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Aliases for ADCY7 Gene

Aliases for ADCY7 Gene

  • Adenylate Cyclase 7 2 3 5
  • Adenylate Cyclase Type VII 3 4
  • ATP Pyrophosphate-Lyase 7 3 4
  • Adenylyl Cyclase 7 3 4
  • EC 4.6.1.1 4 63
  • KIAA0037 4
  • EC 4.6.1 63
  • AC7 3

External Ids for ADCY7 Gene

Previous GeneCards Identifiers for ADCY7 Gene

  • GC16P040735
  • GC16P050347
  • GC16P050045
  • GC16P050099
  • GC16P048880
  • GC16P036209
  • GC16P050280

Summaries for ADCY7 Gene

Entrez Gene Summary for ADCY7 Gene

  • This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

GeneCards Summary for ADCY7 Gene

ADCY7 (Adenylate Cyclase 7) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and Insulin secretion. GO annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY3.

UniProtKB/Swiss-Prot for ADCY7 Gene

  • This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Tocris Summary for ADCY7 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY7 Gene

Genomics for ADCY7 Gene

Regulatory Elements for ADCY7 Gene

Enhancers for ADCY7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADCY7 on UCSC Golden Path with GeneCards custom track

Promoters for ADCY7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADCY7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADCY7 Gene

Chromosome:
16
Start:
50,244,749 bp from pter
End:
50,318,135 bp from pter
Size:
73,387 bases
Orientation:
Plus strand

Genomic View for ADCY7 Gene

Genes around ADCY7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY7 Gene

Proteins for ADCY7 Gene

  • Protein details for ADCY7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51828-ADCY7_HUMAN
    Recommended name:
    Adenylate cyclase type 7
    Protein Accession:
    P51828
    Secondary Accessions:
    • A0AVA6

    Protein attributes for ADCY7 Gene

    Size:
    1080 amino acids
    Molecular mass:
    120308 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA05021.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADCY7 Gene

Proteomics data for ADCY7 Gene at MOPED

Post-translational modifications for ADCY7 Gene

  • Ubiquitination at Lys 443, Lys 579, and Lys 1073
  • Glycosylation at Asn 701, Asn 776, and Asn 781
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for ADCY7

Domains & Families for ADCY7 Gene

Gene Families for ADCY7 Gene

Protein Domains for ADCY7 Gene

Suggested Antigen Peptide Sequences for ADCY7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51828

UniProtKB/Swiss-Prot:

ADCY7_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Contains 2 guanylate cyclase domains.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY7: view

Function for ADCY7 Gene

Molecular function for ADCY7 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type VII
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Enzyme Numbers (IUBMB) for ADCY7 Gene

genes like me logo Genes that share phenotypes with ADCY7: view

Animal Models for ADCY7 Gene

MGI Knock Outs for ADCY7:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY7 Gene

Localization for ADCY7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY7 Gene COMPARTMENTS Subcellular localization image for ADCY7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADCY7: view

Pathways & Interactions for ADCY7 Gene

SuperPathways for ADCY7 Gene

Superpath Contained pathways
1 DAG and IP3 signaling
2 Interleukin-3, 5 and GM-CSF signaling
3 Circadian entrainment
4 Development Endothelin-1/EDNRA signaling
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with ADCY7: view

SIGNOR curated interactions for ADCY7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006833 water transport TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity TAS --
genes like me logo Genes that share ontologies with ADCY7: view

Drugs & Compounds for ADCY7 Gene

(12) Drugs for ADCY7 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Pyruvic acid Approved Nutra 0
Forskolin Experimental Pharma Adenylyl cyclase activator 0
cyclic amp Experimental Pharma 0
Cyclic GMP Experimental Pharma 0

(6) Additional Compounds for ADCY7 Gene - From: Tocris, HMDB, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
NKH 477
138605-00-2
PACAP 1-27
127317-03-7
PACAP 1-38
137061-48-4
SQ 22536
17318-31-9

(5) Tocris Compounds for ADCY7 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
PACAP 1-27 Potent stimulator of adenylyl cyclase 127317-03-7
PACAP 1-38 Potent stimulator of adenylyl cyclase 137061-48-4
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9
genes like me logo Genes that share compounds with ADCY7: view

Transcripts for ADCY7 Gene

Unigene Clusters for ADCY7 Gene

Adenylate cyclase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: -
SP3: - - - - -
SP4:
SP5:

ExUns: 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ADCY7 Gene

GeneLoc Exon Structure for
ADCY7
ECgene alternative splicing isoforms for
ADCY7

Expression for ADCY7 Gene

mRNA expression in normal human tissues for ADCY7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY7 Gene

This gene is overexpressed in Whole Blood (x6.5).

Protein differential expression in normal tissues from HIPED for ADCY7 Gene

This gene is overexpressed in Monocytes (27.6), Peripheral blood mononuclear cells (12.2), Placenta (11.3), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADCY7 Gene



SOURCE GeneReport for Unigene cluster for ADCY7 Gene Hs.513578

genes like me logo Genes that share expression patterns with ADCY7: view

Protein tissue co-expression partners for ADCY7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADCY7 Gene

Orthologs for ADCY7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADCY7 35
  • 85.92 (n)
  • 86.42 (a)
ADCY7 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY7 35
  • 85.66 (n)
  • 86.41 (a)
ADCY7 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy7 35
  • 83.04 (n)
  • 84.44 (a)
Adcy7 16
Adcy7 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADCY7 35
  • 98.37 (n)
  • 98.34 (a)
ADCY7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy7 35
  • 83.38 (n)
  • 84.72 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCY7 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY7 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCY7 35
  • 64.62 (n)
  • 69.78 (a)
ADCY7 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY7 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy7 35
  • 61.75 (n)
  • 64.22 (a)
Str.13076 35
African clawed frog
(Xenopus laevis)
Amphibia LOC399055 35
zebrafish
(Danio rerio)
Actinopterygii adcy7 35
  • 61.37 (n)
  • 58.24 (a)
adcy7 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 37
  • 38 (a)
ACXB 37
  • 27 (a)
ACXD 37
  • 28 (a)
Ac76E 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acy-2 37
  • 41 (a)
acy-4 37
  • 50 (a)
acy-2 36
  • 29 (a)
OneToMany
Species with no ortholog for ADCY7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY7 Gene

ENSEMBL:
Gene Tree for ADCY7 (if available)
TreeFam:
Gene Tree for ADCY7 (if available)

Paralogs for ADCY7 Gene

Paralogs for ADCY7 Gene

Pseudogenes.org Pseudogenes for ADCY7 Gene

genes like me logo Genes that share paralogs with ADCY7: view

Variants for ADCY7 Gene

Sequence variations from dbSNP and Humsavar for ADCY7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3892156 -- 50,286,084(+) TTTGT(A/G)TCAGT intron-variant, upstream-variant-2KB
rs3915616 -- 50,251,778(-) GAGGC(C/G)AGGCG intron-variant
rs3915617 -- 50,251,483(-) CTTCA(C/T)CTCTC intron-variant
rs3916091 -- 50,263,147(-) TAGAA(G/T)AAGGC intron-variant
rs4082435 -- 50,296,245(-) CAAAA(C/T)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY7 Gene

Variant ID Type Subtype PubMed ID
nsv906662 CNV Loss 21882294
nsv1805 CNV Loss 18451855

Variation tolerance for ADCY7 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCY7 Gene

HapMap Linkage Disequilibrium report
ADCY7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY7 Gene

Disorders for ADCY7 Gene

Relevant External Links for ADCY7

Genetic Association Database (GAD)
ADCY7
Human Genome Epidemiology (HuGE) Navigator
ADCY7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY7

No disorders were found for ADCY7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY7 Gene

Publications for ADCY7 Gene

  1. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. (PMID: 7860067) Hellevuo K. … Tabakoff B. (Hum. Genet. 1995) 2 3 23 67
  2. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. (PMID: 15581358) Beeler J.A. … Tang W.J. (Biochemistry 2004) 3 23
  3. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. (PMID: 12454008) Nelson E.J. … Tabakoff B. (J. Biol. Chem. 2003) 3 23
  4. ADCY7 supports development of acute myeloid leukemia. (PMID: 26220344) Li C. … Zhang C.C. (Biochem. Biophys. Res. Commun. 2015) 3
  5. Higher TNFI+ responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression. (PMID: 25959651) RisA … Dahle M.K. (Hum. Immunol. 2015) 3

Products for ADCY7 Gene

Sources for ADCY7 Gene

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