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Aliases for CHRNB3 Gene

Aliases for CHRNB3 Gene

  • Cholinergic Receptor Nicotinic Beta 3 Subunit 2 3
  • Cholinergic Receptor, Nicotinic Beta 3 2 5
  • Cholinergic Receptor, Nicotinic, Beta Polypeptide 3 2
  • Cholinergic Receptor, Nicotinic, Beta 3 (Neuronal) 2
  • Acetylcholine Receptor 2
  • Beta 3 (Neuronal) 2
  • Nicotinic 2

External Ids for CHRNB3 Gene

Previous GeneCards Identifiers for CHRNB3 Gene

  • GC08P042340
  • GC08P042622
  • GC08P042569
  • GC08P042552
  • GC08P041074

Summaries for CHRNB3 Gene

Entrez Gene Summary for CHRNB3 Gene

  • The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]

GeneCards Summary for CHRNB3 Gene

CHRNB3 (Cholinergic Receptor Nicotinic Beta 3 Subunit) is a Protein Coding gene. Diseases associated with CHRNB3 include duane retraction syndrome and cocaine dependence. Among its related pathways are Transmission across Chemical Synapses and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include drug binding and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is CHRNA3.

UniProtKB/Swiss-Prot for CHRNB3 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Gene Wiki entry for CHRNB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNB3 Gene

Genomics for CHRNB3 Gene

Regulatory Elements for CHRNB3 Gene

Genomic Location for CHRNB3 Gene

42,697,376 bp from pter
42,737,407 bp from pter
40,032 bases
Plus strand

Genomic View for CHRNB3 Gene

Genes around CHRNB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRNB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRNB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNB3 Gene

Proteins for CHRNB3 Gene

  • Protein details for CHRNB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal acetylcholine receptor subunit beta-3
    Protein Accession:
    Secondary Accessions:
    • Q15827

    Protein attributes for CHRNB3 Gene

    458 amino acids
    Molecular mass:
    52729 Da
    Quaternary structure:
    • Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.

neXtProt entry for CHRNB3 Gene

Proteomics data for CHRNB3 Gene at MOPED

Post-translational modifications for CHRNB3 Gene

  • Glycosylation at Asn 51, Asn 138, and Asn 166
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRNB3 Gene

Domains & Families for CHRNB3 Gene

Gene Families for CHRNB3 Gene

Suggested Antigen Peptide Sequences for CHRNB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily.
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily.
genes like me logo Genes that share domains with CHRNB3: view

Function for CHRNB3 Gene

Molecular function for CHRNB3 Gene

GENATLAS Biochemistry:
cholinergic receptor,nicotinic,beta 3 polypeptide,neuronal
UniProtKB/Swiss-Prot Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Gene Ontology (GO) - Molecular Function for CHRNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0015267 channel activity TAS 7690916
GO:0015276 ligand-gated ion channel activity TAS --
GO:0015464 contributes_to acetylcholine receptor activity IBA --
genes like me logo Genes that share ontologies with CHRNB3: view
genes like me logo Genes that share phenotypes with CHRNB3: view

Animal Models for CHRNB3 Gene

MGI Knock Outs for CHRNB3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRNB3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHRNB3 Gene

Localization for CHRNB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNB3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CHRNB3 Gene COMPARTMENTS Subcellular localization image for CHRNB3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CHRNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005892 acetylcholine-gated channel complex IEA --
GO:0016021 integral component of membrane IEA,NAS 8906617
genes like me logo Genes that share ontologies with CHRNB3: view

Pathways & Interactions for CHRNB3 Gene

genes like me logo Genes that share pathways with CHRNB3: view

Interacting Proteins for CHRNB3 Gene

Gene Ontology (GO) - Biological Process for CHRNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 7690916
GO:0006811 ion transport IEA --
GO:0007165 signal transduction TAS 7690916
GO:0007271 synaptic transmission, cholinergic TAS 7690916
GO:0051291 protein heterooligomerization IEA --
genes like me logo Genes that share ontologies with CHRNB3: view

No data available for SIGNOR curated interactions for CHRNB3 Gene

Drugs & Compounds for CHRNB3 Gene

(3) Drugs for CHRNB3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 1839
Galantamine Approved Pharma Target, allosteric modulator 103
Nicotine Approved Pharma Antagonist, Target, agonist 973
genes like me logo Genes that share compounds with CHRNB3: view

Transcripts for CHRNB3 Gene

mRNA/cDNA for CHRNB3 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRNB3 Gene

Cholinergic receptor, nicotinic, beta 3 (neuronal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNB3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP3: -

Relevant External Links for CHRNB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRNB3 Gene

mRNA expression in normal human tissues for CHRNB3 Gene

mRNA differential expression in normal tissues according to GTEx for CHRNB3 Gene

This gene is overexpressed in Brain - Substantia nigra (x15.4), Brain - Cerebellar Hemisphere (x11.1), Brain - Cerebellum (x8.5), and Pancreas (x5.7).

SOURCE GeneReport for Unigene cluster for CHRNB3 Gene Hs.654576

genes like me logo Genes that share expression patterns with CHRNB3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CHRNB3 Gene

Orthologs for CHRNB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHRNB3 35
  • 82.68 (n)
  • 90.17 (a)
  • 86 (a)
(Canis familiaris)
Mammalia CHRNB3 35
  • 86 (n)
  • 91.68 (a)
  • 91 (a)
(Mus musculus)
Mammalia Chrnb3 35
  • 81.98 (n)
  • 88.69 (a)
Chrnb3 16
Chrnb3 36
  • 85 (a)
(Pan troglodytes)
Mammalia CHRNB3 35
  • 99.64 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Chrnb3 35
  • 82.58 (n)
  • 88.91 (a)
(Monodelphis domestica)
Mammalia CHRNB3 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia CHRNB3 36
  • 83 (a)
(Gallus gallus)
Aves CHRNB3 35
  • 75.19 (n)
  • 85.33 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia CHRNB3 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chrnb3 35
  • 71.67 (n)
  • 82.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia chrnb3-prov 35
(Danio rerio)
Actinopterygii -- 35
chrnb3a 35
  • 69.63 (n)
  • 79 (a)
chrnb3a 36
  • 74 (a)
chrnb3b 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-30D 37
  • 44 (a)
nAcRalpha-7E 37
  • 50 (a)
nAcRalpha-96Aa 37
  • 53 (a)
nAcRalpha-96Ab 37
  • 48 (a)
nAcRbgr-21C 37
  • 30 (a)
nAcRbgr-96A 37
  • 43 (a)
(Caenorhabditis elegans)
Secernentea acr-13 37
  • 32 (a)
acr-14 37
  • 28 (a)
acr-2 37
  • 40 (a)
acr-22 37
  • 29 (a)
acr-3 37
  • 38 (a)
acr-8 37
  • 32 (a)
F18G5.4 37
  • 31 (a)
lev-1 37
  • 38 (a)
unc-29 37
  • 37 (a)
unc-63 37
  • 44 (a)
Y73F8A.30 37
  • 29 (a)
ZK973.5 37
  • 35 (a)
Species with no ortholog for CHRNB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNB3 Gene

Gene Tree for CHRNB3 (if available)
Gene Tree for CHRNB3 (if available)

Paralogs for CHRNB3 Gene

(18) SIMAP similar genes for CHRNB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHRNB3: view

Variants for CHRNB3 Gene

Sequence variations from dbSNP and Humsavar for CHRNB3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs35327613 - 42,736,592(-) CATCT(C/T)CAAAG reference, missense
rs4952 -- 42,731,922(+) CTGAA(C/T)GCAAA reference, synonymous-codon
rs4953 -- 42,732,516(+) ATTTC(A/C/G/T)AGACA reference, synonymous-codon
rs4954 -- 42,732,653(+) GTGAC(A/G)TTATA intron-variant
rs4236926 -- 42,722,916(+) ACTTA(G/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRNB3 Gene

Variant ID Type Subtype PubMed ID
esv2666038 CNV Deletion 23128226
esv2668251 CNV Deletion 23128226
nsv397520 CNV Loss 16902084
esv2662041 CNV Deletion 23128226

Variation tolerance for CHRNB3 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRNB3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNB3 Gene

Disorders for CHRNB3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CHRNB3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
duane retraction syndrome
  • duane's syndrome
cocaine dependence
cannabis abuse
  • marijuana abuse
autosomal dominant nocturnal frontal lobe epilepsy
  • epilepsy, nocturnal frontal lobe, 1
nicotine dependence, protection against
  • nicotine dependence
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CHRNB3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CHRNB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRNB3 Gene

Publications for CHRNB3 Gene

  1. Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. (PMID: 19482438) Etter J.F. … Bertrand D. (Addict Behav 2009) 3 23 48 67
  2. Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. (PMID: 23641218) Hendrickson L.M. … Tapper A.R. (Front Psychiatry 2013) 25 26
  3. Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans. (PMID: 1505988) Anand R. … Lindstrom J. (Genomics 1992) 2 3
  4. A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations. (PMID: 25823894) Song Y. … Hu L. (Carcinogenesis 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CHRNB3 Gene

Sources for CHRNB3 Gene

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