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Aliases for DUSP10 Gene

Aliases for DUSP10 Gene

  • Dual Specificity Phosphatase 10 2 3
  • Mitogen-Activated Protein Kinase Phosphatase 5 3 4
  • MKP-5 3 4
  • MKP5 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Phosphatase MKP-5 3
  • Map Kinase Phosphatase 5 3
  • MAP Kinase Phosphatase 5 4
  • EC 4
  • EC 4

External Ids for DUSP10 Gene

Previous GeneCards Identifiers for DUSP10 Gene

  • GC01M220468
  • GC01M217790
  • GC01M218406
  • GC01M218931
  • GC01M218263
  • GC01M219941
  • GC01M221874
  • GC01M192550

Summaries for DUSP10 Gene

Entrez Gene Summary for DUSP10 Gene

  • Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for DUSP10 Gene

DUSP10 (Dual Specificity Phosphatase 10) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP10 Gene

  • Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.

Gene Wiki entry for DUSP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP10 Gene

Genomics for DUSP10 Gene

Regulatory Elements for DUSP10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP10 Gene

221,701,420 bp from pter
221,742,176 bp from pter
40,757 bases
Minus strand

Genomic View for DUSP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP10 Gene

Proteins for DUSP10 Gene

  • Protein details for DUSP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 10
    Protein Accession:
    Secondary Accessions:
    • D3DTB4
    • Q6GSI4
    • Q9H9Z5

    Protein attributes for DUSP10 Gene

    482 amino acids
    Molecular mass:
    52642 Da
    Quaternary structure:
    • Monomer. Interacts with MAPK14.

    Three dimensional structures from OCA and Proteopedia for DUSP10 Gene

    Alternative splice isoforms for DUSP10 Gene


neXtProt entry for DUSP10 Gene

Proteomics data for DUSP10 Gene at MOPED

Post-translational modifications for DUSP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP10 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP10 (MKP-5)

No data available for DME Specific Peptides for DUSP10 Gene

Domains & Families for DUSP10 Gene

Gene Families for DUSP10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP10: view

Function for DUSP10 Gene

Molecular function for DUSP10 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 10,expressed in various tissues and organs,located evently in nucleus and cytoplasm and inactivating p38 and SAPK/SNK kinases
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.

Enzyme Numbers (IUBMB) for DUSP10 Gene

Gene Ontology (GO) - Molecular Function for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 10391943
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity IDA 16806267
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP10: view
genes like me logo Genes that share phenotypes with DUSP10: view

Animal Models for DUSP10 Gene

MGI Knock Outs for DUSP10:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targets and HOMER Transcription for DUSP10 Gene

Localization for DUSP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for DUSP10 Gene COMPARTMENTS Subcellular localization image for DUSP10 gene
Compartment Confidence
nucleus 5
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10391943
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 10391943
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with DUSP10: view

Pathways & Interactions for DUSP10 Gene

SuperPathways for DUSP10 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 MAPK signaling pathway
3 Immune System
4 Signaling by GPCR
5 Developmental Biology
genes like me logo Genes that share pathways with DUSP10: view

Pathways by source for DUSP10 Gene

1 Qiagen pathway for DUSP10 Gene
1 Cell Signaling Technology pathway for DUSP10 Gene
1 KEGG pathway for DUSP10 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for DUSP10 Gene


Gene Ontology (GO) - Biological Process for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IDA 22375048
GO:0002819 regulation of adaptive immune response IEA --
GO:0006470 protein dephosphorylation IDA 22375048
GO:0006950 response to stress TAS 10391943
GO:0007254 JNK cascade TAS 10391943
genes like me logo Genes that share ontologies with DUSP10: view

Drugs & Compounds for DUSP10 Gene

(2) Drugs for DUSP10 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
vitamin d Pharma 1463

(4) Additional Compounds for DUSP10 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DUSP10: view

Transcripts for DUSP10 Gene

Unigene Clusters for DUSP10 Gene

Dual specificity phosphatase 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for DUSP10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP10 Gene

mRNA expression in normal human tissues for DUSP10 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP10 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for DUSP10 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP10 Gene

SOURCE GeneReport for Unigene cluster for DUSP10 Gene Hs.497822

mRNA Expression by UniProt/SwissProt for DUSP10 Gene

Tissue specificity: Detected in brain.
genes like me logo Genes that share expression patterns with DUSP10: view

Protein tissue co-expression partners for DUSP10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DUSP10 Gene

Orthologs for DUSP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP10 35
  • 94.4 (n)
  • 96.68 (a)
DUSP10 36
  • 97 (a)
(Canis familiaris)
Mammalia DUSP10 35
  • 94.26 (n)
  • 96.27 (a)
DUSP10 36
  • 96 (a)
(Mus musculus)
Mammalia Dusp10 35
  • 92.25 (n)
  • 96.68 (a)
Dusp10 16
Dusp10 36
  • 96 (a)
(Pan troglodytes)
Mammalia DUSP10 35
  • 99.65 (n)
  • 99.79 (a)
DUSP10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dusp10 35
  • 91.22 (n)
  • 95.85 (a)
(Monodelphis domestica)
Mammalia DUSP10 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP10 36
  • 91 (a)
(Gallus gallus)
Aves DUSP10 35
  • 83.51 (n)
  • 88.47 (a)
DUSP10 36
  • 88 (a)
(Anolis carolinensis)
Reptilia DUSP10 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497288 35
  • 80.88 (n)
  • 90.05 (a)
(Danio rerio)
Actinopterygii si:ch211-180b22.4 35
  • 69.33 (n)
  • 71.11 (a)
DUSP10 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta puc 37
  • 42 (a)
puc 36
  • 22 (a)
Species with no ortholog for DUSP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP10 Gene

Gene Tree for DUSP10 (if available)
Gene Tree for DUSP10 (if available)

Paralogs for DUSP10 Gene

Paralogs for DUSP10 Gene

(11) SIMAP similar genes for DUSP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP10: view

Variants for DUSP10 Gene

Sequence variations from dbSNP and Humsavar for DUSP10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs870302 -- 221,701,624(-) AAATA(C/T)TTTCC utr-variant-3-prime, nc-transcript-variant
rs908857 -- 221,701,342(-) ATATA(C/T)AACAA downstream-variant-500B
rs982292 -- 221,718,010(-) TCAGG(A/C/T)AGCCC intron-variant
rs982293 -- 221,718,001(-) CCACA(A/G)GTTTT intron-variant
rs982294 -- 221,717,577(-) GTCCA(C/T)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP10 Gene

Variant ID Type Subtype PubMed ID
nsv469786 CNV Complex 16826518
esv7152 CNV Gain 19470904

Variation tolerance for DUSP10 Gene

Residual Variation Intolerance Score: 17.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP10 Gene

Disorders for DUSP10 Gene

Relevant External Links for DUSP10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DUSP10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP10 Gene

Publications for DUSP10 Gene

  1. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PMID: 10391943) Tanoue T. … Nishida E. (J. Biol. Chem. 1999) 2 23 67
  2. Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment. (PMID: 19926709) Krishnan A.V. … Feldman D. (Endocr. Relat. Cancer 2010) 23 67
  3. Dual-specificity phosphatase 10 is fused to MDS1/EVI1-like gene 1 in a case of acute myelogenous leukemia with der1t1;1(p36.3;q21). (PMID: 17321999) Noguchi M. … Shirafuji N. (Int. J. Hematol. 2007) 23 67
  4. Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer. (PMID: 17229571) Krishnan A.V. … Feldman D. (J. Steroid Biochem. Mol. Biol. 2007) 23 67
  5. Calcitriol as a chemopreventive and therapeutic agent in prostate cancer: role of anti-inflammatory activity. (PMID: 18290727) Krishnan A.V. … Feldman D. (J. Bone Miner. Res. 2007) 23 67

Products for DUSP10 Gene

Sources for DUSP10 Gene

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