Aliases for TMC6 Gene
Aliases for TMC6 Gene
External Ids for TMC6 Gene
- HGNC: 18021
- Entrez Gene: 11322
- Ensembl: ENSG00000141524
- OMIM: 605828
- UniProtKB: Q7Z403
Previous HGNC Symbols for TMC6 Gene
- EVER1
Previous GeneCards Identifiers for TMC6 Gene
- GC17M073619
- GC17M076108
- GC17M071533
Summaries for TMC6 Gene
-
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
GeneCards Summary for TMC6 Gene
TMC6 (Transmembrane Channel Like 6) is a Protein Coding gene. Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis. Among its related pathways are Innate Immune System. An important paralog of this gene is TMC5.
UniProtKB/Swiss-Prot for TMC6 Gene
-
Probable ion channel.
Additional gene information for TMC6 Gene
- Monarch Initiative
- Search for TMC6 at DataMed
- Search for TMC6 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC6 Gene
Genomics for TMC6 Gene
GeneHancer (GH) Regulatory Elements for TMC6 Gene
Promoters and enhancers for TMC6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TMC6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TMC6 gene promoter:
Regulatory Element Products
Genomic Locations for TMC6 Gene
Genomic Locations for TMC6 Gene
- chr17:78,110,458-78,132,407
- (GRCh38/hg38)
- Size:
- 21,950 bases
- Orientation:
- Minus strand
- chr17:76,106,539-76,128,488
- (GRCh37/hg19)
Genomic View for TMC6 Gene
Genes around TMC6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
TMC6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMC6 Gene
Proteins for TMC6 Gene
-
Protein details for TMC6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z403-TMC6_HUMAN
- Recommended name:
- Transmembrane channel-like protein 6
- Protein Accession:
- Q7Z403
- O43284
- Q45VJ2
- Q8IU98
- Q8IUI7
- Q8IWU8
- Q8TEQ7
- Q9HAG5
Protein attributes for TMC6 Gene
- Size:
- 805 amino acids
- Molecular mass:
- 90045 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH35648.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA24179.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84891.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for TMC6 Gene
Post-translational modifications for TMC6 Gene
Other Protein References for TMC6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TMC6
- Novus Biologicals Antibodies for TMC6
-
Abcam antibodies for TMC6
- Invitrogen Antibodies for TMC6
- Search GeneTex for Antibodies for TMC6
-
Custom Antibody ServicesProSci Antibodies for TMC6
-
Santa Cruz Biotechnology (SCBT) Antibodies for TMC6
Protein Products
-
OriGene Purified Proteins for TMC6
- Search Origene for MassSpec and Protein Over-expression Lysates for TMC6
- Origene Custom Protein Services for TMC6
- antibodies-online: Search results for 5 available TMC6 Proteins ranked by validation data
- Compare Top TMC6 Proteins
-
Quality Products:
- Search GeneTex for Proteins for TMC6
-
Abcam proteins for TMC6
Assay Products
- antibodies-online: Search results for available TMC6 related products ranked by validation data
No data available for DME Specific Peptides for TMC6 Gene
Domains & Families for TMC6 Gene
Gene Families for TMC6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for TMC6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z403- Family:
-
- Belongs to the TMC family.
Function for TMC6 Gene
Molecular function for TMC6 Gene
- UniProtKB/Swiss-Prot Function:
- Probable ion channel.
Phenotypes From GWAS Catalog for TMC6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 18158319 |
Phenotypes for TMC6 Gene
- MGI mutant phenotypes for TMC6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TMC6:
Animal Models for TMC6 Gene
- MGI Knock Outs for TMC6:
-
- Tmc6 tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TMC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMC6 gene
- Search ViGene Biosciences for TMC6
CRISPR Products
-
OriGene CRISPR knockouts for TMC6
- genomics-online: gRNA clones - Search results for available TMC6 gene related products
- Applied Biological Materials CRISPR for TMC6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMC6
- GenScript: Design CRISPR guide RNA sequences for TMC6
miRNA for TMC6 Gene
- miRTarBase miRNAs that target TMC6
miRNA Products
- Search ViGene Biosciences for TMC6
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMC6
- Browse OriGene Inhibitory RNA Products For TMC6
- genomics-online: shRNA clones - Search results for available TMC6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TMC6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available TMC6 gene related products
- orf clones - Search results for available TMC6 gene related products
- Applied Biological Materials Clones for TMC6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TMC6
-
ViGene Biosciences adenoviral particle packaged cDNA for TMC6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMC6 gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMC6 Gene
Localization for TMC6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMC6 Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| endosome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 12426567 |
| GO:0005783 | endoplasmic reticulum | IDA,IEA | 12426567 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | 18158319 |
| GO:0005886 | plasma membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMC6 Gene
Pathways & Interactions for TMC6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for TMC6 Gene
3 Reactome pathways for TMC6 Gene
Interacting Proteins for TMC6 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| ZDHHC17 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for TMC6 Gene
Transcripts for TMC6 Gene
mRNA/cDNA for TMC6 Gene
- (11) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (244) Selected AceView cDNA sequences:
- (24) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMC6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMC6
- genomics-online: gRNA clones - Search results for available TMC6 gene related products
- Applied Biological Materials CRISPR for TMC6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMC6
- GenScript: Design CRISPR guide RNA sequences for TMC6
miRNA Products
- Search ViGene Biosciences for TMC6
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMC6
- Browse OriGene Inhibitory RNA Products For TMC6
- genomics-online: shRNA clones - Search results for available TMC6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TMC6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available TMC6 gene related products
- orf clones - Search results for available TMC6 gene related products
- Applied Biological Materials Clones for TMC6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | · | 3g | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: |
| ExUns: | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||
| SP19: |
Expression for TMC6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Bone (Muscoskeletal System)
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TMC6 Gene
This gene is overexpressed in Whole Blood (x6.2) and Spleen (x5.0).
This gene is overexpressed in Monocytes (22.6), Plasma (12.6), Peripheral blood mononuclear cells (10.5), NK cells (6.9), and CD8 Tcells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMC6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TMC6 Gene:
TMC6SOURCE GeneReport for Unigene cluster for TMC6 Gene:
Hs.632227mRNA Expression by UniProt/SwissProt for TMC6 Gene:
Q7Z403-TMC6_HUMAN
Tissue specificity:
Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes.
Evidence on tissue expression from TISSUES for TMC6 Gene
- Spleen(4.4)
- Nervous system(4.4)
- Blood(3)
- Skin(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TMC6 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
Organs:
Limb:
- digit
- foot
- lower limb
- toe
General:
- blood
- blood vessel
- hair
- skin
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for TMC6
-
OriGene qPCR primer pairs for TMC6
- genomics-online: primer clones - Search results for available TMC6 gene related products
Orthologs for TMC6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TMC6 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TMC6 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TMC6 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tmc6 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TMC6 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TMC6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100859142 33 |
|
||
| TMC6 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TMC6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmc6 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6120 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmc6b 33 |
|
||
| TMC6 (1 of 2) 34 |
|
OneToMany | |||
| tmc6a 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG3280 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | tmc-2 34 |
|
ManyToMany | |
| tmc-1 34 |
|
ManyToMany |
- Species where no ortholog for TMC6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TMC6 Gene
(1) SIMAP similar genes for TMC6 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for TMC6 Gene
Variants for TMC6 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs114853749 | benign, EPIDERMODYSPLASIA VERRUCIFORMIS | 78,121,077(-) | G/A | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs121908327 | pathogenic, EPIDERMODYSPLASIA VERRUCIFORMIS | 78,125,876(-) | G/A | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, stop_gained, upstream_transcript_variant | |
| rs121908328 | pathogenic, EPIDERMODYSPLASIA VERRUCIFORMIS | 78,119,382(-) | C/A/T | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant, stop_gained | |
| rs121908329 | pathogenic, EPIDERMODYSPLASIA VERRUCIFORMIS | 78,124,671(-) | G/T | coding_sequence_variant, intron_variant, non_coding_transcript_variant, stop_gained | |
| rs139557408 | likely-benign, EPIDERMODYSPLASIA VERRUCIFORMIS | 78,125,841(-) | C/T | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2716301 | CNV | deletion | 23290073 |
| esv2716302 | CNV | deletion | 23290073 |
| esv2716303 | CNV | deletion | 23290073 |
| esv2716304 | CNV | deletion | 23290073 |
| nsv1113890 | CNV | deletion | 24896259 |
| nsv470607 | CNV | loss | 18288195 |
| nsv515500 | CNV | loss | 19592680 |
| nsv833554 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.76;
94.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMC6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC6 Gene
Disorders for TMC6 Gene
(3) MalaCards diseases for TMC6 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epidermodysplasia verruciformis |
|
|
| superficial mycosis |
|
|
| pityriasis versicolor |
|
|
Search TMC6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TMC6_HUMAN- Epidermodysplasia verruciformis (EV) [MIM:226400]: Rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. {ECO:0000269 PubMed:12426567, ECO:0000269 PubMed:15042430}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TMC6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for TMC6 Gene
Publications for TMC6 Gene
- Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. (PMID: 12426567) Ramoz N … Favre M (Nature genetics 2002) 2 3 4 22 58
- Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. (PMID: 15042430) Tate G … Mitsuya T (Journal of human genetics 2004) 3 4 22 58
- Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K … Griffith AJ (Genomics 2003) 3 4 22 58
- Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation. (PMID: 19706093) McDermott DF … Hwang ST (Pediatric dermatology 2009) 3 22 58
- Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. (PMID: 18158319) Lazarczyk M … Favre M (The Journal of experimental medicine 2008) 3 22 58
Products for TMC6 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TMC6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TMC6
- Search Origene for MassSpec and Protein Over-expression Lysates for TMC6
- Origene Custom Protein Services for TMC6
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMC6
- Browse OriGene Inhibitory RNA Products For TMC6
- OriGene qPCR primer pairs and template standards for TMC6
- OriGene qPCR primer pairs for TMC6
- OriGene CRISPR knockouts for TMC6
- OriGene ORF clones in human for TMC6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TMC6
- GenScript: Next-day shipping of latest version cDNA ORF clones for TMC6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TMC6
- GenScript Custom Assay Services for TMC6
- GenScript Custom overexpressing Cell Line Services for TMC6
- GenScript: Design CRISPR guide RNA sequences for TMC6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TMC6
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TMC6
- Novus Biologicals proteins and lysates for TMC6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for TMC6
- Abcam proteins for TMC6
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TMC6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 44 available TMC6 Antibodies ranked by validation data
- Compare Top TMC6 Antibodies
- Quality Products:
- antibodies-online: Search results for available TMC6 related products ranked by validation data
- antibodies-online: Search results for 5 available TMC6 Proteins ranked by validation data
- Compare Top TMC6 Proteins
- Quality Products:
- Search GeneTex for Antibodies for TMC6
- Search GeneTex for Proteins for TMC6
- ViGene Biosciences adenoviral particle packaged cDNA for TMC6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMC6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMC6 gene
- Search ViGene Biosciences for TMC6
- Santa Cruz Biotechnology (SCBT) Antibodies for TMC6
- Search Santa Cruz Biotechnology (SCBT) for TMC6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TMC6
- Horizon Cell Lines for TMC6
- genomics-online: cdna clones - Search results for available TMC6 gene related products
- orf clones - Search results for available TMC6 gene related products
- genomics-online: gRNA clones - Search results for available TMC6 gene related products
- genomics-online: primer clones - Search results for available TMC6 gene related products
- genomics-online: shRNA clones - Search results for available TMC6 gene related products
Sources for TMC6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew