Aliases for ACOT7 Gene
External Ids for ACOT7 Gene
Previous GeneCards Identifiers for ACOT7 Gene
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACOT7 Gene
ACOT7 (Acyl-CoA Thioesterase 7) is a Protein Coding gene. Diseases associated with ACOT7 include Meckel's Diverticulum and Temporal Lobe Epilepsy. Among its related pathways are Fatty acid elongation and Metabolism. GO annotations related to this gene include protein homodimerization activity and fatty-acyl-CoA binding. An important paralog of this gene is ACOT12.
UniProtKB/Swiss-Prot for ACOT7 Gene
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.