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Aliases for PADI2 Gene

Aliases for PADI2 Gene

  • Peptidyl Arginine Deiminase, Type II 2 3
  • Protein-Arginine Deiminase Type II 3 4
  • EC 4 63
  • PAD-H19 3 4
  • PDI2 3 4
  • Protein-Arginine Deiminase Type-2 3
  • Peptidylarginine Deiminase II 4
  • KIAA0994 4
  • PAD2 3

External Ids for PADI2 Gene

Previous GeneCards Identifiers for PADI2 Gene

  • GC01M017130
  • GC01M016434
  • GC01M016775
  • GC01M016776
  • GC01M017138
  • GC01M017265
  • GC01M017393
  • GC01M015637

Summaries for PADI2 Gene

Entrez Gene Summary for PADI2 Gene

  • This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PADI2 Gene

PADI2 (Peptidyl Arginine Deiminase, Type II) is a Protein Coding gene. Diseases associated with PADI2 include alzheimer disease. GO annotations related to this gene include calcium ion binding and protein-arginine deiminase activity. An important paralog of this gene is PADI3.

UniProtKB/Swiss-Prot for PADI2 Gene

  • Catalyzes the deimination of arginine residues of proteins.

Gene Wiki entry for PADI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PADI2 Gene

Genomics for PADI2 Gene

Regulatory Elements for PADI2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PADI2 Gene

17,066,761 bp from pter
17,119,453 bp from pter
52,693 bases
Minus strand

Genomic View for PADI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PADI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PADI2 Gene

Proteins for PADI2 Gene

  • Protein details for PADI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-arginine deiminase type-2
    Protein Accession:
    Secondary Accessions:
    • Q96DA7
    • Q9UPN2

    Protein attributes for PADI2 Gene

    665 amino acids
    Molecular mass:
    75564 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=BAA76838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PADI2 Gene

    Alternative splice isoforms for PADI2 Gene


neXtProt entry for PADI2 Gene

Proteomics data for PADI2 Gene at MOPED

Selected DME Specific Peptides for PADI2 Gene

Post-translational modifications for PADI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PADI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for PADI2 Gene

Gene Families for PADI2 Gene

Protein Domains for PADI2 Gene

Suggested Antigen Peptide Sequences for PADI2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein arginine deiminase family.
  • Belongs to the protein arginine deiminase family.
genes like me logo Genes that share domains with PADI2: view

Function for PADI2 Gene

Molecular function for PADI2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein L-arginine + H(2)O = protein L-citrulline + NH(3)
UniProtKB/Swiss-Prot Function:
Catalyzes the deimination of arginine residues of proteins.

Enzyme Numbers (IUBMB) for PADI2 Gene

Gene Ontology (GO) - Molecular Function for PADI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004668 protein-arginine deiminase activity IDA 12392711
GO:0005509 calcium ion binding IEA --
GO:0030331 estrogen receptor binding IPI 22853951
genes like me logo Genes that share ontologies with PADI2: view

Phenotypes for PADI2 Gene

genes like me logo Genes that share phenotypes with PADI2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PADI2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PADI2 Gene

Localization for PADI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PADI2 Gene


Subcellular locations from

Jensen Localization Image for PADI2 Gene COMPARTMENTS Subcellular localization image for PADI2 gene
Compartment Confidence
mitochondrion 3
cytosol 2
cytoskeleton 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PADI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12392711
GO:0035327 transcriptionally active chromatin IDA 22853951
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PADI2: view

Pathways for PADI2 Gene

SuperPathways for PADI2 Gene

No Data Available

Interacting Proteins for PADI2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000364635 Q9Y2J8-PADI2_HUMAN for PADI2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PADI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010848 regulation of chromatin disassembly IDA 22853951
GO:0018101 protein citrullination IDA 12392711
GO:0021762 substantia nigra development IEP 22926577
GO:0030520 intracellular estrogen receptor signaling pathway IMP 22853951
GO:0036413 histone H3-R26 citrullination IDA 22853951
genes like me logo Genes that share ontologies with PADI2: view

No data available for Pathways by source for PADI2 Gene

Drugs for PADI2 Gene

(1) Drugbank Compounds for PADI2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (S)-2-Amino-5-ureidopentanoic acid
372-75-8 9750 Target approved, nutraceutical

(4) HMDB Compounds for PADI2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ammonia anhydrous
  • Ca
  • (2S)-2-amino-5-(carbamoylamino)pentanoate
  • Dihydrogen oxide
genes like me logo Genes that share compounds with PADI2: view

Transcripts for PADI2 Gene

Unigene Clusters for PADI2 Gene

Peptidyl arginine deiminase, type II:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PADI2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PADI2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for PADI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PADI2 Gene

mRNA expression in normal human tissues for PADI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PADI2 Gene

This gene is overexpressed in Muscle - Skeletal (11.1), Whole Blood (9.1), and Brain - Spinal cord (cervical c-1) (7.6).

Protein differential expression in normal tissues for PADI2 Gene

This gene is overexpressed in Spinal cord (35.2), Retina (6.5), and Frontal cortex (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PADI2 Gene

SOURCE GeneReport for Unigene cluster for PADI2 Gene Hs.33455

genes like me logo Genes that share expressions with PADI2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for PADI2 Gene

Orthologs for PADI2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PADI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PADI2 35
  • 91.48 (n)
  • 94.48 (a)
PADI2 36
  • 95 (a)
(Mus musculus)
Mammalia Padi2 35
  • 88.02 (n)
  • 93.23 (a)
Padi2 16
Padi2 36
  • 92 (a)
(Pan troglodytes)
Mammalia PADI2 35
  • 99.45 (n)
  • 100 (a)
PADI2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Padi2 35
  • 88.37 (n)
  • 93.68 (a)
(Bos Taurus)
Mammalia PADI2 36
  • 92 (a)
(Monodelphis domestica)
Mammalia PADI2 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PADI2 36
  • 71 (a)
(Gallus gallus)
Aves PADI2 35
  • 70.44 (n)
  • 68.78 (a)
PADI2 36
  • 68 (a)
(Anolis carolinensis)
Reptilia PADI2 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia padi2 35
  • 65.75 (n)
  • 61.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia padi2-prov 35
(Danio rerio)
Actinopterygii padi2 35
  • 59.95 (n)
  • 56.32 (a)
sbcb968 35
padi2 36
  • 53 (a)
Species with no ortholog for PADI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PADI2 Gene

Gene Tree for PADI2 (if available)
Gene Tree for PADI2 (if available)

Paralogs for PADI2 Gene

Paralogs for PADI2 Gene

(4) SIMAP similar genes for PADI2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PADI2: view

Variants for PADI2 Gene

Sequence variations from dbSNP and Humsavar for PADI2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs719262 -- 17,067,214(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs730387 -- 17,084,062(-) TTCCC(C/T)CCCTC intron-variant
rs733785 -- 17,087,274(-) AACCT(A/G)TCTTT intron-variant
rs737428 -- 17,102,690(-) GTGTT(C/T)CCCCC intron-variant
rs742795 -- 17,087,810(-) GCTGT(G/T)ATGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PADI2 Gene

Variant ID Type Subtype PubMed ID
dgv29e1 CNV Complex 17122850
nsv428421 CNV Gain+Loss 18775914
dgv40e1 CNV Complex 17122850
nsv834280 CNV Loss 17160897
esv2422314 CNV Duplication 17116639
nsv460662 CNV Loss 19166990
esv269737 CNV Insertion 20981092
esv274605 CNV Insertion 20981092

Relevant External Links for PADI2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PADI2 Gene

Disorders for PADI2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PADI2 Gene in MalaCards »

(1) Disease for PADI2 Gene

Relevant External Links for PADI2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PADI2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PADI2 Gene

Publications for PADI2 Gene

  1. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. (PMID: 15854045) Dong S. … Takahara H. (J. Invest. Dermatol. 2005) 23 25 26
  2. Increased peptidylarginine deiminase type II in hypoxic astrocytes. (PMID: 15555572) Sambandam T. … Nicholas A.P. (Biochem. Biophys. Res. Commun. 2004) 3 23
  3. Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. (PMID: 12392711) Ishigami A. … Maruyama N. (Arch. Biochem. Biophys. 2002) 3 4
  4. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PMID: 15087120) Chavanas S. … Simon M. (Gene 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for PADI2 Gene

Sources for PADI2 Gene

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