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Aliases for ADCY8 Gene

Aliases for ADCY8 Gene

  • Adenylate Cyclase 8 (Brain) 2 3
  • Ca(2+)/Calmodulin-Activated Adenylyl Cyclase 3 4
  • Adenylate Cyclase Type VIII 3 4
  • ATP Pyrophosphate-Lyase 8 3 4
  • Adenylyl Cyclase 8 3 4
  • EC 4 63
  • ADCY3 3 6
  • AC8 3 4
  • Adenylyl Cyclase-8, Brain 3
  • Adenylate Cyclase Type 8 3
  • HBAC1 3

External Ids for ADCY8 Gene

Previous HGNC Symbols for ADCY8 Gene

  • ADCY3

Previous GeneCards Identifiers for ADCY8 Gene

  • GC08M130592
  • GC08M131808
  • GC08M131463
  • GC08M131749
  • GC08M131725
  • GC08M131861
  • GC08M127112

Summaries for ADCY8 Gene

Entrez Gene Summary for ADCY8 Gene

  • Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY8 Gene

ADCY8 (Adenylate Cyclase 8 (Brain)) is a Protein Coding gene. Diseases associated with ADCY8 include thyroid adenoma and precocious puberty. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include adenylate cyclase activity and calcium- and calmodulin-responsive adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY8 Gene

  • This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Tocris Summary for ADCY8 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY8 Gene

Genomics for ADCY8 Gene

Regulatory Elements for ADCY8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCY8 Gene

130,780,300 bp from pter
131,042,426 bp from pter
262,127 bases
Minus strand

Genomic View for ADCY8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY8 Gene

Proteins for ADCY8 Gene

  • Protein details for ADCY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenylate cyclase type 8
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ADCY8 Gene

    1251 amino acids
    Molecular mass:
    140122 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for ADCY8 Gene

Proteomics data for ADCY8 Gene at MOPED

Post-translational modifications for ADCY8 Gene

  • Glycosylation at Asn817, Asn821, and Asn888
  • Modification sites at PhosphoSitePlus

Other Protein References for ADCY8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADCY8 Gene

Gene Families for ADCY8 Gene

  • ADCY :Adenylate cyclases

Protein Domains for ADCY8 Gene

Suggested Antigen Peptide Sequences for ADCY8 Gene

Graphical View of Domain Structure for InterPro Entry



  • P40145
  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY8: view

Function for ADCY8 Gene

Molecular function for ADCY8 Gene

GENATLAS Biochemistry:
adenylyl cyclase type VIII,brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by calcium/calmodulin
UniProtKB/Swiss-Prot Function:
This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Enzyme Numbers (IUBMB) for ADCY8 Gene

Gene Ontology (GO) - Molecular Function for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004016 adenylate cyclase activity TAS 8076676
GO:0005524 ATP binding IEA --
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity TAS 8163524
GO:0016849 phosphorus-oxygen lyase activity --
genes like me logo Genes that share ontologies with ADCY8: view
genes like me logo Genes that share phenotypes with ADCY8: view

Animal Models for ADCY8 Gene

MGI Knock Outs for ADCY8:

miRNA for ADCY8 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY8

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ADCY8 Gene

Localization for ADCY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADCY8 Gene COMPARTMENTS Subcellular localization image for ADCY8 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 8163524
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCY8: view

Pathways for ADCY8 Gene

SuperPathways for ADCY8 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process IEA --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY8: view

Compounds for ADCY8 Gene

(5) Tocris Compounds for ADCY8 Gene

Compound Action Cas Number
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
PACAP 1-38 Potent stimulator of adenylyl cyclase [137061-48-4]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(1) ApexBio Compounds for ADCY8 Gene

Compound Action Cas Number
Forskolin [66575-29-9]

(11) HMDB Compounds for ADCY8 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • Ca
Cyclic AMP
  • Cyclic AMP
Cyclic GMP
  • 3',5'-cyclic GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with ADCY8: view

Transcripts for ADCY8 Gene

mRNA/cDNA for ADCY8 Gene

(21) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADCY8 Gene

Adenylate cyclase 8 (brain):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP2: - - -

Relevant External Links for ADCY8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCY8 Gene

mRNA expression in normal human tissues for ADCY8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY8 Gene

This gene is overexpressed in Brain - Amygdala (5.4), Brain - Hippocampus (4.7), and Brain - Anterior cingulate cortex (BA24) (4.2).

Protein differential expression in normal tissues for ADCY8 Gene

This gene is overexpressed in Liver, secretome (32.4) and Spinal cord (26.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCY8 Gene

SOURCE GeneReport for Unigene cluster for ADCY8 Gene Hs.591859

genes like me logo Genes that share expressions with ADCY8: view

Expression partners for ADCY8 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADCY8 Gene

Orthologs for ADCY8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCY8 35
  • 91.79 (n)
  • 97.68 (a)
ADCY8 36
  • 98 (a)
(Canis familiaris)
Mammalia ADCY8 35
  • 92.27 (n)
  • 97.6 (a)
ADCY8 36
  • 98 (a)
(Mus musculus)
Mammalia Adcy8 35
  • 90.21 (n)
  • 96.96 (a)
Adcy8 16
Adcy8 36
  • 97 (a)
(Pan troglodytes)
Mammalia ADCY8 35
  • 99.19 (n)
  • 99.51 (a)
ADCY8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Adcy8 35
  • 90.28 (n)
  • 97.04 (a)
(Monodelphis domestica)
Mammalia ADCY8 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia ADCY8 36
  • 94 (a)
(Gallus gallus)
Aves ADCY8 35
  • 81.04 (n)
  • 90.79 (a)
ADCY8 36
  • 91 (a)
(Anolis carolinensis)
Reptilia ADCY8 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy8 35
  • 79.42 (n)
  • 90.83 (a)
(Danio rerio)
Actinopterygii adcy8 35
  • 74.61 (n)
  • 82.96 (a)
adcy8 36
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ac3 37
  • 36 (a)
Ac78C 37
  • 43 (a)
  • 28 (a)
  • 30 (a)
  • 29 (a)
  • 28 (a)
  • 28 (a)
rut 37
  • 45 (a)
Ac78C 35
  • 52.28 (n)
  • 42.46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002262 35
  • 53.07 (n)
  • 42.5 (a)
(Caenorhabditis elegans)
Secernentea acy-2 37
  • 36 (a)
acy-4 37
  • 41 (a)
acy-4 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
-- 36
  • 49 (a)
Species with no ortholog for ADCY8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY8 Gene

Gene Tree for ADCY8 (if available)
Gene Tree for ADCY8 (if available)

Paralogs for ADCY8 Gene

Selected SIMAP similar genes for ADCY8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY8: view

Variants for ADCY8 Gene

Sequence variations from dbSNP and Humsavar for ADCY8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs16929 -- 130,946,013(-) AAAAA(G/T)AGCAT intron-variant
rs70994 -- 130,809,676(-) ACTAG(C/T)GTGTG intron-variant
rs166402 -- 130,800,921(-) TTTGC(C/T)TTGCT intron-variant
rs166403 -- 130,823,072(+) CTGCC(C/T)GGCAC intron-variant
rs166404 -- 130,816,335(+) GAAAA(C/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY8 Gene

Variant ID Type Subtype PubMed ID
nsv891448 CNV Gain 21882294
nsv831462 CNV Gain 17160897
esv1011202 CNV Deletion 20482838
nsv512069 CNV Loss 21212237
esv2669733 CNV Deletion 23128226
dgv1195n67 CNV Gain 20364138
nsv821256 CNV Deletion 20802225
nsv824732 CNV Loss 20364138
nsv819677 CNV Gain 19587683
esv2737587 CNV Deletion 23290073
esv6594 CNV Loss 19470904
esv1000595 CNV Deletion 20482838
esv2675868 CNV Deletion 23128226
nsv396197 CNV Loss 16902084
esv25237 CNV Gain+Loss 19812545
nsv525692 CNV Gain 19592680
esv1235416 CNV Deletion 17803354
nsv512966 CNV Insertion 21212237
esv2655219 CNV Insertion 19546169
nsv6397 CNV Insertion 18451855
nsv891449 CNV Loss 21882294

Relevant External Links for ADCY8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY8 Gene

Disorders for ADCY8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADCY8 Gene in MalaCards »

(3) Diseases for ADCY8 Gene including...

(1) University of Copenhagen DISEASES for ADCY8 Gene

Relevant External Links for ADCY8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADCY8: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ADCY8 Gene

Publications for ADCY8 Gene

  1. Molecular cloning of the human type VIII adenylyl cyclase. (PMID: 8076676) Defer N. … Hanoune J. (FEBS Lett. 1994) 2 3 4
  2. Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain. (PMID: 1715695) Parma J. … Hanoune J. (Biochem. Biophys. Res. Commun. 1991) 3 4
  3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 48
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ADCY8 Gene

Sources for ADCY8 Gene

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