Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STK38 Gene

Aliases for STK38 Gene

  • Serine/Threonine Kinase 38 2 3 5
  • Nuclear Dbf2-Related Kinase 1 3 4
  • NDR1 Protein Kinase 3 4
  • EC 4 63
  • NDR1 3 4
  • Ndr Ser/Thr Kinase-Like Protein 3
  • EC 2.7.11 63
  • NDR 3

External Ids for STK38 Gene

Previous GeneCards Identifiers for STK38 Gene

  • GC06M036463
  • GC06M036508
  • GC06M036569
  • GC06M036461
  • GC06M036180

Summaries for STK38 Gene

Entrez Gene Summary for STK38 Gene

  • This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for STK38 Gene

STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.

UniProtKB/Swiss-Prot for STK38 Gene

  • Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Gene Wiki entry for STK38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK38 Gene

Genomics for STK38 Gene

Regulatory Elements for STK38 Gene

Enhancers for STK38 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK38 on UCSC Golden Path with GeneCards custom track

Promoters for STK38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK38 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK38 Gene

36,493,889 bp from pter
36,547,479 bp from pter
53,591 bases
Minus strand

Genomic View for STK38 Gene

Genes around STK38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK38 Gene

Proteins for STK38 Gene

  • Protein details for STK38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 38
    Protein Accession:
    Secondary Accessions:
    • Q503A1

    Protein attributes for STK38 Gene

    465 amino acids
    Molecular mass:
    54190 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2. Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain). Forms a tripartite complex with MOBKL1B and STK3/MST2.

    Three dimensional structures from OCA and Proteopedia for STK38 Gene

neXtProt entry for STK38 Gene

Proteomics data for STK38 Gene at MOPED

Post-translational modifications for STK38 Gene

Other Protein References for STK38 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for STK38 Gene

Gene Families for STK38 Gene

Suggested Antigen Peptide Sequences for STK38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK38: view

Function for STK38 Gene

Molecular function for STK38 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.
UniProtKB/Swiss-Prot Function:
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Enzyme Numbers (IUBMB) for STK38 Gene

Gene Ontology (GO) - Molecular Function for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12493777
GO:0031435 mitogen-activated protein kinase kinase kinase binding IPI 17906693
genes like me logo Genes that share ontologies with STK38: view
genes like me logo Genes that share phenotypes with STK38: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK38

CRISPR Products

miRNA for STK38 Gene

miRTarBase miRNAs that target STK38

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK38 Gene

Localization for STK38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK38 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for STK38 Gene COMPARTMENTS Subcellular localization image for STK38 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for STK38 Gene

Pathways & Interactions for STK38 Gene

SuperPathways for STK38 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK38: view

Pathways by source for STK38 Gene

1 Qiagen pathway for STK38 Gene

SIGNOR curated interactions for STK38 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 12493777
genes like me logo Genes that share ontologies with STK38: view

Drugs & Compounds for STK38 Gene

(3) Drugs for STK38 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK38 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK38: view

Transcripts for STK38 Gene

mRNA/cDNA for STK38 Gene

Unigene Clusters for STK38 Gene

Serine/threonine kinase 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK38 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP5: - - -
SP6: -

Relevant External Links for STK38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK38 Gene

mRNA expression in normal human tissues for STK38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK38 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for STK38 Gene

This gene is overexpressed in Lymph node (16.4), Peripheral blood mononuclear cells (14.0), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK38 Gene

SOURCE GeneReport for Unigene cluster for STK38 Gene Hs.409578

mRNA Expression by UniProt/SwissProt for STK38 Gene

Tissue specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with STK38: view

Protein tissue co-expression partners for STK38 Gene

- Elite partner

Primer Products

Orthologs for STK38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK38 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STK38 35
  • 96.85 (n)
  • 99.35 (a)
STK38 36
  • 99 (a)
(Canis familiaris)
Mammalia STK38 35
  • 96.34 (n)
  • 99.78 (a)
STK38 36
  • 100 (a)
(Mus musculus)
Mammalia Stk38 35
  • 92.76 (n)
  • 98.71 (a)
Stk38 16
Stk38 36
  • 99 (a)
(Pan troglodytes)
Mammalia STK38 35
  • 99.93 (n)
  • 99.78 (a)
STK38 36
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
-- 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia STK38 36
  • 88 (a)
(Gallus gallus)
Aves STK38 35
  • 84.73 (n)
  • 98.06 (a)
STK38 36
  • 98 (a)
(Anolis carolinensis)
Reptilia STK38 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk38 35
  • 78.92 (n)
  • 92.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia trc-prov 35
(Danio rerio)
Actinopterygii Dr.18403 35
stk38a 35
  • 76.85 (n)
  • 92.26 (a)
stk38a 36
  • 92 (a)
stk38b 36
  • 89 (a)
fruit fly
(Drosophila melanogaster)
Insecta trc 37
  • 69 (a)
trc 35
  • 64.59 (n)
  • 72.58 (a)
trc 36
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005521 35
  • 62.8 (n)
  • 72.32 (a)
(Caenorhabditis elegans)
Secernentea sax-1 37
  • 66 (a)
sax-1 36
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBK1 36
  • 30 (a)
CBK1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G09890 35
  • 53.15 (n)
  • 48.29 (a)
(Glycine max)
eudicotyledons Gma.15237 35
(Oryza sativa)
Liliopsida Os.21326 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
Species with no ortholog for STK38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK38 Gene

Gene Tree for STK38 (if available)
Gene Tree for STK38 (if available)

Paralogs for STK38 Gene

Paralogs for STK38 Gene

genes like me logo Genes that share paralogs with STK38: view

Variants for STK38 Gene

Sequence variations from dbSNP and Humsavar for STK38 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_041196 A metastatic melanoma sample
rs56005153 - 36,517,798(+) ACTGT(C/T)TGCCT nc-transcript-variant, reference, missense
rs56105564 - 36,506,617(+) CTGCT(C/T)TCCTT nc-transcript-variant, reference, missense
rs1138668 -- 36,502,246(-) agaat(C/T)ccttg intron-variant
rs1138669 -- 36,502,281(-) cctac(A/G)gtccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK38 Gene

Variant ID Type Subtype PubMed ID
nsv885806 CNV Gain 21882294
nsv5260 CNV Loss 18451855

Variation tolerance for STK38 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.20; 96.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STK38 Gene

Disorders for STK38 Gene

Relevant External Links for STK38

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STK38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK38 Gene

Publications for STK38 Gene

  1. Molecular cloning and characterization of a conserved nuclear serine/threonine protein kinase. (PMID: 7761441) Millward T.A. … Hemmings B.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 67
  2. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A. … Miyagawa K. (Oncogene 2008) 3 23
  3. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PMID: 18362890) Hirabayashi S. … Hata Y. (Oncogene 2008) 3 23
  4. HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. (PMID: 15582665) Devroe E. … Engelman A. (Virology 2005) 3 23
  5. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PMID: 15197186) Bichsel S.J. … Hemmings B.A. (J. Biol. Chem. 2004) 3 23

Products for STK38 Gene

Sources for STK38 Gene