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Aliases for CHRM3 Gene

Aliases for CHRM3 Gene

  • Cholinergic Receptor, Muscarinic 3 2 3
  • Acetylcholine Receptor, Muscarinic 3 3
  • Acetylcholine Receptor 2
  • M3 Muscarinic Receptor 3
  • Muscarinic 3 2
  • EGBRS 3
  • PBS 3
  • HM3 3

External Ids for CHRM3 Gene

Previous GeneCards Identifiers for CHRM3 Gene

  • GC01P238144
  • GC01P235523
  • GC01P235846
  • GC01P237111
  • GC01P236396
  • GC01P237858
  • GC01P239549
  • GC01P210250

Summaries for CHRM3 Gene

Entrez Gene Summary for CHRM3 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM3 Gene

CHRM3 (Cholinergic Receptor, Muscarinic 3) is a Protein Coding gene. Diseases associated with CHRM3 include prune belly syndrome and ureterocele. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for CHRM3 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Tocris Summary for CHRM3 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.

Gene Wiki entry for CHRM3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM3 Gene

Genomics for CHRM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHRM3 Gene

Chromosome:
1
Start:
239,386,565 bp from pter
End:
239,915,452 bp from pter
Size:
528,888 bases
Orientation:
Plus strand

Genomic View for CHRM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRM3 Gene

Proteins for CHRM3 Gene

  • Protein details for CHRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20309-ACM3_HUMAN
    Recommended name:
    Muscarinic acetylcholine receptor M3
    Protein Accession:
    P20309
    Secondary Accessions:
    • Q0VAJ8
    • Q4QRI3
    • Q5VXY2
    • Q9HB60

    Protein attributes for CHRM3 Gene

    Size:
    590 amino acids
    Molecular mass:
    66128 Da
    Quaternary structure:
    • Homodimer; the dimers can form tetramers.

    Three dimensional structures from OCA and Proteopedia for CHRM3 Gene

neXtProt entry for CHRM3 Gene

Proteomics data for CHRM3 Gene at MOPED

Post-translational modifications for CHRM3 Gene

  • Glycosylation at Asn 5, Asn 6, Asn 15, Asn 41, and Asn 48
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRM3 Gene

Domains & Families for CHRM3 Gene

Gene Families for CHRM3 Gene

Suggested Antigen Peptide Sequences for CHRM3 Gene

Graphical View of Domain Structure for InterPro Entry

P20309

UniProtKB/Swiss-Prot:

ACM3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
genes like me logo Genes that share domains with CHRM3: view

Function for CHRM3 Gene

Molecular function for CHRM3 Gene

GENATLAS Biochemistry:
cholinergic receptor,muscarinic 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Gene Ontology (GO) - Molecular Function for CHRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 1905013
GO:0004872 receptor activity TAS 10940357
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding IPI 19575010
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with CHRM3: view
genes like me logo Genes that share phenotypes with CHRM3: view

Animal Models for CHRM3 Gene

MGI Knock Outs for CHRM3:

Animal Model Products

miRNA for CHRM3 Gene

miRTarBase miRNAs that target CHRM3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CHRM3 Gene

Localization for CHRM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM3 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRM3 Gene COMPARTMENTS Subcellular localization image for CHRM3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CHRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRM3: view

Pathways & Interactions for CHRM3 Gene

genes like me logo Genes that share pathways with CHRM3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003056 regulation of vascular smooth muscle contraction IBA --
GO:0006112 energy reserve metabolic process TAS --
GO:0006464 cellular protein modification process TAS 10051746
GO:0006939 smooth muscle contraction IEA --
GO:0007165 signal transduction TAS 10940357
genes like me logo Genes that share ontologies with CHRM3: view

No data available for SIGNOR curated interactions for CHRM3 Gene

Drugs & Compounds for CHRM3 Gene

(161) Drugs for CHRM3 Gene - From: NovoSeek, IUPHAR, DGIdb, DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Darifenacin Approved, Investigational Pharma Antagonist, antagonist, Target 22
Atropine Approved Pharma Antagonist, antagonist, Target MAChRs antagonist 101
Pilocarpine Approved Pharma Partial agonist, Agonist, agonist, Target 23
Tiotropium Approved Pharma Antagonist, antagonist, Target 302
Cevimeline Approved Pharma agonist, Target 5

(30) Additional Compounds for CHRM3 Gene - From: NovoSeek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)aceclidine
Partial agonist, Agonist
(+)aceclidine
Full agonist, Agonist
AF-DX 116
Antagonist 102394-31-0
Gouml 7874
Negative, Allosteric regulator
HHSiD
Antagonist
genes like me logo Genes that share compounds with CHRM3: view

Drug Products

Transcripts for CHRM3 Gene

Unigene Clusters for CHRM3 Gene

Cholinergic receptor, muscarinic 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM3 Gene

No ASD Table

Relevant External Links for CHRM3 Gene

GeneLoc Exon Structure for
CHRM3
ECgene alternative splicing isoforms for
CHRM3

Expression for CHRM3 Gene

mRNA expression in normal human tissues for CHRM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHRM3 Gene

This gene is overexpressed in Pancreas (x4.9), Esophagus - Muscularis (x4.7), and Bladder (x4.0).

Protein differential expression in normal tissues from HIPED for CHRM3 Gene

This gene is overexpressed in Heart (21.4), Retina (19.7), Pancreas (15.8), and Frontal cortex (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRM3 Gene



SOURCE GeneReport for Unigene cluster for CHRM3 Gene Hs.7138

genes like me logo Genes that share expression patterns with CHRM3: view

Protein tissue co-expression partners for CHRM3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHRM3 Gene

Orthologs for CHRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHRM3 35
  • 90.51 (n)
  • 94.92 (a)
CHRM3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRM3 35
  • 88.34 (n)
  • 92.7 (a)
CHRM3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrm3 35
  • 87.04 (n)
  • 91.85 (a)
Chrm3 16
Chrm3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHRM3 35
  • 99.6 (n)
  • 99.66 (a)
CHRM3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrm3 35
  • 87.61 (n)
  • 91.85 (a)
oppossum
(Monodelphis domestica)
Mammalia CHRM3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRM3 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHRM3 35
  • 76.6 (n)
  • 81.43 (a)
CHRM3 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRM3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493547 35
  • 65.04 (n)
  • 69.79 (a)
zebrafish
(Danio rerio)
Actinopterygii chrm3a 35
  • 64.77 (n)
  • 67.19 (a)
chrm3a 36
  • 58 (a)
OneToMany
chrm3b 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7918 37
  • 36 (a)
mAcR-60C 37
  • 60 (a)
mAcR-60C 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gar-3 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for CHRM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRM3 Gene

ENSEMBL:
Gene Tree for CHRM3 (if available)
TreeFam:
Gene Tree for CHRM3 (if available)

Paralogs for CHRM3 Gene

Paralogs for CHRM3 Gene

(7) SIMAP similar genes for CHRM3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHRM3: view

Variants for CHRM3 Gene

Sequence variations from dbSNP and Humsavar for CHRM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs20437 -- 239,508,651(-) ATTTC(A/G)TAAGA intron-variant
rs20438 -- 239,508,806(+) GATAT(G/T)TTACT intron-variant
rs62630 -- 239,839,766(+) GAATG(A/T)CTGGG intron-variant
rs472907 -- 239,772,442(+) cacca(C/T)gccca intron-variant
rs474448 -- 239,767,191(-) ATCAC(A/G)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRM3 Gene

Variant ID Type Subtype PubMed ID
nsv873351 CNV Gain 21882294
nsv873352 CNV Loss 21882294
dgv194e1 CNV Complex 17122850
nsv506986 CNV Insertion 20534489
esv2725851 CNV Deletion 23290073
esv2376547 CNV Deletion 18987734
esv2725862 CNV Deletion 23290073
esv1778820 CNV Insertion 17803354
esv35011 CNV Gain 17911159
essv4530 CNV CNV 17122850
dgv553n71 CNV Gain 21882294
nsv827531 CNV Gain 20364138
nsv873355 CNV Gain 21882294
nsv519393 CNV Gain 19592680
esv5899 CNV Gain 19470904
nsv5065 CNV Insertion 18451855
nsv508067 CNV Loss 20534489
nsv873356 CNV Gain 21882294

Variation tolerance for CHRM3 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRM3 Gene

HapMap Linkage Disequilibrium report
CHRM3
Human Gene Mutation Database (HGMD)
CHRM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRM3 Gene

Disorders for CHRM3 Gene

MalaCards: The human disease database

(26) MalaCards diseases for CHRM3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
prune belly syndrome
  • eagle-barrett syndrome
ureterocele
necrotizing gastritis
bladder diverticulum
  • diverticulum of bladder
low compliance bladder
  • hyperactivity of bladder
- elite association
Search CHRM3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ACM3_HUMAN
  • Prune belly syndrome (PBS) [MIM:100100]: A syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. {ECO:0000269 PubMed:22077972}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CHRM3

Genetic Association Database (GAD)
CHRM3
Human Genome Epidemiology (HuGE) Navigator
CHRM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRM3
genes like me logo Genes that share disorders with CHRM3: view

No data available for Genatlas for CHRM3 Gene

Publications for CHRM3 Gene

  1. Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells. (PMID: 19460789) Gosens R. … Zuyderduyn S. (Eur. Respir. J. 2009) 23 25 26 67
  2. Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptor. (PMID: 19498041) Sykes D.A. … Charlton S.J. (Mol. Pharmacol. 2009) 23 25 26 67
  3. Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans. (PMID: 20395537) Bharucha A.E. … Zinsmeister A.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010) 25 26 67
  4. Role of muscarinic receptor activation in regulating immune cell activity in nasal mucosa. (PMID: 19951374) Liu T. … Yang P.C. (Allergy 2010) 25 26 67
  5. Muscarinic acetylcholine receptors present in human osteoblast and bone tissue. (PMID: 20888332) Liu P.S. … Yu T.C. (Eur. J. Pharmacol. 2011) 25 26

Products for CHRM3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CHRM3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM3
    • Block miRNA regulation of CHRM3 using miScript Target Protectors

    Sources for CHRM3 Gene

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