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Aliases for SLC22A9 Gene

Aliases for SLC22A9 Gene

  • Solute Carrier Family 22 (Organic Anion Transporter), Member 9 2 3
  • Organic Anion Transporter 7 3 4
  • HOAT4 3 4
  • Ust3 3 4
  • OAT7 3 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 9 3
  • Solute Carrier Family 22 Member 9 3
  • Organic Anion Transporter 4 3
  • UST3H 3
  • OAT4 3

External Ids for SLC22A9 Gene

Summaries for SLC22A9 Gene

GeneCards Summary for SLC22A9 Gene

SLC22A9 (Solute Carrier Family 22 (Organic Anion Transporter), Member 9) is a Protein Coding gene. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A9 Gene

  • Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.

Gene Wiki entry for SLC22A9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A9 Gene

Genomics for SLC22A9 Gene

Genomic Location for SLC22A9 Gene

Start:
63,369,670 bp from pter
End:
63,410,919 bp from pter
Size:
41,250 bases
Orientation:
Plus strand

Genomic View for SLC22A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A9 Gene

Regulatory Elements for SLC22A9 Gene

Proteins for SLC22A9 Gene

  • Protein details for SLC22A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVM8-S22A9_HUMAN
    Recommended name:
    Solute carrier family 22 member 9
    Protein Accession:
    Q8IVM8
    Secondary Accessions:
    • A0AVB7
    • A4PB24
    • Q8TCC8
    • Q8TEC0
    • Q8WYN7

    Protein attributes for SLC22A9 Gene

    Size:
    553 amino acids
    Molecular mass:
    62169 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A9 Gene

Proteomics data for SLC22A9 Gene at MOPED

Post-translational modifications for SLC22A9 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn39, Asn56, and Asn102

Other Protein References for SLC22A9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A9 Gene

Domains for SLC22A9 Gene

Gene Families for SLC22A9 Gene

Protein Domains for SLC22A9 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S22A9_HUMAN
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.:
    • Q8IVM8
genes like me logo Genes that share domains with SLC22A9: view

Function for SLC22A9 Gene

Molecular function for SLC22A9 Gene

UniProtKB/Swiss-Prot Function: Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.

Gene Ontology (GO) - Molecular Function for SLC22A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015301 anion:anion antiporter activity IDA 17393504
GO:0015347 sodium-independent organic anion transmembrane transporter activity IDA 17393504
GO:0015636 short-chain fatty acid uptake transporter activity IDA 17393504
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC22A9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC22A9 Gene

Localization for SLC22A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A9 Gene

Basolateral cell membrane; Multi-pass membrane protein. Note=Enriched at the sinusoidal part of the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A9 Gene COMPARTMENTS Subcellular localization image for SLC22A9 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC22A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 17393504
genes like me logo Genes that share ontologies with SLC22A9: view

Pathways for SLC22A9 Gene

SuperPathways for SLC22A9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC22A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009914 hormone transport IDA 17393504
GO:0015913 short-chain fatty acid import IDA 17393504
GO:0043252 sodium-independent organic anion transport IDA 17393504
GO:0055085 transmembrane transport --
GO:0098656 anion transmembrane transport IDA 17393504
genes like me logo Genes that share ontologies with SLC22A9: view

No data available for Pathways by source for SLC22A9 Gene

Transcripts for SLC22A9 Gene

mRNA/cDNA for SLC22A9 Gene

Unigene Clusters for SLC22A9 Gene

Solute carrier family 22 (organic anion transporter), member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A9 Gene

No ASD Table

Relevant External Links for SLC22A9 Gene

GeneLoc Exon Structure for
SLC22A9
ECgene alternative splicing isoforms for
SLC22A9

Expression for SLC22A9 Gene

mRNA expression in normal human tissues for SLC22A9 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A9 Gene

This gene is overexpressed in Liver (39.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC22A9 Gene

SOURCE GeneReport for Unigene cluster for SLC22A9 Gene Hs.502772

mRNA Expression by UniProt/SwissProt for SLC22A9 Gene

Q8IVM8-S22A9_HUMAN
Tissue specificity: Specifically expressed in liver by hepatocytes (at protein level).
genes like me logo Genes that share expressions with SLC22A9: view

Orthologs for SLC22A9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A9 36
  • 98.98 (n)
  • 99.28 (a)
SLC22A9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 62 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
LOC517475 36
  • 76.04 (n)
  • 62.07 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc22a19 37
  • 55 (a)
ManyToMany
Slc22a26 37
  • 53 (a)
ManyToMany
Slc22a27 37
  • 54 (a)
ManyToMany
Slc22a28 37
  • 53 (a)
ManyToMany
Slc22a29 37
  • 54 (a)
ManyToMany
Slc22a30 16
Slc22a30 37
  • 53 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 41 (a)
ManyToMany
-- 37
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc22a25 36
  • 69.87 (n)
  • 56.52 (a)
Species with no ortholog for SLC22A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC22A9 Gene

ENSEMBL:
Gene Tree for SLC22A9 (if available)
TreeFam:
Gene Tree for SLC22A9 (if available)

Paralogs for SLC22A9 Gene

Selected SIMAP similar genes for SLC22A9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC22A9: view

Variants for SLC22A9 Gene

Sequence variations from dbSNP and Humsavar for SLC22A9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471044 -- 63,383,964(-) TGAAG(C/T)GATTC intron-variant
rs475053 -- 63,390,068(-) AATAT(C/T)CAGAA intron-variant
rs480013 -- 63,380,130(-) TTATC(A/G)TGGTT intron-variant
rs488374 -- 63,394,667(+) TCCTT(C/T)GTCTT intron-variant
rs491983 -- 63,388,480(+) taacc(A/C)atatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A9 Gene

Variant ID Type Subtype PubMed ID
esv2653139 CNV Insertion 19546169
esv268271 CNV Insertion 20981092

Relevant External Links for SLC22A9 Gene

HapMap Linkage Disequilibrium report
SLC22A9
Human Gene Mutation Database (HGMD)
SLC22A9

Disorders for SLC22A9 Gene

Relevant External Links for SLC22A9

Genetic Association Database (GAD)
SLC22A9
Human Genome Epidemiology (HuGE) Navigator
SLC22A9
genes like me logo Genes that share disorders with SLC22A9: view

No data available for UniProtKB/Swiss-Prot for SLC22A9 Gene

Publications for SLC22A9 Gene

  1. Isolation of a family of organic anion transporters from human liver and kidney. (PMID: 11327718) Sun W. … Erion M.D. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  2. Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. (PMID: 17393504) Shin H.J. … Kanai Y. (Hepatology 2007) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta. (PMID: 18501590) Ugele B. … Rex-Haffner M. (J. Steroid Biochem. Mol. Biol. 2008) 3 23

Products for SLC22A9 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Transporters in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLC22A9
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A9
    • Block miRNA regulation of SLC22A9 using miScript Target Protectors

    Sources for SLC22A9 Gene

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