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Aliases for DUSP10 Gene

Aliases for DUSP10 Gene

  • Dual Specificity Phosphatase 10 2 3
  • MKP5 3 4 6
  • Mitogen-Activated Protein Kinase Phosphatase 5 3 4
  • MKP-5 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 10 3
  • Dual Specificity Phosphatase MKP-5 3
  • Map Kinase Phosphatase 5 3
  • MAP Kinase Phosphatase 5 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP10 Gene

Previous GeneCards Identifiers for DUSP10 Gene

  • GC01M220468
  • GC01M217790
  • GC01M218406
  • GC01M218931
  • GC01M218263
  • GC01M219941
  • GC01M221874
  • GC01M192550

Summaries for DUSP10 Gene

Entrez Gene Summary for DUSP10 Gene

  • Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for DUSP10 Gene

DUSP10 (Dual Specificity Phosphatase 10) is a Protein Coding gene. Diseases associated with DUSP10 include prostate cancer. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP10 Gene

  • Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.

Gene Wiki entry for DUSP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP10 Gene

Genomics for DUSP10 Gene

Regulatory Elements for DUSP10 Gene

Genomic Location for DUSP10 Gene

Start:
221,701,422 bp from pter
End:
221,742,176 bp from pter
Size:
40,755 bases
Orientation:
Minus strand

Genomic View for DUSP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP10 Gene

Proteins for DUSP10 Gene

  • Protein details for DUSP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W6-DUS10_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 10
    Protein Accession:
    Q9Y6W6
    Secondary Accessions:
    • D3DTB4
    • Q6GSI4
    • Q9H9Z5

    Protein attributes for DUSP10 Gene

    Size:
    482 amino acids
    Molecular mass:
    52642 Da
    Quaternary structure:
    • Monomer. Interacts with MAPK14.

    Three dimensional structures from OCA and Proteopedia for DUSP10 Gene

    Alternative splice isoforms for DUSP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP10 Gene

Proteomics data for DUSP10 Gene at MOPED

Post-translational modifications for DUSP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP10 Gene

No data available for DME Specific Peptides for DUSP10 Gene

Domains for DUSP10 Gene

Gene Families for DUSP10 Gene

HGNC:
  • DUSPT :Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

Graphical View of Domain Structure for InterPro Entry

Q9Y6W6

UniProtKB/Swiss-Prot:

DUS10_HUMAN :
  • Q9Y6W6
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP10: view

Function for DUSP10 Gene

Molecular function for DUSP10 Gene

GENATLAS Biochemistry: dual specificity (tyr/thr) phosphatase 10,expressed in various tissues and organs,located evently in nucleus and cytoplasm and inactivating p38 and SAPK/SNK kinases
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.

Enzyme Numbers (IUBMB) for DUSP10 Gene

Gene Ontology (GO) - Molecular Function for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 10391943
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity IDA 16806267
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP10: view
genes like me logo Genes that share phenotypes with DUSP10: view

Animal Models for DUSP10 Gene

MGI Knock Outs for DUSP10:

miRNA for DUSP10 Gene

miRTarBase miRNAs that target DUSP10

No data available for Transcription Factor Targeting and HOMER Transcription for DUSP10 Gene

Localization for DUSP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP10 Gene COMPARTMENTS Subcellular localization image for DUSP10 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10391943
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 10391943
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with DUSP10: view

Pathways for DUSP10 Gene

genes like me logo Genes that share pathways with DUSP10: view

Pathways by source for DUSP10 Gene

1 Qiagen pathway for DUSP10 Gene
2 Cell Signaling Technology pathways for DUSP10 Gene

Gene Ontology (GO) - Biological Process for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IDA 22375048
GO:0002819 regulation of adaptive immune response IEA --
GO:0006470 protein dephosphorylation IDA 22375048
GO:0006950 response to stress TAS 10391943
GO:0007254 JNK cascade TAS 10391943
genes like me logo Genes that share ontologies with DUSP10: view

Compounds for DUSP10 Gene

(3) HMDB Compounds for DUSP10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(2) Novoseek inferred chemical compound relationships for DUSP10 Gene

Compound -log(P) Hits PubMed IDs
vitamin d 56.2 2
1,25 dihydroxy vitamin d3 54.7 1
genes like me logo Genes that share compounds with DUSP10: view

Transcripts for DUSP10 Gene

Unigene Clusters for DUSP10 Gene

Dual specificity phosphatase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for DUSP10 Gene

GeneLoc Exon Structure for
DUSP10
ECgene alternative splicing isoforms for
DUSP10

Expression for DUSP10 Gene

mRNA expression in normal human tissues for DUSP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP10 Gene

This gene is overexpressed in Liver (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUSP10 Gene

SOURCE GeneReport for Unigene cluster for DUSP10 Gene Hs.497822

mRNA Expression by UniProt/SwissProt for DUSP10 Gene

Q9Y6W6-DUS10_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expressions with DUSP10: view

Orthologs for DUSP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP10 35
  • 99.65 (n)
  • 99.79 (a)
DUSP10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP10 35
  • 94.4 (n)
  • 96.68 (a)
DUSP10 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP10 35
  • 94.26 (n)
  • 96.27 (a)
DUSP10 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp10 35
  • 92.25 (n)
  • 96.68 (a)
Dusp10 16
Dusp10 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP10 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP10 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp10 35
  • 91.22 (n)
  • 95.85 (a)
chicken
(Gallus gallus)
Aves DUSP10 35
  • 83.51 (n)
  • 88.47 (a)
DUSP10 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP10 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497288 35
  • 80.88 (n)
  • 90.05 (a)
zebrafish
(Danio rerio)
Actinopterygii DUSP10 36
  • 69 (a)
OneToOne
si:ch211-180b22.4 35
  • 69.33 (n)
  • 71.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta puc 36
  • 22 (a)
OneToOne
puc 37
  • 42 (a)
Species with no ortholog for DUSP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP10 Gene

ENSEMBL:
Gene Tree for DUSP10 (if available)
TreeFam:
Gene Tree for DUSP10 (if available)

Paralogs for DUSP10 Gene

Paralogs for DUSP10 Gene

Selected SIMAP similar genes for DUSP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP10: view

Variants for DUSP10 Gene

Sequence variations from dbSNP and Humsavar for DUSP10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs870302 -- 221,701,624(-) AAATA(C/T)TTTCC utr-variant-3-prime, nc-transcript-variant
rs908857 -- 221,701,342(-) ATATA(C/T)AACAA downstream-variant-500B
rs908858 -- 221,709,883(-) CATCA(A/G)GGTTC intron-variant
rs982292 -- 221,718,010(-) TCAGG(A/C/T)AGCCC intron-variant
rs982293 -- 221,718,001(-) CCACA(A/G)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP10 Gene

Variant ID Type Subtype PubMed ID
nsv469786 CNV Complex 16826518
esv7152 CNV Gain 19470904

Relevant External Links for DUSP10 Gene

HapMap Linkage Disequilibrium report
DUSP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP10 Gene

Disorders for DUSP10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DUSP10 Gene including...

Search for DUSP10 Gene in MalaCards »

(2) Novoseek inferred disease relationships for DUSP10 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 47.6 3
cancer 0 1

Relevant External Links for DUSP10

Genetic Association Database (GAD)
DUSP10
Human Genome Epidemiology (HuGE) Navigator
DUSP10
genes like me logo Genes that share disorders with DUSP10: view

No data available for UniProtKB/Swiss-Prot for DUSP10 Gene

Publications for DUSP10 Gene

  1. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PMID: 10391943) Tanoue T. … Nishida E. (J. Biol. Chem. 1999) 2 3 4 23
  2. Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. (PMID: 16806267) Jeong D.G. … Kim S.J. (J. Mol. Biol. 2006) 3 4 23
  3. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. (PMID: 10597297) Theodosiou A. … Ashworth A. (Oncogene 1999) 2 3 4
  4. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. (PMID: 16166642) Kadoya T. … Ronai Z. (Mol. Cell. Biol. 2005) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DUSP10 Gene

Sources for DUSP10 Gene

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