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Aliases for CHRM1 Gene

Aliases for CHRM1 Gene

  • Cholinergic Receptor, Muscarinic 1 2 3
  • Acetylcholine Receptor, Muscarinic 1 3
  • Muscarinic Acetylcholine Receptor M1 3
  • Acetylcholine Receptor 2
  • Muscarinic 1 2
  • HM1 3
  • M1R 3
  • M1 3

External Ids for CHRM1 Gene

Previous GeneCards Identifiers for CHRM1 Gene

  • GC11M065188
  • GC11M064251
  • GC11M062452
  • GC11M062453
  • GC11M062432
  • GC11M062677
  • GC11M059005
  • GC11M062692
  • GC11M062695
  • GC11M062714

Summaries for CHRM1 Gene

Entrez Gene Summary for CHRM1 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM1 Gene

CHRM1 (Cholinergic Receptor, Muscarinic 1) is a Protein Coding gene. Diseases associated with CHRM1 include central nervous system disease and nervous system disease. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include drug binding and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for CHRM1 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Tocris Summary for CHRM1 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists could prove useful in the research and treatment of a wide range of central nervous system diseases including Alzheimer's and Parkinson's.

Gene Wiki entry for CHRM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM1 Gene

Genomics for CHRM1 Gene

Regulatory Elements for CHRM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHRM1 Gene

Start:
62,908,679 bp from pter
End:
62,921,807 bp from pter
Size:
13,129 bases
Orientation:
Minus strand

Genomic View for CHRM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRM1 Gene

Proteins for CHRM1 Gene

  • Protein details for CHRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11229-ACM1_HUMAN
    Recommended name:
    Muscarinic acetylcholine receptor M1
    Protein Accession:
    P11229
    Secondary Accessions:
    • Q96RH1

    Protein attributes for CHRM1 Gene

    Size:
    460 amino acids
    Molecular mass:
    51421 Da
    Quaternary structure:
    • Interacts with GPRASP2.

    Alternative splice isoforms for CHRM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHRM1 Gene

Proteomics data for CHRM1 Gene at MOPED

Post-translational modifications for CHRM1 Gene

  • Glycosylation at Asn2 and Asn12
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRM1 Gene

Domains for CHRM1 Gene

Gene Families for CHRM1 Gene

HGNC:
  • CHR :Cholinergic receptors
  • CHRM :GPCR / Class A : Cholinergic receptors, muscarinic
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P11229

UniProtKB/Swiss-Prot:

ACM1_HUMAN :
  • P11229
Family:
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
genes like me logo Genes that share domains with CHRM1: view

Function for CHRM1 Gene

Molecular function for CHRM1 Gene

GENATLAS Biochemistry: cholinergic receptor,muscarinic 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Gene Ontology (GO) - Molecular Function for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 9614217
GO:0004930 G-protein coupled receptor activity --
GO:0008144 drug binding IEA --
GO:0016907 G-protein coupled acetylcholine receptor activity IEA --
genes like me logo Genes that share ontologies with CHRM1: view
genes like me logo Genes that share phenotypes with CHRM1: view

Animal Models for CHRM1 Gene

MGI Knock Outs for CHRM1:

Animal Model Products

CRISPR Products

miRNA for CHRM1 Gene

miRTarBase miRNAs that target CHRM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CHRM1 Gene

Localization for CHRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRM1 Gene COMPARTMENTS Subcellular localization image for CHRM1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane TAS 7925360
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CHRM1: view

Pathways for CHRM1 Gene

genes like me logo Genes that share pathways with CHRM1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 1411529
GO:0007165 signal transduction TAS 3443095
GO:0007186 G-protein coupled receptor signaling pathway TAS 7925360
GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 9603968
genes like me logo Genes that share ontologies with CHRM1: view

Compounds for CHRM1 Gene

(5) Tocris Compounds for CHRM1 Gene

Compound Action Cas Number
Cevimeline hydrochloride Selective M1 agonist [107220-28-0]
McN-A 343 Selective M1 muscarinic agonist [55-45-8]
Pirenzepine dihydrochloride Selective M1 muscarinic antagonist [29868-97-1]
VU 0255035 Highly selective muscarinic M1 antagonist [1135243-19-4]
Xanomeline oxalate Functionally selective M1 agonist [141064-23-5]

(3) HMDB Compounds for CHRM1 Gene

Compound Synonyms Cas Number PubMed IDs
Doxylamine
  • Alsadorm
562-10-7
Olanzapine
  • Lanzac
132539-06-1
Scopolamine
  • (+)-Hyoscine
51-34-3

(75) Drugbank Compounds for CHRM1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aclidinium
  • 14115700
320345-99-1 target antagonist
Amitriptyline
  • Amitriprolidine
50-48-6 target antagonist
Amoxapine
14028-44-5 target antagonist
Anisotropine Methylbromide
80-50-2 target antagonist
Arecoline
63-75-2 target

(66) IUPHAR Ligand for CHRM1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]QNB None None 10.7
N-methyl scopolamine Antagonist Antagonist 10.4
propantheline Antagonist Antagonist 10
[3H]N-methyl scopolamine Antagonist Antagonist 9.7
atropine Antagonist Antagonist 9.7
tripitramine Antagonist Antagonist 9.6
[3H]darifenacin Antagonist Antagonist 9.5
scopolamine Antagonist Antagonist 9.4
4-DAMP Antagonist Antagonist 9
ipratropium Antagonist Antagonist 8.8
darifenacin Antagonist Antagonist 8.6
NNC 11-1585 Agonist Full agonist 8.3
NNC 11-1607 Agonist Full agonist 8.2
pentylthio-TZTP Agonist Full agonist 8.1
[3H]pirenzepine Antagonist Antagonist 7.9
NNC 11-1314 Agonist Full agonist 7.8
N-desmethylclozapine Allosteric regulator Positive 7.3
HHSiD Antagonist Antagonist 7.2
methoctramine Antagonist Antagonist 7.2
MT1 Antagonist Antagonist 7.1
sabcomeline Agonist Partial agonist 7.1
pirenzepine Antagonist Antagonist 6.9
clozapine Antagonist Antagonist 6.7
himbacine Antagonist Antagonist 6.5
KT 5720 Allosteric regulator Neutral 6.4
p-F-HHSiD Antagonist Antagonist 6.3
AFDX384 Antagonist Antagonist 6.3
AC-42 Allosteric regulator Negative 6.2
acetylcholine Agonist Full agonist 6.1
MT3 Antagonist Antagonist 6
xanomeline Agonist Full agonist 5.9
MT2 Antagonist Antagonist 5.9
alcuronium Allosteric regulator Negative 5.8
arecaidine propargyl ester Agonist Full agonist 5.7
KT 5823 Allosteric regulator Positive 5.7
vincamine Allosteric regulator Neutral 5.7
VU0255035 Antagonist Antagonist 5.6
AF-DX 116 Antagonist Antagonist 5.6
WIN 51,708 Allosteric regulator Negative 5.5
(+)aceclidine Agonist Full agonist 5.5
arecoline Agonist Full agonist 5.4
milameline Agonist Partial agonist 5.4
staurosporine Allosteric regulator Neutral 5.3
oxotremorine Agonist Full agonist 5.3
eburnamonine Allosteric regulator Neutral 5.2
Gouml 7874 Allosteric regulator Negative 5.1
WIN 62,577 Allosteric regulator Positive 5.1
K-252a Allosteric regulator Positive 5.1
oxotremorine-M Agonist Full agonist 5.1
(-)aceclidine Agonist Partial agonist 5.1
MT7 Antagonist Antagonist 5
pilocarpine Agonist Partial agonist 5
carbachol Agonist Full agonist 4.9
McN-A-343 Agonist Partial agonist 4.9
(-)YM796 Agonist Partial agonist 4.8
(plusmn)YM796 Agonist Partial agonist 4.7
methylfurmethide Agonist Full agonist 4.6
thiochrome Allosteric regulator Neutral 4.4
N-chloromethyl-brucine Allosteric regulator Negative 4.4
bethanechol Agonist Full agonist 4.2
furmethide Agonist Full agonist 4.1
N-benzyl brucine Allosteric regulator Neutral 3.7
brucine Allosteric regulator Negative 2.9
brucine N-oxide Allosteric regulator Positive 2.3
strychnine Antagonist Antagonist
[11C]xanomeline None None

(49) Novoseek inferred chemical compound relationships for CHRM1 Gene

Compound -log(P) Hits PubMed IDs
iqnp 82.5 2
oxotremorine m 79.4 3
xanomeline 78.7 3
carbachol 78.3 25
pirenzepine 77.8 10
genes like me logo Genes that share compounds with CHRM1: view

Transcripts for CHRM1 Gene

mRNA/cDNA for CHRM1 Gene

Unigene Clusters for CHRM1 Gene

Cholinergic receptor, muscarinic 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM1 Gene

No ASD Table

Relevant External Links for CHRM1 Gene

GeneLoc Exon Structure for
CHRM1
ECgene alternative splicing isoforms for
CHRM1

Expression for CHRM1 Gene

mRNA expression in normal human tissues for CHRM1 Gene

mRNA differential expression in normal tissues according to GTEx for CHRM1 Gene

This gene is overexpressed in Brain - Cortex (8.8), Brain - Frontal Cortex (BA9) (7.2), Brain - Nucleus accumbens (basal ganglia) (5.7), Brain - Anterior cingulate cortex (BA24) (5.6), Brain - Putamen (basal ganglia) (5.3), Brain - Hippocampus (4.4), and Brain - Caudate (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHRM1 Gene

SOURCE GeneReport for Unigene cluster for CHRM1 Gene Hs.632119

genes like me logo Genes that share expressions with CHRM1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHRM1 Gene

Orthologs for CHRM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRM1 35
  • 99.86 (n)
  • 100 (a)
CHRM1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHRM1 35
  • 93.04 (n)
  • 98.91 (a)
CHRM1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRM1 35
  • 92.39 (n)
  • 98.04 (a)
CHRM1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrm1 35
  • 91.38 (n)
  • 98.91 (a)
Chrm1 16
Chrm1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHRM1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrm1 35
  • 91.59 (n)
  • 98.7 (a)
lizard
(Anolis carolinensis)
Reptilia CHRM1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490434 35
  • 62.54 (n)
  • 64.68 (a)
zebrafish
(Danio rerio)
Actinopterygii CHRM1 (1 of 2) 36
  • 45 (a)
OneToMany
CU019640.1 36
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRMAC1 35
  • 59.98 (n)
  • 55.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta mAcR-60C 35
  • 63.75 (n)
  • 57.93 (a)
mAcR-60C 36
  • 24 (a)
OneToMany
mAcR-60C 37
  • 55 (a)
CG7918 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea gar-3 35
  • 50.95 (n)
  • 46.87 (a)
gar-3 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for CHRM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRM1 Gene

ENSEMBL:
Gene Tree for CHRM1 (if available)
TreeFam:
Gene Tree for CHRM1 (if available)

Paralogs for CHRM1 Gene

Paralogs for CHRM1 Gene

Selected SIMAP similar genes for CHRM1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHRM1: view

Variants for CHRM1 Gene

Sequence variations from dbSNP and Humsavar for CHRM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs509813 -- 62,921,701(+) CTCCC(C/G)CCAGC upstream-variant-2KB
rs542269 -- 62,918,065(+) CCTGC(C/T)CTTGA intron-variant
rs544978 -- 62,917,758(+) TAATA(A/C)TATCA intron-variant
rs1065428 -- 62,911,038(-) AAGGG(G/T)CCCTG synonymous-codon, reference
rs1065429 -- 62,910,954(-) ATCTC(C/T)TTCAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CHRM1 Gene

Variant ID Type Subtype PubMed ID
nsv483055 CNV Loss 15286789
esv34011 CNV Loss 18971310

Relevant External Links for CHRM1 Gene

HapMap Linkage Disequilibrium report
CHRM1
Human Gene Mutation Database (HGMD)
CHRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRM1 Gene

Disorders for CHRM1 Gene

(14) Novoseek inferred disease relationships for CHRM1 Gene

Disease -log(P) Hits PubMed IDs
cognitive disorder 50.5 1
alzheimers disease 49 7
congenital heart block 40.3 4
schizophrenia 32 7
lung diseases obstructive 19.9 1

Relevant External Links for CHRM1

Genetic Association Database (GAD)
CHRM1
Human Genome Epidemiology (HuGE) Navigator
CHRM1
genes like me logo Genes that share disorders with CHRM1: view

No data available for UniProtKB/Swiss-Prot for CHRM1 Gene

Publications for CHRM1 Gene

  1. Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. (PMID: 16874522) Lou X.Y. … Li M.D. (Hum. Genet. 2006) 3 23 48
  2. Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects. (PMID: 16931638) Maeda Y. … Nishimura M. (Am. J. Respir. Crit. Care Med. 2006) 3 23 48
  3. Muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia. (PMID: 19753311) Lin H.J. … Tsai F.J. (Mol. Vis. 2009) 3 23 48
  4. Immunohistochemical localisation of cholinergic muscarinic receptor subtype 1 (M1r) in the guinea pig and human enteric nervous system. (PMID: 17462859) Harrington A.M. … Southwell B.R. (J. Chem. Neuroanat. 2007) 3 23
  5. Intact coupling of M1 receptors and preserved M2 and M4 receptors in the cortex in progressive supranuclear palsy: contrast with other dementias. (PMID: 18282687) Warren N.M. … Burn D.J. (J. Chem. Neuroanat. 2008) 3 23

Products for CHRM1 Gene

Sources for CHRM1 Gene

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