Free for academic non-profit institutions. Other users need a Commercial license

SLCO2B1 Gene(Protein Coding)

Solute Carrier Organic Anion Transporter Family Member 2B1

GCID:
GC11P075108
GIFtS:
63
Genes Participants
UDN Logo

Aliases for SLCO2B1 Gene

Aliases for SLCO2B1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 2B1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 9 2 3
  • Solute Carrier Organic Anion Transporter Family, Member 2B1 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 2 3 4
  • Organic Anion Transporter B 3 4
  • OATP-RP2 3 4
  • SLC21A9 3 4
  • OATP2B1 3 4
  • OATP-B 3 4
  • OATPB 3 4
  • Solute Carrier Family 21 Member 9 4
  • KIAA0880 4
  • OATPRP2 4

External Ids for SLCO2B1 Gene

Previous HGNC Symbols for SLCO2B1 Gene

  • SLC21A9

Previous GeneCards Identifiers for SLCO2B1 Gene

  • GC11P074588
  • GC11P074539
  • GC11P074862
  • GC11P071159
  • GC11P074864
  • GC11P074901
  • GC11P074949
  • GC11P075101

Summaries for SLCO2B1 Gene

Entrez Gene Summary for SLCO2B1 Gene

  • This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

GeneCards Summary for SLCO2B1 Gene

SLCO2B1 (Solute Carrier Organic Anion Transporter Family Member 2B1) is a Protein Coding gene. Diseases associated with SLCO2B1 include Persistent Fetal Circulation Syndrome. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO2B1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Gene Wiki entry for SLCO2B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO2B1 Gene

Genomics for SLCO2B1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SLCO2B1 Gene

Enhancers for SLCO2B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLCO2B1 on UCSC Golden Path with GeneCards custom track

Promoters for SLCO2B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLCO2B1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SLCO2B1 gene promoter:

Genomic Location for SLCO2B1 Gene

Chromosome:
11
Start:
75,100,563 bp from pter
End:
75,206,549 bp from pter
Size:
105,987 bases
Orientation:
Plus strand

Genomic View for SLCO2B1 Gene

Genes around SLCO2B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO2B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO2B1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLCO2B1 Gene

Proteins for SLCO2B1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SLCO2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94956-SO2B1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 2B1
    Protein Accession:
    O94956
    Secondary Accessions:
    • A8K2G9
    • B4DGA9
    • B4DTB0
    • E7ERN5
    • E9PPU8
    • Q9H2Z0
    • Q9UFU1

    Protein attributes for SLCO2B1 Gene

    Size:
    709 amino acids
    Molecular mass:
    76711 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLCO2B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO2B1 Gene

Proteomics data for SLCO2B1 Gene at MOPED

Protein Expression for SLCO2B1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SLCO2B1 Gene

  • Glycosylation at Asn 176 and Asn 538
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO2B1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLCO2B1 Gene

Domains & Families for SLCO2B1 Gene

Gene Families for SLCO2B1 Gene

HGNC:
IUPHAR :

Protein Domains for SLCO2B1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLCO2B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94956

UniProtKB/Swiss-Prot:

SO2B1_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO2B1: view

Function for SLCO2B1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SLCO2B1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Gene Ontology (GO) - Molecular Function for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008514 organic anion transmembrane transporter activity IDA 18501590
GO:0015125 bile acid transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO2B1: view

Phenotypes for SLCO2B1 Gene

MGI mutant phenotypes for SLCO2B1:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLCO2B1:
genes like me logo Genes that share phenotypes with SLCO2B1: view

Animal Models for SLCO2B1 Gene

MGI Knock Outs for SLCO2B1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO2B1

CRISPR Products

miRNA for SLCO2B1 Gene

miRTarBase miRNAs that target SLCO2B1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLCO2B1 Gene

Localization for SLCO2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO2B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO2B1 Gene COMPARTMENTS Subcellular localization image for SLCO2B1 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLCO2B1: view

Pathways & Interactions for SLCO2B1 Gene

genes like me logo Genes that share pathways with SLCO2B1: view

Interacting Proteins for SLCO2B1 Gene

Gene Ontology (GO) - Biological Process for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015721 bile acid and bile salt transport IBA --
GO:0043252 sodium-independent organic anion transport IBA,TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLCO2B1: view

No data available for SIGNOR curated interactions for SLCO2B1 Gene

Drugs & Compounds for SLCO2B1 Gene

Products:

  1. Drug

(39) Drugs for SLCO2B1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyburide Approved Pharma Channel blocker, blocker, Transporter, substrate 109
Montelukast Approved Pharma Antagonist, Transporter, substrate 265
Fexofenadine Approved Pharma Transporter, substrate 58
Ergoloid mesylate Approved Pharma Target, inhibitor 0
Estradiol Approved, Investigational Pharma Transporter, inhibitor Sex hormone 1235

(6) Additional Compounds for SLCO2B1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Thromboxane B2
  • TXB2
 54397-85-2

(1) ApexBio Compounds for SLCO2B1 Gene

Compound Action Cas Number
Probenecid 57-66-9
genes like me logo Genes that share compounds with SLCO2B1: view

Transcripts for SLCO2B1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SLCO2B1 Gene

(3) REFSEQ mRNAs :
(21) Additional mRNA sequences :
(187) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLCO2B1 Gene

Solute carrier organic anion transporter family, member 2B1:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO2B1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6:
SP7:

Relevant External Links for SLCO2B1 Gene

GeneLoc Exon Structure for
SLCO2B1
ECgene alternative splicing isoforms for
SLCO2B1

Expression for SLCO2B1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SLCO2B1 Gene

mRNA expression in normal human tissues for SLCO2B1 Gene
mRNA expression by BioGPS for SLCO2B1 GenemRNA expression by GTEx for SLCO2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO2B1 Gene

This gene is overexpressed in Liver (x6.8).

Protein differential expression in normal tissues from HIPED for SLCO2B1 Gene

This gene is overexpressed in Heart (19.8), Gallbladder (10.1), Fetal Liver (10.0), and Liver (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLCO2B1 Gene



SOURCE GeneReport for Unigene cluster for SLCO2B1 Gene Hs.7884

mRNA Expression by UniProt/SwissProt for SLCO2B1 Gene

O94956-SO2B1_HUMAN
Tissue specificity: Isoform 1 has its highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.
genes like me logo Genes that share expression patterns with SLCO2B1: view

Protein tissue co-expression partners for SLCO2B1 Gene

Primer Products

Orthologs for SLCO2B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO2B1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SLCO2B1 35
  • 84.93 (n)
  • 81.21 (a)
SLCO2B1 36
  • 81 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SLCO2B1 35
  • 85.33 (n)
  • 80.25 (a)
SLCO2B1 36
  • 80 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Slco2b1 35
  • 79.77 (n)
  • 75.55 (a)
Slco2b1 16
Slco2b1 36
  • 75 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SLCO2B1 35
  • 99.44 (n)
  • 99.15 (a)
SLCO2B1 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Slco2b1 35
  • 80.42 (n)
  • 77.07 (a)
oppossum
(Monodelphis domestica)
 Mammalia SLCO2B1 36
  • 63 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 54 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves SLCO2B1 35
  • 63.2 (n)
  • 55.75 (a)
SLCO2B1 36
  • 52 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SLCO2B1 36
  • 49 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia slco2b1 35
  • 61.74 (n)
  • 54.22 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15841 35
zebrafish
(Danio rerio)
 Actinopterygii slco2b1 35
  • 55.06 (n)
  • 49.6 (a)
slco2b1 36
  • 45 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea F21G4.1 35
  • 41.74 (n)
  • 29.72 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 25 (a)
 OneToMany
Species with no ortholog for SLCO2B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO2B1 Gene

ENSEMBL:
Gene Tree for SLCO2B1 (if available)
TreeFam:
Gene Tree for SLCO2B1 (if available)

Paralogs for SLCO2B1 Gene

Paralogs for SLCO2B1 Gene

(13) SIMAP similar genes for SLCO2B1 Gene using alignment to 11 proteins:

genes like me logo Genes that share paralogs with SLCO2B1: view

Variants for SLCO2B1 Gene

Sequence variations from dbSNP and Humsavar for SLCO2B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2306168 - 75,196,537(+) GCTGT(C/T)TCCAA reference, missense
VAR_036412 A breast cancer sample
rs35199625 - 75,169,325(+) TGGGC(A/G)TGGGC reference, missense
rs12422149 - 75,172,532(+) TCGGC(A/G)AAAGG reference, missense
rs1621378 - 75,193,317(-) GGAAG(A/G)TGGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLCO2B1 Gene

Variant ID Type Subtype PubMed ID
nsv897919 CNV Loss 21882294

Variation tolerance for SLCO2B1 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.46; 85.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO2B1 Gene

Human Gene Mutation Database (HGMD)
SLCO2B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO2B1 Gene

Disorders for SLCO2B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLCO2B1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO2B1

Genetic Association Database (GAD)
SLCO2B1
Human Genome Epidemiology (HuGE) Navigator
SLCO2B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO2B1
genes like me logo Genes that share disorders with SLCO2B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO2B1 Gene

Publications for SLCO2B1 Gene

  1. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PMID: 15226675) Niemi M. … KivistAP K.T. (Pharmacogenetics 2004) 3 23 48 67
  2. Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. (PMID: 19151602) Mougey E.B. … Lima J.J. (Pharmacogenet. Genomics 2009) 23 25 26
  3. Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. (PMID: 11683238) Tamai I. … Tsuji A. (Pharm. Res. 2001) 23 25 26
  4. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I. … Tsuji A. (Biochem. Biophys. Res. Commun. 2000) 3 25 26
  5. The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. (PMID: 20019365) Kraft M.E. … Zolk O. (Invest. Ophthalmol. Vis. Sci. 2010) 25 26

Products for SLCO2B1 Gene

Sources for SLCO2B1 Gene

Content