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Aliases for SNX18 Gene

Aliases for SNX18 Gene

  • Sorting Nexin 18 2 3 5
  • Sorting Nexin Associated Golgi Protein 1 2 3
  • Sorting Nexin-Associated Golgi Protein 1 3 4
  • SH3 And PX Domain-Containing Protein 3B 3 4
  • SH3PXD3B 3 4
  • SNAG1 3 4
  • Sorting Nexin-18 3
  • SH3PX2 3

External Ids for SNX18 Gene

Previous HGNC Symbols for SNX18 Gene

  • SNAG1

Previous GeneCards Identifiers for SNX18 Gene

  • GC05P053850
  • GC05P050787

Summaries for SNX18 Gene

Entrez Gene Summary for SNX18 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX18 Gene

SNX18 (Sorting Nexin 18) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. GO annotations related to this gene include phosphatidylinositol binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is SNX33.

UniProtKB/Swiss-Prot for SNX18 Gene

  • Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.

Gene Wiki entry for SNX18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX18 Gene

Genomics for SNX18 Gene

Regulatory Elements for SNX18 Gene

Enhancers for SNX18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G054669 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.7 +154.3 154260 6.0 CTCF ESRRA ZIC2 RAD21 ZNF507 CTBP1 ZNF316 GATA3 POLR2A FOS SNX18 LOC100130990 CDC20B LOC105378969 LOC105378968
GH05G054624 1.1 FANTOM5 ENCODE 33.4 +108.0 108007 2.5 PKNOX1 ZFP64 FEZF1 RAD21 YY1 SCRT2 ZSCAN5C OVOL3 ZNF426 ZNF623 SNX18 DHX29 LOC105378967 LOC105378968
GH05G054831 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +317.7 317737 7.8 TAF1 RAD21 YY1 FOSL1 POLR2A GATA2 FOS MAFK RFX1 RNF2 SNX18 LOC100130990 CDC20B LOC102467080
GH05G054609 1.2 FANTOM5 Ensembl ENCODE 22.2 +93.1 93119 2.0 MTA2 BHLHE40 BACH1 JUNB BMI1 DPF2 TBX21 ARID3A IKZF1 ETV6 SNX18 LOC105378967 PIR52196
GH05G054741 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14 +226.4 226391 4.8 ATF1 CREB3L1 ARNT TCF12 ELK1 GATA2 FOS KLF13 CAVIN1 NCOA1 SNX18 LOC102467080 LOC105378969
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX18 on UCSC Golden Path with GeneCards custom track

Promoters for SNX18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180615 341 1801 ATF1 ARNT CREB3L1 AGO1 ARID4B SIN3A ZNF48 YY1 ZNF766 GLIS2

Genomic Location for SNX18 Gene

Chromosome:
5
Start:
54,517,759 bp from pter
End:
54,546,586 bp from pter
Size:
28,828 bases
Orientation:
Plus strand

Genomic View for SNX18 Gene

Genes around SNX18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX18 Gene

Proteins for SNX18 Gene

  • Protein details for SNX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RF0-SNX18_HUMAN
    Recommended name:
    Sorting nexin-18
    Protein Accession:
    Q96RF0
    Secondary Accessions:
    • B4E2B3
    • H7BXX3
    • Q05BB3
    • Q0VG02

    Protein attributes for SNX18 Gene

    Size:
    628 amino acids
    Molecular mass:
    68894 Da
    Quaternary structure:
    • Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex.

    Alternative splice isoforms for SNX18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX18 Gene

Post-translational modifications for SNX18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX18 Gene

Antibody Products

  • Abcam antibodies for SNX18
  • Santa Cruz Biotechnology (SCBT) Antibodies for SNX18

No data available for DME Specific Peptides for SNX18 Gene

Domains & Families for SNX18 Gene

Gene Families for SNX18 Gene

Protein Domains for SNX18 Gene

Suggested Antigen Peptide Sequences for SNX18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RF0

UniProtKB/Swiss-Prot:

SNX18_HUMAN :
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX18: view

Function for SNX18 Gene

Molecular function for SNX18 Gene

UniProtKB/Swiss-Prot Function:
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.

Gene Ontology (GO) - Molecular Function for SNX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20427313
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 23878278
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX18: view
genes like me logo Genes that share phenotypes with SNX18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX18 Gene

Localization for SNX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX18 Gene

Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX18 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for SNX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA --
GO:0010008 endosome membrane IEA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SNX18: view

Pathways & Interactions for SNX18 Gene

genes like me logo Genes that share pathways with SNX18: view

Pathways by source for SNX18 Gene

Gene Ontology (GO) - Biological Process for SNX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 22718350
GO:0006810 transport IEA --
GO:0006897 endocytosis IMP 22718350
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with SNX18: view

No data available for SIGNOR curated interactions for SNX18 Gene

Transcripts for SNX18 Gene

Unigene Clusters for SNX18 Gene

Sorting nexin 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX18 Gene

No ASD Table

Relevant External Links for SNX18 Gene

GeneLoc Exon Structure for
SNX18
ECgene alternative splicing isoforms for
SNX18

Expression for SNX18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX18 Gene

Protein differential expression in normal tissues from HIPED for SNX18 Gene

This gene is overexpressed in Ovary (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX18 Gene



Protein tissue co-expression partners for SNX18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNX18 Gene:

SNX18

SOURCE GeneReport for Unigene cluster for SNX18 Gene:

Hs.432755

Evidence on tissue expression from TISSUES for SNX18 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SNX18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX18 Gene

Orthologs for SNX18 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX18 34 35
  • 99.2 (n)
cow
(Bos Taurus)
Mammalia SNX18 34 35
  • 93.38 (n)
dog
(Canis familiaris)
Mammalia SNX18 34 35
  • 92.38 (n)
mouse
(Mus musculus)
Mammalia Snx18 34 16 35
  • 90.46 (n)
rat
(Rattus norvegicus)
Mammalia Snx18 34
  • 89.65 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX18 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SNX18 34 35
  • 84.94 (n)
lizard
(Anolis carolinensis)
Reptilia SNX18 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx18 34
  • 74.93 (n)
Str.3290 34
zebrafish
(Danio rerio)
Actinopterygii snx18a 34 35
  • 70.55 (n)
snx18b 35
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta SH3PX1 34 35
  • 54.02 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011751 34
  • 51.85 (n)
worm
(Caenorhabditis elegans)
Secernentea lst-4 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for SNX18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX18 Gene

ENSEMBL:
Gene Tree for SNX18 (if available)
TreeFam:
Gene Tree for SNX18 (if available)

Paralogs for SNX18 Gene

Paralogs for SNX18 Gene

(4) SIMAP similar genes for SNX18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNX18: view

Variants for SNX18 Gene

Sequence variations from dbSNP and Humsavar for SNX18 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000001095 -- 54,607,255(+) TGTGG(A/C/G)CCCCC intron-variant, utr-variant-3-prime
rs1000012986 -- 54,604,224(+) TCTCA(A/G)AAAGT intron-variant
rs1000062664 -- 54,602,489(+) GTTAG(C/T)GGTGG intron-variant
rs1000093310 -- 54,554,606(+) CTATG(A/T)ATTAA intron-variant
rs1000109432 -- 54,594,755(+) GTTTT(A/G)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX18 Gene

Variant ID Type Subtype PubMed ID
esv26784 CNV loss 19812545
esv2763881 CNV loss 21179565
esv34152 CNV loss 18971310
nsv968175 CNV duplication 23825009

Variation tolerance for SNX18 Gene

Residual Variation Intolerance Score: 8.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX18 Gene

Disorders for SNX18 Gene

Relevant External Links for SNX18

Genetic Association Database (GAD)
SNX18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX18

No disorders were found for SNX18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX18 Gene

Publications for SNX18 Gene

  1. SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1- positive endosomal trafficking. (PMID: 18411244) Haberg K. … Carlsson S.R. (J. Cell Sci. 2008) 3 4 22 64
  2. A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells. (PMID: 17761170) Thornhill P.B. … Desbarats J. (FEBS Lett. 2007) 2 3 22 64
  3. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. (PMID: 22718350) Ma M.P. … Chircop M. (J. Cell. Sci. 2012) 3 4 64
  4. SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane. (PMID: 20427313) Park J. … Chang S. (J. Cell Sci. 2010) 3 4 64
  5. The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain. (PMID: 20491914) Baumann C. … Levy F. (FEBS J. 2010) 3 4 64

Products for SNX18 Gene

Sources for SNX18 Gene

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