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Aliases for STX1B Gene

Aliases for STX1B Gene

  • Syntaxin 1B 2 3
  • Syntaxin-1B1 3 4
  • Syntaxin-1B2 3 4
  • STX1B1 3 4
  • STX1B2 3 4
  • Syntaxin 1B1 2
  • Syntaxin 1B2 2
  • Syntaxin-1B 3
  • GEFSP9 3

External Ids for STX1B Gene

Previous HGNC Symbols for STX1B Gene

  • STX1B1
  • STX1B2

Previous GeneCards Identifiers for STX1B Gene

  • GC16M030912
  • GC16M028563

Summaries for STX1B Gene

Entrez Gene Summary for STX1B Gene

  • The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015]

GeneCards Summary for STX1B Gene

STX1B (Syntaxin 1B) is a Protein Coding gene. Diseases associated with STX1B include generalized epilepsy with febrile seizures plus, type 9 and generalized epilepsy with febrile seizures plus. Among its related pathways are Disease and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein domain specific binding and SNAP receptor activity. An important paralog of this gene is STX4.

UniProtKB/Swiss-Prot for STX1B Gene

  • Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity).

Gene Wiki entry for STX1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX1B Gene

Genomics for STX1B Gene

Regulatory Elements for STX1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STX1B Gene

30,989,256 bp from pter
31,010,628 bp from pter
21,373 bases
Minus strand

Genomic View for STX1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX1B Gene

Proteins for STX1B Gene

  • Protein details for STX1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q15531
    • Q2VPS2

    Protein attributes for STX1B Gene

    288 amino acids
    Molecular mass:
    33245 Da
    Quaternary structure:
    • Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity).

    Alternative splice isoforms for STX1B Gene


neXtProt entry for STX1B Gene

Proteomics data for STX1B Gene at MOPED

Post-translational modifications for STX1B Gene

Other Protein References for STX1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STX1B Gene

Domains for STX1B Gene

Protein Domains for STX1B Gene

Suggested Antigen Peptide Sequences for STX1B Gene

Graphical View of Domain Structure for InterPro Entry



  • P61266
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX1B: view

No data available for Gene Families for STX1B Gene

Function for STX1B Gene

Molecular function for STX1B Gene

GENATLAS Biochemistry: syntaxin 1B,brain,forming a synaptic core complex with synaptosome associated proteins,and synaptobrevin,binding to N-type Ca2+ channels,involved in vesicular transport and in Ca2 dependent synaptic transmission,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
UniProtKB/Swiss-Prot Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity).

Gene Ontology (GO) - Molecular Function for STX1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding --
GO:0019901 protein kinase binding ISS --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with STX1B: view
genes like me logo Genes that share phenotypes with STX1B: view

Animal Model Products

miRNA for STX1B Gene

miRTarBase miRNAs that target STX1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX1B Gene

Localization for STX1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX1B Gene

Isoform 1: Membrane; Single-pass type IV membrane protein.
Isoform 2: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.

Subcellular locations from

Jensen Localization Image for STX1B Gene COMPARTMENTS Subcellular localization image for STX1B gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for STX1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STX1B: view

Pathways for STX1B Gene

genes like me logo Genes that share pathways with STX1B: view

Pathways by source for STX1B Gene

1 Qiagen pathway for STX1B Gene
1 BioSystems pathway for STX1B Gene
2 Reactome pathways for STX1B Gene

Gene Ontology (GO) - Biological Process for STX1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001956 positive regulation of neurotransmitter secretion ISS --
GO:0006886 intracellular protein transport IBA --
GO:0010468 regulation of gene expression ISS --
GO:0010807 regulation of synaptic vesicle priming ISS --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with STX1B: view

Transcripts for STX1B Gene

mRNA/cDNA for STX1B Gene

Unigene Clusters for STX1B Gene

Syntaxin 1B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX1B Gene

No ASD Table

Relevant External Links for STX1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX1B Gene

mRNA expression in normal human tissues for STX1B Gene

mRNA differential expression in normal tissues according to GTEx for STX1B Gene

This gene is overexpressed in Brain - Cerebellum (7.0), Brain - Cortex (6.8), Brain - Cerebellar Hemisphere (6.4), Brain - Frontal Cortex (BA9) (5.8), and Brain - Anterior cingulate cortex (BA24) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX1B Gene

SOURCE GeneReport for Unigene cluster for STX1B Gene Hs.542230

genes like me logo Genes that share expressions with STX1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for STX1B Gene

Orthologs for STX1B Gene

This gene was present in the common ancestor of animals.

Orthologs for STX1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX1B 35
  • 99.88 (n)
  • 100 (a)
STX1B 36
  • 100 (a)
(Bos Taurus)
Mammalia STX1B 35
  • 93.63 (n)
  • 99.65 (a)
STX1B 36
  • 100 (a)
(Canis familiaris)
Mammalia STX1B 35
  • 95.56 (n)
  • 100 (a)
STX1B 36
  • 100 (a)
(Mus musculus)
Mammalia Stx1b 35
  • 92.13 (n)
  • 100 (a)
Stx1b 16
Stx1b 36
  • 100 (a)
(Monodelphis domestica)
Mammalia STX1B 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Stx1b 35
  • 90.97 (n)
  • 100 (a)
(Anolis carolinensis)
Reptilia STX1B 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stx1b 35
  • 84.03 (n)
  • 98.61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12062 35
(Danio rerio)
Actinopterygii stx1b 35
  • 82.18 (n)
  • 96.87 (a)
stx1b 36
  • 97 (a)
syntaxin1b 35
fruit fly
(Drosophila melanogaster)
Insecta Syx1A 36
  • 67 (a)
(Caenorhabditis elegans)
Secernentea unc-64 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
Species with no ortholog for STX1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX1B Gene

Gene Tree for STX1B (if available)
Gene Tree for STX1B (if available)

Paralogs for STX1B Gene

Paralogs for STX1B Gene

Selected SIMAP similar genes for STX1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STX1B: view

Variants for STX1B Gene

Sequence variations from dbSNP and Humsavar for STX1B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs729482 -- 31,005,649(-) AGAAT(A/G)TGACC intron-variant
rs2014236 -- 31,004,412(-) acagg(C/T)gtgag intron-variant
rs2199036 -- 30,995,651(+) atgcc(C/T)ggcta intron-variant
rs2335012 -- 31,004,675(-) tttaa(A/G)aaacg intron-variant
rs3186882 -- 30,997,536(+) AGGAA(A/C)GGTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STX1B Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
nsv905733 CNV Loss 21882294
dgv35n68 CNV Loss 17160897
dgv2670n71 CNV Loss 21882294
dgv2671n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897
nsv905739 CNV Loss 21882294
esv270787 CNV Insertion 20981092

Relevant External Links for STX1B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX1B Gene

Disorders for STX1B Gene


  • Generalized epilepsy with febrile seizures plus 9 (GEFSP9) [MIM:616172]: An autosomal dominant neurologic disorder characterized by febrile and/or afebrile seizures manifesting in early childhood. Seizure are variable and include generalized tonic-clonic, atonic, myoclonic, complex partial, and absence types. Most patients have remission of seizures later in childhood with no residual neurologic deficits. Rarely, patients may show mild developmental delay or mild intellectual disabilities. {ECO:0000269 PubMed:25362483}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for STX1B Gene

genes like me logo Genes that share disorders with STX1B: view

Publications for STX1B Gene

  1. Nuclear localization of a novel human syntaxin 1B isoform. (PMID: 18691641) Pereira S. … Szepetowski P. (Gene 2008) 3 4
  2. Mutations in STX1B, encoding a presynaptic protein, cause fever- associated epilepsy syndromes. (PMID: 25362483) Schubert J. … Lerche H. (Nat. Genet. 2014) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (PMID: 17500595) Kaltenbach L.S. … Hughes R.E. (PLoS Genet. 2007) 3
  5. The RIT2 and STX1B polymorphisms are associated with Parkinson's disease. (PMID: 25534083) Wang J.Y. … Zhu J.H. (Parkinsonism Relat. Disord. 2015) 3

Products for STX1B Gene

Sources for STX1B Gene

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