Aliases for SLAMF6 Gene
External Ids for SLAMF6 Gene
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
GeneCards Summary for SLAMF6 Gene
SLAMF6 (SLAM Family Member 6) is a Protein Coding gene. Diseases associated with SLAMF6 include griscelli syndrome and bare lymphocyte syndrome, type i. GO annotations related to this gene include receptor activity. An important paralog of this gene is CD84.
UniProtKB/Swiss-Prot for SLAMF6 Gene
Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.