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Aliases for CYGB Gene

Aliases for CYGB Gene

  • Cytoglobin 2 3
  • Stellate Cell Activation-Associated Protein 2 3 4
  • Histoglobin 2 3 4
  • STAP 3 4
  • HGB 3 4

External Ids for CYGB Gene

Previous GeneCards Identifiers for CYGB Gene

  • GC17M074357
  • GC17M077515
  • GC17M074987
  • GC17M075120
  • GC17M072035
  • GC17M074523
  • GC17M069951

Summaries for CYGB Gene

Entrez Gene Summary for CYGB Gene

  • This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

GeneCards Summary for CYGB Gene

CYGB (Cytoglobin) is a Protein Coding gene. Diseases associated with CYGB include galactokinase deficiency with cataracts and cholinergic urticaria. Among its related pathways are Metabolism and eNOS activation and regulation. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is MB.

UniProtKB/Swiss-Prot for CYGB Gene

  • May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer

Gene Wiki entry for CYGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYGB Gene

Genomics for CYGB Gene

Regulatory Elements for CYGB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYGB Gene

Chromosome:
17
Start:
76,527,348 bp from pter
End:
76,557,597 bp from pter
Size:
30,250 bases
Orientation:
Minus strand

Genomic View for CYGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYGB Gene

Proteins for CYGB Gene

  • Protein details for CYGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWM9-CYGB_HUMAN
    Recommended name:
    Cytoglobin
    Protein Accession:
    Q8WWM9
    Secondary Accessions:
    • Q541Y7
    • Q8N2X5

    Protein attributes for CYGB Gene

    Size:
    190 amino acids
    Molecular mass:
    21405 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CYGB Gene

neXtProt entry for CYGB Gene

Proteomics data for CYGB Gene at MOPED

Post-translational modifications for CYGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYGB Gene

Antibody Products

No data available for DME Specific Peptides for CYGB Gene

Domains & Families for CYGB Gene

Protein Domains for CYGB Gene

Suggested Antigen Peptide Sequences for CYGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWM9

UniProtKB/Swiss-Prot:

CYGB_HUMAN :
  • Belongs to the globin family.
Family:
  • Belongs to the globin family.
genes like me logo Genes that share domains with CYGB: view

No data available for Gene Families for CYGB Gene

Function for CYGB Gene

Molecular function for CYGB Gene

UniProtKB/Swiss-Prot Function:
May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer

Gene Ontology (GO) - Molecular Function for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004096 catalase activity IEA --
GO:0004601 peroxidase activity ISS 11320098
GO:0005344 oxygen transporter activity NAS 11919282
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CYGB: view
genes like me logo Genes that share phenotypes with CYGB: view

Animal Models for CYGB Gene

MGI Knock Outs for CYGB:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CYGB Gene

Localization for CYGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYGB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYGB Gene COMPARTMENTS Subcellular localization image for CYGB gene
Compartment Confidence
cytosol 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CYGB: view

Pathways & Interactions for CYGB Gene

genes like me logo Genes that share pathways with CYGB: view

Pathways by source for CYGB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006979 response to oxidative stress ISS 11320098
GO:0010764 negative regulation of fibroblast migration IEA --
GO:0015671 oxygen transport NAS 11919282
GO:0019395 fatty acid oxidation IEA --
genes like me logo Genes that share ontologies with CYGB: view

No data available for SIGNOR curated interactions for CYGB Gene

Drugs & Compounds for CYGB Gene

(6) Drugs for CYGB Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved Pharma 957
Nitric Oxide Approved Pharma 540
heme Pharma Agonist 0
Xenon Pharma 47
cysteine Nutra 143

(3) Additional Compounds for CYGB Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
H2O2
genes like me logo Genes that share compounds with CYGB: view

Transcripts for CYGB Gene

Unigene Clusters for CYGB Gene

Cytoglobin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYGB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYGB Gene

No ASD Table

Relevant External Links for CYGB Gene

GeneLoc Exon Structure for
CYGB
ECgene alternative splicing isoforms for
CYGB

Expression for CYGB Gene

mRNA expression in normal human tissues for CYGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYGB Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.7).

Protein differential expression in normal tissues from HIPED for CYGB Gene

This gene is overexpressed in Bone marrow stromal cell (7.4) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYGB Gene



SOURCE GeneReport for Unigene cluster for CYGB Gene Hs.95120

mRNA Expression by UniProt/SwissProt for CYGB Gene

Q8WWM9-CYGB_HUMAN
Tissue specificity: Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.
genes like me logo Genes that share expression patterns with CYGB: view

Protein tissue co-expression partners for CYGB Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYGB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYGB 35
  • 94.04 (n)
  • 96.84 (a)
CYGB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYGB 35
  • 94.87 (n)
  • 95.27 (a)
CYGB 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cygb 35
  • 92.81 (n)
  • 95.26 (a)
Cygb 16
Cygb 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYGB 35
  • 99.3 (n)
  • 99.47 (a)
CYGB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cygb 35
  • 91.05 (n)
  • 93.68 (a)
oppossum
(Monodelphis domestica)
Mammalia CYGB 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYGB 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYGB 35
  • 78.65 (n)
  • 77.53 (a)
CYGB 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYGB 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cygb 35
  • 71.35 (n)
  • 69.66 (a)
zebrafish
(Danio rerio)
Actinopterygii cygb 35
cygb2 35
  • 68.38 (n)
  • 71.15 (a)
CYGB (2 of 3) 36
  • 57 (a)
OneToMany
cygb1 36
  • 45 (a)
OneToMany
cygb2 36
  • 67 (a)
OneToMany
Species with no ortholog for CYGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYGB Gene

ENSEMBL:
Gene Tree for CYGB (if available)
TreeFam:
Gene Tree for CYGB (if available)

Paralogs for CYGB Gene

Paralogs for CYGB Gene

(10) SIMAP similar genes for CYGB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYGB: view

Variants for CYGB Gene

Sequence variations from dbSNP and Humsavar for CYGB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4647884 -- 76,554,436(+) AGCGA(C/T)GTCCA intron-variant
rs6501904 -- 76,554,316(+) GCTGC(A/G)CAGTG intron-variant
rs6501905 -- 76,554,327(+) TACTT(C/T)ACATG intron-variant
rs7219588 -- 76,555,481(+) atggc(A/G)tttgt intron-variant
rs8070138 -- 76,554,253(+) CTTGC(C/T)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYGB Gene

Variant ID Type Subtype PubMed ID
nsv833549 CNV Gain 17160897
nsv908831 CNV Loss 21882294

Variation tolerance for CYGB Gene

Residual Variation Intolerance Score: 27.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.51; 92.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYGB Gene

HapMap Linkage Disequilibrium report
CYGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYGB Gene

Disorders for CYGB Gene

MalaCards: The human disease database

(3) MalaCards diseases for CYGB Gene - From: DISEASES

Disorder Aliases PubMed IDs
galactokinase deficiency with cataracts
  • galactokinase deficiency
cholinergic urticaria
ancylostomiasis
  • ancylostomosis
- elite association
Search CYGB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CYGB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYGB
genes like me logo Genes that share disorders with CYGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYGB Gene

Publications for CYGB Gene

  1. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. (PMID: 11919282) Burmester T. … Hankeln T. (Mol. Biol. Evol. 2002) 2 23 67
  2. Epoetin delta reduces oxidative stress in primary human renal tubular cells. (PMID: 20454536) De Beuf A. … Verhulst A. (J. Biomed. Biotechnol. 2010) 23 67
  3. Distinct proteomic features of two fibrogenic liver cell populations: hepatic stellate cells and portal myofibroblasts. (PMID: 20049859) Bosselut N. … Baudin B. (Proteomics 2010) 23 67
  4. Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver. (PMID: 19052772) Van Rossen E. … Geerts A. (Histochem. Cell Biol. 2009) 23 67
  5. The structure of neuroglobin at high Xe and Kr pressure reveals partial conservation of globin internal cavities. (PMID: 19751675) Moschetti T. … Vallone B. (Biophys. J. 2009) 23 67

Products for CYGB Gene

Sources for CYGB Gene

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