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Aliases for RNF24 Gene

Aliases for RNF24 Gene

  • Ring Finger Protein 24 2 3 5
  • G1L 3

External Ids for RNF24 Gene

Previous GeneCards Identifiers for RNF24 Gene

  • GC20M003901
  • GC20M003861
  • GC20M003908
  • GC20M003860
  • GC20M003912
  • GC20M003916

Summaries for RNF24 Gene

Entrez Gene Summary for RNF24 Gene

  • This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]

GeneCards Summary for RNF24 Gene

RNF24 (Ring Finger Protein 24) is a Protein Coding gene. An important paralog of this gene is RNF122.

UniProtKB/Swiss-Prot for RNF24 Gene

  • May play a role in TRPCs intracellular trafficking.

Gene Wiki entry for RNF24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF24 Gene

Genomics for RNF24 Gene

Regulatory Elements for RNF24 Gene

Promoters for RNF24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF24 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF24 Gene

Chromosome:
20
Start:
3,927,309 bp from pter
End:
4,015,582 bp from pter
Size:
88,274 bases
Orientation:
Minus strand

Genomic View for RNF24 Gene

Genes around RNF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF24 Gene

Proteins for RNF24 Gene

  • Protein details for RNF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y225-RNF24_HUMAN
    Recommended name:
    RING finger protein 24
    Protein Accession:
    Q9Y225
    Secondary Accessions:
    • D3DVZ2
    • D3DVZ3
    • Q9UMH1

    Protein attributes for RNF24 Gene

    Size:
    148 amino acids
    Molecular mass:
    17210 Da
    Quaternary structure:
    • Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.

    Three dimensional structures from OCA and Proteopedia for RNF24 Gene

    Alternative splice isoforms for RNF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF24 Gene

Proteomics data for RNF24 Gene at MOPED

Post-translational modifications for RNF24 Gene

  • Ubiquitination at Lys 61 and Lys 107
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF24 Gene

No data available for DME Specific Peptides for RNF24 Gene

Domains & Families for RNF24 Gene

Gene Families for RNF24 Gene

Protein Domains for RNF24 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y225

UniProtKB/Swiss-Prot:

RNF24_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF24: view

Function for RNF24 Gene

Molecular function for RNF24 Gene

UniProtKB/Swiss-Prot Function:
May play a role in TRPCs intracellular trafficking.
genes like me logo Genes that share phenotypes with RNF24: view

Animal Model Products

miRNA for RNF24 Gene

miRTarBase miRNAs that target RNF24

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF24 Gene

Localization for RNF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF24 Gene

Golgi apparatus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF24 Gene COMPARTMENTS Subcellular localization image for RNF24 gene
Compartment Confidence
golgi apparatus 4
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RNF24 Gene

Pathways & Interactions for RNF24 Gene

SuperPathways for RNF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNF24 Gene

Drugs & Compounds for RNF24 Gene

No Compound Related Data Available

Transcripts for RNF24 Gene

Unigene Clusters for RNF24 Gene

Ring finger protein 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: -

Relevant External Links for RNF24 Gene

GeneLoc Exon Structure for
RNF24
ECgene alternative splicing isoforms for
RNF24

Expression for RNF24 Gene

mRNA expression in normal human tissues for RNF24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF24 Gene

This gene is overexpressed in Whole Blood (x13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF24 Gene



SOURCE GeneReport for Unigene cluster for RNF24 Gene Hs.589884

genes like me logo Genes that share expression patterns with RNF24: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNF24 Gene

Orthologs for RNF24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF24 35
  • 99.8 (n)
  • 100 (a)
RNF24 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF24 36
  • 99 (a)
OneToOne
RNF24 35
  • 95.27 (n)
  • 99.32 (a)
dog
(Canis familiaris)
Mammalia RNF24 35
  • 95.72 (n)
  • 100 (a)
RNF24 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf24 16
Rnf24 35
  • 92.57 (n)
  • 97.97 (a)
Rnf24 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF24 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF24 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF24 36
  • 83 (a)
OneToOne
RNF24 35
  • 83.56 (n)
  • 95.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15788 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485988 35
  • 76.83 (n)
  • 89.02 (a)
Str.3540 35
zebrafish
(Danio rerio)
Actinopterygii rnf24 36
  • 85 (a)
OneToOne
rnf24 35
  • 75.9 (n)
  • 85.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for RNF24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF24 Gene

ENSEMBL:
Gene Tree for RNF24 (if available)
TreeFam:
Gene Tree for RNF24 (if available)

Paralogs for RNF24 Gene

Paralogs for RNF24 Gene

(4) SIMAP similar genes for RNF24 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF24: view

Variants for RNF24 Gene

Sequence variations from dbSNP and Humsavar for RNF24 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs241636 -- 3,946,495(+) AGGAG(C/T)CTGGG intron-variant
rs241637 -- 3,946,655(+) tgatc(A/G)tgcca intron-variant
rs241638 -- 3,946,723(+) TGATA(A/G)GACTG intron-variant
rs241639 -- 3,947,075(+) CTGTC(A/G)TCCCA intron-variant
rs241635 -- 3,946,441(+) AGAAG(C/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF24 Gene

Variant ID Type Subtype PubMed ID
nsv828673 CNV Gain 20364138
nsv527924 CNV Gain 19592680
nsv912623 CNV Gain 21882294

Variation tolerance for RNF24 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF24 Gene

HapMap Linkage Disequilibrium report
RNF24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF24 Gene

Disorders for RNF24 Gene

Relevant External Links for RNF24

Genetic Association Database (GAD)
RNF24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF24

No disorders were found for RNF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF24 Gene

Publications for RNF24 Gene

  1. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PMID: 17850865) Lussier M.P. … Boulay G. (Cell Calcium 2008) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3

Products for RNF24 Gene

Sources for RNF24 Gene

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