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Aliases for PHB2 Gene

Aliases for PHB2 Gene

  • Prohibitin 2 2 3 5
  • B-Cell Receptor-Associated Protein BAP37 3 4
  • Repressor Of Estrogen Receptor Activity 3 4
  • D-Prohibitin 3 4
  • BAP 3 4
  • REA 3 4
  • B-Cell Associated Protein 3
  • Prohibitin-2 3
  • PNAS-141 3
  • BCAP37 3
  • Bap37 3
  • HBAP 3
  • P22 3

External Ids for PHB2 Gene

Previous GeneCards Identifiers for PHB2 Gene

  • GC12M007074

Summaries for PHB2 Gene

GeneCards Summary for PHB2 Gene

PHB2 (Prohibitin 2) is a Protein Coding gene. Diseases associated with PHB2 include Urethritis and Loiasis. Among its related pathways are GPCR Pathway and MAPK Signaling: Mitogen Stimulation Pathway. Gene Ontology (GO) annotations related to this gene include estrogen receptor binding.

UniProtKB/Swiss-Prot for PHB2 Gene

  • Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Gene Wiki entry for PHB2 Gene

Additional gene information for PHB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHB2 Gene

Genomics for PHB2 Gene

GeneHancer (GH) Regulatory Elements for PHB2 Gene

Promoters and enhancers for PHB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I006967 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.9 908 5.4 FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 EMG1 PHB2 ZNF384 CHD4 ENSG00000247853 NOP2 ENSG00000219410 SCARNA12 GDF3 LPCAT3
GH12I006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.1 +17.2 17167 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2 SCARNA12 ENSG00000256967 NCAPD2
GH12I006923 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.5 +43.7 43674 6.8 HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ZNF143 FOS ATN1 ZNF384 LRRC23 CHD4 ENSG00000219410 ENSG00000247853 SCARNA12 EMG1 PHB2 RPL13P5
GH12I006762 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +204.4 204421 7.2 ZFP64 FEZF1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 MLF2 PTMS ENSG00000219410 ZNF384 CHD4 NCAPD2 EMG1 ENSG00000247853 PTPN6 SPSB2
GH12I006602 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +365.1 365097 7.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CHD4 ZNF384 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 ING4 SPSB2 EMG1 SCARNA12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PHB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PHB2 gene promoter:

Genomic Locations for PHB2 Gene

Genomic Locations for PHB2 Gene
chr12:6,965,327-6,970,825
(GRCh38/hg38)
Size:
5,499 bases
Orientation:
Minus strand
chr12:7,074,490-7,079,988
(GRCh37/hg19)

Genomic View for PHB2 Gene

Genes around PHB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHB2 Gene

Proteins for PHB2 Gene

  • Protein details for PHB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99623-PHB2_HUMAN
    Recommended name:
    Prohibitin-2
    Protein Accession:
    Q99623
    Secondary Accessions:
    • B4DP75
    • Q2YDA4
    • Q7KYU3
    • Q92978

    Protein attributes for PHB2 Gene

    Size:
    299 amino acids
    Molecular mass:
    33296 Da
    Quaternary structure:
    • Interacts with PHB, ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703 (PubMed:21328542). Interacts with STOML2 (PubMed:21746876). Interacts with ARFGEF3 (PubMed:19496786).

    Alternative splice isoforms for PHB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHB2 Gene

Post-translational modifications for PHB2 Gene

  • Ubiquitination at Lys6, isoforms=297, isoforms=2147, isoforms=224, and Lys244

No data available for DME Specific Peptides for PHB2 Gene

Domains & Families for PHB2 Gene

Gene Families for PHB2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PHB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99623

UniProtKB/Swiss-Prot:

PHB2_HUMAN :
  • Belongs to the prohibitin family.
Family:
  • Belongs to the prohibitin family.
genes like me logo Genes that share domains with PHB2: view

Function for PHB2 Gene

Molecular function for PHB2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
UniProtKB/Swiss-Prot Induction:
Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.

Phenotypes From GWAS Catalog for PHB2 Gene

Gene Ontology (GO) - Molecular Function for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10359819
GO:0008022 protein C-terminus binding IPI 19906925
GO:0030331 estrogen receptor binding NAS 10359819
GO:0033218 amide binding IPI 19116139
GO:0047485 protein N-terminus binding IPI 18629613
genes like me logo Genes that share ontologies with PHB2: view
genes like me logo Genes that share phenotypes with PHB2: view

Animal Models for PHB2 Gene

MGI Knock Outs for PHB2:

miRNA for PHB2 Gene

miRTarBase miRNAs that target PHB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHB2 Gene

Localization for PHB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHB2 Gene

Mitochondrion inner membrane. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHB2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 4
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA,IDA 19116139
GO:0005739 mitochondrion IDA 19906925
GO:0005741 mitochondrial outer membrane IDA 17008324
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with PHB2: view

Pathways & Interactions for PHB2 Gene

genes like me logo Genes that share pathways with PHB2: view

Pathways by source for PHB2 Gene

1 R&D Systems pathway for PHB2 Gene
1 Qiagen pathway for PHB2 Gene

SIGNOR curated interactions for PHB2 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 17008324
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006851 mitochondrial calcium ion transmembrane transport TAS --
GO:0007005 mitochondrion organization IMP 17008324
genes like me logo Genes that share ontologies with PHB2: view

Drugs & Compounds for PHB2 Gene

(3) Drugs for PHB2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capsaicin Approved Pharma Potentiation, Activator, Target TRPV1 receptor agonist 188
genes like me logo Genes that share compounds with PHB2: view

Transcripts for PHB2 Gene

Unigene Clusters for PHB2 Gene

Prohibitin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHB2 Gene

No ASD Table

Relevant External Links for PHB2 Gene

GeneLoc Exon Structure for
PHB2
ECgene alternative splicing isoforms for
PHB2

Expression for PHB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHB2 Gene

This gene is overexpressed in Nasal epithelium (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHB2 Gene



Protein tissue co-expression partners for PHB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHB2 Gene:

PHB2

SOURCE GeneReport for Unigene cluster for PHB2 Gene:

Hs.504620

Evidence on tissue expression from TISSUES for PHB2 Gene

  • Skin(4.8)
  • Blood(4.6)
  • Liver(4.6)
  • Lymph node(4.5)
  • Spleen(4.5)
  • Nervous system(4.5)
  • Lung(3.9)
  • Eye(3.8)
  • Intestine(3.8)
  • Pancreas(3.8)
  • Muscle(3.1)
  • Heart(2.7)
  • Kidney(2.6)
  • Stomach(2.5)
  • Bone marrow(2.3)
genes like me logo Genes that share expression patterns with PHB2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB2 Gene

Orthologs for PHB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHB2 33
  • 99.67 (n)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-141 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHB2 33 34
  • 91.86 (n)
mouse
(Mus musculus)
Mammalia Phb2 33 16 34
  • 91.3 (n)
cow
(Bos Taurus)
Mammalia PHB2 33 34
  • 90.19 (n)
rat
(Rattus norvegicus)
Mammalia Phb2 33
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PHB2 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHB2 33 34
  • 81.16 (n)
lizard
(Anolis carolinensis)
Reptilia PHB2 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phb2 33
  • 76.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15834 33
zebrafish
(Danio rerio)
Actinopterygii phb2a 34
  • 77 (a)
OneToMany
phb2b 33 34
  • 70.82 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009642 33
  • 69.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)03709 33 34
  • 69.04 (n)
worm
(Caenorhabditis elegans)
Secernentea phb-2 33 34
  • 60.24 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL141W 33
  • 61.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHB2 33 34
  • 57.84 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15731g 33
  • 55.23 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHB1 33
  • 55.88 (n)
rice
(Oryza sativa)
Liliopsida Os07g0262200 33
  • 58.24 (n)
Os.32013 33
barley
(Hordeum vulgare)
Liliopsida Hv.3698 33
wheat
(Triticum aestivum)
Liliopsida Ta.14391 33
corn
(Zea mays)
Liliopsida Zm.496 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7966 34
  • 64 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03310 33
  • 57.69 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes phb2 33
  • 55.72 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4663 33
Species where no ortholog for PHB2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PHB2 Gene

ENSEMBL:
Gene Tree for PHB2 (if available)
TreeFam:
Gene Tree for PHB2 (if available)

Paralogs for PHB2 Gene

(3) SIMAP similar genes for PHB2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PHB2 Gene

genes like me logo Genes that share paralogs with PHB2: view

No data available for Paralogs for PHB2 Gene

Variants for PHB2 Gene

Sequence variations from dbSNP and Humsavar for PHB2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs36061201 likely-benign, not provided 6,970,961(-) G/T upstream_transcript_variant
rs11064480 benign, not specified 6,971,024(-) C/G upstream_transcript_variant
rs1001818135 -- 6,969,935(-) C/G intron_variant
rs1003756868 -- 6,971,006(-) A/C/G upstream_transcript_variant
rs1004234904 -- 6,971,408(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PHB2 Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Variation tolerance for PHB2 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHB2 Gene

Human Gene Mutation Database (HGMD)
PHB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB2 Gene

Disorders for PHB2 Gene

MalaCards: The human disease database

(17) MalaCards diseases for PHB2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
urethritis
  • non-gonococcal urethritis
loiasis
  • african eye worm
enthesopathy
  • rheumatic diseases
urethral syndrome
  • urethral disease
balanitis
- elite association - COSMIC cancer census association via MalaCards
Search PHB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PHB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PHB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHB2 Gene

Publications for PHB2 Gene

  1. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. (PMID: 11302691) Coates PJ … Wright EG (Experimental cell research 2001) 2 3 4 58
  2. Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function. (PMID: 21746876) Christie DA … Madrenas J (Molecular and cellular biology 2011) 3 4 58
  3. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. (PMID: 21328542) Sircoulomb F … Ginestier C (EMBO molecular medicine 2011) 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein. (PMID: 19906925) Emerson V … Bosch V (Journal of virology 2010) 3 22 58

Products for PHB2 Gene

Sources for PHB2 Gene