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Aliases for PTH2 Gene

Aliases for PTH2 Gene

  • Parathyroid Hormone 2 2 3 4 5
  • TIP39 3 4
  • Tuberoinfundibular 39 Residue Protein 3
  • Tuberoinfundibular 39 Residues 2
  • TIPF39 4

External Ids for PTH2 Gene

Previous GeneCards Identifiers for PTH2 Gene

  • GC19M054618
  • GC19M049925
  • GC19M046302

Summaries for PTH2 Gene

Entrez Gene Summary for PTH2 Gene

  • This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015]

GeneCards Summary for PTH2 Gene

PTH2 (Parathyroid Hormone 2) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR.

UniProtKB/Swiss-Prot for PTH2 Gene

  • Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.

Gene Wiki entry for PTH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTH2 Gene

Genomics for PTH2 Gene

Regulatory Elements for PTH2 Gene

Enhancers for PTH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTH2 Gene

Chromosome:
19
Start:
49,422,414 bp from pter
End:
49,426,263 bp from pter
Size:
3,850 bases
Orientation:
Minus strand

Genomic View for PTH2 Gene

Genes around PTH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTH2 Gene

Proteins for PTH2 Gene

  • Protein details for PTH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A98-TIP39_HUMAN
    Recommended name:
    Tuberoinfundibular peptide of 39 residues
    Protein Accession:
    Q96A98
    Secondary Accessions:
    • Q96DJ4

    Protein attributes for PTH2 Gene

    Size:
    100 amino acids
    Molecular mass:
    11202 Da
    Quaternary structure:
    • Ligand of high affinity for the PTH2 receptor (PTH2R).

neXtProt entry for PTH2 Gene

Proteomics data for PTH2 Gene at MOPED

Post-translational modifications for PTH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTH2 Gene

Domains & Families for PTH2 Gene

Gene Families for PTH2 Gene

Protein Domains for PTH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A98

UniProtKB/Swiss-Prot:

TIP39_HUMAN :
  • Belongs to the parathyroid hormone family.
Family:
  • Belongs to the parathyroid hormone family.
genes like me logo Genes that share domains with PTH2: view

Function for PTH2 Gene

Molecular function for PTH2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
genes like me logo Genes that share phenotypes with PTH2: view

Animal Models for PTH2 Gene

MGI Knock Outs for PTH2:

Animal Model Products

miRNA for PTH2 Gene

miRTarBase miRNAs that target PTH2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTH2 Gene

Localization for PTH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTH2 Gene COMPARTMENTS Subcellular localization image for PTH2 gene
Compartment Confidence
extracellular 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for PTH2 Gene

Pathways & Interactions for PTH2 Gene

genes like me logo Genes that share pathways with PTH2: view

SIGNOR curated interactions for PTH2 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTH2 Gene

None

Drugs & Compounds for PTH2 Gene

(2) Drugs for PTH2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Parathyroid Hormone (1-34), bovine Pharma Enhancer of blood calcium level 0
calcium Nutra 0

(1) ApexBio Compounds for PTH2 Gene

Compound Action Cas Number
Parathyroid Hormone (1-34), bovine Enhancer of blood calcium level 12583-68-5
genes like me logo Genes that share compounds with PTH2: view

Transcripts for PTH2 Gene

mRNA/cDNA for PTH2 Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PTH2 Gene

No ASD Table

Relevant External Links for PTH2 Gene

GeneLoc Exon Structure for
PTH2
ECgene alternative splicing isoforms for
PTH2

Expression for PTH2 Gene

mRNA expression in normal human tissues for PTH2 Gene

mRNA differential expression in normal tissues according to GTEx for PTH2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x19.2), Brain - Cerebellum (x17.4), and Testis (x6.6).

Protein differential expression in normal tissues from HIPED for PTH2 Gene

This gene is overexpressed in Adipocyte (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTH2 Gene



SOURCE GeneReport for Unigene cluster for PTH2 Gene Hs.339845

mRNA Expression by UniProt/SwissProt for PTH2 Gene

Q96A98-TIP39_HUMAN
Tissue specificity: Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart.
genes like me logo Genes that share expression patterns with PTH2: view

Protein tissue co-expression partners for PTH2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PTH2 Gene

Orthologs for PTH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PTH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTH2 35
  • 87.41 (n)
  • 86.73 (a)
PTH2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTH2 35
  • 90.48 (n)
  • 89.8 (a)
PTH2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pth2 35
  • 80 (n)
  • 79 (a)
Pth2 16
Pth2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pth2 35
  • 79.33 (n)
  • 80 (a)
Species with no ortholog for PTH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTH2 Gene

ENSEMBL:
Gene Tree for PTH2 (if available)
TreeFam:
Gene Tree for PTH2 (if available)

Paralogs for PTH2 Gene

No data available for Paralogs for PTH2 Gene

Variants for PTH2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PTH2 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
nsv912261 CNV Loss 21882294
nsv912262 CNV Loss 21882294
nsv912263 CNV Loss 21882294

Variation tolerance for PTH2 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for PTH2 Gene

Disorders for PTH2 Gene

Relevant External Links for PTH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTH2

No disorders were found for PTH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTH2 Gene

Publications for PTH2 Gene

  1. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. (PMID: 11861531) John M.R. … Jueppner H. (Endocrinology 2002) 2 3 4 23 67
  2. Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. (PMID: 19401215) BagA^ A.G. … Dobolyi A. (Neuroscience 2009) 3 23
  3. PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation. (PMID: 12754053) Misiano P. … Garnier M. (Eur. J. Pharmacol. 2003) 3 23
  4. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PMID: 18240029) Luttrell L.M. (Mol. Biotechnol. 2008) 3
  5. Differential expression of tuberoinfundibular peptide 38 and glucose-6-phosphatase in tilapia. (PMID: 16375902) Shoemaker J.M. … Rubin D.A. (Gen. Comp. Endocrinol. 2006) 23

Products for PTH2 Gene

Sources for PTH2 Gene

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