Aliases for ADCY8 Gene
External Ids for ADCY8 Gene
Previous HGNC Symbols for ADCY8 Gene
Previous GeneCards Identifiers for ADCY8 Gene
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
GeneCards Summary for ADCY8 Gene
ADCY8 (Adenylate Cyclase 8) is a Protein Coding gene. Diseases associated with ADCY8 include Wolfram Syndrome. Among its related pathways are Signaling in Gap Junctions and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include nucleotide binding and adenylate cyclase activity. An important paralog of this gene is ADCY5.
UniProtKB/Swiss-Prot for ADCY8 Gene
This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.