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SAT2 Gene(Protein Coding)

Spermidine/Spermine N1-Acetyltransferase Family Member 2

GCID:
GC17M007626
GIFtS:
57
Genes Participants
UDN Logo

Aliases for SAT2 Gene

Subcategory (RNA class) for SAT2 Gene

lncRNA

Aliases for SAT2 Gene

  • Spermidine/Spermine N1-Acetyltransferase Family Member 2 2 3 5
  • Spermidine/Spermine N(1)-Acetyltransferase 2 3 4
  • Thialysine N-Epsilon-Acetyltransferase 3 4
  • Polyamine N-Acetyltransferase 2 3 4
  • Diamine N-Acetyltransferase 2 2 3
  • SSAT2 3 4
  • Spermidine/Spermine N1-Acetyltransferase 2 2
  • EC 2.3.1.57 4

External Ids for SAT2 Gene

ORGUL Members for SAT2 Gene

Previous GeneCards Identifiers for SAT2 Gene

  • GC17M007472
  • GC17M007730
  • GC17M007470
  • GC17M007529
  • GC17M007423

Summaries for SAT2 Gene

GeneCards Summary for SAT2 Gene

SAT2 (Spermidine/Spermine N1-Acetyltransferase Family Member 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Metabolism and spermine and spermidine degradation I. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and diamine N-acetyltransferase activity. An important paralog of this gene is SATL1.

UniProtKB/Swiss-Prot for SAT2 Gene

  • Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.

Gene Wiki entry for SAT2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAT2 Gene

Genomics for SAT2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SAT2 Gene

Enhancers for SAT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SAT2 on UCSC Golden Path with GeneCards custom track

Promoters for SAT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SAT2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SAT2 gene promoter:

Genomic Location for SAT2 Gene

Chromosome:
17
Start:
7,626,234 bp from pter
End:
7,627,876 bp from pter
Size:
1,643 bases
Orientation:
Minus strand

Genomic View for SAT2 Gene

Genes around SAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAT2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SAT2 Gene

Proteins for SAT2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F10-SAT2_HUMAN
    Recommended name:
    Diamine acetyltransferase 2
    Protein Accession:
    Q96F10

    Protein attributes for SAT2 Gene

    Size:
    170 amino acids
    Molecular mass:
    19155 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland expressed only SSAT2.

    Three dimensional structures from OCA and Proteopedia for SAT2 Gene

neXtProt entry for SAT2 Gene

Proteomics data for SAT2 Gene at MOPED

Protein Expression for SAT2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAT2 Gene

Domains & Families for SAT2 Gene

Gene Families for SAT2 Gene

HGNC:

Protein Domains for SAT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F10

UniProtKB/Swiss-Prot:

SAT2_HUMAN :
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family.
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family.
genes like me logo Genes that share domains with SAT2: view

Function for SAT2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
UniProtKB/Swiss-Prot Function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
UniProtKB/Swiss-Prot Induction:
Not inducible by polyamine analogs.

Enzyme Numbers (IUBMB) for SAT2 Gene

Phenotypes for SAT2 Gene

GenomeRNAi human phenotypes for SAT2:
genes like me logo Genes that share phenotypes with SAT2: view

Animal Model Products

miRNA for SAT2 Gene

miRTarBase miRNAs that target SAT2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAT2 Gene

Localization for SAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAT2 Gene

Cytoplasm. Note=Intracellular organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAT2 Gene COMPARTMENTS Subcellular localization image for SAT2 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for SAT2 Gene

Pathways & Interactions for SAT2 Gene

genes like me logo Genes that share pathways with SAT2: view

Pathways by source for SAT2 Gene

2 KEGG pathways for SAT2 Gene

UniProtKB/Swiss-Prot Q96F10-SAT2_HUMAN

  • Pathway: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.

Gene Ontology (GO) - Biological Process for SAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0046204 nor-spermidine metabolic process IDA 12803540
genes like me logo Genes that share ontologies with SAT2: view

No data available for SIGNOR curated interactions for SAT2 Gene

Drugs & Compounds for SAT2 Gene

Products:

  1. Drug

(4) Drugs for SAT2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermine Approved Nutra Full agonist, Agonist, Enzyme, substrate 0
putrescine Experimental Pharma Antagonist, Pore Blocker 0
Coenzyme A Nutra 0

(4) Additional Compounds for SAT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
 72-89-9
N1-Acetylspermidine
  • 1-N-Acetylspermidine
  • An N-acetylspermidine
  • N(1)-Acetylspermidine
  • N-(3-((4-Aminobutyl)amino)propyl)-Acetamide
  • N-(3-((4-Aminobutyl)amino)propyl)acetamide
 14278-49-0
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
 25593-72-0
N-Acetylputrescine
  • Acetylputrescine
  • Monoacetylputrescine
  • N-(4-Aminobutyl)acetamide
 18233-70-0
genes like me logo Genes that share compounds with SAT2: view

Transcripts for SAT2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SAT2 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(204) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAT2 Gene

Spermidine/spermine N1-acetyltransferase family member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11: -

Relevant External Links for SAT2 Gene

GeneLoc Exon Structure for
SAT2
ECgene alternative splicing isoforms for
SAT2

Expression for SAT2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SAT2 Gene

mRNA expression in normal human tissues for SAT2 Gene
mRNA expression by BioGPS for SAT2 GenemRNA expression by GTEx for SAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAT2 Gene

This gene is overexpressed in Liver, secretome (12.7), Kidney (11.4), Liver (9.6), and Adrenal (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAT2 Gene



SOURCE GeneReport for Unigene cluster for SAT2 Gene Hs.10846

mRNA Expression by UniProt/SwissProt for SAT2 Gene

Q96F10-SAT2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SAT2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SAT2 Gene

Orthologs for SAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SAT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SAT2 35
  • 88.63 (n)
  • 87.65 (a)
SAT2 36
  • 84 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SAT2 35
  • 86.27 (n)
  • 85.88 (a)
SAT2 36
  • 83 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Sat2 35
  • 82.75 (n)
  • 80 (a)
Sat2 16
Sat2 36
  • 79 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SAT2 35
  • 99.8 (n)
  • 99.41 (a)
SAT2 36
  • 62 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Sat2 35
  • 84.42 (n)
  • 81.07 (a)
oppossum
(Monodelphis domestica)
 Mammalia SAT2 36
  • 60 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SAT2 36
  • 41 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100487185 35
  • 58.82 (n)
  • 52.21 (a)
zebrafish
(Danio rerio)
 Actinopterygii sat2b 35
  • 57.67 (n)
  • 54.6 (a)
sat2b 36
  • 51 (a)
 ManyToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002239 35
  • 51.72 (n)
  • 40.61 (a)
fruit fly
(Drosophila melanogaster)
 Insecta CG4210 35
  • 47.59 (n)
  • 39.62 (a)
CG4210 36
  • 36 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea CELE_D2023.4 35
  • 46.41 (n)
  • 37.97 (a)
D2023.4 36
  • 37 (a)
 OneToMany
bread mold
(Neurospora crassa)
 Ascomycetes NCU07589 35
  • 51.57 (n)
  • 40.25 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ats1 35
  • 47.38 (n)
  • 42.77 (a)
Species with no ortholog for SAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAT2 Gene

ENSEMBL:
Gene Tree for SAT2 (if available)
TreeFam:
Gene Tree for SAT2 (if available)

Paralogs for SAT2 Gene

Paralogs for SAT2 Gene

(4) SIMAP similar genes for SAT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SAT2: view

Variants for SAT2 Gene

Sequence variations from dbSNP and Humsavar for SAT2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_020465 -

Structural Variations from Database of Genomic Variants (DGV) for SAT2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294

Variation tolerance for SAT2 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SAT2 Gene

Disorders for SAT2 Gene

Relevant External Links for SAT2

Genetic Association Database (GAD)
SAT2
Human Genome Epidemiology (HuGE) Navigator
SAT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAT2

No disorders were found for SAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAT2 Gene

Publications for SAT2 Gene

  1. Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. (PMID: 15283699) Coleman C.S. … Pegg A.E. (Biochem. J. 2004) 2 3 23 25 26 67
  2. Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. (PMID: 12803540) Chen Y. … Porter C.W. (Biochem. J. 2003) 3 23 25 26
  3. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. (PMID: 17558023) Baek J.H. … Semenza G.L. (J. Biol. Chem. 2007) 2 3 23
  4. Spermidine/Spermine N1-Acetyltransferase 2 (SSAT2) functions as a coactivator for NF-kappaB and cooperates with CBP and P/CAF to enhance NF-kappaB-dependent transcription. (PMID: 17011643) Vogel N.L. … Ashburner B.P. (Biochim. Biophys. Acta 2006) 23 25 26
  5. Spermidine acetyltransferase is required to prevent spermidine toxicity at low temperatures in Escherichia coli. (PMID: 10986239) Limsuwun K. … Jones P.G. (J. Bacteriol. 2000) 25 26

Products for SAT2 Gene

Sources for SAT2 Gene

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