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Aliases for GPRASP2 Gene

Aliases for GPRASP2 Gene

  • G Protein-Coupled Receptor Associated Sorting Protein 2 2 3 5
  • GASP-2 4
  • GASP2 3

External Ids for GPRASP2 Gene

Previous GeneCards Identifiers for GPRASP2 Gene

  • GC0XP101773
  • GC0XP101853
  • GC0XP101974
  • GC0XP091571
  • GC0XP101977
  • GC0XP101979
  • GC0XP101985

Summaries for GPRASP2 Gene

Entrez Gene Summary for GPRASP2 Gene

  • The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for GPRASP2 Gene

GPRASP2 (G Protein-Coupled Receptor Associated Sorting Protein 2) is a Protein Coding gene. Diseases associated with GPRASP2 include Autism Spectrum Disorder. GO annotations related to this gene include binding and beta-amyloid binding. An important paralog of this gene is ARMCX6.

UniProtKB/Swiss-Prot for GPRASP2 Gene

  • May play a role in regulation of a variety of G-protein coupled receptors.

Gene Wiki entry for GPRASP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRASP2 Gene

Genomics for GPRASP2 Gene

Regulatory Elements for GPRASP2 Gene

Enhancers for GPRASP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPRASP2 on UCSC Golden Path with GeneCards custom track

Promoters for GPRASP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPRASP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPRASP2 Gene

Chromosome:
X
Start:
102,712,176 bp from pter
End:
102,717,733 bp from pter
Size:
5,558 bases
Orientation:
Plus strand

Genomic View for GPRASP2 Gene

Genes around GPRASP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRASP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRASP2 Gene

Proteins for GPRASP2 Gene

  • Protein details for GPRASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D09-GASP2_HUMAN
    Recommended name:
    G-protein coupled receptor-associated sorting protein 2
    Protein Accession:
    Q96D09
    Secondary Accessions:
    • D3DXA0
    • Q8NAB4

    Protein attributes for GPRASP2 Gene

    Size:
    838 amino acids
    Molecular mass:
    93773 Da
    Quaternary structure:
    • Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.

neXtProt entry for GPRASP2 Gene

Proteomics data for GPRASP2 Gene at MOPED

Post-translational modifications for GPRASP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRASP2 Gene

Antibody Products

No data available for DME Specific Peptides for GPRASP2 Gene

Domains & Families for GPRASP2 Gene

Gene Families for GPRASP2 Gene

Protein Domains for GPRASP2 Gene

Suggested Antigen Peptide Sequences for GPRASP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96D09

UniProtKB/Swiss-Prot:

GASP2_HUMAN :
  • Belongs to the GPRASP family.
Family:
  • Belongs to the GPRASP family.
genes like me logo Genes that share domains with GPRASP2: view

Function for GPRASP2 Gene

Molecular function for GPRASP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulation of a variety of G-protein coupled receptors.

Gene Ontology (GO) - Molecular Function for GPRASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GPRASP2: view

Phenotypes for GPRASP2 Gene

genes like me logo Genes that share phenotypes with GPRASP2: view

Animal Model Products

CRISPR Products

miRNA for GPRASP2 Gene

miRTarBase miRNAs that target GPRASP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPRASP2 Gene

Localization for GPRASP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPRASP2 Gene COMPARTMENTS Subcellular localization image for GPRASP2 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPRASP2 Gene

Pathways & Interactions for GPRASP2 Gene

SuperPathways for GPRASP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPRASP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPRASP2 Gene

Drugs & Compounds for GPRASP2 Gene

No Compound Related Data Available

Transcripts for GPRASP2 Gene

Unigene Clusters for GPRASP2 Gene

G protein-coupled receptor associated sorting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPRASP2 Gene

No ASD Table

Relevant External Links for GPRASP2 Gene

GeneLoc Exon Structure for
GPRASP2
ECgene alternative splicing isoforms for
GPRASP2

Expression for GPRASP2 Gene

mRNA expression in normal human tissues for GPRASP2 Gene

Protein differential expression in normal tissues from HIPED for GPRASP2 Gene

This gene is overexpressed in Adrenal (21.6), Fetal Brain (19.7), and Heart (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPRASP2 Gene



SOURCE GeneReport for Unigene cluster for GPRASP2 Gene Hs.731996

mRNA Expression by UniProt/SwissProt for GPRASP2 Gene

Q96D09-GASP2_HUMAN
Tissue specificity: Expressed in the brain.
genes like me logo Genes that share expression patterns with GPRASP2: view

Protein tissue co-expression partners for GPRASP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GPRASP2 Gene

Orthologs for GPRASP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRASP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPRASP2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPRASP2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gprasp2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GPRASP2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 36
  • 18 (a)
OneToMany
Species with no ortholog for GPRASP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRASP2 Gene

ENSEMBL:
Gene Tree for GPRASP2 (if available)
TreeFam:
Gene Tree for GPRASP2 (if available)

Paralogs for GPRASP2 Gene

(1) SIMAP similar genes for GPRASP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPRASP2: view

Variants for GPRASP2 Gene

Sequence variations from dbSNP and Humsavar for GPRASP2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_049265 -

Structural Variations from Database of Genomic Variants (DGV) for GPRASP2 Gene

Variant ID Type Subtype PubMed ID
nsv526716 CNV Gain 19592680

Variation tolerance for GPRASP2 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPRASP2 Gene

Disorders for GPRASP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPRASP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autism spectrum disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPRASP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPRASP2
genes like me logo Genes that share disorders with GPRASP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPRASP2 Gene

Publications for GPRASP2 Gene

  1. Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PMID: 15086532) Simonin F. … Kieffer B.L. (J. Neurochem. 2004) 2 3 4 67
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for GPRASP2 Gene

Sources for GPRASP2 Gene

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