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Aliases for SLC6A14 Gene

Aliases for SLC6A14 Gene

  • Solute Carrier Family 6 (Amino Acid Transporter), Member 14 2 3
  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 14 2 3
  • Amino Acid Transporter ATB0+ 3 4
  • BMIQ11 3 6
  • Sodium- And Chloride-Dependent Neutral And Basic Amino Acid Transporter B(0+) 3
  • Solute Carrier Family 6 Member 14 4
  • Amino Acid Transporter B0+ 3
  • OBX 6

External Ids for SLC6A14 Gene

Summaries for SLC6A14 Gene

Entrez Gene Summary for SLC6A14 Gene

  • This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]

GeneCards Summary for SLC6A14 Gene

SLC6A14 (Solute Carrier Family 6 (Amino Acid Transporter), Member 14) is a Protein Coding gene. Diseases associated with SLC6A14 include obesity bmiq11 and meconium ileus. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neurotransmitter:sodium symporter activity and amino acid transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC6A14 Gene

  • Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner.

Gene Wiki entry for SLC6A14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A14 Gene

Genomics for SLC6A14 Gene

Genomic Location for SLC6A14 Gene

Start:
116,436,579 bp from pter
End:
116,461,458 bp from pter
Size:
24,880 bases
Orientation:
Plus strand

Genomic View for SLC6A14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC6A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A14 Gene

Regulatory Elements for SLC6A14 Gene

Proteins for SLC6A14 Gene

  • Protein details for SLC6A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN76-S6A14_HUMAN
    Recommended name:
    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
    Protein Accession:
    Q9UN76
    Secondary Accessions:
    • Q5H942

    Protein attributes for SLC6A14 Gene

    Size:
    642 amino acids
    Molecular mass:
    72153 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid)

neXtProt entry for SLC6A14 Gene

Proteomics data for SLC6A14 Gene at MOPED

Post-translational modifications for SLC6A14 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn155, Asn163, Asn174, Asn189, Asn197, Asn202, Asn230, and Asn302

Other Protein References for SLC6A14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC6A14 Gene

Domains for SLC6A14 Gene

Gene Families for SLC6A14 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC6A14 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S6A14_HUMAN
Family:
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily.:
    • Q9UN76
genes like me logo Genes that share domains with SLC6A14: view

Function for SLC6A14 Gene

Molecular function for SLC6A14 Gene

UniProtKB/Swiss-Prot Function: Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner.

Gene Ontology (GO) - Molecular Function for SLC6A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005328 neurotransmitter:sodium symporter activity IEA --
GO:0015171 amino acid transmembrane transporter activity TAS 10446133
genes like me logo Genes that share ontologies with SLC6A14: view

Phenotypes for SLC6A14 Gene

genes like me logo Genes that share phenotypes with SLC6A14: view

miRNA for SLC6A14 Gene

miRTarBase miRNAs that target SLC6A14

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC6A14 Gene

Localization for SLC6A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC6A14 Gene COMPARTMENTS Subcellular localization image for SLC6A14 gene
Compartment Confidence
plasma membrane 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC6A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0031526 brush border membrane IEA --
GO:0031982 vesicle IDA 19190083
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SLC6A14: view

Pathways for SLC6A14 Gene

genes like me logo Genes that share pathways with SLC6A14: view

Interacting Proteins for SLC6A14 Gene

Gene Ontology (GO) - Biological Process for SLC6A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport TAS 10446133
GO:0006520 cellular amino acid metabolic process TAS 10446133
GO:0006810 transport TAS 10446133
GO:0006811 ion transport TAS --
GO:0006836 neurotransmitter transport IEA --
genes like me logo Genes that share ontologies with SLC6A14: view

Compounds for SLC6A14 Gene

(1) HMDB Compounds for SLC6A14 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(4) Drugbank Compounds for SLC6A14 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
D-Serine
312-84-5 transporter
L-Proline
  • (-)-2-Pyrrolidinecarboxylic acid
147-85-3 target
Valaciclovir
  • Valaciclovir Hcl
124832-27-5 transporter
Valganciclovir
  • Cymeval
175865-60-8 transporter

(1) IUPHAR Ligand for SLC6A14 Gene

Ligand Type Action Affinity Pubmed IDs
alpha-methyl-D,L-tryptophan Inhibitor Inhibition 3.6
genes like me logo Genes that share compounds with SLC6A14: view

Transcripts for SLC6A14 Gene

mRNA/cDNA for SLC6A14 Gene

Unigene Clusters for SLC6A14 Gene

Solute carrier family 6 (amino acid transporter), member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:
SP2: -

Relevant External Links for SLC6A14 Gene

GeneLoc Exon Structure for
SLC6A14
ECgene alternative splicing isoforms for
SLC6A14

Expression for SLC6A14 Gene

mRNA expression in normal human tissues for SLC6A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A14 Gene

This gene is overexpressed in Minor Salivary Gland (17.3), Lung (13.3), and Vagina (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC6A14 Gene

SOURCE GeneReport for Unigene cluster for SLC6A14 Gene Hs.522109

mRNA Expression by UniProt/SwissProt for SLC6A14 Gene

Q9UN76-S6A14_HUMAN
Tissue specificity: Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.
genes like me logo Genes that share expressions with SLC6A14: view

Orthologs for SLC6A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC6A14 36
  • 94.26 (n)
  • 92.38 (a)
cow
(Bos Taurus)
Mammalia SLC6A14 36
  • 88.58 (n)
  • 87.17 (a)
dog
(Canis familiaris)
Mammalia SLC6A14 36
  • 92.28 (n)
  • 93.9 (a)
mouse
(Mus musculus)
Mammalia Slc6a14 36
  • 87.98 (n)
  • 89.5 (a)
Slc6a14 16
rat
(Rattus norvegicus)
Mammalia Slc6a14 36
  • 87.22 (n)
  • 89.98 (a)
chicken
(Gallus gallus)
Aves SLC6A14 36
  • 71.14 (n)
  • 74.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23471 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a14.1 36
  • 69.21 (n)
  • 71.87 (a)
Str.1195 36
zebrafish
(Danio rerio)
Actinopterygii slc6a14 36
  • 63.66 (n)
  • 65.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS03431.1 38
  • 35 (a)
CG5549 38
  • 43 (a)
CG3252 38
  • 38 (a)
CG8850 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea snf-8 38
  • 24 (a)
snf-4 38
  • 36 (a)
snf-5 38
  • 31 (a)
snf-9 38
  • 31 (a)
snf-6 38
  • 31 (a)
snf-2 38
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6688 36
Species with no ortholog for SLC6A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A14 Gene

ENSEMBL:
Gene Tree for SLC6A14 (if available)
TreeFam:
Gene Tree for SLC6A14 (if available)

Paralogs for SLC6A14 Gene

Selected SIMAP similar genes for SLC6A14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC6A14: view

No data available for Paralogs for SLC6A14 Gene

Variants for SLC6A14 Gene

Sequence variations from dbSNP and Humsavar for SLC6A14 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2011162 -- 116,459,133(+) CTCAG(C/G)CATGT utr-variant-3-prime
rs2011198 -- 116,458,613(+) TAGCT(A/C)CATTT intron-variant
rs2032525 -- 116,457,946(+) acatg(C/G)tattt intron-variant
rs2071877 -- 116,457,272(+) AAAAG(C/T)TCAAT intron-variant
rs2312054 -- 116,436,924(+) AGAAA(A/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A14 Gene

Variant ID Type Subtype PubMed ID
nsv523582 CNV Gain 19592680
nsv527804 CNV Gain 19592680
nsv438153 CNV Loss 16468122
nsv526428 CNV Gain 19592680
dgv526n21 CNV Gain 19592680

Relevant External Links for SLC6A14 Gene

HapMap Linkage Disequilibrium report
SLC6A14
Human Gene Mutation Database (HGMD)
SLC6A14
Locus Specific Mutation Databases (LSDB)
SLC6A14

Disorders for SLC6A14 Gene

(1) OMIM Diseases for SLC6A14 Gene (300444)

UniProtKB/Swiss-Prot

S6A14_HUMAN
  • Note=Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.

Relevant External Links for SLC6A14

Genetic Association Database (GAD)
SLC6A14
Human Genome Epidemiology (HuGE) Navigator
SLC6A14
genes like me logo Genes that share disorders with SLC6A14: view

Publications for SLC6A14 Gene

  1. The SLC6A14 gene shows evidence of association with obesity. (PMID: 14660752) Suviolahti E. … Pajukanta P. (J. Clin. Invest. 2003) 3 4 23 49
  2. Cloning and functional expression of a human Na(+) and Cl(-)- dependent neutral and cationic amino acid transporter B(0+). (PMID: 10446133) Sloan J.L. … Mager S. (J. Biol. Chem. 1999) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  4. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. (PMID: 19876004) Corpeleijn E. … Blaak E.E. (Obesity (Silver Spring) 2010) 3 49
  5. Human solute carrier SLC6A14 is the beta-alanine carrier. (PMID: 18599538) Anderson C.M. … Thwaites D.T. (J. Physiol. (Lond.) 2008) 3 23

Products for SLC6A14 Gene

  • antibodies-online peptides for SLC6A14
  • antibodies-online antibodies for SLC6A14
  • antibodies-online kits for SLC6A14

Sources for SLC6A14 Gene

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