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Aliases for CYGB Gene

Aliases for CYGB Gene

  • Cytoglobin 2 3
  • Stellate Cell Activation-Associated Protein 2 3 4
  • Histoglobin 2 3 4
  • STAP 3 4 6
  • HGB 3 4 6

External Ids for CYGB Gene

Previous GeneCards Identifiers for CYGB Gene

  • GC17M074357
  • GC17M077515
  • GC17M074987
  • GC17M075120
  • GC17M072035
  • GC17M074523
  • GC17M069951

Summaries for CYGB Gene

Entrez Gene Summary for CYGB Gene

  • This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

GeneCards Summary for CYGB Gene

CYGB (Cytoglobin) is a Protein Coding gene. Diseases associated with CYGB include alveolar soft-part sarcoma. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is MB.

UniProtKB/Swiss-Prot for CYGB Gene

  • May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer

Gene Wiki entry for CYGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYGB Gene

Genomics for CYGB Gene

Regulatory Elements for CYGB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYGB Gene

76,527,348 bp from pter
76,551,175 bp from pter
23,828 bases
Minus strand

Genomic View for CYGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYGB Gene

Proteins for CYGB Gene

  • Protein details for CYGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q541Y7
    • Q8N2X5

    Protein attributes for CYGB Gene

    190 amino acids
    Molecular mass:
    21405 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CYGB Gene

neXtProt entry for CYGB Gene

Proteomics data for CYGB Gene at MOPED

Post-translational modifications for CYGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYGB Gene

Antibody Products

No data available for DME Specific Peptides for CYGB Gene

Domains for CYGB Gene

Protein Domains for CYGB Gene

Suggested Antigen Peptide Sequences for CYGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the globin family.
  • Belongs to the globin family.
genes like me logo Genes that share domains with CYGB: view

No data available for Gene Families for CYGB Gene

Function for CYGB Gene

Molecular function for CYGB Gene

UniProtKB/Swiss-Prot Function:
May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer

Gene Ontology (GO) - Molecular Function for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity ISS 11320098
GO:0005344 oxygen transporter activity NAS 11919282
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008941 nitric oxide dioxygenase activity TAS --
genes like me logo Genes that share ontologies with CYGB: view

Phenotypes for CYGB Gene

genes like me logo Genes that share phenotypes with CYGB: view

Animal Models for CYGB Gene

MGI Knock Outs for CYGB:

miRNA for CYGB Gene

miRTarBase miRNAs that target CYGB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CYGB Gene

Localization for CYGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYGB Gene


Subcellular locations from

Jensen Localization Image for CYGB Gene COMPARTMENTS Subcellular localization image for CYGB gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CYGB: view

Pathways for CYGB Gene

SuperPathways for CYGB Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress ISS 11320098
GO:0015671 oxygen transport NAS 11919282
GO:0044281 small molecule metabolic process TAS --
GO:0046209 nitric oxide metabolic process TAS --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
genes like me logo Genes that share ontologies with CYGB: view

No data available for Pathways by source for CYGB Gene

Compounds for CYGB Gene

(2) HMDB Compounds for CYGB Gene

Compound Synonyms Cas Number PubMed IDs
  • (protoporphyrinato)iron
  • Oxygen

(8) Novoseek inferred chemical compound relationships for CYGB Gene

Compound -log(P) Hits PubMed IDs
fe2+ 69.1 5
oxygen 51.8 14
histidine 47.8 3
xenon 34.6 2
nitric oxide 19.5 4
genes like me logo Genes that share compounds with CYGB: view

Transcripts for CYGB Gene

Unigene Clusters for CYGB Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYGB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYGB Gene

No ASD Table

Relevant External Links for CYGB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYGB Gene

mRNA expression in normal human tissues for CYGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYGB Gene

This gene is overexpressed in Heart - Atrial Appendage (4.7).

Protein differential expression in normal tissues for CYGB Gene

This gene is overexpressed in Bone marrow stromal cell (7.4) and Pancreas (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYGB Gene

SOURCE GeneReport for Unigene cluster for CYGB Gene Hs.95120

mRNA Expression by UniProt/SwissProt for CYGB Gene

Tissue specificity: Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.
genes like me logo Genes that share expressions with CYGB: view

Expression partners for CYGB Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYGB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYGB 35
  • 94.04 (n)
  • 96.84 (a)
  • 97 (a)
(Canis familiaris)
Mammalia CYGB 35
  • 94.87 (n)
  • 95.27 (a)
  • 96 (a)
(Mus musculus)
Mammalia Cygb 35
  • 92.81 (n)
  • 95.26 (a)
Cygb 16
Cygb 36
  • 95 (a)
(Pan troglodytes)
Mammalia CYGB 35
  • 99.3 (n)
  • 99.47 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cygb 35
  • 91.05 (n)
  • 93.68 (a)
(Monodelphis domestica)
Mammalia CYGB 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CYGB 36
  • 85 (a)
(Gallus gallus)
Aves CYGB 35
  • 78.65 (n)
  • 77.53 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia CYGB 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cygb 35
  • 71.35 (n)
  • 69.66 (a)
(Danio rerio)
Actinopterygii cygb 35
cygb2 35
  • 68.38 (n)
  • 71.15 (a)
CYGB (2 of 3) 36
  • 57 (a)
cygb1 36
  • 45 (a)
cygb2 36
  • 67 (a)
Species with no ortholog for CYGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYGB Gene

Gene Tree for CYGB (if available)
Gene Tree for CYGB (if available)

Paralogs for CYGB Gene

Paralogs for CYGB Gene

(10) SIMAP similar genes for CYGB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYGB: view

Variants for CYGB Gene

Structural Variations from Database of Genomic Variants (DGV) for CYGB Gene

Variant ID Type Subtype PubMed ID
nsv833549 CNV Gain 17160897
nsv908831 CNV Loss 21882294

Relevant External Links for CYGB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CYGB Gene

Disorders for CYGB Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CYGB Gene in MalaCards »

(1) Disease for CYGB Gene

(3) Novoseek inferred disease relationships for CYGB Gene

Disease -log(P) Hits PubMed IDs
cancer lung 0 3
tumors 0 8
cancer 0 4
genes like me logo Genes that share disorders with CYGB: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for CYGB Gene

Publications for CYGB Gene

  1. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. (PMID: 11919282) Burmester T. … Hankeln T. (Mol. Biol. Evol. 2002) 2 3 4 23
  2. Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. (PMID: 15095869) de Sanctis D. … Bolognesi M. (J. Mol. Biol. 2004) 3 4 23
  3. Structural basis of human cytoglobin for ligand binding. (PMID: 15165856) Sugimoto H. … Shiro Y. (J. Mol. Biol. 2004) 3 4 23
  4. High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode. (PMID: 16699195) Makino M. … Shiro Y. (Acta Crystallogr. D 2006) 3 4 23
  5. Characterization of human cytoglobin gene promoter region. (PMID: 16797742) Guo X. … Tan-Un K.C. (Biochim. Biophys. Acta 2006) 3 23

Products for CYGB Gene

Sources for CYGB Gene

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