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Aliases for CDCA5 Gene

Aliases for CDCA5 Gene

  • Cell Division Cycle Associated 5 2 3
  • Cell Division Cycle-Associated Protein 5 3 4
  • P35 3 4
  • Sororin 2
  • SORORIN 3

External Ids for CDCA5 Gene

Previous GeneCards Identifiers for CDCA5 Gene

  • GC11U990624
  • GC11M065095
  • GC11M064620
  • GC11M064601
  • GC11M064844
  • GC11M061171
  • GC11M064833

Summaries for CDCA5 Gene

GeneCards Summary for CDCA5 Gene

CDCA5 (Cell Division Cycle Associated 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and MicroRNAs in cancer. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for CDCA5 Gene

  • Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.

Gene Wiki entry for CDCA5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA5 Gene

Genomics for CDCA5 Gene

Regulatory Elements for CDCA5 Gene

Genomic Location for CDCA5 Gene

Chromosome:
11
Start:
65,061,009 bp from pter
End:
65,084,164 bp from pter
Size:
23,156 bases
Orientation:
Minus strand

Genomic View for CDCA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDCA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA5 Gene

Proteins for CDCA5 Gene

  • Protein details for CDCA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FF9-CDCA5_HUMAN
    Recommended name:
    Sororin
    Protein Accession:
    Q96FF9
    Secondary Accessions:
    • A8K625

    Protein attributes for CDCA5 Gene

    Size:
    252 amino acids
    Molecular mass:
    27601 Da
    Quaternary structure:
    • Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPAL.
    Miscellaneous:
    • Named sororin after the Latin word soror, which means sister, because of its critical role in sister chromatid cohesion

neXtProt entry for CDCA5 Gene

Proteomics data for CDCA5 Gene at MOPED

Post-translational modifications for CDCA5 Gene

  • Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPAL by CDCA5.
  • Ubiquitinated by the APC/C complex in G1, leading to its degradation.
  • Ubiquitination at Lys 99
  • Modification sites at PhosphoSitePlus

Other Protein References for CDCA5 Gene

No data available for DME Specific Peptides for CDCA5 Gene

Domains & Families for CDCA5 Gene

Protein Domains for CDCA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FF9

UniProtKB/Swiss-Prot:

CDCA5_HUMAN :
  • The KEN box is required for the association with the APC/C complex.
  • Belongs to the sororin family.
Domain:
  • The KEN box is required for the association with the APC/C complex.
Family:
  • Belongs to the sororin family.
genes like me logo Genes that share domains with CDCA5: view

No data available for Gene Families for CDCA5 Gene

Function for CDCA5 Gene

Molecular function for CDCA5 Gene

UniProtKB/Swiss-Prot Function:
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.

Gene Ontology (GO) - Molecular Function for CDCA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 15837422
GO:0005515 protein binding IPI 21111234
genes like me logo Genes that share ontologies with CDCA5: view
genes like me logo Genes that share phenotypes with CDCA5: view

Animal Model Products

miRNA for CDCA5 Gene

miRTarBase miRNAs that target CDCA5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDCA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA5 Gene

Localization for CDCA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA5 Gene

Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA5 Gene COMPARTMENTS Subcellular localization image for CDCA5 gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CDCA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin --
GO:0000790 nuclear chromatin ISS --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CDCA5: view

Pathways & Interactions for CDCA5 Gene

genes like me logo Genes that share pathways with CDCA5: view

Pathways by source for CDCA5 Gene

1 KEGG pathway for CDCA5 Gene

Gene Ontology (GO) - Biological Process for CDCA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 15837422
GO:0000278 mitotic cell cycle TAS --
GO:0006302 double-strand break repair IMP 17349791
GO:0007064 mitotic sister chromatid cohesion IPI 21111234
GO:0007067 mitotic nuclear division IDA 15837422
genes like me logo Genes that share ontologies with CDCA5: view

No data available for SIGNOR curated interactions for CDCA5 Gene

Drugs & Compounds for CDCA5 Gene

No Compound Related Data Available

Transcripts for CDCA5 Gene

Unigene Clusters for CDCA5 Gene

Cell division cycle associated 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDCA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for CDCA5 Gene

GeneLoc Exon Structure for
CDCA5
ECgene alternative splicing isoforms for
CDCA5

Expression for CDCA5 Gene

mRNA expression in normal human tissues for CDCA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCA5 Gene

This gene is overexpressed in Testis (x9.5).

Protein differential expression in normal tissues from HIPED for CDCA5 Gene

This gene is overexpressed in Fetal ovary (55.8) and Fetal Liver (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDCA5 Gene



SOURCE GeneReport for Unigene cluster for CDCA5 Gene Hs.434886

genes like me logo Genes that share expression patterns with CDCA5: view

Protein tissue co-expression partners for CDCA5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CDCA5 Gene

Orthologs for CDCA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDCA5 35
  • 80.97 (n)
  • 76.11 (a)
CDCA5 36
  • 35 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC612071 35
  • 84.13 (n)
  • 78 (a)
CDCA5 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca5 35
  • 74.9 (n)
  • 71.26 (a)
Cdca5 16
Cdca5 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDCA5 35
  • 99.47 (n)
  • 98.81 (a)
CDCA5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910252 35
  • 75.21 (n)
  • 69.23 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA5 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca5 35
  • 48.61 (n)
  • 45 (a)
Str.11789 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12922 35
Species with no ortholog for CDCA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDCA5 Gene

ENSEMBL:
Gene Tree for CDCA5 (if available)
TreeFam:
Gene Tree for CDCA5 (if available)

Paralogs for CDCA5 Gene

No data available for Paralogs for CDCA5 Gene

Variants for CDCA5 Gene

Sequence variations from dbSNP and Humsavar for CDCA5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471538 -- 65,065,819(+) TATCT(A/C)CAGGC downstream-variant-500B, intron-variant
rs475089 -- 65,065,467(-) CTACT(A/G)AAAAT intron-variant
rs489489 -- 65,077,966(+) ATCCA(A/C)ACTAT utr-variant-3-prime, intron-variant
rs491465 -- 65,063,477(+) CACAC(A/T)AAATC intron-variant
rs492262 -- 65,063,541(+) TGTCC(A/G)GGCAC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CDCA5 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Variation tolerance for CDCA5 Gene

Residual Variation Intolerance Score: 80.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDCA5 Gene

HapMap Linkage Disequilibrium report
CDCA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA5 Gene

Disorders for CDCA5 Gene

Relevant External Links for CDCA5

Genetic Association Database (GAD)
CDCA5
Human Genome Epidemiology (HuGE) Navigator
CDCA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCA5
genes like me logo Genes that share disorders with CDCA5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDCA5 Gene

Publications for CDCA5 Gene

  1. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. (PMID: 15837422) Rankin S. … Kirschner M.W. (Mol. Cell 2005) 2 23 67
  2. Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. (PMID: 17349791) Schmitz J. … Peters J.M. (Curr. Biol. 2007) 23 67
  3. Regulation of centromeric cohesion by sororin independently of the APC/C. (PMID: 17361102) DA-az-MartA-nez L.A. … Clarke D.J. (Cell Cycle 2007) 23 67
  4. Caspase independence of radio-induced cell death. (PMID: 16862186) Zhang P. … Bourhis J. (Oncogene 2006) 23 67
  5. Sororin, the cell cycle and sister chromatid cohesion. (PMID: 16082205) Rankin S. (Cell Cycle 2005) 23 67

Products for CDCA5 Gene

Sources for CDCA5 Gene

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