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Aliases for ADCY8 Gene

Aliases for ADCY8 Gene

  • Adenylate Cyclase 8 2 3 5
  • Ca(2+)/Calmodulin-Activated Adenylyl Cyclase 3 4
  • Adenylate Cyclase 8 (Brain) 2 3
  • Adenylate Cyclase Type VIII 3 4
  • ATP Pyrophosphate-Lyase 8 3 4
  • Adenylyl Cyclase 8 3 4
  • EC 4.6.1.1 4 56
  • AC8 3 4
  • Epididymis Secretory Sperm Binding Protein Li 172mP 3
  • Adenylyl Cyclase-8, Brain 3
  • Adenylate Cyclase Type 8 3
  • HEL-S-172mP 3
  • HBAC1 3
  • ADCY3 3

External Ids for ADCY8 Gene

Previous HGNC Symbols for ADCY8 Gene

  • ADCY3

Previous GeneCards Identifiers for ADCY8 Gene

  • GC08M130592
  • GC08M131808
  • GC08M131463
  • GC08M131749
  • GC08M131725
  • GC08M131861
  • GC08M127112

Summaries for ADCY8 Gene

Entrez Gene Summary for ADCY8 Gene

  • Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY8 Gene

ADCY8 (Adenylate Cyclase 8) is a Protein Coding gene. Among its related pathways are Salivary secretion and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include nucleotide binding and adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY8 Gene

  • This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Tocris Summary for ADCY8 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY8 Gene

Additional gene information for ADCY8 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY8 Gene

Genomics for ADCY8 Gene

GeneHancer (GH) Regulatory Elements for ADCY8 Gene

Promoters and enhancers for ADCY8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I131042 Promoter/Enhancer 1 EPDnew ENCODE 550.8 0.0 -24 0.2 USF1 POLR2A CREB1 SIN3A ATF2 EZH2 ADCY8 LOC105375760 PIR45591
GH08I131041 Promoter 0.7 EPDnew 550.8 +0.9 868 0.1 SUZ12 EZH2 ADCY8 LOC105375760
GH08I131043 Enhancer 0.5 ENCODE 550.8 +0.2 236 0.2 SUZ12 POLR2A CREB1 SIN3A EZH2 ADCY8 LOC105375760
GH08I131044 Enhancer 0.4 ENCODE 550.8 +0.7 666 0 SUZ12 EZH2 ADCY8 LOC105375760
GH08I130852 Enhancer 0.4 FANTOM5 3.9 +190.0 190025 0.4 CTCF ADCY8 LOC105375762 LOC105375761
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADCY8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADCY8 gene promoter:

Genomic Locations for ADCY8 Gene

Genomic Locations for ADCY8 Gene
chr8:130,780,300-131,042,426
(GRCh38/hg38)
Size:
262,127 bases
Orientation:
Minus strand
chr8:131,792,547-132,054,672
(GRCh37/hg19)

Genomic View for ADCY8 Gene

Genes around ADCY8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY8 Gene

Proteins for ADCY8 Gene

  • Protein details for ADCY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40145-ADCY8_HUMAN
    Recommended name:
    Adenylate cyclase type 8
    Protein Accession:
    P40145

    Protein attributes for ADCY8 Gene

    Size:
    1251 amino acids
    Molecular mass:
    140122 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for ADCY8 Gene

Selected DME Specific Peptides for ADCY8 Gene

P40145:
  • VLCGVLGLRKWQ
  • LERLYQRYF
  • SRMDSTGV
  • RIKILGDCYYC
  • TYMAVSGL
  • EKIKTIG
  • VDMRIGIH
  • EELYSQSYD
  • CGVLGLRKWQFDVWS
  • DHAHCCVEMG
  • ECLRLLNEII

Post-translational modifications for ADCY8 Gene

  • Glycosylation at Asn817, posLast=821821, and posLast=888888

Other Protein References for ADCY8 Gene

Domains & Families for ADCY8 Gene

Gene Families for ADCY8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADCY8 Gene

Graphical View of Domain Structure for InterPro Entry

P40145

UniProtKB/Swiss-Prot:

ADCY8_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY8: view

Function for ADCY8 Gene

Molecular function for ADCY8 Gene

GENATLAS Biochemistry:
adenylyl cyclase type VIII,brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by calcium/calmodulin.
UniProtKB/Swiss-Prot Function:
This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Enzyme Numbers (IUBMB) for ADCY8 Gene

Phenotypes From GWAS Catalog for ADCY8 Gene

Gene Ontology (GO) - Molecular Function for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IEA,TAS --
GO:0004383 guanylate cyclase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity TAS 8163524
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with ADCY8: view
genes like me logo Genes that share phenotypes with ADCY8: view

Animal Models for ADCY8 Gene

MGI Knock Outs for ADCY8:

miRNA for ADCY8 Gene

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY8 Gene

Localization for ADCY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY8 gene
Compartment Confidence
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0008074 guanylate cyclase complex, soluble IBA --
GO:0016020 membrane IEA,TAS 8163524
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCY8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADCY8 Gene

Pathways & Interactions for ADCY8 Gene

SuperPathways for ADCY8 Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
2 RET signaling
3 Aldosterone synthesis and secretion
4 Aquaporin-mediated transport
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with ADCY8: view

SIGNOR curated interactions for ADCY8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006171 cAMP biosynthetic process IEA --
GO:0006182 cGMP biosynthetic process IBA --
GO:0007165 signal transduction TAS 8076676
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADCY8: view

Drugs & Compounds for ADCY8 Gene

(16) Drugs for ADCY8 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0
NADH Approved Nutra 0
Pyruvic acid Approved, Investigational Nutra 0

(1) Additional Compounds for ADCY8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(5) Tocris Compounds for ADCY8 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
KH 7 Selective soluble adenylyl cyclase inhibitor 330676-02-3
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9

(1) ApexBio Compounds for ADCY8 Gene

Compound Action Cas Number
Forskolin 66575-29-9
genes like me logo Genes that share compounds with ADCY8: view

Drug Products

Transcripts for ADCY8 Gene

mRNA/cDNA for ADCY8 Gene

Unigene Clusters for ADCY8 Gene

Adenylate cyclase 8 (brain):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2: - - -

Relevant External Links for ADCY8 Gene

GeneLoc Exon Structure for
ADCY8
ECgene alternative splicing isoforms for
ADCY8

Expression for ADCY8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCY8 Gene

mRNA differential expression in normal tissues according to GTEx for ADCY8 Gene

This gene is overexpressed in Brain - Amygdala (x5.4), Brain - Hippocampus (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for ADCY8 Gene

This gene is overexpressed in Liver, secretome (32.4) and Spinal cord (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCY8 Gene



Protein tissue co-expression partners for ADCY8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADCY8 Gene:

ADCY8

SOURCE GeneReport for Unigene cluster for ADCY8 Gene:

Hs.591859

mRNA Expression by UniProt/SwissProt for ADCY8 Gene:

P40145-ADCY8_HUMAN
Tissue specificity: Detected in brain cortex.

Evidence on tissue expression from TISSUES for ADCY8 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ADCY8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY8 Gene

Orthologs for ADCY8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY8 33 34
  • 99.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY8 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCY8 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY8 33 34
  • 92.27 (n)
cow
(Bos Taurus)
Mammalia ADCY8 33 34
  • 91.79 (n)
rat
(Rattus norvegicus)
Mammalia Adcy8 33
  • 90.28 (n)
mouse
(Mus musculus)
Mammalia Adcy8 16 34 33
  • 90.21 (n)
chicken
(Gallus gallus)
Aves ADCY8 34 33
  • 81.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY8 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy8 33
  • 79.42 (n)
zebrafish
(Danio rerio)
Actinopterygii adcy8 33 34
  • 74.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002262 33
  • 53.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ac78C 35 33
  • 52.28 (n)
rut 35
  • 45 (a)
Ac3 35
  • 36 (a)
ACXB 35
  • 30 (a)
ACXC 35
  • 29 (a)
ACXA 35
  • 28 (a)
ACXD 35
  • 28 (a)
ACXE 35
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-4 35 34
  • 41 (a)
acy-2 35
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
Species where no ortholog for ADCY8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY8 Gene

ENSEMBL:
Gene Tree for ADCY8 (if available)
TreeFam:
Gene Tree for ADCY8 (if available)

Paralogs for ADCY8 Gene

Paralogs for ADCY8 Gene

(9) SIMAP similar genes for ADCY8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY8: view

Variants for ADCY8 Gene

Sequence variations from dbSNP and Humsavar for ADCY8 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
VAR_036328 A colorectal cancer sample p.Phe881Leu
rs1000002124 -- 130,835,680(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000021955 -- 131,016,617(-) G/A intron_variant
rs1000035821 -- 131,041,153(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000042520 -- 130,926,279(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY8 Gene

Variant ID Type Subtype PubMed ID
dgv1195n67 CNV gain 20364138
dgv12333n54 CNV loss 21841781
dgv12334n54 CNV loss 21841781
dgv12335n54 CNV loss 21841781
dgv12336n54 CNV loss 21841781
dgv12337n54 CNV loss 21841781
dgv3904n106 CNV deletion 24896259
dgv7311n100 CNV gain 25217958
esv1000595 CNV deletion 20482838
esv1011202 CNV deletion 20482838
esv1235416 CNV deletion 17803354
esv25237 CNV gain+loss 19812545
esv2655219 CNV insertion 19546169
esv2669733 CNV deletion 23128226
esv2675868 CNV deletion 23128226
esv2737587 CNV deletion 23290073
esv2761471 CNV gain 21179565
esv3270163 CNV deletion 24192839
esv3362459 CNV duplication 20981092
esv3379880 CNV duplication 20981092
esv3385643 CNV duplication 20981092
esv3544214 CNV deletion 23714750
esv3572992 CNV loss 25503493
esv3572993 CNV loss 25503493
esv3618837 CNV loss 21293372
esv3618838 CNV gain 21293372
esv3618839 CNV loss 21293372
esv3618840 CNV loss 21293372
esv6594 CNV loss 19470904
nsv1016494 CNV gain 25217958
nsv1028579 CNV gain 25217958
nsv1122202 CNV deletion 24896259
nsv1142034 OTHER inversion 24896259
nsv396197 CNV deletion 16902084
nsv472660 CNV novel sequence insertion 20440878
nsv475802 CNV novel sequence insertion 20440878
nsv478549 CNV novel sequence insertion 20440878
nsv512069 CNV loss 21212237
nsv512966 CNV insertion 21212237
nsv525692 CNV gain 19592680
nsv612294 CNV gain 21841781
nsv612295 CNV loss 21841781
nsv6397 CNV insertion 18451855
nsv819677 CNV gain 19587683
nsv821256 CNV deletion 20802225
nsv824732 CNV loss 20364138
nsv831462 CNV gain 17160897
nsv957657 CNV deletion 24416366
nsv972586 CNV deletion 23825009

Variation tolerance for ADCY8 Gene

Residual Variation Intolerance Score: 2.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADCY8 Gene

Human Gene Mutation Database (HGMD)
ADCY8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY8 Gene

Disorders for ADCY8 Gene

Additional Disease Information for ADCY8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADCY8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY8 Gene

Publications for ADCY8 Gene

  1. Molecular cloning of the human type VIII adenylyl cyclase. (PMID: 8076676) Defer N … Hanoune J (FEBS letters 1994) 2 3 4 58
  2. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 44 58

Products for ADCY8 Gene

Sources for ADCY8 Gene

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