 Gene

Proteins for FCRL3 Gene

  • Protein details for FCRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P31-FCRL3_HUMAN
    Recommended name:
    Fc receptor-like protein 3
    Protein Accession:
    Q96P31
    Secondary Accessions:
    • A0N0M4
    • A8MTH7
    • D3DVD2
    • Q5VXZ8
    • Q8N6S2
    • Q96LA4
    • Q96P27
    • Q96P28
    • Q96P29
    • Q96P30

    Protein attributes for FCRL3 Gene

    Size:
    734 amino acids
    Molecular mass:
    80856 Da
    Quaternary structure:
    • Interacts with PTPN6, PTPN11, SYK and ZAP70.

    Alternative splice isoforms for FCRL3 Gene

neXtProt entry for FCRL3 Gene

Proteomics data for FCRL3 Gene at MOPED

Post-translational modifications for FCRL3 Gene

  • Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.
  • Glycosylation at Asn561
  • Modification sites at PhosphoSitePlus

Other Protein References for FCRL3 Gene

No data available for DME Specific Peptides for FCRL3 Gene

Domains for FCRL3 Gene

Gene Families for FCRL3 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCRL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96P31

UniProtKB/Swiss-Prot:

FCRL3_HUMAN :
  • Q96P31
Domain:
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCRL3: view

Function for FCRL3 Gene

Gene Ontology (GO) - Molecular Function for FCRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FCRL3: view

Phenotypes for FCRL3 Gene

GenomeRNAi human phenotypes for FCRL3:
genes like me logo Genes that share phenotypes with FCRL3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCRL3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FCRL3 Gene

Localization for FCRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCRL3 Gene COMPARTMENTS Subcellular localization image for FCRL3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FCRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCRL3: view

Pathways for FCRL3 Gene

SuperPathways for FCRL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCRL3 Gene

None

No data available for Pathways by source for FCRL3 Gene

Transcripts for FCRL3 Gene

Unigene Clusters for FCRL3 Gene

Fc receptor-like 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCRL3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FCRL3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -
SP3: - - -
SP4:
SP5: -
SP6:
SP7: -
SP8:

Relevant External Links for FCRL3 Gene

GeneLoc Exon Structure for
FCRL3
ECgene alternative splicing isoforms for
FCRL3

Expression for FCRL3 Gene

mRNA expression in normal human tissues for FCRL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRL3 Gene

This gene is overexpressed in Spleen (22.0), Whole Blood (12.0), and Small Intestine - Terminal Ileum (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCRL3 Gene

SOURCE GeneReport for Unigene cluster for FCRL3 Gene Hs.292449

mRNA Expression by UniProt/SwissProt for FCRL3 Gene

Q96P31-FCRL3_HUMAN
Tissue specificity: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level).
genes like me logo Genes that share expressions with FCRL3: view

In Situ Assay Products

Orthologs for FCRL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCRL3 35
  • 99.05 (n)
  • 98.23 (a)
FCRL3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCRL3 35
  • 77.17 (n)
  • 63.03 (a)
FCRL3 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
ManyToMany
FCRL3 35
  • 76.15 (n)
  • 63.05 (a)
mouse
(Mus musculus)
Mammalia Fcrl5 16
chicken
(Gallus gallus)
Aves FCRL2 35
  • 49.73 (n)
  • 39.04 (a)
FCRL2 36
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494132 35
  • 46.75 (n)
  • 37.34 (a)
Species with no ortholog for FCRL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL3 Gene

ENSEMBL:
Gene Tree for FCRL3 (if available)
TreeFam:
Gene Tree for FCRL3 (if available)

Paralogs for FCRL3 Gene

genes like me logo Genes that share paralogs with FCRL3: view

Variants for FCRL3 Gene

Sequence variations from dbSNP and Humsavar for FCRL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs944626 -- 157,677,578(+) ACACT(C/G)TGGAA utr-variant-3-prime, intron-variant
rs944627 - 157,680,749(+) AAATC(A/G)GGTTG reference, missense, nc-transcript-variant
rs945635 -- 157,700,500(+) CCGGC(C/G)GGGCA utr-variant-5-prime, nc-transcript-variant
rs1537947 -- 157,684,873(+) TTTTA(C/G)AAAAA intron-variant
rs1806798 -- 157,681,227(-) ACCCA(A/G)GCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL3 Gene

Variant ID Type Subtype PubMed ID
nsv520011 CNV Loss 19592680

Relevant External Links for FCRL3 Gene

HapMap Linkage Disequilibrium report
FCRL3
Human Gene Mutation Database (HGMD)
FCRL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL3 Gene

Disorders for FCRL3 Gene

UniProtKB/Swiss-Prot

FCRL3_HUMAN
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:15838509, ECO:0000269 PubMed:16176992, ECO:0000269 PubMed:16476711, ECO:0000269 PubMed:16859508, ECO:0000269 PubMed:17133579, ECO:0000269 PubMed:17179172, ECO:0000269 PubMed:17763442}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.

(2) University of Copenhagen DISEASES for FCRL3 Gene

(5) Novoseek inferred disease relationships for FCRL3 Gene

Disease -log(P) Hits PubMed IDs
autoimmune thyroid disease 74.6 3
autoimmune diseases 71.8 16
rheumatoid arthritis 62.2 12
lupus erythematosus systemic 55.2 5
autoimmunity 42 6

Relevant External Links for FCRL3

Genetic Association Database (GAD)
FCRL3
Human Genome Epidemiology (HuGE) Navigator
FCRL3
genes like me logo Genes that share disorders with FCRL3: view

Publications for FCRL3 Gene

  1. Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis. (PMID: 16176992) Ikari K. … Kamatani N. (Ann. Rheum. Dis. 2006) 3 4 23 48
  2. Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis. (PMID: 16476711) Martinez A. … Martin J. (Ann. Rheum. Dis. 2006) 3 4 23 48
  3. Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? (PMID: 16859508) Eyre S. … Barton A. (Arthritis Res. Ther. 2006) 3 4 23 48
  4. FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians. (PMID: 17179172) Thabet M.M. … Huizinga T.W.J. (Ann. Rheum. Dis. 2007) 3 4 23 48
  5. Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. (PMID: 17133579) Newman W.G. … Siminovitch K.A. (Arthritis Rheum. 2006) 3 4 23 48

Products for FCRL3 Gene

Sources for FCRL3 Gene

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