Aliases for KLF12 Gene
External Ids for KLF12 Gene
Previous GeneCards Identifiers for KLF12 Gene
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLF12 Gene
KLF12 (Kruppel-Like Factor 12) is a Protein Coding gene. Diseases associated with KLF12 include Wegener Granulomatosis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is KLF8.
UniProtKB/Swiss-Prot for KLF12 Gene
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.