Aliases for GABARAP Gene
External Ids for GABARAP Gene
Previous GeneCards Identifiers for GABARAP Gene
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
GeneCards Summary for GABARAP Gene
GABARAP (GABA(A) Receptor-Associated Protein) is a Protein Coding gene. Diseases associated with GABARAP include stiff-person syndrome. Among its related pathways are Cellular Senescence and FoxO signaling pathway. GO annotations related to this gene include microtubule binding and GABA receptor binding. An important paralog of this gene is MAP1LC3C.
UniProtKB/Swiss-Prot for GABARAP Gene
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.