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Aliases for ADCY8 Gene

Aliases for ADCY8 Gene

  • Adenylate Cyclase 8 (Brain) 2 3 5
  • Ca(2+)/Calmodulin-Activated Adenylyl Cyclase 3 4
  • Adenylate Cyclase Type VIII 3 4
  • ATP Pyrophosphate-Lyase 8 3 4
  • Adenylyl Cyclase 8 3 4
  • EC 4.6.1.1 4 63
  • AC8 3 4
  • Epididymis Secretory Sperm Binding Protein Li 172mP 3
  • Adenylyl Cyclase-8, Brain 3
  • HEL-S-172mP 3
  • HBAC1 3
  • ADCY3 3

External Ids for ADCY8 Gene

Previous HGNC Symbols for ADCY8 Gene

  • ADCY3

Previous GeneCards Identifiers for ADCY8 Gene

  • GC08M130592
  • GC08M131808
  • GC08M131463
  • GC08M131749
  • GC08M131725
  • GC08M131861
  • GC08M127112

Summaries for ADCY8 Gene

Entrez Gene Summary for ADCY8 Gene

  • Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY8 Gene

ADCY8 (Adenylate Cyclase 8 (Brain)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include nucleotide binding and adenylate cyclase activity. An important paralog of this gene is ADCY3.

UniProtKB/Swiss-Prot for ADCY8 Gene

  • This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Tocris Summary for ADCY8 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY8 Gene

Genomics for ADCY8 Gene

Regulatory Elements for ADCY8 Gene

Genomic Location for ADCY8 Gene

Chromosome:
8
Start:
130,780,300 bp from pter
End:
131,042,426 bp from pter
Size:
262,127 bases
Orientation:
Minus strand

Genomic View for ADCY8 Gene

Genes around ADCY8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY8 Gene

Proteins for ADCY8 Gene

  • Protein details for ADCY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40145-ADCY8_HUMAN
    Recommended name:
    Adenylate cyclase type 8
    Protein Accession:
    P40145

    Protein attributes for ADCY8 Gene

    Size:
    1251 amino acids
    Molecular mass:
    140122 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for ADCY8 Gene

Proteomics data for ADCY8 Gene at MOPED

Post-translational modifications for ADCY8 Gene

  • Glycosylation at Asn 817, Asn 821, and Asn 888
  • Modification sites at PhosphoSitePlus

Other Protein References for ADCY8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for ADCY8

Domains & Families for ADCY8 Gene

Gene Families for ADCY8 Gene

Protein Domains for ADCY8 Gene

Suggested Antigen Peptide Sequences for ADCY8 Gene

Graphical View of Domain Structure for InterPro Entry

P40145

UniProtKB/Swiss-Prot:

ADCY8_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Contains 2 guanylate cyclase domains.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY8: view

Function for ADCY8 Gene

Molecular function for ADCY8 Gene

GENATLAS Biochemistry:
adenylyl cyclase type VIII,brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by calcium/calmodulin.
UniProtKB/Swiss-Prot Function:
This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Enzyme Numbers (IUBMB) for ADCY8 Gene

genes like me logo Genes that share phenotypes with ADCY8: view

Animal Models for ADCY8 Gene

MGI Knock Outs for ADCY8:

Animal Model Products

miRNA for ADCY8 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY8 Gene

Localization for ADCY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY8 Gene COMPARTMENTS Subcellular localization image for ADCY8 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 8163524
genes like me logo Genes that share ontologies with ADCY8: view

Pathways & Interactions for ADCY8 Gene

SuperPathways for ADCY8 Gene

Superpath Contained pathways
1 DAG and IP3 signaling
2 Interleukin-3, 5 and GM-CSF signaling
3 Circadian entrainment
4 Aquaporin-mediated transport
5 G-Beta Gamma Signaling
genes like me logo Genes that share pathways with ADCY8: view

SIGNOR curated interactions for ADCY8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006833 water transport TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity TAS --
genes like me logo Genes that share ontologies with ADCY8: view

Drugs & Compounds for ADCY8 Gene

(11) Drugs for ADCY8 Gene - From: HMDB, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Pyruvic acid Approved Nutra 0
Forskolin Experimental Pharma Adenylyl cyclase activator 0
cyclic amp Experimental Pharma 0
Cyclic GMP Experimental Pharma 0

(5) Additional Compounds for ADCY8 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
NKH 477
138605-00-2
PACAP 1-27
127317-03-7
PACAP 1-38
137061-48-4
SQ 22536
17318-31-9

(5) Tocris Compounds for ADCY8 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
PACAP 1-27 Potent stimulator of adenylyl cyclase 127317-03-7
PACAP 1-38 Potent stimulator of adenylyl cyclase 137061-48-4
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9

(1) ApexBio Compounds for ADCY8 Gene

Compound Action Cas Number
Forskolin 66575-29-9
genes like me logo Genes that share compounds with ADCY8: view

Transcripts for ADCY8 Gene

mRNA/cDNA for ADCY8 Gene

Unigene Clusters for ADCY8 Gene

Adenylate cyclase 8 (brain):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2: - - -

Relevant External Links for ADCY8 Gene

GeneLoc Exon Structure for
ADCY8
ECgene alternative splicing isoforms for
ADCY8

Expression for ADCY8 Gene

mRNA expression in normal human tissues for ADCY8 Gene

mRNA differential expression in normal tissues according to GTEx for ADCY8 Gene

This gene is overexpressed in Brain - Amygdala (x5.4), Brain - Hippocampus (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for ADCY8 Gene

This gene is overexpressed in Liver, secretome (32.4) and Spinal cord (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCY8 Gene



SOURCE GeneReport for Unigene cluster for ADCY8 Gene Hs.591859

mRNA Expression by UniProt/SwissProt for ADCY8 Gene

P40145-ADCY8_HUMAN
Tissue specificity: Detected in brain cortex.
genes like me logo Genes that share expression patterns with ADCY8: view

Protein tissue co-expression partners for ADCY8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADCY8 Gene

Orthologs for ADCY8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADCY8 35
  • 91.79 (n)
  • 97.68 (a)
ADCY8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY8 35
  • 92.27 (n)
  • 97.6 (a)
ADCY8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy8 35
  • 90.21 (n)
  • 96.96 (a)
Adcy8 16
Adcy8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADCY8 35
  • 99.19 (n)
  • 99.51 (a)
ADCY8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy8 35
  • 90.28 (n)
  • 97.04 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCY8 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY8 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCY8 35
  • 81.04 (n)
  • 90.79 (a)
ADCY8 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY8 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy8 35
  • 79.42 (n)
  • 90.83 (a)
zebrafish
(Danio rerio)
Actinopterygii adcy8 35
  • 74.61 (n)
  • 82.96 (a)
adcy8 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ac3 37
  • 36 (a)
Ac78C 37
  • 43 (a)
ACXA 37
  • 28 (a)
ACXB 37
  • 30 (a)
ACXC 37
  • 29 (a)
ACXD 37
  • 28 (a)
ACXE 37
  • 28 (a)
rut 37
  • 45 (a)
Ac78C 35
  • 52.28 (n)
  • 42.46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002262 35
  • 53.07 (n)
  • 42.5 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-2 37
  • 36 (a)
acy-4 37
  • 41 (a)
acy-4 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
Species with no ortholog for ADCY8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY8 Gene

ENSEMBL:
Gene Tree for ADCY8 (if available)
TreeFam:
Gene Tree for ADCY8 (if available)

Paralogs for ADCY8 Gene

Paralogs for ADCY8 Gene

(9) SIMAP similar genes for ADCY8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY8: view

Variants for ADCY8 Gene

Sequence variations from dbSNP and Humsavar for ADCY8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_029188 -
VAR_036328 A colorectal cancer sample
rs16929 -- 130,946,013(-) AAAAA(G/T)AGCAT intron-variant
rs70994 -- 130,809,676(-) ACTAG(C/T)GTGTG intron-variant
rs166402 -- 130,800,921(-) TTTGC(C/T)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY8 Gene

Variant ID Type Subtype PubMed ID
nsv891448 CNV Gain 21882294
nsv831462 CNV Gain 17160897
esv1011202 CNV Deletion 20482838
nsv512069 CNV Loss 21212237
esv2669733 CNV Deletion 23128226
dgv1195n67 CNV Gain 20364138
nsv821256 CNV Deletion 20802225
nsv824732 CNV Loss 20364138
nsv819677 CNV Gain 19587683
esv2737587 CNV Deletion 23290073
esv6594 CNV Loss 19470904
esv1000595 CNV Deletion 20482838
esv2675868 CNV Deletion 23128226
nsv396197 CNV Loss 16902084
esv25237 CNV Gain+Loss 19812545
nsv525692 CNV Gain 19592680
esv1235416 CNV Deletion 17803354
nsv512966 CNV Insertion 21212237
esv2655219 CNV Insertion 19546169
nsv6397 CNV Insertion 18451855
nsv891449 CNV Loss 21882294

Variation tolerance for ADCY8 Gene

Residual Variation Intolerance Score: 2.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCY8 Gene

HapMap Linkage Disequilibrium report
ADCY8
Human Gene Mutation Database (HGMD)
ADCY8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY8 Gene

Disorders for ADCY8 Gene

Relevant External Links for ADCY8

Genetic Association Database (GAD)
ADCY8
Human Genome Epidemiology (HuGE) Navigator
ADCY8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY8

No disorders were found for ADCY8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY8 Gene

Publications for ADCY8 Gene

  1. Molecular cloning of the human type VIII adenylyl cyclase. (PMID: 8076676) Defer N. … Hanoune J. (FEBS Lett. 1994) 2 3 4 67
  2. A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample. (PMID: 24677629) Wolf E.J. … Miller M.W. (Depress Anxiety 2014) 3
  3. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3
  4. GI+(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells. (PMID: 23200849) Obara Y. … Nakahata N. (Cell. Signal. 2013) 3
  5. Genetic markers of comorbid depression and alcoholism in women. (PMID: 23278386) Procopio D.O. … Tabakoff B. (Alcohol. Clin. Exp. Res. 2013) 3

Products for ADCY8 Gene

Sources for ADCY8 Gene

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