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SAT2 Gene(Protein Coding)

Spermidine/Spermine N1-Acetyltransferase Family Member 2

GCID:
GC17M007626
GIFtS:
48
Genes Participants
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Aliases for SAT2 Gene

Subcategory (RNA class) for SAT2 Gene

lncRNA

Aliases for SAT2 Gene

  • Spermidine/Spermine N1-Acetyltransferase Family Member 2 2 3 5
  • Spermidine/Spermine N(1)-Acetyltransferase 2 3 4
  • Thialysine N-Epsilon-Acetyltransferase 3 4
  • Polyamine N-Acetyltransferase 2 3 4
  • Diamine N-Acetyltransferase 2 2 3
  • SSAT2 3 4
  • Spermidine/Spermine N1-Acetyltransferase 2 2
  • Diamine Acetyltransferase 2 3
  • EC 2.3.1.57 4

External Ids for SAT2 Gene

ORGUL Members for SAT2 Gene

Previous GeneCards Identifiers for SAT2 Gene

  • GC17M007472
  • GC17M007730
  • GC17M007470
  • GC17M007529
  • GC17M007423

Summaries for SAT2 Gene

GeneCards Summary for SAT2 Gene

SAT2 (Spermidine/Spermine N1-Acetyltransferase Family Member 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are spermine and spermidine degradation I and Arginine and proline metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and diamine N-acetyltransferase activity. An important paralog of this gene is SAT1.

UniProtKB/Swiss-Prot for SAT2 Gene

  • Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.

Gene Wiki entry for SAT2 Gene

Additional gene information for SAT2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAT2 Gene

Genomics for SAT2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SAT2 Gene

Promoters and enhancers for SAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I007625 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 576.4 -0.3 -347 5.8 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF416 SP3 NFYC MXD4 SAT2 GC17P007715 GC17P007716 GC17P007740 SHBG CHRNB1 DVL2 TP53 WRAP53 EFNB3
GH17I007571 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 25.4 +49.7 49717 14.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SNORD10 EIF4A1 CD68 GC17P007735 GC17P007737 GC17P007739 GC17P007742 PIR46508 SNORA67 MPDU1
GH17I007548 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 22.5 +76.7 76662 6 HDGF ARID4B SIN3A IRF4 ZNF48 TCF12 ATF7 KLF7 RUNX3 SP5 TNFSF12 GC17M007548 TNFSF12-TNFSF13 SAT2 CHRNB1 ATP1B2 TMEM102 CD68 ACAP1 WRAP53
GH17I007556 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 23.1 +68.1 68085 7.1 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF213 ZNF143 DEK TNFSF13 ENSG00000276384 GC17P007747 SENP3 SAT2 CHRNB1 TNFSF12 SNORA48 SENP3-EIF4A1 TNFSF12-TNFSF13
GH17I007586 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 25.5 +38.6 38566 5.7 PKNOX1 ARID4B KLF17 SIN3A ZNF2 RAD21 ZNF335 GLIS2 ZNF143 SMARCC2 GC17M007593 SOX15 SAT2 TNFSF12 CHRNB1 ATP1B2 LOC100996842 MPDU1 FXR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAT2 gene promoter:

Genomic Locations for SAT2 Gene

Genomic Locations for SAT2 Gene
chr17:7,626,234-7,627,876
(GRCh38/hg38)
Size:
1,643 bases
Orientation:
Minus strand
chr17:7,529,552-7,531,194
(GRCh37/hg19)

Genomic View for SAT2 Gene

Genes around SAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAT2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SAT2 Gene

Proteins for SAT2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F10-SAT2_HUMAN
    Recommended name:
    Diamine acetyltransferase 2
    Protein Accession:
    Q96F10

    Protein attributes for SAT2 Gene

    Size:
    170 amino acids
    Molecular mass:
    19155 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland expressed only SSAT2.

    Three dimensional structures from OCA and Proteopedia for SAT2 Gene

neXtProt entry for SAT2 Gene

Protein Expression for SAT2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SAT2 Gene

No Post-translational modifications

Other Protein References for SAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAT2 Gene

Domains & Families for SAT2 Gene

Gene Families for SAT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SAT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F10

UniProtKB/Swiss-Prot:

SAT2_HUMAN :
  • Belongs to the acetyltransferase family.
Family:
  • Belongs to the acetyltransferase family.
genes like me logo Genes that share domains with SAT2: view

Function for SAT2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
UniProtKB/Swiss-Prot Function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
UniProtKB/Swiss-Prot Induction:
Not inducible by polyamine analogs.

Enzyme Numbers (IUBMB) for SAT2 Gene

Phenotypes From GWAS Catalog for SAT2 Gene

Gene Ontology (GO) - Molecular Function for SAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004145 diamine N-acetyltransferase activity IDA 12803540
GO:0005515 protein binding IPI 16189514
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with SAT2: view

Phenotypes for SAT2 Gene

GenomeRNAi human phenotypes for SAT2:
genes like me logo Genes that share phenotypes with SAT2: view

Animal Model Products

miRNA for SAT2 Gene

miRTarBase miRNAs that target SAT2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAT2 Gene

Localization for SAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAT2 Gene

Cytoplasm. Note=Intracellular organelles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAT2 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with SAT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SAT2 Gene

Pathways & Interactions for SAT2 Gene

genes like me logo Genes that share pathways with SAT2: view

Pathways by source for SAT2 Gene

UniProtKB/Swiss-Prot Q96F10-SAT2_HUMAN

  • Pathway: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.

Gene Ontology (GO) - Biological Process for SAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009447 putrescine catabolic process IEA --
GO:0032918 spermidine acetylation IDA 12803540
GO:0032919 spermine acetylation IDA 12803540
GO:0032920 putrescine acetylation IDA 12803540
GO:0046204 nor-spermidine metabolic process IDA 12803540
genes like me logo Genes that share ontologies with SAT2: view

No data available for SIGNOR curated interactions for SAT2 Gene

Drugs & Compounds for SAT2 Gene

Products:

  1. Drug

(4) Drugs for SAT2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermine Approved Nutra Full agonist, Agonist, Enzyme, substrate 0
putrescine Experimental Pharma Antagonist, Pore Blocker 0
Coenzyme A Investigational Nutra 0

(4) Additional Compounds for SAT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
 72-89-9
N1-Acetylspermidine
  • 1-N-Acetylspermidine
  • An N-acetylspermidine
  • N(1)-Acetylspermidine
  • N-(3-((4-Aminobutyl)amino)propyl)-Acetamide
  • N-(3-((4-Aminobutyl)amino)propyl)acetamide
 14278-49-0
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
 25593-72-0
N-Acetylputrescine
  • Acetylputrescine
  • Monoacetylputrescine
  • N-(4-Aminobutyl)acetamide
 18233-70-0
genes like me logo Genes that share compounds with SAT2: view

Transcripts for SAT2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SAT2 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(204) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAT2 Gene

Spermidine/spermine N1-acetyltransferase family member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11: -

Relevant External Links for SAT2 Gene

GeneLoc Exon Structure for
SAT2
ECgene alternative splicing isoforms for
SAT2

Expression for SAT2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAT2 Gene

mRNA expression in normal human tissues for SAT2 Gene
mRNA expression by GTEx for SAT2 GenemRNA expression by BioGPS for SAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAT2 Gene

This gene is overexpressed in Liver, secretome (12.7), Kidney (11.4), Liver (9.6), and Adrenal (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAT2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SAT2 Gene:

SAT2

SOURCE GeneReport for Unigene cluster for SAT2 Gene:

Hs.10846

mRNA Expression by UniProt/SwissProt for SAT2 Gene:

Q96F10-SAT2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SAT2 Gene

  • Liver(4.4)
  • Lung(4.4)
  • Nervous system(3)
  • Kidney(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with SAT2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAT2 Gene

Orthologs for SAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SAT2 33 34
  • 99.8 (n)
cow
(Bos Taurus)
 Mammalia SAT2 33 34
  • 88.63 (n)
dog
(Canis familiaris)
 Mammalia SAT2 33 34
  • 86.27 (n)
rat
(Rattus norvegicus)
 Mammalia Sat2 33
  • 84.42 (n)
mouse
(Mus musculus)
 Mammalia Sat2 33 16 34
  • 82.75 (n)
oppossum
(Monodelphis domestica)
 Mammalia SAT2 34
  • 60 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SAT2 34
  • 41 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100487185 33
  • 58.82 (n)
zebrafish
(Danio rerio)
 Actinopterygii sat2b 33 34
  • 57.67 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002239 33
  • 51.72 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG4210 33 34
  • 47.59 (n)
worm
(Caenorhabditis elegans)
 Secernentea CELE_D2023.4 33
  • 46.41 (n)
D2023.4 34
  • 37 (a)
 OneToMany
bread mold
(Neurospora crassa)
 Ascomycetes NCU07589 33
  • 51.57 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ats1 33
  • 47.38 (n)
Species where no ortholog for SAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAT2 Gene

ENSEMBL:
Gene Tree for SAT2 (if available)
TreeFam:
Gene Tree for SAT2 (if available)

Paralogs for SAT2 Gene

Paralogs for SAT2 Gene

(4) SIMAP similar genes for SAT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SAT2: view

Variants for SAT2 Gene

Sequence variations from dbSNP and Humsavar for SAT2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000367065 -- 7,629,760(-) T/C upstream_transcript_variant
rs1001483022 -- 7,628,374(-) C/T upstream_transcript_variant
rs1002271599 -- 7,629,177(-) A/G upstream_transcript_variant
rs1002375114 -- 7,627,313(-) C/T intron_variant
rs1002387688 -- 7,628,996(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SAT2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for SAT2 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAT2 Gene

Disorders for SAT2 Gene

Additional Disease Information for SAT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAT2 Gene

Publications for SAT2 Gene

  1. Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. (PMID: 15283699) Coleman CS … Pegg AE (The Biochemical journal 2004) 2 3 22 25 58
  2. Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. (PMID: 12803540) Chen Y … Porter CW (The Biochemical journal 2003) 3 4 22 25 58
  3. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. (PMID: 17558023) Baek JH … Semenza GL (The Journal of biological chemistry 2007) 2 3 22 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 44 58

Products for SAT2 Gene

Sources for SAT2 Gene

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