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Aliases for RPL35 Gene

Aliases for RPL35 Gene

  • Ribosomal Protein L35 2 3
  • 60S Ribosomal Protein L35 2 3
  • RPL35A 6
  • DBA5 6
  • L35 3

External Ids for RPL35 Gene

Summaries for RPL35 Gene

Entrez Gene Summary for RPL35 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL35 Gene

RPL35 (Ribosomal Protein L35) is a Protein Coding gene. Diseases associated with RPL35 include pure red-cell aplasia and diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome and mRNA binding.

Gene Wiki entry for RPL35 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL35 Gene

Genomics for RPL35 Gene

Genomic Location for RPL35 Gene

Start:
124,857,879 bp from pter
End:
124,861,981 bp from pter
Size:
4,103 bases
Orientation:
Minus strand

Genomic View for RPL35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL35 Gene

Regulatory Elements for RPL35 Gene

Proteins for RPL35 Gene

  • Protein details for RPL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42766-RL35_HUMAN
    Recommended name:
    60S ribosomal protein L35
    Protein Accession:
    P42766
    Secondary Accessions:
    • A8K4V7
    • Q4VBY5
    • Q5JTN5
    • Q6IBC7
    • Q96QJ7
    • Q9BYF4

    Protein attributes for RPL35 Gene

    Size:
    123 amino acids
    Molecular mass:
    14551 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI39638.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL35 Gene

neXtProt entry for RPL35 Gene

Proteomics data for RPL35 Gene at MOPED

Post-translational modifications for RPL35 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys25, Lys66, and Lys79

Other Protein References for RPL35 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL35 Gene

Domains for RPL35 Gene

Gene Families for RPL35 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL35 Gene

Suggested Antigen Peptide Sequences for RPL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42766

UniProtKB/Swiss-Prot:

RL35_HUMAN
Family:
  • Belongs to the ribosomal protein L29P family.:
    • P42766
genes like me logo Genes that share domains with RPL35: view

Function for RPL35 Gene

Molecular function for RPL35 Gene

GENATLAS Biochemistry: 60S ribosomal protein L35,12kDa

Gene Ontology (GO) - Molecular Function for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding TAS 2891103
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL35: view
genes like me logo Genes that share phenotypes with RPL35: view

miRNA for RPL35 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL35 Gene

Localization for RPL35 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL35 Gene COMPARTMENTS Subcellular localization image for RPL35 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus TAS 2891103
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPL35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL35 Gene

Pathways for RPL35 Gene

genes like me logo Genes that share pathways with RPL35: view

Pathways by source for RPL35 Gene

1 GeneGo (Thomson Reuters) pathway for RPL35 Gene
1 BioSystems pathway for RPL35 Gene

Gene Ontology (GO) - Biological Process for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL35: view

Transcripts for RPL35 Gene

Unigene Clusters for RPL35 Gene

Ribosomal protein L35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for RPL35 Gene

GeneLoc Exon Structure for
RPL35
ECgene alternative splicing isoforms for
RPL35

Expression for RPL35 Gene

mRNA expression in normal human tissues for RPL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL35 Gene

SOURCE GeneReport for Unigene cluster for RPL35 Gene Hs.182825

genes like me logo Genes that share expressions with RPL35: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL35 Gene

Orthologs for RPL35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL35 35
  • 100 (n)
  • 100 (a)
RPL35 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
OneToMany
RPL35 35
  • 91.6 (n)
  • 99.19 (a)
RPL35 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL35 35
  • 92.68 (n)
  • 99.19 (a)
RPL35 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm10269 36
  • 96 (a)
OneToMany
Gm2000 36
  • 98 (a)
OneToMany
Rpl35 35
  • 89.16 (n)
  • 98.37 (a)
Rpl35 16
Rpl35 36
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL35 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL35 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl35 35
  • 89.7 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves RPL35 35
  • 82.66 (n)
  • 98.37 (a)
RPL35 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL35 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29067 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76336 35
rpl35 35
  • 77.78 (n)
  • 93.5 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8401 35
zebrafish
(Danio rerio)
Actinopterygii rpl35 35
  • 80.22 (n)
  • 92.68 (a)
rpl35 36
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001408 35
  • 67.21 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL35 35
  • 66.12 (n)
  • 65.85 (a)
RpL35 36
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-35 35
  • 63.41 (n)
  • 67.48 (a)
rpl-35 36
  • 67 (a)
OneToOne
rpl-35 37
  • 67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR095W 35
  • 58.33 (n)
  • 57.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL35A 36
  • 58 (a)
OneToMany
RPL35B 35
  • 54.44 (n)
  • 57.5 (a)
RPL35B 36
  • 58 (a)
OneToMany
RPL35B 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05247g 35
  • 55 (n)
  • 55.83 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7399 35
soybean
(Glycine max)
eudicotyledons Gma.9631 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02610 35
  • 63.96 (n)
  • 64.23 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.314 35
corn
(Zea mays)
Liliopsida Zm.878 35
rice
(Oryza sativa)
Liliopsida Os.37768 35
Os04g0376000 35
  • 67.21 (n)
  • 67.48 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28696 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10498 35
  • 60.06 (n)
  • 54.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl35 35
  • 56.11 (n)
  • 55.83 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3995 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4820 36
  • 79 (a)
OneToOne
Species with no ortholog for RPL35:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL35 Gene

ENSEMBL:
Gene Tree for RPL35 (if available)
TreeFam:
Gene Tree for RPL35 (if available)

Paralogs for RPL35 Gene

Selected SIMAP similar genes for RPL35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPL35: view

No data available for Paralogs for RPL35 Gene

Variants for RPL35 Gene

Sequence variations from dbSNP and Humsavar for RPL35 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs944953 -- 124,859,726(+) ACACT(A/C)AAGCC intron-variant
rs2067553 -- 124,859,794(-) TGAGG(C/T)CTAGA intron-variant
rs2274969 -- 124,859,095(-) GCTAC(A/G)TGTGT intron-variant
rs3215945 -- 124,858,912(-) CTGCC(-/C)ACCTG intron-variant
rs3780591 -- 124,859,365(+) gtgat(A/G)tggaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL35 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV Gain 17160897

Relevant External Links for RPL35 Gene

HapMap Linkage Disequilibrium report
RPL35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL35 Gene

Disorders for RPL35 Gene

(1) OMIM Diseases for RPL35 Gene (180468)

(2) University of Copenhagen DISEASES for RPL35 Gene

genes like me logo Genes that share disorders with RPL35: view

No data available for UniProtKB/Swiss-Prot for RPL35 Gene

Publications for RPL35 Gene

  1. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. (PMID: 11401437) Uechi T. … Kenmochi N. (Genomics 2001) 2 3 4
  2. The role of expansion segment of human ribosomal protein L35 in nuclear entry, translation activity, and endoplasmic reticulum docking. (PMID: 18523488) Chen I.J. … Lin A. (Biochem. Cell Biol. 2008) 3 23
  3. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPL35 Gene

Sources for RPL35 Gene

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