Aliases for PHB2 Gene
External Ids for PHB2 Gene
Previous GeneCards Identifiers for PHB2 Gene
GeneCards Summary for PHB2 Gene
PHB2 (Prohibitin 2) is a Protein Coding gene. Diseases associated with PHB2 include marinesco-sjogren syndrome and urethritis. Among its related pathways are Akt Signaling Pathway and GPCR Pathway. GO annotations related to this gene include estrogen receptor binding.
UniProtKB/Swiss-Prot for PHB2 Gene
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.