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Aliases for GALNT6 Gene

Aliases for GALNT6 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 6 2 3 5
  • Polypeptide GalNAc Transferase 6 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 6 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 6 3 4
  • Pp-GaNTase 6 3 4
  • EC 2.4.1.41 4 63
  • GALNAC-T6 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine: Polypeptide N-Acetylgalactosaminyltransferase 6 3
  • GalNAc Transferase 6 3
  • GalNAcT6 3

External Ids for GALNT6 Gene

Previous GeneCards Identifiers for GALNT6 Gene

  • GC12M051903
  • GC12M051769
  • GC12M051463
  • GC12M050033
  • GC12M048778

Summaries for GALNT6 Gene

Entrez Gene Summary for GALNT6 Gene

  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALNT6 Gene

GALNT6 (Polypeptide N-Acetylgalactosaminyltransferase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Mucin type O-Glycan biosynthesis. GO annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT6 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.

Gene Wiki entry for GALNT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT6 Gene

Genomics for GALNT6 Gene

Regulatory Elements for GALNT6 Gene

Enhancers for GALNT6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GALNT6 on UCSC Golden Path with GeneCards custom track

Promoters for GALNT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GALNT6 on UCSC Golden Path with GeneCards custom track

Genomic Location for GALNT6 Gene

Chromosome:
12
Start:
51,351,247 bp from pter
End:
51,392,867 bp from pter
Size:
41,621 bases
Orientation:
Minus strand

Genomic View for GALNT6 Gene

Genes around GALNT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT6 Gene

Proteins for GALNT6 Gene

  • Protein details for GALNT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL4-GALT6_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 6
    Protein Accession:
    Q8NCL4
    Secondary Accessions:
    • Q8IYH4
    • Q9H6G2
    • Q9UIV5

    Protein attributes for GALNT6 Gene

    Size:
    622 amino acids
    Molecular mass:
    71159 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15297.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GALNT6 Gene

Proteomics data for GALNT6 Gene at MOPED

Post-translational modifications for GALNT6 Gene

  • Glycosylation at Thr 38, Asn 86, and Asn 476
  • Modification sites at PhosphoSitePlus

Domains & Families for GALNT6 Gene

Gene Families for GALNT6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCL4

UniProtKB/Swiss-Prot:

GALT6_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT6: view

Function for GALNT6 Gene

Molecular function for GALNT6 Gene

GENATLAS Biochemistry:
galactosamine
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.

Enzyme Numbers (IUBMB) for GALNT6 Gene

genes like me logo Genes that share phenotypes with GALNT6: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT6 Gene

Localization for GALNT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT6 Gene COMPARTMENTS Subcellular localization image for GALNT6 gene
Compartment Confidence
golgi apparatus 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IDA 12506059
genes like me logo Genes that share ontologies with GALNT6: view

Pathways & Interactions for GALNT6 Gene

genes like me logo Genes that share pathways with GALNT6: view

Pathways by source for GALNT6 Gene

UniProtKB/Swiss-Prot Q8NCL4-GALT6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with GALNT6: view

No data available for SIGNOR curated interactions for GALNT6 Gene

Drugs & Compounds for GALNT6 Gene

(3) Drugs for GALNT6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0
Manganese Pharma 32
calcium Nutra 0

(3) Additional Compounds for GALNT6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT6: view

Transcripts for GALNT6 Gene

Unigene Clusters for GALNT6 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8 ^ 9 ^ 10 ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5:
SP6: - - - - - - - - -
SP7: - - - - -
SP8: -
SP9: - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13:

ExUns: 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GALNT6 Gene

GeneLoc Exon Structure for
GALNT6
ECgene alternative splicing isoforms for
GALNT6

Expression for GALNT6 Gene

mRNA expression in normal human tissues for GALNT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT6 Gene

This gene is overexpressed in Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for GALNT6 Gene

This gene is overexpressed in Stomach (34.6), Lung (14.7), and Salivary gland (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT6 Gene



SOURCE GeneReport for Unigene cluster for GALNT6 Gene Hs.505575

mRNA Expression by UniProt/SwissProt for GALNT6 Gene

Q8NCL4-GALT6_HUMAN
Tissue specificity: Expressed in placenta and trachea. Weakly expressed in brain and pancreas. Expressed in fibroblast. Weakly or not expressed in lung, liver, muscle, kidney, spleen, thymus, prostate, testis, ovary, intestine, colon, leukocyte, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland and bone marrow.
genes like me logo Genes that share expression patterns with GALNT6: view

Protein tissue co-expression partners for GALNT6 Gene

Primer Products

Orthologs for GALNT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GALNT6 35
  • 89.17 (n)
  • 89.23 (a)
GALNT6 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT6 35
  • 90.12 (n)
  • 90.66 (a)
GALNT6 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt6 35
  • 86.87 (n)
  • 88.59 (a)
Galnt6 16
Galnt6 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GALNT6 35
  • 96.57 (n)
  • 95.98 (a)
GALNT6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt6 35
  • 86.98 (n)
  • 87.94 (a)
chicken
(Gallus gallus)
Aves GALNT6 35
  • 74.83 (n)
  • 76.33 (a)
GALNT6 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT6 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt6 35
  • 68.77 (n)
  • 73.51 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
galnt6 35
  • 66.5 (n)
  • 68.75 (a)
galnt6 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11246 35
fruit fly
(Drosophila melanogaster)
Insecta CG7297 37
  • 33 (a)
CG7304 37
  • 32 (a)
CG7579 37
  • 30 (a)
GalNAc-T1 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39E4B.12a 37
  • 44 (a)
Y39E4B.12b 37
  • 45 (a)
Y39E4B.12c 37
  • 45 (a)
Y47D3A.23 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for GALNT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT6 Gene

ENSEMBL:
Gene Tree for GALNT6 (if available)
TreeFam:
Gene Tree for GALNT6 (if available)

Paralogs for GALNT6 Gene

genes like me logo Genes that share paralogs with GALNT6: view

Variants for GALNT6 Gene

Sequence variations from dbSNP and Humsavar for GALNT6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs747300 - 51,359,233(-) CTAGT(A/G)TCATT reference, missense
rs2042866 -- 51,378,891(-) GTTTG(C/G)GGGGG intron-variant
rs2067763 -- 51,366,543(+) TACCA(C/T)GGACC intron-variant
rs2067764 -- 51,366,652(+) GATCC(A/G)TGATC intron-variant
rs2519 -- 51,351,906(-) GTCTC(A/G)GTGGA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GALNT6 Gene

Variant ID Type Subtype PubMed ID
nsv832408 CNV Gain 17160897
esv2745883 CNV Deletion 23290073

Variation tolerance for GALNT6 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GALNT6 Gene

Disorders for GALNT6 Gene

Relevant External Links for GALNT6

Genetic Association Database (GAD)
GALNT6
Human Genome Epidemiology (HuGE) Navigator
GALNT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALNT6

No disorders were found for GALNT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT6 Gene

Publications for GALNT6 Gene

  1. Cloning and characterization of a close homologue of human UDP-N- acetyl--D-galactosamine:polypeptide N-acetylgalactosaminyltransferase- T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. (PMID: 10464263) Bennett E.P. … Clausen H. (J. Biol. Chem. 1999) 2 3 4 67
  2. Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. (PMID: 18854599) Gomes J. … Reis C.A. (J. Histochem. Cytochem. 2009) 3 23
  3. Prognostic utility of glycosyltransferase expression in breast cancer. (PMID: 19287074) Patani N. … Mokbel K. (Cancer Genomics Proteomics 2008) 3 23
  4. Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin. (PMID: 21472136) Park J.H. … Nakamura Y. (Neoplasia 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for GALNT6 Gene

Sources for GALNT6 Gene

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