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Aliases for RNF13 Gene

Aliases for RNF13 Gene

  • Ring Finger Protein 13 2 3
  • RZF 3 4
  • E3 Ubiquitin-Protein Ligase RNF13 3
  • RING Zinc Finger Protein 3
  • RING Finger Protein 13 4
  • EC 6.3.2.- 4

External Ids for RNF13 Gene

Previous GeneCards Identifiers for RNF13 Gene

  • GC03P146460
  • GC03P150415
  • GC03P150812
  • GC03P150851
  • GC03P151013
  • GC03P149531
  • GC03P146902

Summaries for RNF13 Gene

Entrez Gene Summary for RNF13 Gene

  • The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF13 Gene

RNF13 (Ring Finger Protein 13) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for RNF13 Gene

  • E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.

Gene Wiki entry for RNF13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF13 Gene

Genomics for RNF13 Gene

Regulatory Elements for RNF13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF13 Gene

149,812,688 bp from pter
149,962,139 bp from pter
149,452 bases
Plus strand

Genomic View for RNF13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF13 Gene

Proteins for RNF13 Gene

  • Protein details for RNF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF13
    Protein Accession:
    Secondary Accessions:
    • A6NC87
    • B3KR12
    • Q05D66
    • Q6IBJ9

    Protein attributes for RNF13 Gene

    381 amino acids
    Molecular mass:
    42814 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH17878.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF13 Gene


neXtProt entry for RNF13 Gene

Proteomics data for RNF13 Gene at MOPED

Post-translational modifications for RNF13 Gene

Antibody Products

No data available for DME Specific Peptides for RNF13 Gene

Domains for RNF13 Gene

Gene Families for RNF13 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF13 Gene

Graphical View of Domain Structure for InterPro Entry



  • O43567
  • The RING-type zinc finger domain is required for E3 ligase activity
  • Contains 1 PA (protease associated) domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF13: view

Function for RNF13 Gene

Molecular function for RNF13 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.

Enzyme Numbers (IUBMB) for RNF13 Gene

Gene Ontology (GO) - Molecular Function for RNF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 19690564
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF13: view
genes like me logo Genes that share phenotypes with RNF13: view

Animal Model Products

miRNA for RNF13 Gene

miRTarBase miRNAs that target RNF13

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF13

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF13 Gene

Localization for RNF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF13 Gene

Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane; Single-pass membrane protein. Lysosome membrane. Nucleus inner membrane. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RNF13 Gene COMPARTMENTS Subcellular localization image for RNF13 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
lysosome 5
vacuole 5
plasma membrane 3
extracellular 2
nucleus 2
peroxisome 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus --
GO:0005637 nuclear inner membrane IEA --
GO:0005765 lysosomal membrane ISS --
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with RNF13: view

Pathways for RNF13 Gene

SuperPathways for RNF13 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat

UniProtKB/Swiss-Prot O43567-RNF13_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051865 protein autoubiquitination ISS --
genes like me logo Genes that share ontologies with RNF13: view

No data available for Pathways by source for RNF13 Gene

Compounds for RNF13 Gene

(1) Novoseek inferred chemical compound relationships for RNF13 Gene

Compound -log(P) Hits PubMed IDs
zinc 30.6 2
genes like me logo Genes that share compounds with RNF13: view

Transcripts for RNF13 Gene

Unigene Clusters for RNF13 Gene

Ring finger protein 13:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF13

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF13 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: - - -
SP3: - - -

Relevant External Links for RNF13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF13 Gene

mRNA expression in normal human tissues for RNF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF13 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.2).

Protein differential expression in normal tissues for RNF13 Gene

This gene is overexpressed in Heart (33.5), Peripheral blood mononuclear cells (9.8), Skin (8.3), and Testis (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF13 Gene

SOURCE GeneReport for Unigene cluster for RNF13 Gene Hs.12333

mRNA Expression by UniProt/SwissProt for RNF13 Gene

Tissue specificity: Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level).
genes like me logo Genes that share expressions with RNF13: view

In Situ Assay Products

No data available for Expression partners for RNF13 Gene

Orthologs for RNF13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF13 35
  • 95.61 (n)
  • 98.16 (a)
RNF13 36
  • 98 (a)
(Canis familiaris)
Mammalia RNF13 35
  • 92.83 (n)
  • 97.64 (a)
RNF13 36
  • 98 (a)
(Mus musculus)
Mammalia Rnf13 35
  • 89.59 (n)
  • 93.44 (a)
Rnf13 16
Rnf13 36
  • 93 (a)
(Pan troglodytes)
Mammalia RNF13 35
  • 100 (n)
  • 100 (a)
RNF13 36
  • 100 (a)
(Monodelphis domestica)
Mammalia RNF13 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RNF13 36
  • 90 (a)
(Gallus gallus)
Aves RNF13 35
  • 80.4 (n)
  • 91.08 (a)
RNF13 36
  • 91 (a)
(Anolis carolinensis)
Reptilia RNF13 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf13 35
  • 70.95 (n)
  • 75.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68556 35
(Danio rerio)
Actinopterygii rnf13 35
  • 68.98 (n)
  • 77.54 (a)
zgc55660 35
fruit fly
(Drosophila melanogaster)
Insecta CG10277 37
  • 39 (a)
CG10277 36
  • 23 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002028 35
  • 45.56 (n)
  • 41.18 (a)
(Caenorhabditis elegans)
Secernentea C18B12.4 36
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RMR1 35
  • 47.84 (n)
  • 35.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7712 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.598 36
  • 32 (a)
Species with no ortholog for RNF13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF13 Gene

Gene Tree for RNF13 (if available)
Gene Tree for RNF13 (if available)

Paralogs for RNF13 Gene Pseudogenes for RNF13 Gene

genes like me logo Genes that share paralogs with RNF13: view

Variants for RNF13 Gene

Sequence variations from dbSNP and Humsavar for RNF13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7856 -- 149,961,227(+) TTTAA(G/T)CAAAT utr-variant-3-prime
rs481885 -- 149,915,896(+) aagat(A/G)aaggc intron-variant
rs481890 -- 149,915,900(+) tgaag(G/T)ctgtg intron-variant
rs481984 -- 149,915,930(+) agcac(A/C)acagt intron-variant
rs484572 -- 149,935,133(+) tatag(A/T)gattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF13 Gene

Variant ID Type Subtype PubMed ID
esv34142 CNV Loss 18971310
esv2597752 CNV Deletion 19546169
nsv877643 CNV Gain 21882294
nsv877644 CNV Loss 21882294
esv2664861 CNV Deletion 23128226
esv993688 CNV Insertion 20482838
esv1516102 CNV Insertion 17803354
esv2676965 CNV Deletion 23128226

Relevant External Links for RNF13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF13 Gene

Disorders for RNF13 Gene

Relevant External Links for RNF13

Genetic Association Database (GAD)

No disorders were found for RNF13 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RNF13 Gene

Publications for RNF13 Gene

  1. Nuclear targeting of an endosomal E3 ubiquitin ligase. (PMID: 20230530) Bocock J.P. … Erickson A.H. (Traffic 2010) 3 23
  2. RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer. (PMID: 18794910) Zhang Q. … Zhu D. (Cell Res. 2009) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4

Products for RNF13 Gene

Sources for RNF13 Gene

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