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Aliases for PHB2 Gene

Aliases for PHB2 Gene

  • Prohibitin 2 2 3 5
  • B-Cell Receptor-Associated Protein BAP37 3 4
  • Repressor Of Estrogen Receptor Activity 3 4
  • D-Prohibitin 3 4
  • BAP 3 4
  • REA 3 4
  • B-Cell Associated Protein 3
  • Prohibitin-2 3
  • PNAS-141 3
  • BCAP37 3
  • Bap37 3
  • HBAP 3
  • P22 3

External Ids for PHB2 Gene

Previous GeneCards Identifiers for PHB2 Gene

  • GC12M007074

Summaries for PHB2 Gene

GeneCards Summary for PHB2 Gene

PHB2 (Prohibitin 2) is a Protein Coding gene. Diseases associated with PHB2 include Balanitis and Loiasis. Among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and GPCR Pathway. GO annotations related to this gene include estrogen receptor binding.

UniProtKB/Swiss-Prot for PHB2 Gene

  • Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Gene Wiki entry for PHB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHB2 Gene

Genomics for PHB2 Gene

Regulatory Elements for PHB2 Gene

Enhancers for PHB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G006923 1.7 FANTOM5 ENCODE dbSUPER 13.2 +43.7 43675 6.8 HDGF ARID4B SIN3A ZNF2 YY1 ZNF143 FOS DEK PAF1 ZNF263 LRRC23 SCARNA12 RPL13P5 USP5 PHB2 EMG1 SPSB2 ENSG00000219410 MIR200CHG MIR200C
GH12G006940 1.9 FANTOM5 ENCODE dbSUPER 10.5 +17.2 17167 25.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SPSB2 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 SCARNA12 ENSG00000256967 ATN1 TNFRSF1A SCNN1A
GH12G006762 1.8 FANTOM5 ENCODE dbSUPER 10.4 +204.4 204421 7.2 CREB3L1 MLX AGO1 ZFP64 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC ENSG00000219410 ENSG00000247853 NCAPD2 SPSB2 GDF3 TNFRSF1A C12orf57 C1RL-AS1 ENSG00000256967 PHB2
GH12G006546 1.8 FANTOM5 ENCODE dbSUPER 10.4 +418.9 418910 10.3 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ENSG00000219410 ENSG00000247853 NCAPD2 TAPBPL NOP2 SCARNA12 VAMP1 SPSB2 SCARNA11 CHD4
GH12G006880 0.9 ENCODE 20.6 +90.0 89954 1.6 ZFP64 ARID4B DMAP1 ZNF202 REST ZNF623 ZNF518A ZNF292 MIER3 ZBTB21 SPSB2 ENSG00000219410 C12orf57 GNB3 PHB2 ENSG00000247853 ENO2 CDCA3 USP5 ATN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PHB2 on UCSC Golden Path with GeneCards custom track

Promoters for PHB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048378 125 2201 PKNOX1 FOXA2 MLX ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Transcription factor binding sites by QIAGEN in the PHB2 gene promoter:

Genomic Location for PHB2 Gene

Chromosome:
12
Start:
6,965,327 bp from pter
End:
6,970,825 bp from pter
Size:
5,499 bases
Orientation:
Minus strand

Genomic View for PHB2 Gene

Genes around PHB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHB2 Gene

Proteins for PHB2 Gene

  • Protein details for PHB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99623-PHB2_HUMAN
    Recommended name:
    Prohibitin-2
    Protein Accession:
    Q99623
    Secondary Accessions:
    • B4DP75
    • Q2YDA4
    • Q7KYU3
    • Q92978

    Protein attributes for PHB2 Gene

    Size:
    299 amino acids
    Molecular mass:
    33296 Da
    Quaternary structure:
    • Interacts with PHB, ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703 (PubMed:21328542). Interacts with STOML2 (PubMed:21746876). Interacts with ARFGEF3 (PubMed:19496786).

    Alternative splice isoforms for PHB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHB2 Gene

Post-translational modifications for PHB2 Gene

  • Ubiquitination at Lys6, Lys97, Lys147, posLast=224224, and posLast=244244
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PHB2 (BAP37)

No data available for DME Specific Peptides for PHB2 Gene

Domains & Families for PHB2 Gene

Protein Domains for PHB2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99623

UniProtKB/Swiss-Prot:

PHB2_HUMAN :
  • Belongs to the prohibitin family.
Family:
  • Belongs to the prohibitin family.
genes like me logo Genes that share domains with PHB2: view

No data available for Gene Families for PHB2 Gene

Function for PHB2 Gene

Molecular function for PHB2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
UniProtKB/Swiss-Prot Induction:
Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.

Gene Ontology (GO) - Molecular Function for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10359819
GO:0008022 protein C-terminus binding IPI 19906925
GO:0030331 estrogen receptor binding NAS 10359819
GO:0033218 amide binding IPI 19116139
GO:0047485 protein N-terminus binding IPI 18629613
genes like me logo Genes that share ontologies with PHB2: view
genes like me logo Genes that share phenotypes with PHB2: view

Animal Models for PHB2 Gene

MGI Knock Outs for PHB2:

miRNA for PHB2 Gene

miRTarBase miRNAs that target PHB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHB2 Gene

Localization for PHB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHB2 Gene

Mitochondrion inner membrane. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHB2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 3
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA,IEA 19116139
GO:0005739 mitochondrion IDA 19906925
GO:0005741 mitochondrial outer membrane IDA 17008324
GO:0005743 mitochondrial inner membrane TAS,ISS --
genes like me logo Genes that share ontologies with PHB2: view

Pathways & Interactions for PHB2 Gene

genes like me logo Genes that share pathways with PHB2: view

Pathways by source for PHB2 Gene

1 R&D Systems pathway for PHB2 Gene
1 Qiagen pathway for PHB2 Gene

SIGNOR curated interactions for PHB2 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 17008324
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006851 mitochondrial calcium ion transport TAS --
GO:0007005 mitochondrion organization IMP 17008324
genes like me logo Genes that share ontologies with PHB2: view

Drugs & Compounds for PHB2 Gene

(2) Drugs for PHB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PHB2: view

Transcripts for PHB2 Gene

Unigene Clusters for PHB2 Gene

Prohibitin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHB2 Gene

No ASD Table

Relevant External Links for PHB2 Gene

GeneLoc Exon Structure for
PHB2
ECgene alternative splicing isoforms for
PHB2

Expression for PHB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHB2 Gene

This gene is overexpressed in Nasal epithelium (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHB2 Gene



Protein tissue co-expression partners for PHB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHB2 Gene:

PHB2

SOURCE GeneReport for Unigene cluster for PHB2 Gene:

Hs.504620

Evidence on tissue expression from TISSUES for PHB2 Gene

  • Skin(4.8)
  • Blood(4.6)
  • Liver(4.6)
  • Lymph node(4.5)
  • Spleen(4.5)
  • Nervous system(4.5)
  • Lung(3.9)
  • Eye(3.8)
  • Intestine(3.8)
  • Pancreas(3.8)
  • Muscle(3.1)
  • Heart(2.7)
  • Kidney(2.6)
  • Stomach(2.6)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with PHB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB2 Gene

Orthologs for PHB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHB2 34
  • 99.67 (n)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-141 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHB2 34 35
  • 91.86 (n)
mouse
(Mus musculus)
Mammalia Phb2 34 16 35
  • 91.3 (n)
cow
(Bos Taurus)
Mammalia PHB2 34 35
  • 90.19 (n)
rat
(Rattus norvegicus)
Mammalia Phb2 34
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PHB2 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHB2 34 35
  • 81.16 (n)
lizard
(Anolis carolinensis)
Reptilia PHB2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phb2 34
  • 76.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15834 34
zebrafish
(Danio rerio)
Actinopterygii phb2a 35
  • 77 (a)
OneToMany
phb2b 34 35
  • 70.82 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009642 34
  • 69.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)03709 34 35
  • 69.04 (n)
worm
(Caenorhabditis elegans)
Secernentea phb-2 34 35
  • 60.24 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL141W 34
  • 61.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHB2 34 35
  • 57.84 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15731g 34
  • 55.23 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHB1 34
  • 55.88 (n)
rice
(Oryza sativa)
Liliopsida Os07g0262200 34
  • 58.24 (n)
Os.32013 34
barley
(Hordeum vulgare)
Liliopsida Hv.3698 34
wheat
(Triticum aestivum)
Liliopsida Ta.14391 34
corn
(Zea mays)
Liliopsida Zm.496 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7966 35
  • 64 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03310 34
  • 57.69 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes phb2 34
  • 55.72 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4663 34
Species where no ortholog for PHB2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PHB2 Gene

ENSEMBL:
Gene Tree for PHB2 (if available)
TreeFam:
Gene Tree for PHB2 (if available)

Paralogs for PHB2 Gene

(3) SIMAP similar genes for PHB2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PHB2 Gene

genes like me logo Genes that share paralogs with PHB2: view

No data available for Paralogs for PHB2 Gene

Variants for PHB2 Gene

Sequence variations from dbSNP and Humsavar for PHB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11064480 Benign 6,971,024(+) AGGGG(C/G)AGGAA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1001818135 -- 6,969,935(+) ACTAG(C/G)CTTGC intron-variant, upstream-variant-2KB
rs1003756868 -- 6,971,006(+) ACCCA(A/G)GCGGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1004234904 -- 6,971,408(+) AGCTG(G/T)GACTA intron-variant, upstream-variant-2KB
rs1004400034 -- 6,971,727(+) TTACT(A/G)GGCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PHB2 Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Variation tolerance for PHB2 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHB2 Gene

Human Gene Mutation Database (HGMD)
PHB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB2 Gene

Disorders for PHB2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for PHB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
balanitis
loiasis
  • african eye worm
urethritis
  • non-gonococcal urethritis
enthesopathy
  • rheumatic diseases
urethral syndrome
  • urethral disease
- elite association - COSMIC cancer census association via MalaCards
Search PHB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PHB2

Genetic Association Database (GAD)
PHB2
Human Genome Epidemiology (HuGE) Navigator
PHB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHB2
genes like me logo Genes that share disorders with PHB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHB2 Gene

Publications for PHB2 Gene

  1. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. (PMID: 11302691) Coates P.J. … Wright E.G. (Exp. Cell Res. 2001) 2 3 4 64
  2. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. (PMID: 21328542) Sircoulomb F. … Ginestier C. (EMBO Mol. Med. 2011) 3 4 64
  3. Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function. (PMID: 21746876) Christie D.A. … Madrenas J. (Mol. Cell. Biol. 2011) 3 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein. (PMID: 19906925) Emerson V. … Bosch V. (J. Virol. 2010) 3 22 64

Products for PHB2 Gene

Sources for PHB2 Gene

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