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Aliases for CYGB Gene

Aliases for CYGB Gene

  • Cytoglobin 2 3 5
  • Stellate Cell Activation-Associated Protein 2 3 4
  • Histoglobin 2 3 4
  • STAP 3 4
  • HGB 3 4

External Ids for CYGB Gene

Previous GeneCards Identifiers for CYGB Gene

  • GC17M074357
  • GC17M077515
  • GC17M074987
  • GC17M075120
  • GC17M072035
  • GC17M074523
  • GC17M069951

Summaries for CYGB Gene

Entrez Gene Summary for CYGB Gene

  • This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

GeneCards Summary for CYGB Gene

CYGB (Cytoglobin) is a Protein Coding gene. Diseases associated with CYGB include Ancylostomiasis and Myopathy, Myofibrillar, 5. Among its related pathways are eNOS activation and regulation and Metabolism. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is MB.

UniProtKB/Swiss-Prot for CYGB Gene

  • May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Gene Wiki entry for CYGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYGB Gene

Genomics for CYGB Gene

Regulatory Elements for CYGB Gene

Enhancers for CYGB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYGB on UCSC Golden Path with GeneCards custom track

Promoters for CYGB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYGB on UCSC Golden Path with GeneCards custom track

Genomic Location for CYGB Gene

Chromosome:
17
Start:
76,527,348 bp from pter
End:
76,557,597 bp from pter
Size:
30,250 bases
Orientation:
Minus strand

Genomic View for CYGB Gene

Genes around CYGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYGB Gene

Proteins for CYGB Gene

  • Protein details for CYGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWM9-CYGB_HUMAN
    Recommended name:
    Cytoglobin
    Protein Accession:
    Q8WWM9
    Secondary Accessions:
    • Q541Y7
    • Q8N2X5

    Protein attributes for CYGB Gene

    Size:
    190 amino acids
    Molecular mass:
    21405 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CYGB Gene

neXtProt entry for CYGB Gene

Proteomics data for CYGB Gene at MOPED

Post-translational modifications for CYGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYGB Gene

No data available for DME Specific Peptides for CYGB Gene

Domains & Families for CYGB Gene

Protein Domains for CYGB Gene

Suggested Antigen Peptide Sequences for CYGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWM9

UniProtKB/Swiss-Prot:

CYGB_HUMAN :
  • Belongs to the globin family.
Family:
  • Belongs to the globin family.
genes like me logo Genes that share domains with CYGB: view

No data available for Gene Families for CYGB Gene

Function for CYGB Gene

Molecular function for CYGB Gene

UniProtKB/Swiss-Prot Function:
May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Gene Ontology (GO) - Molecular Function for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA,ISS 11320098
GO:0005344 oxygen transporter activity IEA,NAS 11919282
genes like me logo Genes that share ontologies with CYGB: view
genes like me logo Genes that share phenotypes with CYGB: view

Animal Models for CYGB Gene

MGI Knock Outs for CYGB:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYGB Gene

Localization for CYGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYGB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYGB Gene COMPARTMENTS Subcellular localization image for CYGB gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CYGB: view

Pathways & Interactions for CYGB Gene

genes like me logo Genes that share pathways with CYGB: view

Pathways by source for CYGB Gene

Gene Ontology (GO) - Biological Process for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0098869 cellular oxidant detoxification ISS 11320098
genes like me logo Genes that share ontologies with CYGB: view

No data available for SIGNOR curated interactions for CYGB Gene

Drugs & Compounds for CYGB Gene

(6) Drugs for CYGB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(3) Additional Compounds for CYGB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with CYGB: view

Transcripts for CYGB Gene

Unigene Clusters for CYGB Gene

Cytoglobin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYGB Gene

No ASD Table

Relevant External Links for CYGB Gene

GeneLoc Exon Structure for
CYGB
ECgene alternative splicing isoforms for
CYGB

Expression for CYGB Gene

mRNA expression in normal human tissues for CYGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYGB Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.7).

Protein differential expression in normal tissues from HIPED for CYGB Gene

This gene is overexpressed in Bone marrow stromal cell (7.4) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYGB Gene



SOURCE GeneReport for Unigene cluster for CYGB Gene Hs.95120

mRNA Expression by UniProt/SwissProt for CYGB Gene

Q8WWM9-CYGB_HUMAN
Tissue specificity: Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.
genes like me logo Genes that share expression patterns with CYGB: view

Protein tissue co-expression partners for CYGB Gene

- Elite partner

Primer Products

Orthologs for CYGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYGB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYGB 35
  • 94.04 (n)
  • 96.84 (a)
CYGB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYGB 35
  • 94.87 (n)
  • 95.27 (a)
CYGB 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cygb 35
  • 92.81 (n)
  • 95.26 (a)
Cygb 16
Cygb 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYGB 35
  • 99.3 (n)
  • 99.47 (a)
CYGB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cygb 35
  • 91.05 (n)
  • 93.68 (a)
oppossum
(Monodelphis domestica)
Mammalia CYGB 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYGB 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYGB 35
  • 78.65 (n)
  • 77.53 (a)
CYGB 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYGB 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cygb 35
  • 71.35 (n)
  • 69.66 (a)
zebrafish
(Danio rerio)
Actinopterygii cygb 35
cygb2 35
  • 68.38 (n)
  • 71.15 (a)
CYGB (2 of 3) 36
  • 57 (a)
OneToMany
cygb1 36
  • 45 (a)
OneToMany
cygb2 36
  • 67 (a)
OneToMany
Species with no ortholog for CYGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYGB Gene

ENSEMBL:
Gene Tree for CYGB (if available)
TreeFam:
Gene Tree for CYGB (if available)

Paralogs for CYGB Gene

Paralogs for CYGB Gene

(10) SIMAP similar genes for CYGB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYGB: view

Variants for CYGB Gene

Sequence variations from dbSNP and Humsavar for CYGB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4647884 -- 76,554,436(+) AGCGA(C/T)GTCCA intron-variant
rs6501904 -- 76,554,316(+) GCTGC(A/G)CAGTG intron-variant
rs6501905 -- 76,554,327(+) TACTT(C/T)ACATG intron-variant
rs7219588 -- 76,555,481(+) atggc(A/G)tttgt intron-variant
rs8070138 -- 76,554,253(+) CTTGC(C/T)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYGB Gene

Variant ID Type Subtype PubMed ID
nsv833549 CNV Gain 17160897
nsv908831 CNV Loss 21882294

Variation tolerance for CYGB Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.51; 92.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYGB Gene

Disorders for CYGB Gene

MalaCards: The human disease database

(4) MalaCards diseases for CYGB Gene - From: DISEASES

Disorder Aliases PubMed IDs
ancylostomiasis
  • ancylostomosis
myopathy, myofibrillar, 5
  • myofibrillar myopathy 5
cholinergic urticaria
galactokinase deficiency with cataracts
  • galactokinase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search CYGB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CYGB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYGB
genes like me logo Genes that share disorders with CYGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYGB Gene

Publications for CYGB Gene

  1. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. (PMID: 11919282) Burmester T. … Hankeln T. (Mol. Biol. Evol. 2002) 2 3 4 23 67
  2. Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation. (PMID: 19147491) Halligan K.E. … Jourd'heuil D. (J. Biol. Chem. 2009) 3 23
  3. Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. (PMID: 19568272) Shaw R.J. … Risk J.M. (Br. J. Cancer 2009) 3 23
  4. Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. (PMID: 18353768) Hodges N.J. … Graham M. (Mutagenesis 2008) 3 23
  5. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. (PMID: 18794132) Shivapurkar N. … Gazdar A.F. (Cancer Res. 2008) 3 23

Products for CYGB Gene

Sources for CYGB Gene

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