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Aliases for TUSC2 Gene

Aliases for TUSC2 Gene

  • Tumor Suppressor Candidate 2 2 3
  • FUS1 3 4 6
  • PDGFA Associated Protein 2 2 3
  • PDGFA-Associated Protein 2 3 4
  • Fusion 1 Protein 3 4
  • Fus-1 Protein 3 4
  • C3orf11 3 4
  • PDAP2 3 4
  • LGCC 4
  • PAP 3

External Ids for TUSC2 Gene

Previous Symbols for TUSC2 Gene

  • PDAP2

Summaries for TUSC2 Gene

Entrez Gene Summary for TUSC2 Gene

  • This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUSC2 Gene

TUSC2 (Tumor Suppressor Candidate 2) is a Protein Coding gene. Diseases associated with TUSC2 include lung cancer.

UniProtKB/Swiss-Prot for TUSC2 Gene

  • May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells

Gene Wiki entry for TUSC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUSC2 Gene

Genomics for TUSC2 Gene

Genomic Location for TUSC2 Gene

Start:
50,320,027 bp from pter
End:
50,328,251 bp from pter
Size:
8,225 bases
Orientation:
Minus strand

Genomic View for TUSC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUSC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC2 Gene

Regulatory Elements for TUSC2 Gene

Transcription factor binding sites by QIAGEN in the TUSC2 gene promoter:

Proteins for TUSC2 Gene

  • Protein details for TUSC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75896-TUSC2_HUMAN
    Recommended name:
    Tumor suppressor candidate 2
    Protein Accession:
    O75896
    Secondary Accessions:
    • B2R4Y9

    Protein attributes for TUSC2 Gene

    Size:
    110 amino acids
    Molecular mass:
    12074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUSC2 Gene

Proteomics data for TUSC2 Gene at MOPED

Post-translational modifications for TUSC2 Gene

Other Protein References for TUSC2 Gene

No data available for DME Specific Peptides for TUSC2 Gene

Domains for TUSC2 Gene

Protein Domains for TUSC2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TUSC2_HUMAN
Family:
  • Belongs to the TUSC2 family.:
    • O75896
genes like me logo Genes that share domains with TUSC2: view

No data available for Gene Families for TUSC2 Gene

Function for TUSC2 Gene

Molecular function for TUSC2 Gene

UniProtKB/Swiss-Prot Function: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells

Gene Ontology (GO) - Molecular Function for TUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TUSC2: view
genes like me logo Genes that share phenotypes with TUSC2: view

Animal Models for TUSC2 Gene

MGI Knock Outs for TUSC2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TUSC2 Gene

Localization for TUSC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUSC2 Gene COMPARTMENTS Subcellular localization image for TUSC2 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with TUSC2: view

Pathways for TUSC2 Gene

SuperPathways for TUSC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0006909 phagocytosis IEA --
GO:0006954 inflammatory response IEA --
GO:0007049 cell cycle IEA --
GO:0007267 cell-cell signaling TAS 8780057
genes like me logo Genes that share ontologies with TUSC2: view

No data available for Pathways by source for TUSC2 Gene

Transcripts for TUSC2 Gene

Unigene Clusters for TUSC2 Gene

Tumor suppressor candidate 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -
SP4: - - -
SP5:

Relevant External Links for TUSC2 Gene

GeneLoc Exon Structure for
TUSC2
ECgene alternative splicing isoforms for
TUSC2

Expression for TUSC2 Gene

mRNA expression in normal human tissues for TUSC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUSC2 Gene

SOURCE GeneReport for Unigene cluster for TUSC2 Gene Hs.517981

mRNA Expression by UniProt/SwissProt for TUSC2 Gene

O75896-TUSC2_HUMAN
Tissue specificity: Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta
genes like me logo Genes that share expressions with TUSC2: view

Orthologs for TUSC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUSC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUSC2 36
  • 99.7 (n)
  • 99.09 (a)
TUSC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUSC2 36
  • 92.73 (n)
  • 94.55 (a)
TUSC2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUSC2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tusc2 36
  • 88.79 (n)
  • 92.73 (a)
Tusc2 16
Tusc2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUSC2 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUSC2 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tusc2 36
  • 90 (n)
  • 93.64 (a)
chicken
(Gallus gallus)
Aves TUSC2 36
  • 83.89 (n)
  • 88.33 (a)
TUSC2 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUSC2 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68809 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5198 36
tusc2 36
  • 67.92 (n)
  • 68.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.974 36
zebrafish
(Danio rerio)
Actinopterygii Dr.15528 36
tusc2a 36
  • 65.15 (n)
  • 70.91 (a)
tusc2a 37
  • 70 (a)
OneToMany
tusc2b 37
  • 65 (a)
OneToMany
Species with no ortholog for TUSC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUSC2 Gene

ENSEMBL:
Gene Tree for TUSC2 (if available)
TreeFam:
Gene Tree for TUSC2 (if available)

Paralogs for TUSC2 Gene

No data available for Paralogs for TUSC2 Gene

Variants for TUSC2 Gene

Sequence variations from dbSNP and Humsavar for TUSC2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1044046 -- 50,325,855(-) CAGCA(C/T)AGCAG utr-variant-3-prime
rs1802314 -- 50,325,080(-) TCCAT(A/G)ATGAT utr-variant-3-prime
rs2236946 -- 50,326,340(+) TGACC(A/G)CTGCC intron-variant
rs9817669 -- 50,326,964(+) AGAAA(A/G)TGGGA intron-variant
rs11549672 -- 50,325,757(+) GTGCT(A/G)TAGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TUSC2 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897
nsv3813 CNV Loss 18451855
dgv5133n71 CNV Loss 21882294

Relevant External Links for TUSC2 Gene

HapMap Linkage Disequilibrium report
TUSC2

Disorders for TUSC2 Gene

(1) MalaCards Diseases for TUSC2 Gene

Search for TUSC2 Gene in MalaCards »

(7) Novoseek inferred disease relationships for TUSC2 Gene

Disease -log(P) Hits PubMed IDs
lung tumor 58.2 3
nsclc 57.5 9
cancer lung 57.5 17
lung metastases 54.3 1
cancer 20.3 4
genes like me logo Genes that share disorders with TUSC2: view

No data available for UniProtKB/Swiss-Prot for TUSC2 Gene

Publications for TUSC2 Gene

  1. Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells. (PMID: 11593436) Kondo M. … Minna J.D. (Oncogene 2001) 2 3 4 23
  2. Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells. (PMID: 15126327) Uno F. … Ji L. (Cancer Res. 2004) 3 4 23
  3. Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. (PMID: 18172250) Prudkin L. … Wistuba I.I. (Clin. Cancer Res. 2008) 3 23
  4. Characterization of a novel platelet-derived growth factor-associated protein. (PMID: 8780057) Fischer W.H. … Schubert D. (J. Neurochem. 1996) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TUSC2 Gene

Sources for TUSC2 Gene

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