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Aliases for SLCO2B1 Gene

Aliases for SLCO2B1 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 2B1 2 3
  • SLC21A9 3 4 6
  • OATPB 3 4 6
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 9 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 2 3 4
  • Organic Anion Transporter B 3 4
  • OATP-RP2 3 4
  • OATP2B1 3 4
  • OATP-B 3 4
  • Solute Carrier Organic Anion Transporter Family Member 2B1 3
  • Solute Carrier Family 21 Member 9 4
  • KIAA0880 4
  • OATPRP2 4

External Ids for SLCO2B1 Gene

Previous HGNC Symbols for SLCO2B1 Gene

  • SLC21A9

Previous GeneCards Identifiers for SLCO2B1 Gene

  • GC11P074588
  • GC11P074539
  • GC11P074862
  • GC11P071159
  • GC11P074864
  • GC11P074901
  • GC11P074949

Summaries for SLCO2B1 Gene

Entrez Gene Summary for SLCO2B1 Gene

  • This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

GeneCards Summary for SLCO2B1 Gene

SLCO2B1 (Solute Carrier Organic Anion Transporter Family, Member 2B1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include organic anion transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO2B1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Gene Wiki entry for SLCO2B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO2B1 Gene

Genomics for SLCO2B1 Gene

Regulatory Elements for SLCO2B1 Gene

Genomic Location for SLCO2B1 Gene

Start:
75,100,563 bp from pter
End:
75,214,669 bp from pter
Size:
114,107 bases
Orientation:
Plus strand

Genomic View for SLCO2B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO2B1 Gene

Proteins for SLCO2B1 Gene

  • Protein details for SLCO2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94956-SO2B1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 2B1
    Protein Accession:
    O94956
    Secondary Accessions:
    • A8K2G9
    • B4DGA9
    • B4DTB0
    • E7ERN5
    • E9PPU8
    • Q9H2Z0
    • Q9UFU1

    Protein attributes for SLCO2B1 Gene

    Size:
    709 amino acids
    Molecular mass:
    76711 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLCO2B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO2B1 Gene

Proteomics data for SLCO2B1 Gene at MOPED

Post-translational modifications for SLCO2B1 Gene

  • Glycosylation at Asn176 and Asn538
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO2B1 Gene

Domains for SLCO2B1 Gene

Gene Families for SLCO2B1 Gene

Protein Domains for SLCO2B1 Gene

Suggested Antigen Peptide Sequences for SLCO2B1 Gene

Graphical View of Domain Structure for InterPro Entry

O94956

UniProtKB/Swiss-Prot:

SO2B1_HUMAN :
  • O94956
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO2B1: view

Function for SLCO2B1 Gene

Molecular function for SLCO2B1 Gene

UniProtKB/Swiss-Prot Function: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Gene Ontology (GO) - Molecular Function for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0008514 organic anion transmembrane transporter activity IDA 18501590
GO:0015125 bile acid transmembrane transporter activity --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IDA 18501590
genes like me logo Genes that share ontologies with SLCO2B1: view

Phenotypes for SLCO2B1 Gene

MGI mutant phenotypes for SLCO2B1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLCO2B1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLCO2B1 Gene

Localization for SLCO2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO2B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO2B1 Gene COMPARTMENTS Subcellular localization image for SLCO2B1 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane --
genes like me logo Genes that share ontologies with SLCO2B1: view

Pathways for SLCO2B1 Gene

genes like me logo Genes that share pathways with SLCO2B1: view

Interacting Proteins for SLCO2B1 Gene

Gene Ontology (GO) - Biological Process for SLCO2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development --
GO:0006810 transport --
GO:0015721 bile acid and bile salt transport --
GO:0043252 sodium-independent organic anion transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLCO2B1: view

Compounds for SLCO2B1 Gene

(1) HMDB Compounds for SLCO2B1 Gene

Compound Synonyms Cas Number PubMed IDs
Thromboxane B2
  • TXB2
54397-85-2

(32) Drugbank Compounds for SLCO2B1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acetic acid
  • Ethanoat
64-19-7 transporter substrate inhibitor
Alprostadil
745-65-3 transporter inhibitor
Atorvastatin
134523-00-5 transporter
Benzoic Acid
65-85-0 transporter inhibitor
Citric Acid
77-92-9 transporter inhibitor

(5) IUPHAR Ligand for SLCO2B1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]estrone-3-sulphate None None
gemfibrozil Inhibitor Inhibition
[3H]BSP None None
rifamycin SV Inhibitor Inhibition
glibenclamide Inhibitor Inhibition

(5) Novoseek inferred chemical compound relationships for SLCO2B1 Gene

Compound -log(P) Hits PubMed IDs
oatp 91 3
estrone sulfate 89.7 9
estradiol-17beta-glucuronide 82.1 4
ribonucleic acid 42.6 1
steroid 34.9 3

(1) PharmGKB related drug/compound annotations for SLCO2B1 Gene

Drug/compound Annotation
montelukast CA
genes like me logo Genes that share compounds with SLCO2B1: view

Transcripts for SLCO2B1 Gene

Unigene Clusters for SLCO2B1 Gene

Solute carrier organic anion transporter family, member 2B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO2B1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6:
SP7:

Relevant External Links for SLCO2B1 Gene

GeneLoc Exon Structure for
SLCO2B1
ECgene alternative splicing isoforms for
SLCO2B1

Expression for SLCO2B1 Gene

mRNA expression in normal human tissues for SLCO2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO2B1 Gene

This gene is overexpressed in Liver (6.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLCO2B1 Gene

SOURCE GeneReport for Unigene cluster for SLCO2B1 Gene Hs.7884

mRNA Expression by UniProt/SwissProt for SLCO2B1 Gene

O94956-SO2B1_HUMAN
Tissue specificity: Isoform 1 has its highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.
genes like me logo Genes that share expressions with SLCO2B1: view

Orthologs for SLCO2B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO2B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO2B1 35
  • 99.44 (n)
  • 99.15 (a)
SLCO2B1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLCO2B1 35
  • 84.93 (n)
  • 81.21 (a)
SLCO2B1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO2B1 35
  • 85.33 (n)
  • 80.25 (a)
SLCO2B1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco2b1 35
  • 79.77 (n)
  • 75.55 (a)
Slco2b1 16
Slco2b1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLCO2B1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slco2b1 35
  • 80.42 (n)
  • 77.07 (a)
chicken
(Gallus gallus)
Aves SLCO2B1 35
  • 63.2 (n)
  • 55.75 (a)
SLCO2B1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLCO2B1 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15841 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slco2b1 35
  • 61.74 (n)
  • 54.22 (a)
zebrafish
(Danio rerio)
Actinopterygii slco2b1 35
  • 55.06 (n)
  • 49.6 (a)
slco2b1 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F21G4.1 35
  • 41.74 (n)
  • 29.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for SLCO2B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO2B1 Gene

ENSEMBL:
Gene Tree for SLCO2B1 (if available)
TreeFam:
Gene Tree for SLCO2B1 (if available)

Paralogs for SLCO2B1 Gene

genes like me logo Genes that share paralogs with SLCO2B1: view

Variants for SLCO2B1 Gene

Sequence variations from dbSNP and Humsavar for SLCO2B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs719610 -- 75,197,413(+) TCCAG(G/T)CAGGG intron-variant
rs765823 -- 75,191,003(+) ATTCC(A/G)GTGCC intron-variant
rs765824 -- 75,191,450(+) AGGAA(A/C)CAGGG intron-variant
rs867627 -- 75,166,108(+) GCCCC(A/C/T)GCCCA intron-variant
rs881217 -- 75,164,900(+) CTATG(A/G)ATACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO2B1 Gene

Variant ID Type Subtype PubMed ID
nsv897919 CNV Loss 21882294

Relevant External Links for SLCO2B1 Gene

HapMap Linkage Disequilibrium report
SLCO2B1
Human Gene Mutation Database (HGMD)
SLCO2B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO2B1 Gene

Disorders for SLCO2B1 Gene

(1) Novoseek inferred disease relationships for SLCO2B1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 7.62 4

Relevant External Links for SLCO2B1

Genetic Association Database (GAD)
SLCO2B1
Human Genome Epidemiology (HuGE) Navigator
SLCO2B1
genes like me logo Genes that share disorders with SLCO2B1: view

No data available for UniProtKB/Swiss-Prot for SLCO2B1 Gene

Publications for SLCO2B1 Gene

  1. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PMID: 15226675) Niemi M. … KivistAP K.T. (Pharmacogenetics 2004) 3 23 48
  2. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I. … Tsuji A. (Biochem. Biophys. Res. Commun. 2000) 3 4 25
  3. Transcriptional control of human organic anion transporting polypeptide 2B1 gene. (PMID: 19383542) Pomari E. … Dalla Valle L. (J. Steroid Biochem. Mol. Biol. 2009) 3 23
  4. Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. (PMID: 11932330) St-Pierre M.V. … Stallmach T. (J. Clin. Endocrinol. Metab. 2002) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for SLCO2B1 Gene

  • antibodies-online peptides for SLCO2B1
  • antibodies-online antibodies for SLCO2B1
  • antibodies-online kits for SLCO2B1

Sources for SLCO2B1 Gene

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