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Aliases for PTH2 Gene

Aliases for PTH2 Gene

  • Parathyroid Hormone 2 2 3 4
  • TIP39 3 4 6
  • Tuberoinfundibular 39 Residues 2 3
  • Tuberoinfundibular Peptide Of 39 Residues 3
  • Tuberoinfundibular 39 Residue Protein 3
  • TIPF39 4

External Ids for PTH2 Gene

Previous GeneCards Identifiers for PTH2 Gene

  • GC19M054618
  • GC19M049925
  • GC19M046302

Summaries for PTH2 Gene

Entrez Gene Summary for PTH2 Gene

  • TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH receptor-2 (PTHR2; MIM 601469) (John et al., 2002 [PubMed 11861531]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PTH2 Gene

PTH2 (Parathyroid Hormone 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR.

UniProtKB/Swiss-Prot for PTH2 Gene

  • Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.

Gene Wiki entry for PTH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTH2 Gene

Genomics for PTH2 Gene

Regulatory Elements for PTH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTH2 Gene

Start:
49,422,414 bp from pter
End:
49,423,441 bp from pter
Size:
1,028 bases
Orientation:
Minus strand

Genomic View for PTH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTH2 Gene

Proteins for PTH2 Gene

  • Protein details for PTH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A98-TIP39_HUMAN
    Recommended name:
    Tuberoinfundibular peptide of 39 residues
    Protein Accession:
    Q96A98
    Secondary Accessions:
    • Q96DJ4

    Protein attributes for PTH2 Gene

    Size:
    100 amino acids
    Molecular mass:
    11202 Da
    Quaternary structure:
    • Ligand of high affinity for the PTH2 receptor (PTH2R)

neXtProt entry for PTH2 Gene

Proteomics data for PTH2 Gene at MOPED

Post-translational modifications for PTH2 Gene

No Post-translational modifications

Other Protein References for PTH2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PTH2 Gene

Domains for PTH2 Gene

Gene Families for PTH2 Gene

HGNC:

Protein Domains for PTH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A98

UniProtKB/Swiss-Prot:

TIP39_HUMAN :
  • Q96A98
Family:
  • Belongs to the parathyroid hormone family.
genes like me logo Genes that share domains with PTH2: view

Function for PTH2 Gene

Molecular function for PTH2 Gene

UniProtKB/Swiss-Prot Function: Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.

Phenotypes for PTH2 Gene

genes like me logo Genes that share phenotypes with PTH2: view

Animal Model Products

CRISPR Products

miRNA for PTH2 Gene

miRTarBase miRNAs that target PTH2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for PTH2 Gene

Localization for PTH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTH2 Gene COMPARTMENTS Subcellular localization image for PTH2 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for PTH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PTH2: view

Pathways for PTH2 Gene

genes like me logo Genes that share pathways with PTH2: view

Pathways by source for PTH2 Gene

Gene Ontology (GO) - Biological Process for PTH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with PTH2: view

Compounds for PTH2 Gene

(1) HMDB Compounds for PTH2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PTH2: view

Transcripts for PTH2 Gene

mRNA/cDNA for PTH2 Gene

(3) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTH2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTH2 Gene

No ASD Table

Relevant External Links for PTH2 Gene

GeneLoc Exon Structure for
PTH2
ECgene alternative splicing isoforms for
PTH2

Expression for PTH2 Gene

mRNA expression in normal human tissues for PTH2 Gene

mRNA differential expression in normal tissues according to GTEx for PTH2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (19.2), Brain - Cerebellum (17.4), and Testis (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTH2 Gene

SOURCE GeneReport for Unigene cluster for PTH2 Gene Hs.339845

mRNA Expression by UniProt/SwissProt for PTH2 Gene

Q96A98-TIP39_HUMAN
Tissue specificity: Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart.
genes like me logo Genes that share expressions with PTH2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PTH2 Gene

Orthologs for PTH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PTH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTH2 35
  • 87.41 (n)
  • 86.73 (a)
PTH2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTH2 35
  • 90.48 (n)
  • 89.8 (a)
PTH2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pth2 35
  • 80 (n)
  • 79 (a)
Pth2 16
Pth2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pth2 35
  • 79.33 (n)
  • 80 (a)
Species with no ortholog for PTH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTH2 Gene

ENSEMBL:
Gene Tree for PTH2 (if available)
TreeFam:
Gene Tree for PTH2 (if available)

Paralogs for PTH2 Gene

No data available for Paralogs for PTH2 Gene

Variants for PTH2 Gene

Sequence variations from dbSNP and Humsavar for PTH2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10417713 -- 49,423,895(+) GGAGA(G/T)GGAGG upstream-variant-2KB
rs11669675 -- 49,421,951(+) GAGGC(A/C)GAAGG downstream-variant-500B
rs12327795 -- 49,423,490(+) CGCCT(C/T)CGCAG upstream-variant-2KB
rs12974629 -- 49,422,410(+) GGAAC(G/T)AGGCG downstream-variant-500B
rs58892842 -- 49,424,274(+) TCTTG(C/T)TCTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTH2 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
nsv912261 CNV Loss 21882294
nsv912262 CNV Loss 21882294
nsv912263 CNV Loss 21882294

Relevant External Links for PTH2 Gene

HapMap Linkage Disequilibrium report
PTH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTH2 Gene

Disorders for PTH2 Gene

No disorders were found for PTH2 Gene.

No data available for UniProtKB/Swiss-Prot for PTH2 Gene

Publications for PTH2 Gene

  1. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. (PMID: 11861531) John M.R. … Jueppner H. (Endocrinology 2002) 2 3 4 23
  2. PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation. (PMID: 12754053) Misiano P. … Garnier M. (Eur. J. Pharmacol. 2003) 3 4 23
  3. Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. (PMID: 19401215) BagA^ A.G. … Dobolyi A. (Neuroscience 2009) 3 23
  4. Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. (PMID: 11818570) Dobolyi A. … Usdin T.B. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  5. Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family. (PMID: 12098667) Hansen I.A. … Blind E. (J. Endocrinol. 2002) 3 4

Products for PTH2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PTH2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PTH2
    • Block miRNA regulation of PTH2 using miScript Target Protectors

    Sources for PTH2 Gene

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