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Aliases for CYP4F8 Gene

Aliases for CYP4F8 Gene

  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 8 2 3
  • Cytochrome P450, Subfamily IVF, Polypeptide 8 2 3
  • CYPIVF8 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Cytochrome P450 4F8 3
  • EC 1.14.14.1 4
  • CPF8 3

External Ids for CYP4F8 Gene

Summaries for CYP4F8 Gene

Entrez Gene Summary for CYP4F8 Gene

  • This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4F8 Gene

CYP4F8 (Cytochrome P450, Family 4, Subfamily F, Polypeptide 8) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding.

UniProtKB/Swiss-Prot for CYP4F8 Gene

  • Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.

Gene Wiki entry for CYP4F8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F8 Gene

Genomics for CYP4F8 Gene

Genomic Location for CYP4F8 Gene

Start:
15,615,218 bp from pter
End:
15,630,638 bp from pter
Size:
15,421 bases
Orientation:
Plus strand

Genomic View for CYP4F8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4F8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F8 Gene

Regulatory Elements for CYP4F8 Gene

Proteins for CYP4F8 Gene

  • Protein details for CYP4F8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98187-CP4F8_HUMAN
    Recommended name:
    Cytochrome P450 4F8
    Protein Accession:
    P98187
    Secondary Accessions:

    Protein attributes for CYP4F8 Gene

    Size:
    520 amino acids
    Molecular mass:
    59995 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4F8 Gene

Proteomics data for CYP4F8 Gene at MOPED

Post-translational modifications for CYP4F8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP4F8 Gene

Domains for CYP4F8 Gene

Gene Families for CYP4F8 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP4F8 Gene

UniProtKB/Swiss-Prot:

CP4F8_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • P98187
genes like me logo Genes that share domains with CYP4F8: view

Function for CYP4F8 Gene

Molecular function for CYP4F8 Gene

GENATLAS Biochemistry: cytochrome p450,subfamily IV-F expressed in seminal vesicles,catalyzing in the synthesis of 19R-hydroxyprostaglandins by a NADPH-dependent omega2-hydroxylation
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=7 uM for 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069); KM=40 uM for 6,9-alpha-methylene-PGI2; Note=The Vmax of the reaction with U-44069 as substrate is 260 pmol/min/pmol enzyme.;
UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function: Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.

Enzyme Numbers (IUBMB) for CYP4F8 Gene

Gene Ontology (GO) - Molecular Function for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0018685 alkane 1-monooxygenase activity TAS 10405341
GO:0020037 heme binding IEA --
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

miRNA for CYP4F8 Gene

miRTarBase miRNAs that target CYP4F8

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP4F8 Gene

Localization for CYP4F8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F8 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4F8 Gene COMPARTMENTS Subcellular localization image for CYP4F8 gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

Pathways for CYP4F8 Gene

genes like me logo Genes that share pathways with CYP4F8: view

Interacting Proteins for CYP4F8 Gene

Selected Interacting proteins: P98187-CP4F8_HUMAN for CYP4F8 Gene via I2D

Symbol External ID(s) Details
DBNL

Gene Ontology (GO) - Biological Process for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006690 icosanoid metabolic process TAS --
GO:0006693 prostaglandin metabolic process TAS 10405341
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

Compounds for CYP4F8 Gene

(9) HMDB Compounds for CYP4F8 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9
13-HETE
  • 13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate
151910-72-4
17-HETE
  • 17-hydroxyeicosatetraenate
Not Available
2beta-Hydroxytestosterone
  • 2beta,17beta-dihydroxyandrost-4-en-3-one
10390-14-4

(5) Novoseek inferred chemical compound relationships for CYP4F8 Gene

Compound -log(P) Hits PubMed IDs
19-hydroxy-pge2 98.7 1
pgh2 86.2 1
leukotriene b4 59.4 1
arachidonic acid 50.1 3
prostaglandin 44.3 1
genes like me logo Genes that share compounds with CYP4F8: view

Transcripts for CYP4F8 Gene

Unigene Clusters for CYP4F8 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for CYP4F8 Gene

GeneLoc Exon Structure for
CYP4F8
ECgene alternative splicing isoforms for
CYP4F8

Expression for CYP4F8 Gene

mRNA expression in normal human tissues for CYP4F8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (28.2), Prostate (9.2), Skin - Sun Exposed (Lower leg) (7.0), and Bladder (5.5).

SOURCE GeneReport for Unigene cluster for CYP4F8 Gene Hs.268554

mRNA Expression by UniProt/SwissProt for CYP4F8 Gene

P98187-CP4F8_HUMAN
Tissue specificity: Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions.
genes like me logo Genes that share expressions with CYP4F8: view

Orthologs for CYP4F8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4F8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC748442 36
  • 99.17 (n)
  • 98.85 (a)
mouse
(Mus musculus)
Mammalia Cyp4f15 36
  • 78.52 (n)
  • 76.88 (a)
Cyp4f15 16
rat
(Rattus norvegicus)
Mammalia Cyp4f4 36
  • 78.46 (n)
  • 75.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp4ae1 38
  • 34 (a)
Cyp4d2 38
  • 38 (a)
Cyp4e3 38
  • 32 (a)
Cyp4d8 38
  • 36 (a)
Cyp4s3 38
  • 34 (a)
Cyp4ac3 38
  • 33 (a)
Cyp4p1 38
  • 33 (a)
Cyp4aa1 38
  • 30 (a)
Cyp4d1 38
  • 34 (a)
Cyp313b1 38
  • 25 (a)
Cyp4d20 38
  • 34 (a)
Cyp313a4 38
  • 29 (a)
Cyp4c3 38
  • 37 (a)
Cyp4e1 38
  • 31 (a)
Cyp311a1 38
  • 30 (a)
Cyp4g1 38
  • 26 (a)
Cyp4p2 38
  • 32 (a)
Cyp4ac1 38
  • 32 (a)
Cyp4ad1 38
  • 29 (a)
Cyp4d21 38
  • 32 (a)
Cyp4d14 38
  • 35 (a)
Cyp4g15 38
  • 35 (a)
Cyp312a1 38
  • 30 (a)
Cyp4p3 38
  • 32 (a)
Cyp4e2 38
  • 32 (a)
Cyp4ac2 38
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea F01D5.9 38
  • 35 (a)
Y80D3A.5 38
  • 32 (a)
F28G4.1 38
  • 33 (a)
C26F1.2 38
  • 32 (a)
Y17G9B.3 38
  • 36 (a)
Y5H2B.5 38
  • 35 (a)
B0331.1 38
  • 35 (a)
Y38C9B.1 38
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP72A15 36
  • 43.55 (n)
  • 34.03 (a)
Species with no ortholog for CYP4F8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP4F8 Gene

ENSEMBL:
Gene Tree for CYP4F8 (if available)
TreeFam:
Gene Tree for CYP4F8 (if available)

Paralogs for CYP4F8 Gene

Selected SIMAP similar genes for CYP4F8 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CYP4F8 Gene

genes like me logo Genes that share paralogs with CYP4F8: view

No data available for Paralogs for CYP4F8 Gene

Variants for CYP4F8 Gene

Sequence variations from dbSNP and Humsavar for CYP4F8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs714772 -- 15,618,245(+) AGCCC(C/G)TTCCT intron-variant
rs714773 -- 15,618,553(+) GGAGG(A/C/G)GTAGC intron-variant
rs1295744 -- 15,627,500(-) TCAAG(A/G)GCTAG intron-variant
rs1316340 -- 15,614,417(-) ACGGA(A/G)TCTTG upstream-variant-2KB
rs1320318 -- 15,614,044(+) TGTTG(C/T)CAGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYP4F8 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
dgv627e199 CNV Deletion 23128226
esv2718235 CNV Deletion 23290073
esv1497518 CNV Insertion 17803354

Relevant External Links for CYP4F8 Gene

HapMap Linkage Disequilibrium report
CYP4F8

Disorders for CYP4F8 Gene

(1) University of Copenhagen DISEASES for CYP4F8 Gene

(1) Novoseek inferred disease relationships for CYP4F8 Gene

Disease -log(P) Hits PubMed IDs
psoriasis 45.7 3

Relevant External Links for CYP4F8

Genetic Association Database (GAD)
CYP4F8
Human Genome Epidemiology (HuGE) Navigator
CYP4F8
genes like me logo Genes that share disorders with CYP4F8: view

No data available for UniProtKB/Swiss-Prot for CYP4F8 Gene

Publications for CYP4F8 Gene

  1. Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. (PMID: 12464258) Stark K. … Oliw E.H. (Arch. Biochem. Biophys. 2003) 3 4 23
  2. On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens. (PMID: 15789615) Stark K. … Oliw E.H. (Prostaglandins Other Lipid Mediat. 2005) 3 4 23
  3. Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. (PMID: 10405341) Bylund J. … Oliw E.H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  4. Identification of CYP4F8 in human seminal vesicles as a prominent 19- hydroxylase of prostaglandin endoperoxides. (PMID: 10791960) Bylund J. … Oliw E.H. (J. Biol. Chem. 2000) 3 4 23
  5. Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. (PMID: 16112640) Stark K. … Oliw E.H. (Arch. Biochem. Biophys. 2005) 3 4

Products for CYP4F8 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP4F8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4F8
    • Block miRNA regulation of CYP4F8 using miScript Target Protectors
    • antibodies-online peptides for CYP4F8
    • antibodies-online antibodies for CYP4F8
    • antibodies-online kits for CYP4F8

    Sources for CYP4F8 Gene

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