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Aliases for SLAMF6 Gene

Aliases for SLAMF6 Gene

  • SLAM Family Member 6 2 3 5
  • Activating NK Receptor 3 4
  • NK-T-B-Antigen 3 4
  • NTB-A 3 4
  • KALI 3 4
  • Natural Killer-, T- And B-Cell Antigen 3
  • NTBA Receptor 3
  • CD352 Antigen 4
  • SF2000 3
  • CD352 3
  • KALIb 3
  • Ly108 3
  • NTBA 3

External Ids for SLAMF6 Gene

Previous GeneCards Identifiers for SLAMF6 Gene

  • GC01M157671
  • GC01M157267
  • GC01M158721
  • GC01M131811

Summaries for SLAMF6 Gene

Entrez Gene Summary for SLAMF6 Gene

  • The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

GeneCards Summary for SLAMF6 Gene

SLAMF6 (SLAM Family Member 6) is a Protein Coding gene. Diseases associated with SLAMF6 include Ovarian Cystic Teratoma and Systemic Lupus Erythematosus. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF7.

UniProtKB/Swiss-Prot for SLAMF6 Gene

  • Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).

Gene Wiki entry for SLAMF6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF6 Gene

Genomics for SLAMF6 Gene

Regulatory Elements for SLAMF6 Gene

Enhancers for SLAMF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G160565 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -44.6 -44646 5.0 HNRNPUL1 HDGF FOXA2 PKNOX1 ARNT CREB3L1 YY1 ZNF766 CBX5 ZNF143 CD84 VANGL2 SLAMF6 KCNJ10 ATP1A4 SLAMF1 LY9 CD48 LOC105371468
GH01G160436 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +85.2 85201 2.5 PKNOX1 ZNF473 KLF17 ZNF335 ZNF121 GLIS2 GATA2 FOS RELB CREM SLAMF6 SLAMF1 CD84 VANGL2 ENSG00000228863 ITLN1 LY9 CD48 DCAF8 LOC105371467
GH01G160573 1.7 FANTOM5 ENCODE dbSUPER 10.6 -53.7 -53675 6.1 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 YBX1 YY1 TCF12 ZNF766 GATA2 SLAMF7 VANGL2 SLAMF6 SLAMF1 CD84 CD48 CD244 ATP1A4 LOC105371468
GH01G160546 1.5 Ensembl ENCODE dbSUPER 11.3 -25.3 -25260 4.5 HDGF PKNOX1 ARNT WRNIP1 YBX1 TCF12 ZNF766 GATA2 ELK1 ZNF207 VANGL2 SLAMF6 SLAMF1 ENSG00000228863 RNU4-42P CD84 LOC105371468
GH01G160605 1.5 Ensembl ENCODE dbSUPER 11 -84.0 -84043 3.1 HDGF CREB3L1 ARNT WRNIP1 ZNF766 CBX5 GATA2 ELK1 ZNF143 REST VANGL2 CD84 ENSG00000228863 SLAMF6 SLAMF1 RNU4-42P LOC646347
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLAMF6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLAMF6 Gene

Chromosome:
1
Start:
160,485,030 bp from pter
End:
160,523,262 bp from pter
Size:
38,233 bases
Orientation:
Minus strand

Genomic View for SLAMF6 Gene

Genes around SLAMF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAMF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAMF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF6 Gene

Proteins for SLAMF6 Gene

  • Protein details for SLAMF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DU3-SLAF6_HUMAN
    Recommended name:
    SLAM family member 6
    Protein Accession:
    Q96DU3
    Secondary Accessions:
    • A6NMW2
    • B2R8X8
    • Q14CF0
    • Q5TAS4
    • Q5TAS6
    • Q5TAT3
    • Q96DV0

    Protein attributes for SLAMF6 Gene

    Size:
    332 amino acids
    Molecular mass:
    37345 Da
    Quaternary structure:
    • Homodimer. Interacts with PTN6. Interacts (phosphorylated) with PTN11. Interacts (phosphorylated on tyrosine residues) with SH2D1A/SAP and SH2D1B/EAT2; SH2D1A and SH2D1B can associate with the same SLAMF6 molecule; interaction with SH2D1B is mediated by ITSM 2.

    Three dimensional structures from OCA and Proteopedia for SLAMF6 Gene

    Alternative splice isoforms for SLAMF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLAMF6 Gene

Post-translational modifications for SLAMF6 Gene

  • Phosphorylation in NK cells upon engagment by SLAMF6-expressing target cells is leading to receptor activation.
  • Glycosylation at isoforms=258, isoforms=287, Asn137, Asn144, isoforms=2, 3161, Asn171, Asn178, and Asn203
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLAMF6 Gene

Domains & Families for SLAMF6 Gene

Protein Domains for SLAMF6 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DU3

UniProtKB/Swiss-Prot:

SLAF6_HUMAN :
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the with the SH2 domain of SH2D1A and SH2D1B. A two-out-of-three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Domain:
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the with the SH2 domain of SH2D1A and SH2D1B. A two-out-of-three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
genes like me logo Genes that share domains with SLAMF6: view

Function for SLAMF6 Gene

Molecular function for SLAMF6 Gene

UniProtKB/Swiss-Prot Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).

Gene Ontology (GO) - Molecular Function for SLAMF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16920955
genes like me logo Genes that share ontologies with SLAMF6: view
genes like me logo Genes that share phenotypes with SLAMF6: view

Animal Models for SLAMF6 Gene

MGI Knock Outs for SLAMF6:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLAMF6

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLAMF6 Gene

Localization for SLAMF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF6 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLAMF6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLAMF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SLAMF6: view

Pathways & Interactions for SLAMF6 Gene

genes like me logo Genes that share pathways with SLAMF6: view

Gene Ontology (GO) - Biological Process for SLAMF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0001787 natural killer cell proliferation IEA --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0032729 positive regulation of interferon-gamma production IMP 16920955
genes like me logo Genes that share ontologies with SLAMF6: view

No data available for SIGNOR curated interactions for SLAMF6 Gene

Drugs & Compounds for SLAMF6 Gene

(1) Drugs for SLAMF6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLAMF6: view

Transcripts for SLAMF6 Gene

Unigene Clusters for SLAMF6 Gene

SLAM family member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for SLAMF6 Gene

GeneLoc Exon Structure for
SLAMF6
ECgene alternative splicing isoforms for
SLAMF6

Expression for SLAMF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLAMF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAMF6 Gene

This gene is overexpressed in Whole Blood (x13.3) and Spleen (x8.0).

Protein differential expression in normal tissues from HIPED for SLAMF6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.3), CD8 Tcells (13.3), and Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLAMF6 Gene



Protein tissue co-expression partners for SLAMF6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLAMF6 Gene:

SLAMF6

SOURCE GeneReport for Unigene cluster for SLAMF6 Gene:

Hs.492348

mRNA Expression by UniProt/SwissProt for SLAMF6 Gene:

Q96DU3-SLAF6_HUMAN
Tissue specificity: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes (PubMed:11489943). Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients (PubMed:22184727).

Evidence on tissue expression from TISSUES for SLAMF6 Gene

  • Lymph node(4.5)
  • Spleen(4.4)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with SLAMF6: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLAMF6 Gene

Orthologs for SLAMF6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLAMF6 34 35
  • 98.69 (n)
cow
(Bos Taurus)
Mammalia SLAMF6 34 35
  • 71.63 (n)
dog
(Canis familiaris)
Mammalia SLAMF6 34 35
  • 66.98 (n)
rat
(Rattus norvegicus)
Mammalia Slamf6 34
  • 65.21 (n)
mouse
(Mus musculus)
Mammalia Slamf6 34 16 35
  • 64.6 (n)
oppossum
(Monodelphis domestica)
Mammalia SLAMF6 35
  • 27 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
Species where no ortholog for SLAMF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF6 Gene

ENSEMBL:
Gene Tree for SLAMF6 (if available)
TreeFam:
Gene Tree for SLAMF6 (if available)

Paralogs for SLAMF6 Gene

Paralogs for SLAMF6 Gene

Pseudogenes.org Pseudogenes for SLAMF6 Gene

genes like me logo Genes that share paralogs with SLAMF6: view

Variants for SLAMF6 Gene

Sequence variations from dbSNP and Humsavar for SLAMF6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000023641 -- 160,507,285(+) TTAGT(A/G)GAGGC intron-variant
rs1000061811 -- 160,488,105(+) AAAAA(A/G)CCAAA intron-variant
rs1000125259 -- 160,506,776(+) AATGA(A/G)ACAAC intron-variant
rs1000238990 -- 160,520,557(+) CCATC(C/T)ATAAA intron-variant
rs1000288483 -- 160,490,738(+) CCACT(C/G)TTCTT intron-variant

Variation tolerance for SLAMF6 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLAMF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLAMF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLAMF6 Gene

Disorders for SLAMF6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLAMF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cystic teratoma
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLAMF6

Genetic Association Database (GAD)
SLAMF6
Human Genome Epidemiology (HuGE) Navigator
SLAMF6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLAMF6
genes like me logo Genes that share disorders with SLAMF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLAMF6 Gene

Publications for SLAMF6 Gene

  1. NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked Lymphoproliferative disease. (PMID: 11489943) Bottino C. … Moretta A. (J. Exp. Med. 2001) 2 3 4 22 64
  2. NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. (PMID: 17045824) Cao E. … Almo S.C. (Immunity 2006) 3 4 22 64
  3. CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORI^t recruitment to the IL17A promoter in human T lymphocytes. (PMID: 22989874) Chatterjee M. … Tsokos G.C. (J. Biol. Chem. 2012) 3 4 64
  4. Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. (PMID: 22184727) Chatterjee M. … Tsokos G.C. (J. Immunol. 2012) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for SLAMF6 Gene

Sources for SLAMF6 Gene

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