Aliases for SLCO2B1 Gene
Aliases for SLCO2B1 Gene
External Ids for SLCO2B1 Gene
- HGNC: 10962
- Entrez Gene: 11309
- Ensembl: ENSG00000137491
- OMIM: 604988
- UniProtKB: O94956
Previous HGNC Symbols for SLCO2B1 Gene
- SLC21A9
Previous GeneCards Identifiers for SLCO2B1 Gene
- GC11P074588
- GC11P074539
- GC11P074862
- GC11P071159
- GC11P074864
- GC11P074901
- GC11P074949
- GC11P075101
- GC11P075108
- GC11P075166
- GC11P075217
- GC11P075267
- GC11P075320
Summaries for SLCO2B1 Gene
-
This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
GeneCards Summary for SLCO2B1 Gene
SLCO2B1 (Solute Carrier Organic Anion Transporter Family Member 2B1) is a Protein Coding gene. Diseases associated with SLCO2B1 include Persistent Fetal Circulation Syndrome. Among its related pathways are Farnesoid X Receptor Pathway and Blood-Brain Barrier Pathway: Anatomy. Gene Ontology (GO) annotations related to this gene include transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO2A1.
UniProtKB/Swiss-Prot for SLCO2B1 Gene
-
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Additional gene information for SLCO2B1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO2B1 Gene
Genomics for SLCO2B1 Gene
GeneHancer (GH) Regulatory Elements for SLCO2B1 Gene
- Top Transcription factor binding sites by QIAGEN in the SLCO2B1 gene promoter:
Regulatory Element Products
Genomic Locations for SLCO2B1 Gene
- chr11:75,100,563-75,206,549
- (GRCh38/hg38)
- Size:
- 105,987 bases
- Orientation:
- Plus strand
- chr11:74,811,608-74,917,594
- (GRCh37/hg19)
Genomic View for SLCO2B1 Gene
- Cytogenetic band:
-
- 11q13.4 by Ensembl
- 11q13.4 by Entrez Gene
- 11q13 by HGNC


RefSeq DNA sequence for SLCO2B1 Gene
Proteins for SLCO2B1 Gene
-
Protein details for SLCO2B1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O94956-SO2B1_HUMAN
- Recommended name:
- Solute carrier organic anion transporter family member 2B1
- Protein Accession:
- O94956
- A8K2G9
- B4DGA9
- B4DTB0
- E7ERN5
- E9PPU8
- Q9H2Z0
- Q9UFU1
Protein attributes for SLCO2B1 Gene
- Size:
- 709 amino acids
- Molecular mass:
- 76711 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for SLCO2B1 Gene
Post-translational modifications for SLCO2B1 Gene
- Glycosylation at isoforms=3, 4176 and isoforms=2, 3, 4538
Other Protein References for SLCO2B1 Gene
Antibody Products
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-
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Protein Products
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-
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Assay Products
No data available for DME Specific Peptides for SLCO2B1 Gene
Domains & Families for SLCO2B1 Gene
Gene Families for SLCO2B1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for SLCO2B1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLCO2B1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O94956- Family:
-
- Belongs to the organo anion transporter (TC 2.A.60) family.
Function for SLCO2B1 Gene
Molecular function for SLCO2B1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005215 | transporter activity | IEA | -- |
GO:0008514 | organic anion transmembrane transporter activity | IDA | 18501590 |
GO:0015125 | bile acid transmembrane transporter activity | IBA | -- |
GO:0015347 | sodium-independent organic anion transmembrane transporter activity | TAS | -- |
Phenotypes for SLCO2B1 Gene
- MGI mutant phenotypes for SLCO2B1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLCO2B1:
Animal Models for SLCO2B1 Gene
- MGI Knock Outs for SLCO2B1:
-
- Slco2b1 tm1a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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CRISPR Products
-
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLCO2B1
- GenScript: Design CRISPR guide RNA sequences for SLCO2B1
miRNA for SLCO2B1 Gene
- miRTarBase miRNAs that target SLCO2B1
miRNA Products
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Inhibitory RNA Products
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- Applied Biological Materials Clones for SLCO2B1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem ES-209, Meso-prx/latp Progenitor for SLCO2B1
-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLCO2B1 Gene
Localization for SLCO2B1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLCO2B1 Gene
- Cell membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0016324 | apical plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO2B1 Gene
Pathways & Interactions for SLCO2B1 Gene
Pathways by source for SLCO2B1 Gene
1 BioSystems pathway for SLCO2B1 Gene
5 PharmGKB pathways for SLCO2B1 Gene
2 R&D Systems pathways for SLCO2B1 Gene
Interacting Proteins for SLCO2B1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0015721 | bile acid and bile salt transport | IBA | -- |
GO:0043252 | sodium-independent organic anion transport | TAS | -- |
GO:0055085 | transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLCO2B1 Gene
Drugs & Compounds for SLCO2B1 Gene
(47) Drugs for SLCO2B1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Glyburide | Approved | Pharma | Channel blocker, Transporter, substrate, blocker | Kir6 (KATP) channel blocker | 116 | |
Montelukast | Approved | Pharma | Antagonist, Transporter, substrate | 280 | ||
Fexofenadine | Approved, Investigational | Pharma | Transporter, substrate | 66 | ||
Ergoloid mesylate | Approved | Pharma | Target, inhibitor | 0 | ||
Estradiol | Approved, Investigational, Vet_approved | Pharma | Transporter, inhibitor | Sex hormone | 1400 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Thromboxane B2 |
|
54397-85-2 |
|
(1) ApexBio Compounds for SLCO2B1 Gene
Compound | Action | Cas Number |
---|---|---|
Probenecid | 57-66-9 |
Transcripts for SLCO2B1 Gene
mRNA/cDNA for SLCO2B1 Gene
- (4) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (187) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLCO2B1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLCO2B1
- genomics-online: gRNA clones - Search results for 126 available SLCO2B1 gene related products
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- Applied Biological Materials CRISPR for SLCO2B1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLCO2B1
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miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 126 available SLCO2B1 gene related products
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Clone Products
-
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||
SP7: |
Expression for SLCO2B1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SLCO2B1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLCO2B1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLCO2B1 Gene:
SLCO2B1SOURCE GeneReport for Unigene cluster for SLCO2B1 Gene:
Hs.7884mRNA Expression by UniProt/SwissProt for SLCO2B1 Gene:
O94956-SO2B1_HUMANEvidence on tissue expression from TISSUES for SLCO2B1 Gene
- Nervous system(4.9)
- Liver(4.7)
- Intestine(2.8)
- Kidney(2.4)
Primer Products
-
OriGene qPCR primer pairs for SLCO2B1
-
OriGene qPCR primer pairs and template standards for SLCO2B1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO2B1 Gene
Orthologs for SLCO2B1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SLCO2B1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | SLCO2B1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | SLCO2B1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Slco2b1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Slco2b1 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SLCO2B1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
chicken (Gallus gallus) |
Aves | SLCO2B1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SLCO2B1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | slco2b1 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15841 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | slco2b1 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | F21G4.1 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for SLCO2B1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLCO2B1 Gene
Paralogs for SLCO2B1 Gene
(13) SIMAP similar genes for SLCO2B1 Gene using alignment to 11 proteins:
Variants for SLCO2B1 Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_036412 | A breast cancer sample | p.Glu77Lys | |||
rs1000000178 | -- | 75,189,846(+) | A/C | intron_variant | |
rs1000002586 | -- | 75,190,438(+) | C/G | intron_variant | |
rs1000065032 | -- | 75,163,493(+) | A/G | intron_variant | |
rs1000070990 | -- | 75,158,123(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1054122 | CNV | loss | 25217958 |
nsv1134156 | CNV | deletion | 24896259 |
Additional Variant Information for SLCO2B1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO2B1 Gene
Disorders for SLCO2B1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
persistent fetal circulation syndrome |
|
|
Additional Disease Information for SLCO2B1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO2B1 Gene
Publications for SLCO2B1 Gene
- High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PMID: 15226675) Niemi M … Kivistö KT (Pharmacogenetics 2004) 3 22 44 58
- Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I … Tsuji A (Biochemical and biophysical research communications 2000) 3 4 25 58
- Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant. (PMID: 23531488) Knauer MJ … Tirona RG (Molecular pharmacology 2013) 3 4 58
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
- Transcriptional control of human organic anion transporting polypeptide 2B1 gene. (PMID: 19383542) Pomari E … Dalla Valle L (The Journal of steroid biochemistry and molecular biology 2009) 3 22 58
Products for SLCO2B1 Gene
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Sources for SLCO2B1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
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