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Aliases for CHRM1 Gene

Aliases for CHRM1 Gene

  • Cholinergic Receptor, Muscarinic 1 2 3
  • Acetylcholine Receptor, Muscarinic 1 3
  • Muscarinic Acetylcholine Receptor M1 3
  • Acetylcholine Receptor 2
  • Muscarinic 1 2
  • HM1 3
  • M1R 3
  • M1 3

External Ids for CHRM1 Gene

Previous GeneCards Identifiers for CHRM1 Gene

  • GC11M065188
  • GC11M064251
  • GC11M062452
  • GC11M062453
  • GC11M062432
  • GC11M062677
  • GC11M059005
  • GC11M062692
  • GC11M062695
  • GC11M062714

Summaries for CHRM1 Gene

Entrez Gene Summary for CHRM1 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM1 Gene

CHRM1 (Cholinergic Receptor, Muscarinic 1) is a Protein Coding gene. Diseases associated with CHRM1 include central nervous system disease and nervous system disease. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include drug binding and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for CHRM1 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Tocris Summary for CHRM1 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists could prove useful in the research and treatment of a wide range of central nervous system diseases including Alzheimer's and Parkinson's.

Gene Wiki entry for CHRM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM1 Gene

Genomics for CHRM1 Gene

Regulatory Elements for CHRM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHRM1 Gene

62,908,679 bp from pter
62,921,807 bp from pter
13,129 bases
Minus strand

Genomic View for CHRM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRM1 Gene

Proteins for CHRM1 Gene

  • Protein details for CHRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Muscarinic acetylcholine receptor M1
    Protein Accession:
    Secondary Accessions:
    • Q96RH1

    Protein attributes for CHRM1 Gene

    460 amino acids
    Molecular mass:
    51421 Da
    Quaternary structure:
    • Interacts with GPRASP2.

    Alternative splice isoforms for CHRM1 Gene


neXtProt entry for CHRM1 Gene

Proteomics data for CHRM1 Gene at MOPED

Post-translational modifications for CHRM1 Gene

  • Glycosylation at Asn2 and Asn12
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRM1 Gene

Domains for CHRM1 Gene

Gene Families for CHRM1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
genes like me logo Genes that share domains with CHRM1: view

Function for CHRM1 Gene

Molecular function for CHRM1 Gene

GENATLAS Biochemistry:
cholinergic receptor,muscarinic 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Gene Ontology (GO) - Molecular Function for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 9614217
GO:0004930 G-protein coupled receptor activity --
GO:0008144 drug binding IEA --
GO:0016907 G-protein coupled acetylcholine receptor activity IEA --
genes like me logo Genes that share ontologies with CHRM1: view
genes like me logo Genes that share phenotypes with CHRM1: view

Animal Models for CHRM1 Gene

MGI Knock Outs for CHRM1:

Animal Model Products

miRNA for CHRM1 Gene

miRTarBase miRNAs that target CHRM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CHRM1 Gene

Localization for CHRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CHRM1 Gene COMPARTMENTS Subcellular localization image for CHRM1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane TAS 7925360
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CHRM1: view

Pathways for CHRM1 Gene

genes like me logo Genes that share pathways with CHRM1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 1411529
GO:0007165 signal transduction TAS 3443095
GO:0007186 G-protein coupled receptor signaling pathway TAS 7925360
GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 9603968
genes like me logo Genes that share ontologies with CHRM1: view

Drugs for CHRM1 Gene

(86) Drugbank Compounds for CHRM1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (-)-Cocaine
50-36-2 Target antagonist approved, illicit
  • Abilify
129722-12-9 60795 Target antagonist approved, investigational
  • (S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
133099-04-4 444031 Target antagonist approved, investigational
  • (+)-Citalopram
128196-01-0 146570 Target antagonist approved, investigational
  • AHR-504
596-51-0 3494 Target antagonist approved, investigational

(5) Tocris Compounds for CHRM1 Gene

Compound Action Cas Number
Cevimeline hydrochloride Selective M1 agonist [107220-28-0]
McN-A 343 Selective M1 muscarinic agonist [55-45-8]
Pirenzepine dihydrochloride Selective M1 muscarinic antagonist [29868-97-1]
VU 0255035 Highly selective muscarinic M1 antagonist [1135243-19-4]
Xanomeline oxalate Functionally selective M1 agonist [141064-23-5]

(14) ApexBio Compounds for CHRM1 Gene

Compound Action Cas Number
5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) [207679-81-0]
Aclidinium Bromide LAMAs antagonist [320345-99-1]
Arecoline hydrobromide Muscarinic receptor agonist [300-08-3]
Biperiden HCl Anticholinergic drug [1235-82-1]
Darifenacin HBr [133099-07-7]
Dicyclomine HCl [67-92-5]
Diphenylpyraline HCl [132-18-3]
Fesoterodine Fumarate [286930-03-8]
Mepenzolate Bromide mAChR antagonist [76-90-4]
Pridinol Methanesulfonate [6856-31-1]
Scopolamine butylbromide [149-64-4]
Scopolamine hydrobromide [114-49-8]
Solifenacin succinate Muscarinic receptor antagonist [242478-38-2]
Tolterodine tartrate [124937-52-6]

(66) HMDB Compounds for CHRM1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Amoxepine
Anisotropine Methylbromide
  • 1,2,5,6-Tetrahydro-1-methylnicotinic acid, methyl ester
  • Abilify
  • Atropin [German]

(66) IUPHAR Ligand for CHRM1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]QNB None None 10.7
N-methyl scopolamine Antagonist Antagonist 10.4
propantheline Antagonist Antagonist 10
atropine Antagonist Antagonist 9.7
[3H]N-methyl scopolamine Antagonist Antagonist 9.7
tripitramine Antagonist Antagonist 9.6
[3H]darifenacin Antagonist Antagonist 9.5
scopolamine Antagonist Antagonist 9.4
4-DAMP Antagonist Antagonist 9
ipratropium Antagonist Antagonist 8.8
darifenacin Antagonist Antagonist 8.6
NNC 11-1585 Agonist Full agonist 8.3
NNC 11-1607 Agonist Full agonist 8.2
pentylthio-TZTP Agonist Full agonist 8.1
[3H]pirenzepine Antagonist Antagonist 7.9
NNC 11-1314 Agonist Full agonist 7.8
N-desmethylclozapine Allosteric regulator Positive 7.3
methoctramine Antagonist Antagonist 7.2
HHSiD Antagonist Antagonist 7.2
sabcomeline Agonist Partial agonist 7.1
MT1 Antagonist Antagonist 7.1
pirenzepine Antagonist Antagonist 6.9
clozapine Antagonist Antagonist 6.7
himbacine Antagonist Antagonist 6.5
KT 5720 Allosteric regulator Neutral 6.4
p-F-HHSiD Antagonist Antagonist 6.3
AFDX384 Antagonist Antagonist 6.3
AC-42 Allosteric regulator Negative 6.2
acetylcholine Agonist Full agonist 6.1
MT3 Antagonist Antagonist 6
xanomeline Agonist Full agonist 5.9
MT2 Antagonist Antagonist 5.9
alcuronium Allosteric regulator Negative 5.8
arecaidine propargyl ester Agonist Full agonist 5.7
vincamine Allosteric regulator Neutral 5.7
KT 5823 Allosteric regulator Positive 5.7
AF-DX 116 Antagonist Antagonist 5.6
VU0255035 Antagonist Antagonist 5.6
(+)aceclidine Agonist Full agonist 5.5
WIN 51,708 Allosteric regulator Negative 5.5
milameline Agonist Partial agonist 5.4
arecoline Agonist Full agonist 5.4
oxotremorine Agonist Full agonist 5.3
staurosporine Allosteric regulator Neutral 5.3
eburnamonine Allosteric regulator Neutral 5.2
(-)aceclidine Agonist Partial agonist 5.1
oxotremorine-M Agonist Full agonist 5.1
Gouml 7874 Allosteric regulator Negative 5.1
WIN 62,577 Allosteric regulator Positive 5.1
K-252a Allosteric regulator Positive 5.1
pilocarpine Agonist Partial agonist 5
MT7 Antagonist Antagonist 5
carbachol Agonist Full agonist 4.9
McN-A-343 Agonist Partial agonist 4.9
(-)YM796 Agonist Partial agonist 4.8
(plusmn)YM796 Agonist Partial agonist 4.7
methylfurmethide Agonist Full agonist 4.6
N-chloromethyl-brucine Allosteric regulator Negative 4.4
thiochrome Allosteric regulator Neutral 4.4
bethanechol Agonist Full agonist 4.2
furmethide Agonist Full agonist 4.1
N-benzyl brucine Allosteric regulator Neutral 3.7
brucine Allosteric regulator Negative 2.9
brucine N-oxide Allosteric regulator Positive 2.3
strychnine Antagonist Antagonist
[11C]xanomeline None None

(49) Novoseek inferred chemical compound relationships for CHRM1 Gene

Compound -log(P) Hits PubMed IDs
iqnp 82.5 2
oxotremorine m 79.4 3
xanomeline 78.7 3
carbachol 78.3 25
pirenzepine 77.8 10
genes like me logo Genes that share compounds with CHRM1: view

Compound Products

Transcripts for CHRM1 Gene

mRNA/cDNA for CHRM1 Gene

Unigene Clusters for CHRM1 Gene

Cholinergic receptor, muscarinic 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM1 Gene

No ASD Table

Relevant External Links for CHRM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRM1 Gene

mRNA expression in normal human tissues for CHRM1 Gene

mRNA differential expression in normal tissues according to GTEx for CHRM1 Gene

This gene is overexpressed in Brain - Cortex (8.8), Brain - Frontal Cortex (BA9) (7.2), Brain - Nucleus accumbens (basal ganglia) (5.7), Brain - Anterior cingulate cortex (BA24) (5.6), Brain - Putamen (basal ganglia) (5.3), Brain - Hippocampus (4.4), and Brain - Caudate (basal ganglia) (4.2).

Protein differential expression in normal tissues for CHRM1 Gene

This gene is overexpressed in Ovary (50.2) and Liver (17.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHRM1 Gene

SOURCE GeneReport for Unigene cluster for CHRM1 Gene Hs.632119

genes like me logo Genes that share expressions with CHRM1: view

Expression partners for CHRM1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHRM1 Gene

Orthologs for CHRM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHRM1 35
  • 93.04 (n)
  • 98.91 (a)
CHRM1 36
  • 97 (a)
(Canis familiaris)
Mammalia CHRM1 35
  • 92.39 (n)
  • 98.04 (a)
CHRM1 36
  • 98 (a)
(Mus musculus)
Mammalia Chrm1 35
  • 91.38 (n)
  • 98.91 (a)
Chrm1 16
Chrm1 36
  • 99 (a)
(Pan troglodytes)
Mammalia CHRM1 35
  • 99.86 (n)
  • 100 (a)
CHRM1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Chrm1 35
  • 91.59 (n)
  • 98.7 (a)
(Monodelphis domestica)
Mammalia CHRM1 36
  • 89 (a)
(Anolis carolinensis)
Reptilia CHRM1 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490434 35
  • 62.54 (n)
  • 64.68 (a)
(Danio rerio)
Actinopterygii CHRM1 (1 of 2) 36
  • 45 (a)
CU019640.1 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7918 37
  • 37 (a)
mAcR-60C 37
  • 55 (a)
mAcR-60C 35
  • 63.75 (n)
  • 57.93 (a)
mAcR-60C 36
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRMAC1 35
  • 59.98 (n)
  • 55.56 (a)
(Caenorhabditis elegans)
Secernentea gar-3 35
  • 50.95 (n)
  • 46.87 (a)
gar-3 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for CHRM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRM1 Gene

Gene Tree for CHRM1 (if available)
Gene Tree for CHRM1 (if available)

Paralogs for CHRM1 Gene

Paralogs for CHRM1 Gene

(16) SIMAP similar genes for CHRM1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHRM1: view

Variants for CHRM1 Gene

Sequence variations from dbSNP and Humsavar for CHRM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs509813 -- 62,921,701(+) CTCCC(C/G)CCAGC upstream-variant-2KB
rs542269 -- 62,918,065(+) CCTGC(C/T)CTTGA intron-variant
rs544978 -- 62,917,758(+) TAATA(A/C)TATCA intron-variant
rs1065428 -- 62,911,038(-) AAGGG(G/T)CCCTG synonymous-codon, reference
rs1065429 -- 62,910,954(-) ATCTC(C/T)TTCAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CHRM1 Gene

Variant ID Type Subtype PubMed ID
nsv483055 CNV Loss 15286789
esv34011 CNV Loss 18971310

Relevant External Links for CHRM1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRM1 Gene

Disorders for CHRM1 Gene

(14) Novoseek inferred disease relationships for CHRM1 Gene

Disease -log(P) Hits PubMed IDs
cognitive disorder 50.5 1
alzheimers disease 49 7
congenital heart block 40.3 4
schizophrenia 32 7
lung diseases obstructive 19.9 1

Relevant External Links for CHRM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CHRM1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CHRM1 Gene

Publications for CHRM1 Gene

  1. Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. (PMID: 16874522) Lou X.Y. … Li M.D. (Hum. Genet. 2006) 3 23 48
  2. Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects. (PMID: 16931638) Maeda Y. … Nishimura M. (Am. J. Respir. Crit. Care Med. 2006) 3 23 48
  3. Muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia. (PMID: 19753311) Lin H.J. … Tsai F.J. (Mol. Vis. 2009) 3 23 48
  4. Pharmacological characterization of human m1 muscarinic acetylcholine receptors with double mutations at the junction of TM VI and the third extracellular domain. (PMID: 9732369) Huang X.P. … Messer W.S. (J. Pharmacol. Exp. Ther. 1998) 23 25 26
  5. Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. (PMID: 10374898) Moriya H. … Hirotsu I. (Life Sci. 1999) 23 25 26

Products for CHRM1 Gene

Sources for CHRM1 Gene

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