Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COPE Gene

Aliases for COPE Gene

  • Coatomer Protein Complex, Subunit Epsilon 2 3
  • Epsilon-Coat Protein 3 4
  • Epsilon-COP 3 4
  • Coatomer Epsilon Subunit 3
  • Coatomer Subunit Epsilon 3
  • Epsilon Coat Protein 3

External Ids for COPE Gene

Summaries for COPE Gene

Entrez Gene Summary for COPE Gene

  • The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for COPE Gene

COPE (Coatomer Protein Complex, Subunit Epsilon) is a Protein Coding gene. Among its related pathways are COPI Mediated Transport and COPI Mediated Transport. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for COPE Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Gene Wiki entry for COPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPE Gene

Genomics for COPE Gene

Genomic Location for COPE Gene

Start:
18,899,514 bp from pter
End:
18,919,397 bp from pter
Size:
19,884 bases
Orientation:
Minus strand

Genomic View for COPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPE Gene

Regulatory Elements for COPE Gene

Proteins for COPE Gene

  • Protein details for COPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14579-COPE_HUMAN
    Recommended name:
    Coatomer subunit epsilon
    Protein Accession:
    O14579
    Secondary Accessions:
    • A6NE29
    • A6NKA3
    • O76097
    • Q6IBB8
    • Q9UGP6

    Protein attributes for COPE Gene

    Size:
    308 amino acids
    Molecular mass:
    34482 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits

    Alternative splice isoforms for COPE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPE Gene

Proteomics data for COPE Gene at MOPED

Post-translational modifications for COPE Gene

  • Phosphorylated by PKA
  • Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys65, Lys265, and Lys278

Other Protein References for COPE Gene

No data available for DME Specific Peptides for COPE Gene

Domains for COPE Gene

Protein Domains for COPE Gene

UniProtKB/Swiss-Prot:

COPE_HUMAN
Family:
  • Belongs to the COPE family.:
    • O14579
genes like me logo Genes that share domains with COPE: view

No data available for Gene Families for COPE Gene

Function for COPE Gene

Molecular function for COPE Gene

GENATLAS Biochemistry: Golgi coatomer complex,epsilon subunit,component of the coat of non clathrin-coated vesicles,involved in the transport between endoplasmic reticulum and Golgi
UniProtKB/Swiss-Prot Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Gene Ontology (GO) - Molecular Function for COPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COPE: view

Phenotypes for COPE Gene

genes like me logo Genes that share phenotypes with COPE: view

miRNA for COPE Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPE Gene

Localization for COPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPE Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPE Gene COMPARTMENTS Subcellular localization image for COPE gene
Compartment Confidence
golgi apparatus 5
cytosol 4
endoplasmic reticulum 2
nucleus 2
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for COPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0030126 COPI vesicle coat ISS --
genes like me logo Genes that share ontologies with COPE: view

Pathways for COPE Gene

genes like me logo Genes that share pathways with COPE: view

Gene Ontology (GO) - Biological Process for COPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006891 intra-Golgi vesicle-mediated transport ISS --
GO:0015031 protein transport IEA --
GO:0048205 COPI coating of Golgi vesicle TAS --
genes like me logo Genes that share ontologies with COPE: view

Compounds for COPE Gene

(1) HMDB Compounds for COPE Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with COPE: view

Transcripts for COPE Gene

Unigene Clusters for COPE Gene

Coatomer protein complex, subunit epsilon:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPE Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5: -
SP6: - -
SP7: -
SP8: - - - - - -
SP9:

Relevant External Links for COPE Gene

GeneLoc Exon Structure for
COPE
ECgene alternative splicing isoforms for
COPE

Expression for COPE Gene

mRNA expression in normal human tissues for COPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPE Gene

SOURCE GeneReport for Unigene cluster for COPE Gene Hs.10326

genes like me logo Genes that share expressions with COPE: view

Orthologs for COPE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPE 36
  • 99.03 (n)
  • 100 (a)
COPE 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPE 36
  • 89.61 (n)
  • 94.16 (a)
COPE 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPE 36
  • 89.94 (n)
  • 94.16 (a)
COPE 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cope 36
  • 85.28 (n)
  • 90.58 (a)
Cope 16
Cope 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPE 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPE 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cope 36
  • 86.14 (n)
  • 92.17 (a)
chicken
(Gallus gallus)
Aves COPE 36
  • 73.05 (n)
  • 78.9 (a)
COPE 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cope 36
  • 71.36 (n)
  • 79.53 (a)
zebrafish
(Danio rerio)
Actinopterygii cope 36
  • 72.43 (n)
  • 78.98 (a)
cope 37
  • 80 (a)
OneToOne
Dr.25629 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006625 36
  • 58.65 (n)
  • 44.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta epsilonCOP 36
  • 53.88 (n)
  • 40.14 (a)
epsilonCOP 37
  • 36 (a)
OneToOne
BcDNA:LD29885 38
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea cope-1 37
  • 36 (a)
OneToOne
F45G2.4 36
  • 48.41 (n)
  • 37.46 (a)
F45G2.4 38
  • 37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34840 36
  • 48.67 (n)
  • 42.91 (a)
rice
(Oryza sativa)
Liliopsida Os04g0612600 36
  • 52.59 (n)
  • 44.4 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4675 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1707 37
  • 66 (a)
OneToOne
Species with no ortholog for COPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPE Gene

ENSEMBL:
Gene Tree for COPE (if available)
TreeFam:
Gene Tree for COPE (if available)

Paralogs for COPE Gene

No data available for Paralogs for COPE Gene

Variants for COPE Gene

Sequence variations from dbSNP and Humsavar for COPE Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10330 - 18,907,053(-) CAACA(C/T)CACCT reference, missense, intron-variant
rs758032 -- 18,908,057(+) TCCTG(A/G)GGCTC intron-variant
rs1044823 -- 18,899,585(-) CCCCT(C/T)TGGGG utr-variant-3-prime
rs1127821 -- 18,900,435(-) TACCC(A/C/G/T)GAGAC reference, synonymous-codon
rs1468460 -- 18,905,299(+) GCTCC(A/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPE Gene

Variant ID Type Subtype PubMed ID
dgv3786n71 CNV Loss 21882294
nsv833777 CNV Loss 17160897
dgv3787n71 CNV Loss 21882294
nsv470132 CNV Loss 18288195
dgv3788n71 CNV Loss 21882294
nsv817819 CNV Loss 17921354
nsv833778 CNV Loss 17160897

Relevant External Links for COPE Gene

HapMap Linkage Disequilibrium report
COPE

Disorders for COPE Gene

Relevant External Links for COPE

Human Genome Epidemiology (HuGE) Navigator
COPE
genes like me logo Genes that share disorders with COPE: view

No data available for UniProtKB/Swiss-Prot for COPE Gene

Publications for COPE Gene

  1. Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes. (PMID: 10469566) Shima D.T. … Pepperkok R. (Curr. Biol. 1999) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. (PMID: 17721809) Maruyama S. … Hatakeyama S. (Mol. Cell. Biochem. 2008) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4

Products for COPE Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate COPE
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for COPE
    • Block miRNA regulation of COPE using miScript Target Protectors

    Sources for COPE Gene

    Back to Top

    Content