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Aliases for GABARAP Gene

Aliases for GABARAP Gene

  • GABA Type A Receptor-Associated Protein 2 3
  • GABA(A) Receptor-Associated Protein 2 3 4 5
  • MM46 3 4
  • GABARAP-A 3
  • ATG8A 3
  • FLC3B 4

External Ids for GABARAP Gene

Previous GeneCards Identifiers for GABARAP Gene

  • GC16M055704
  • GC17M007873
  • GC17M007086
  • GC17M007344
  • GC17M007084
  • GC17M007143
  • GC17M007035

Summaries for GABARAP Gene

Entrez Gene Summary for GABARAP Gene

  • Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for GABARAP Gene

GABARAP (GABA Type A Receptor-Associated Protein) is a Protein Coding gene. Diseases associated with GABARAP include stiff-person syndrome. Among its related pathways are Cellular Senescence and Circadian entrainment. GO annotations related to this gene include microtubule binding and GABA receptor binding. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for GABARAP Gene

  • Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Wiki entry for GABARAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABARAP Gene

Genomics for GABARAP Gene

Regulatory Elements for GABARAP Gene

Promoters for GABARAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GABARAP on UCSC Golden Path with GeneCards custom track

Genomic Location for GABARAP Gene

Chromosome:
17
Start:
7,240,014 bp from pter
End:
7,242,770 bp from pter
Size:
2,757 bases
Orientation:
Minus strand

Genomic View for GABARAP Gene

Genes around GABARAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABARAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABARAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABARAP Gene

Proteins for GABARAP Gene

  • Protein details for GABARAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95166-GBRAP_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein
    Protein Accession:
    O95166

    Protein attributes for GABARAP Gene

    Size:
    117 amino acids
    Molecular mass:
    13918 Da
    Quaternary structure:
    • Interacts with GPHN and NSF (By similarity). Interacts with ATG3, ATG7, ATG13, RB1CC1, GABRG2, beta-tubulin and ULK1. Interacts with CALR. Interacts with DDX47. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1. Interacts with MAPK15. Interacts with TECPR2 and PCM1. Interacts with TBC1D5 (PubMed:22354992). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV and TRIM21 (PubMed:26347139).

    Three dimensional structures from OCA and Proteopedia for GABARAP Gene

neXtProt entry for GABARAP Gene

Proteomics data for GABARAP Gene at MOPED

Post-translational modifications for GABARAP Gene

  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GABARAP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GABARAP (GABARAP)

No data available for DME Specific Peptides for GABARAP Gene

Domains & Families for GABARAP Gene

Gene Families for GABARAP Gene

Protein Domains for GABARAP Gene

Suggested Antigen Peptide Sequences for GABARAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95166

UniProtKB/Swiss-Prot:

GBRAP_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with GABARAP: view

Function for GABARAP Gene

Molecular function for GABARAP Gene

GENATLAS Biochemistry:
GABA (A) receptor-associated protein binding GABA-A receptors,gamma 2 subunit and linking the receptors to the cytoskeleton,highly homolog to microtubule associated proteins 1A and 1B ganglioside expression factor homolog 2
UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Ontology (GO) - Molecular Function for GABARAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 25127057
genes like me logo Genes that share ontologies with GABARAP: view
genes like me logo Genes that share phenotypes with GABARAP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GABARAP Gene

Localization for GABARAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABARAP Gene

Endomembrane system. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABARAP Gene COMPARTMENTS Subcellular localization image for GABARAP gene
Compartment Confidence
cytosol 5
plasma membrane 5
vacuole 5
cytoskeleton 4
golgi apparatus 4
endoplasmic reticulum 3
lysosome 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GABARAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000421 autophagosome membrane TAS --
GO:0005776 autophagosome IDA 19056683
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with GABARAP: view

Pathways & Interactions for GABARAP Gene

genes like me logo Genes that share pathways with GABARAP: view

Pathways by source for GABARAP Gene

1 BioSystems pathway for GABARAP Gene
2 Reactome pathways for GABARAP Gene

SIGNOR curated interactions for GABARAP Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GABARAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0007268 synaptic transmission TAS 9892355
genes like me logo Genes that share ontologies with GABARAP: view

Drugs & Compounds for GABARAP Gene

(3) Drugs for GABARAP Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gamma-Aminobutyric acid Pharma 75

(1) Additional Compounds for GABARAP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GABARAP: view

Transcripts for GABARAP Gene

Unigene Clusters for GABARAP Gene

GABA(A) receptor-associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABARAP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for GABARAP Gene

GeneLoc Exon Structure for
GABARAP
ECgene alternative splicing isoforms for
GABARAP

Expression for GABARAP Gene

mRNA expression in normal human tissues for GABARAP Gene

Protein differential expression in normal tissues from HIPED for GABARAP Gene

This gene is overexpressed in Frontal cortex (11.7) and Fetal gut (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GABARAP Gene



SOURCE GeneReport for Unigene cluster for GABARAP Gene Hs.647421

mRNA Expression by UniProt/SwissProt for GABARAP Gene

O95166-GBRAP_HUMAN
Tissue specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with GABARAP: view

Protein tissue co-expression partners for GABARAP Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GABARAP Gene

Orthologs for GABARAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GABARAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GABARAP 35
  • 95.44 (n)
  • 100 (a)
GABARAP 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABARAP 35
  • 96.01 (n)
  • 100 (a)
GABARAP 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabarap 35
  • 95.44 (n)
  • 100 (a)
Gabarap 16
Gabarap 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GABARAP 35
  • 99.72 (n)
  • 100 (a)
GABARAP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gabarap 35
  • 95.44 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gabarapa 35
  • 81.9 (n)
  • 98.28 (a)
GABARAP (2 of 2) 36
  • 97 (a)
OneToMany
gabarapa 36
  • 93 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12334 37
  • 77 (a)
Atg8a 36
  • 88 (a)
OneToMany
Atg8b 36
  • 75 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lgg-1 37
  • 83 (a)
lgg-1 36
  • 79 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 55 (a)
OneToMany
Species with no ortholog for GABARAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GABARAP Gene

ENSEMBL:
Gene Tree for GABARAP (if available)
TreeFam:
Gene Tree for GABARAP (if available)

Paralogs for GABARAP Gene

Paralogs for GABARAP Gene

Pseudogenes.org Pseudogenes for GABARAP Gene

genes like me logo Genes that share paralogs with GABARAP: view

Variants for GABARAP Gene

Sequence variations from dbSNP and Humsavar for GABARAP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs222843 -- 7,242,662(-) TTTAG(A/G)GTAAT upstream-variant-2KB
rs374487 -- 7,242,504(+) CCCCG(A/C)TAAGA upstream-variant-2KB
rs3214155 -- 7,241,912(+) TCTTA(-/ATCA)GACGG intron-variant
rs7216047 -- 7,241,962(+) GCAAC(C/G)TTAGC intron-variant
rs8192511 -- 7,241,733(-) GACAG(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABARAP Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294

Variation tolerance for GABARAP Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GABARAP Gene

HapMap Linkage Disequilibrium report
GABARAP
Human Gene Mutation Database (HGMD)
GABARAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABARAP Gene

Disorders for GABARAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for GABARAP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
stiff-person syndrome
  • stiff man syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GABARAP

Genetic Association Database (GAD)
GABARAP
Human Genome Epidemiology (HuGE) Navigator
GABARAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GABARAP
genes like me logo Genes that share disorders with GABARAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GABARAP Gene

Publications for GABARAP Gene

  1. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. (PMID: 9892355) Wang H. … Olsen R.W. (Nature 1999) 2 3 4 23 67
  2. A functional analysis of GABARAP on 17p13.1 by knockdown zebrafish. (PMID: 20111057) Komoike Y. … Yamamoto T. (J. Hum. Genet. 2010) 3 23
  3. Nix, a receptor protein for mitophagy in mammals. (PMID: 20200478) Kanki T. (Autophagy 2010) 3 23
  4. The TP53INP2 protein is required for autophagy in mammalian cells. (PMID: 19056683) Nowak J. … Iovanna J.L. (Mol. Biol. Cell 2009) 3 23
  5. Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones. (PMID: 19154346) Thielmann Y. … Willbold D. (FEBS J. 2009) 3 23

Products for GABARAP Gene

Sources for GABARAP Gene

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