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Aliases for CYP4F8 Gene

Aliases for CYP4F8 Gene

  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 8 2 3
  • Cytochrome P450, Subfamily IVF, Polypeptide 8 2 3
  • CYPIVF8 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • EC 1.14.14.1 4
  • CPF8 3

External Ids for CYP4F8 Gene

Previous GeneCards Identifiers for CYP4F8 Gene

  • GC19P016105
  • GC19P016014
  • GC19P015481
  • GC19P015587
  • GC19P015726
  • GC19P015293

Summaries for CYP4F8 Gene

Entrez Gene Summary for CYP4F8 Gene

  • This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4F8 Gene

CYP4F8 (Cytochrome P450, Family 4, Subfamily F, Polypeptide 8) is a Protein Coding gene. Among its related pathways are Metabolism and Linoleic acid metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.

UniProtKB/Swiss-Prot for CYP4F8 Gene

  • Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.

Gene Wiki entry for CYP4F8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F8 Gene

Genomics for CYP4F8 Gene

Regulatory Elements for CYP4F8 Gene

Genomic Location for CYP4F8 Gene

Chromosome:
19
Start:
15,615,218 bp from pter
End:
15,631,867 bp from pter
Size:
16,650 bases
Orientation:
Plus strand

Genomic View for CYP4F8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4F8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F8 Gene

Proteins for CYP4F8 Gene

  • Protein details for CYP4F8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98187-CP4F8_HUMAN
    Recommended name:
    Cytochrome P450 4F8
    Protein Accession:
    P98187

    Protein attributes for CYP4F8 Gene

    Size:
    520 amino acids
    Molecular mass:
    59995 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4F8 Gene

Proteomics data for CYP4F8 Gene at MOPED

Post-translational modifications for CYP4F8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F8 Gene

No data available for DME Specific Peptides for CYP4F8 Gene

Domains & Families for CYP4F8 Gene

Gene Families for CYP4F8 Gene

Protein Domains for CYP4F8 Gene

Suggested Antigen Peptide Sequences for CYP4F8 Gene

Graphical View of Domain Structure for InterPro Entry

P98187

UniProtKB/Swiss-Prot:

CP4F8_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F8: view

Function for CYP4F8 Gene

Molecular function for CYP4F8 Gene

GENATLAS Biochemistry:
cytochrome p450,subfamily IV-F expressed in seminal vesicles,catalyzing in the synthesis of 19R-hydroxyprostaglandins by a NADPH-dependent omega2-hydroxylation
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7 uM for 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069); KM=40 uM for 6,9-alpha-methylene-PGI2; Note=The Vmax of the reaction with U-44069 as substrate is 260 pmol/min/pmol enzyme.;
UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function:
Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.

Enzyme Numbers (IUBMB) for CYP4F8 Gene

Gene Ontology (GO) - Molecular Function for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0018685 alkane 1-monooxygenase activity TAS 10405341
GO:0020037 heme binding IEA --
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

Phenotypes for CYP4F8 Gene

GenomeRNAi human phenotypes for CYP4F8:
genes like me logo Genes that share phenotypes with CYP4F8: view

Animal Model Products

CRISPR Products

miRNA for CYP4F8 Gene

miRTarBase miRNAs that target CYP4F8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4F8

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4F8 Gene

Localization for CYP4F8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F8 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.

Gene Ontology (GO) - Cellular Components for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

No data available for Subcellular locations from COMPARTMENTS for CYP4F8 Gene

Pathways & Interactions for CYP4F8 Gene

genes like me logo Genes that share pathways with CYP4F8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat

Interacting Proteins for CYP4F8 Gene

Selected Interacting proteins: P98187-CP4F8_HUMAN for CYP4F8 Gene via I2D

Symbol External ID(s) Details
DBNL

Gene Ontology (GO) - Biological Process for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006690 icosanoid metabolic process TAS --
GO:0006693 prostaglandin metabolic process TAS 10405341
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

No data available for SIGNOR curated interactions for CYP4F8 Gene

Drugs & Compounds for CYP4F8 Gene

(2) Drugs for CYP4F8 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
arachidonic acid Experimental Nutra Potentiation, Activator 27
heme Pharma Agonist 0

(11) Additional Compounds for CYP4F8 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
79551-86-3
20-Hydroxy-leukotriene B4
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoate
  • (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic acid
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate
79516-82-8
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with CYP4F8: view

Transcripts for CYP4F8 Gene

Unigene Clusters for CYP4F8 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4F8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for CYP4F8 Gene

GeneLoc Exon Structure for
CYP4F8
ECgene alternative splicing isoforms for
CYP4F8

Expression for CYP4F8 Gene

mRNA expression in normal human tissues for CYP4F8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x28.2), Prostate (x9.2), Skin - Sun Exposed (Lower leg) (x7.0), and Bladder (x5.5).

SOURCE GeneReport for Unigene cluster for CYP4F8 Gene Hs.268554

mRNA Expression by UniProt/SwissProt for CYP4F8 Gene

P98187-CP4F8_HUMAN
Tissue specificity: Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions.
genes like me logo Genes that share expression patterns with CYP4F8: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CYP4F8 Gene

Orthologs for CYP4F8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4F8 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cyp4f15 35
  • 78.52 (n)
  • 76.88 (a)
Cyp4f15 16
chimpanzee
(Pan troglodytes)
Mammalia LOC748442 35
  • 99.17 (n)
  • 98.85 (a)
rat
(Rattus norvegicus)
Mammalia Cyp4f4 35
  • 78.46 (n)
  • 75.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp311a1 37
  • 30 (a)
Cyp312a1 37
  • 30 (a)
Cyp313a4 37
  • 29 (a)
Cyp313b1 37
  • 25 (a)
Cyp4aa1 37
  • 30 (a)
Cyp4ac1 37
  • 32 (a)
Cyp4ac2 37
  • 32 (a)
Cyp4ac3 37
  • 33 (a)
Cyp4ad1 37
  • 29 (a)
Cyp4ae1 37
  • 34 (a)
Cyp4c3 37
  • 37 (a)
Cyp4d1 37
  • 34 (a)
Cyp4d14 37
  • 35 (a)
Cyp4d2 37
  • 38 (a)
Cyp4d20 37
  • 34 (a)
Cyp4d21 37
  • 32 (a)
Cyp4d8 37
  • 36 (a)
Cyp4e1 37
  • 31 (a)
Cyp4e2 37
  • 32 (a)
Cyp4e3 37
  • 32 (a)
Cyp4g1 37
  • 26 (a)
Cyp4g15 37
  • 35 (a)
Cyp4p1 37
  • 33 (a)
Cyp4p2 37
  • 32 (a)
Cyp4p3 37
  • 32 (a)
Cyp4s3 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea B0331.1 37
  • 35 (a)
C26F1.2 37
  • 32 (a)
F01D5.9 37
  • 35 (a)
F28G4.1 37
  • 33 (a)
Y17G9B.3 37
  • 36 (a)
Y38C9B.1 37
  • 34 (a)
Y5H2B.5 37
  • 35 (a)
Y80D3A.5 37
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP72A15 35
  • 43.55 (n)
  • 34.03 (a)
Species with no ortholog for CYP4F8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP4F8 Gene

ENSEMBL:
Gene Tree for CYP4F8 (if available)
TreeFam:
Gene Tree for CYP4F8 (if available)

Paralogs for CYP4F8 Gene

(13) SIMAP similar genes for CYP4F8 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CYP4F8 Gene

genes like me logo Genes that share paralogs with CYP4F8: view

No data available for Paralogs for CYP4F8 Gene

Variants for CYP4F8 Gene

Sequence variations from dbSNP and Humsavar for CYP4F8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs714772 -- 15,618,245(+) AGCCC(A/C/G)TTCCT intron-variant
rs714773 -- 15,618,553(+) GGAGG(A/C/G)GTAGC intron-variant
rs1022413 -- 15,631,174(+) gacac(A/G)tgcaa utr-variant-3-prime
rs1022414 -- 15,631,563(+) ATTAG(C/T)GGTCC utr-variant-3-prime
rs1295744 -- 15,627,500(-) TCAAG(A/G)GCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4F8 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
dgv627e199 CNV Deletion 23128226
esv2718235 CNV Deletion 23290073
esv1497518 CNV Insertion 17803354

Relevant External Links for CYP4F8 Gene

HapMap Linkage Disequilibrium report
CYP4F8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CYP4F8 Gene

Disorders for CYP4F8 Gene

Relevant External Links for CYP4F8

Genetic Association Database (GAD)
CYP4F8
Human Genome Epidemiology (HuGE) Navigator
CYP4F8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4F8
genes like me logo Genes that share disorders with CYP4F8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4F8 Gene

Publications for CYP4F8 Gene

  1. Co-localization of COX-2, CYP4F8, and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions. (PMID: 16516815) Stark K. … Oliw E.H. (Prostaglandins Other Lipid Mediat. 2006) 23 67
  2. On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens. (PMID: 15789615) Stark K. … Oliw E.H. (Prostaglandins Other Lipid Mediat. 2005) 23 67
  3. Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. (PMID: 12464258) Stark K. … Oliw E.H. (Arch. Biochem. Biophys. 2003) 23 67
  4. cDNA cloning and expression of CYP4F12, a novel human cytochrome P450. (PMID: 11162607) Bylund J. … Oliw E.H. (Biochem. Biophys. Res. Commun. 2001) 23 67
  5. A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization. (PMID: 10964514) Cui X. … Strobel H.W. (Genomics 2000) 23 67

Products for CYP4F8 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP4F8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4F8
    • Block miRNA regulation of CYP4F8 using miScript Target Protectors

    Sources for CYP4F8 Gene

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