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Aliases for SNX18 Gene

Aliases for SNX18 Gene

  • Sorting Nexin 18 2 3
  • Sorting Nexin Associated Golgi Protein 1 2 3
  • Sorting Nexin-Associated Golgi Protein 1 3 4
  • SH3 And PX Domain-Containing Protein 3B 3 4
  • SH3PXD3B 3 4
  • SNAG1 3 4
  • Sorting Nexin-18 3
  • SH3PX2 3

External Ids for SNX18 Gene

Previous HGNC Symbols for SNX18 Gene

  • SNAG1

Previous GeneCards Identifiers for SNX18 Gene

  • GC05P053850
  • GC05P050787

Summaries for SNX18 Gene

Entrez Gene Summary for SNX18 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX18 Gene

SNX18 (Sorting Nexin 18) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX33.

UniProtKB/Swiss-Prot for SNX18 Gene

  • Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.

Gene Wiki entry for SNX18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX18 Gene

Genomics for SNX18 Gene

Regulatory Elements for SNX18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX18 Gene

Start:
54,517,759 bp from pter
End:
54,546,586 bp from pter
Size:
28,828 bases
Orientation:
Plus strand

Genomic View for SNX18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX18 Gene

Proteins for SNX18 Gene

  • Protein details for SNX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RF0-SNX18_HUMAN
    Recommended name:
    Sorting nexin-18
    Protein Accession:
    Q96RF0
    Secondary Accessions:
    • B4E2B3
    • H7BXX3
    • Q05BB3
    • Q0VG02

    Protein attributes for SNX18 Gene

    Size:
    628 amino acids
    Molecular mass:
    68894 Da
    Quaternary structure:
    • Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex.

    Alternative splice isoforms for SNX18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX18 Gene

Proteomics data for SNX18 Gene at MOPED

Post-translational modifications for SNX18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX18 Gene

No data available for DME Specific Peptides for SNX18 Gene

Domains for SNX18 Gene

Gene Families for SNX18 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX18 Gene

Suggested Antigen Peptide Sequences for SNX18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RF0

UniProtKB/Swiss-Prot:

SNX18_HUMAN :
  • Q96RF0
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate
  • Contains 1 BAR domain.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX18: view

Function for SNX18 Gene

Molecular function for SNX18 Gene

UniProtKB/Swiss-Prot Function: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.

Gene Ontology (GO) - Molecular Function for SNX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20427313
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 23878278
GO:0035091 phosphatidylinositol binding --
genes like me logo Genes that share ontologies with SNX18: view

Phenotypes for SNX18 Gene

GenomeRNAi human phenotypes for SNX18:
genes like me logo Genes that share phenotypes with SNX18: view

Animal Model Products

CRISPR Products

miRNA for SNX18 Gene

miRTarBase miRNAs that target SNX18

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX18 Gene

Localization for SNX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX18 Gene

Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX18 Gene COMPARTMENTS Subcellular localization image for SNX18 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SNX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0010008 endosome membrane IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IDA 22718350
GO:0030136 colocalizes_with clathrin-coated vesicle IDA 20427313
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with SNX18: view

Pathways for SNX18 Gene

SuperPathways for SNX18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 22718350
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IMP 22718350
GO:0007067 mitotic nuclear division IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with SNX18: view

No data available for Pathways by source for SNX18 Gene

Transcripts for SNX18 Gene

Unigene Clusters for SNX18 Gene

Sorting nexin 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX18

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SNX18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX18 Gene

No ASD Table

Relevant External Links for SNX18 Gene

GeneLoc Exon Structure for
SNX18
ECgene alternative splicing isoforms for
SNX18

Expression for SNX18 Gene

mRNA expression in normal human tissues for SNX18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX18 Gene

SOURCE GeneReport for Unigene cluster for SNX18 Gene Hs.432755

genes like me logo Genes that share expressions with SNX18: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX18 Gene

Orthologs for SNX18 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX18 35
  • 99.2 (n)
  • 99.68 (a)
SNX18 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX18 35
  • 93.38 (n)
  • 97.44 (a)
SNX18 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX18 35
  • 92.38 (n)
  • 95.39 (a)
SNX18 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx18 35
  • 90.46 (n)
  • 96.91 (a)
Snx18 16
Snx18 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX18 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Snx18 35
  • 89.65 (n)
  • 96.42 (a)
chicken
(Gallus gallus)
Aves SNX18 35
  • 84.94 (n)
  • 87.52 (a)
SNX18 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX18 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx18 35
  • 74.93 (n)
  • 73.31 (a)
Str.3290 35
zebrafish
(Danio rerio)
Actinopterygii snx18a 35
  • 70.55 (n)
  • 76.68 (a)
snx18a 36
  • 64 (a)
OneToMany
snx18b 36
  • 58 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011751 35
  • 51.85 (n)
  • 38.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta SH3PX1 35
  • 54.02 (n)
  • 40.64 (a)
SH3PX1 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lst-4 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for SNX18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX18 Gene

ENSEMBL:
Gene Tree for SNX18 (if available)
TreeFam:
Gene Tree for SNX18 (if available)

Paralogs for SNX18 Gene

Paralogs for SNX18 Gene

Selected SIMAP similar genes for SNX18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNX18: view

Variants for SNX18 Gene

Sequence variations from dbSNP and Humsavar for SNX18 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1611 -- 54,545,728(-) AGAAC(A/G)TTAGA utr-variant-3-prime
rs741583 -- 54,529,336(+) AGACT(A/G)CAGCC intron-variant
rs874180 -- 54,529,403(+) TTTTG(C/T)ATTTT intron-variant
rs980921 -- 54,540,554(-) GATGT(C/G)CATCC intron-variant
rs1003371 -- 54,542,641(-) ACAGT(C/T)ATGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX18 Gene

Variant ID Type Subtype PubMed ID
nsv880713 CNV Gain 21882294
dgv6067n71 CNV Gain 21882294
nsv881404 CNV Gain 21882294
dgv6069n71 CNV Gain 21882294
esv34152 CNV Loss 18971310
esv26784 CNV Loss 19812545

Relevant External Links for SNX18 Gene

HapMap Linkage Disequilibrium report
SNX18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX18 Gene

Disorders for SNX18 Gene

Relevant External Links for SNX18

Genetic Association Database (GAD)
SNX18
genes like me logo Genes that share disorders with SNX18: view

No data available for UniProtKB/Swiss-Prot for SNX18 Gene

Publications for SNX18 Gene

  1. A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells. (PMID: 17761170) Thornhill P.B. … Desbarats J. (FEBS Lett. 2007) 2 3 23
  2. SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1- positive endosomal trafficking. (PMID: 18411244) Haberg K. … Carlsson S.R. (J. Cell Sci. 2008) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. (PMID: 22718350) Ma M.P. … Chircop M. (J. Cell. Sci. 2012) 3 4
  5. SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane. (PMID: 20427313) Park J. … Chang S. (J. Cell Sci. 2010) 3 4

Products for SNX18 Gene

Sources for SNX18 Gene

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