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Aliases for SLAMF6 Gene

Aliases for SLAMF6 Gene

  • SLAM Family Member 6 2 3
  • Activating NK Receptor 3 4
  • NK-T-B-Antigen 3 4
  • NTB-A 3 4
  • NTBA 3 6
  • KALI 3 4
  • Natural Killer-, T- And B-Cell Antigen 3
  • NTBA Receptor 3
  • CD352 Antigen 4
  • SF2000 3
  • CD352 3
  • KALIb 3
  • Ly108 3

External Ids for SLAMF6 Gene

Previous GeneCards Identifiers for SLAMF6 Gene

  • GC01M157671
  • GC01M157267
  • GC01M158721
  • GC01M131811

Summaries for SLAMF6 Gene

Entrez Gene Summary for SLAMF6 Gene

  • The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

GeneCards Summary for SLAMF6 Gene

SLAMF6 (SLAM Family Member 6) is a Protein Coding gene. Diseases associated with SLAMF6 include bare lymphocyte syndrome, type i and griscelli syndrome. GO annotations related to this gene include receptor activity. An important paralog of this gene is CD84.

UniProtKB/Swiss-Prot for SLAMF6 Gene

  • Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.

Gene Wiki entry for SLAMF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF6 Gene

Genomics for SLAMF6 Gene

Regulatory Elements for SLAMF6 Gene

Genomic Location for SLAMF6 Gene

160,485,030 bp from pter
160,523,262 bp from pter
38,233 bases
Minus strand

Genomic View for SLAMF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLAMF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF6 Gene

Proteins for SLAMF6 Gene

  • Protein details for SLAMF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLAM family member 6
    Protein Accession:
    Secondary Accessions:
    • A6NMW2
    • B2R8X8
    • Q14CF0
    • Q5TAS4
    • Q5TAS6
    • Q5TAT3
    • Q96DV0

    Protein attributes for SLAMF6 Gene

    332 amino acids
    Molecular mass:
    37345 Da
    Quaternary structure:
    • Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP.

    Three dimensional structures from OCA and Proteopedia for SLAMF6 Gene

    Alternative splice isoforms for SLAMF6 Gene


neXtProt entry for SLAMF6 Gene

Proteomics data for SLAMF6 Gene at MOPED

Post-translational modifications for SLAMF6 Gene

  • Glycosylation at Asn58, Asn87, Asn137, Asn144, Asn161, Asn171, Asn178, and Asn203
  • Modification sites at PhosphoSitePlus

Other Protein References for SLAMF6 Gene

Antibody Products

  • R&D Systems Antibodies for SLAMF6 (NTB-A/SLAMF6)

No data available for DME Specific Peptides for SLAMF6 Gene

Domains for SLAMF6 Gene

Protein Domains for SLAMF6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SLAMF6: view

Function for SLAMF6 Gene

Molecular function for SLAMF6 Gene

UniProtKB/Swiss-Prot Function:
Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.

Gene Ontology (GO) - Molecular Function for SLAMF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLAMF6: view
genes like me logo Genes that share phenotypes with SLAMF6: view

Animal Models for SLAMF6 Gene

MGI Knock Outs for SLAMF6:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SLAMF6 Gene

Localization for SLAMF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF6 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SLAMF6 Gene COMPARTMENTS Subcellular localization image for SLAMF6 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLAMF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SLAMF6: view

Pathways for SLAMF6 Gene

SuperPathways for SLAMF6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLAMF6 Gene


No data available for Pathways by source for SLAMF6 Gene

Drugs for SLAMF6 Gene

(1) Novoseek inferred chemical compound relationships for SLAMF6 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 24.6 3
genes like me logo Genes that share compounds with SLAMF6: view

Transcripts for SLAMF6 Gene

Unigene Clusters for SLAMF6 Gene

SLAM family member 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLAMF6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for SLAMF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLAMF6 Gene

mRNA expression in normal human tissues for SLAMF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAMF6 Gene

This gene is overexpressed in Whole Blood (13.3) and Spleen (8.0).

Protein differential expression in normal tissues for SLAMF6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.3), CD8 Tcells (13.3), and Lymph node (7.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLAMF6 Gene

SOURCE GeneReport for Unigene cluster for SLAMF6 Gene Hs.492348

mRNA Expression by UniProt/SwissProt for SLAMF6 Gene

Tissue specificity: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes.
genes like me logo Genes that share expressions with SLAMF6: view

Expression partners for SLAMF6 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLAMF6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLAMF6 35
  • 71.63 (n)
  • 55.34 (a)
  • 51 (a)
(Canis familiaris)
Mammalia SLAMF6 35
  • 66.98 (n)
  • 47.83 (a)
  • 47 (a)
(Mus musculus)
Mammalia Slamf6 35
  • 64.6 (n)
  • 47.23 (a)
Slamf6 16
Slamf6 36
  • 41 (a)
(Pan troglodytes)
Mammalia SLAMF6 35
  • 98.69 (n)
  • 97.28 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Slamf6 35
  • 65.21 (n)
  • 46.25 (a)
(Monodelphis domestica)
Mammalia SLAMF6 36
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
Species with no ortholog for SLAMF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF6 Gene

Gene Tree for SLAMF6 (if available)
Gene Tree for SLAMF6 (if available)

Paralogs for SLAMF6 Gene

Paralogs for SLAMF6 Gene Pseudogenes for SLAMF6 Gene

genes like me logo Genes that share paralogs with SLAMF6: view

Variants for SLAMF6 Gene

Sequence variations from dbSNP and Humsavar for SLAMF6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs480348 -- 160,499,433(+) gtgta(A/C)cggta intron-variant
rs614136 -- 160,497,606(+) atagg(C/T)agtta intron-variant
rs634791 -- 160,485,319(-) atccc(A/T)gtact utr-variant-3-prime
rs678456 -- 160,494,758(-) CTCCC(A/G)GCTTC intron-variant
rs723155 -- 160,501,046(-) tgttt(C/T)ggggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF6 Gene

Variant ID Type Subtype PubMed ID
nsv872491 CNV Loss 21882294

Relevant External Links for SLAMF6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAMF6 Gene

Disorders for SLAMF6 Gene

(4) Novoseek inferred disease relationships for SLAMF6 Gene

Disease -log(P) Hits PubMed IDs
lymphoproliferative syndrome 58.6 2
tumors 24.1 8
virus infection 21.3 2
melanoma 0 2

Relevant External Links for SLAMF6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLAMF6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SLAMF6 Gene

Publications for SLAMF6 Gene

  1. NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked Lymphoproliferative disease. (PMID: 11489943) Bottino C. … Moretta A. (J. Exp. Med. 2001) 2 3 4 23
  2. NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. (PMID: 17045824) Cao E. … Almo S.C. (Immunity 2006) 3 4 23
  3. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PMID: 12928397) Tangye S.G. … van de Weerdt B.C.M. (J. Immunol. 2003) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for SLAMF6 Gene

Sources for SLAMF6 Gene

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