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Aliases for PHB2 Gene

Aliases for PHB2 Gene

  • Prohibitin 2 2 3
  • REA 3 4 6
  • B-Cell Receptor-Associated Protein BAP37 3 4
  • Repressor Of Estrogen Receptor Activity 3 4
  • D-Prohibitin 3 4
  • BAP 3 4
  • B-Cell Associated Protein 3
  • Prohibitin-2 3
  • PNAS-141 3
  • BCAP37 3
  • Bap37 3
  • P22 3

External Ids for PHB2 Gene

Summaries for PHB2 Gene

GeneCards Summary for PHB2 Gene

PHB2 (Prohibitin 2) is a Protein Coding gene. Diseases associated with PHB2 include enthesopathy and dysentery. Among its related pathways are GPCR Pathway and Protein Stability. GO annotations related to this gene include estrogen receptor binding.

UniProtKB/Swiss-Prot for PHB2 Gene

  • Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Gene Wiki entry for PHB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHB2 Gene

Genomics for PHB2 Gene

Genomic Location for PHB2 Gene

Start:
6,965,327 bp from pter
End:
6,970,825 bp from pter
Size:
5,499 bases
Orientation:
Minus strand

Genomic View for PHB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHB2 Gene

Regulatory Elements for PHB2 Gene

Transcription factor binding sites by QIAGEN in the PHB2 gene promoter:

Proteins for PHB2 Gene

  • Protein details for PHB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99623-PHB2_HUMAN
    Recommended name:
    Prohibitin-2
    Protein Accession:
    Q99623
    Secondary Accessions:
    • B4DP75
    • Q2YDA4
    • Q7KYU3
    • Q92978

    Protein attributes for PHB2 Gene

    Size:
    299 amino acids
    Molecular mass:
    33296 Da
    Quaternary structure:
    • Interacts with PHB, ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703. Interacts with STOML2.

    Alternative splice isoforms for PHB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHB2 Gene

Proteomics data for PHB2 Gene at MOPED

Post-translational modifications for PHB2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys6, Lys97, Lys147, Lys224, and Lys244

No data available for DME Specific Peptides for PHB2 Gene

Domains for PHB2 Gene

Protein Domains for PHB2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PHB2_HUMAN
Family:
  • Belongs to the prohibitin family.:
    • Q99623
genes like me logo Genes that share domains with PHB2: view

No data available for Gene Families for PHB2 Gene

Function for PHB2 Gene

Molecular function for PHB2 Gene

UniProtKB/Swiss-Prot Function: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
UniProtKB/Swiss-Prot Induction: Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.

Gene Ontology (GO) - Molecular Function for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10359819
GO:0030331 estrogen receptor binding NAS 10359819
genes like me logo Genes that share ontologies with PHB2: view
genes like me logo Genes that share phenotypes with PHB2: view

Animal Models for PHB2 Gene

MGI Knock Outs for PHB2:

miRNA for PHB2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PHB2 Gene

Localization for PHB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHB2 Gene

Mitochondrion inner membrane. Cytoplasm. Nucleus. Note=Also cytoplasmic and nuclear. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHB2 Gene COMPARTMENTS Subcellular localization image for PHB2 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IDA 17008324
GO:0005743 mitochondrial inner membrane ISS --
GO:0009986 cell surface IDA 22417827
genes like me logo Genes that share ontologies with PHB2: view

Pathways for PHB2 Gene

SuperPathways for PHB2 Gene

Superpath Contained pathways
1 GPCR Pathway
2 Protein Stability
genes like me logo Genes that share pathways with PHB2: view

Pathways by source for PHB2 Gene

1 Qiagen pathway for PHB2 Gene
1 Cell Signaling Technology pathway for PHB2 Gene

Gene Ontology (GO) - Biological Process for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007005 mitochondrion organization IMP 17008324
GO:0030449 NOT regulation of complement activation IDA 17070910
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IEA --
GO:0033600 negative regulation of mammary gland epithelial cell proliferation IEA --
genes like me logo Genes that share ontologies with PHB2: view

Compounds for PHB2 Gene

(2) Novoseek inferred chemical compound relationships for PHB2 Gene

Compound -log(P) Hits PubMed IDs
estrogen 37.8 4
estradiol 16.6 1
genes like me logo Genes that share compounds with PHB2: view

Transcripts for PHB2 Gene

Unigene Clusters for PHB2 Gene

Prohibitin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHB2 Gene

No ASD Table

Relevant External Links for PHB2 Gene

GeneLoc Exon Structure for
PHB2
ECgene alternative splicing isoforms for
PHB2

Expression for PHB2 Gene

mRNA expression in normal human tissues for PHB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHB2 Gene

SOURCE GeneReport for Unigene cluster for PHB2 Gene Hs.504620

genes like me logo Genes that share expressions with PHB2: view

Orthologs for PHB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHB2 36
  • 99.67 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PHB2 36
  • 90.19 (n)
  • 98.66 (a)
PHB2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHB2 36
  • 91.86 (n)
  • 98.66 (a)
PHB2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phb2 36
  • 91.3 (n)
  • 100 (a)
Phb2 16
Phb2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-141 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHB2 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phb2 36
  • 88.96 (n)
  • 99.67 (a)
chicken
(Gallus gallus)
Aves PHB2 36
  • 81.16 (n)
  • 94.98 (a)
PHB2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHB2 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15834 36
tropical clawed frog
(Silurana tropicalis)
Amphibia phb2 36
  • 76.38 (n)
  • 90.51 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
phb2a 37
  • 77 (a)
OneToMany
phb2b 36
  • 70.82 (n)
  • 82.35 (a)
phb2b 37
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009642 36
  • 69.46 (n)
  • 76.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)03709 36
  • 69.04 (n)
  • 71.19 (a)
l(2)03709 37
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea phb-2 36
  • 60.24 (n)
  • 66.55 (a)
phb-2 37
  • 61 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL141W 36
  • 61.82 (n)
  • 57.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHB2 36
  • 57.84 (n)
  • 56.34 (a)
PHB2 37
  • 50 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15731g 36
  • 55.23 (n)
  • 55.84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHB1 36
  • 55.88 (n)
  • 55.88 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3698 36
corn
(Zea mays)
Liliopsida Zm.496 36
rice
(Oryza sativa)
Liliopsida Os.32013 36
Os07g0262200 36
  • 58.24 (n)
  • 55.31 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14391 36
bread mold
(Neurospora crassa)
Ascomycetes NCU03310 36
  • 57.69 (n)
  • 57.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes phb2 36
  • 55.72 (n)
  • 55.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4663 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7966 37
  • 64 (a)
OneToOne
Species with no ortholog for PHB2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PHB2 Gene

ENSEMBL:
Gene Tree for PHB2 (if available)
TreeFam:
Gene Tree for PHB2 (if available)

Paralogs for PHB2 Gene

Selected SIMAP similar genes for PHB2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PHB2 Gene

genes like me logo Genes that share paralogs with PHB2: view

No data available for Paralogs for PHB2 Gene

Variants for PHB2 Gene

Sequence variations from dbSNP and Humsavar for PHB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9669 -- 6,965,531(-) AGGAA(A/G)ACTGA utr-variant-3-prime, nc-transcript-variant
rs1044544 -- 6,965,510(-) CTTTT(C/T)TGGGG utr-variant-3-prime, nc-transcript-variant
rs1044632 -- 6,965,449(-) GATTT(C/T)TCAGT utr-variant-3-prime, nc-transcript-variant
rs2110073 -- 6,966,719(+) CTTGA(C/T)AGGAG intron-variant
rs2269362 -- 6,964,965(+) CACTG(A/G)GCTTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PHB2 Gene

Variant ID Type Subtype PubMed ID
nsv898641 CNV Loss 21882294
nsv509453 CNV Insertion 20534489

Relevant External Links for PHB2 Gene

HapMap Linkage Disequilibrium report
PHB2
Human Gene Mutation Database (HGMD)
PHB2

Disorders for PHB2 Gene

Relevant External Links for PHB2

Genetic Association Database (GAD)
PHB2
Human Genome Epidemiology (HuGE) Navigator
PHB2
genes like me logo Genes that share disorders with PHB2: view

No data available for UniProtKB/Swiss-Prot for PHB2 Gene

Publications for PHB2 Gene

  1. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. (PMID: 11302691) Coates P.J. … Wright E.G. (Exp. Cell Res. 2001) 2 3 4
  2. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari M.A. … Gibbs R.A. (Genome Res. 1997) 3 4
  3. The prohibitin family of mitochondrial proteins regulate replicative lifespan. (PMID: 9259555) Coates P.J. … Hall P.A. (Curr. Biol. 1997) 2 3
  4. An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens. (PMID: 10359819) Montano M.M. … Katzenellenbogen B.S. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4

Products for PHB2 Gene

Sources for PHB2 Gene

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