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Aliases for AKAP11 Gene

Aliases for AKAP11 Gene

  • A Kinase (PRKA) Anchor Protein 11 2 3
  • AKAP220 3 4 6
  • Protein Kinase A Anchoring Protein 11 2 3
  • Protein Kinase A-Anchoring Protein 11 3 4
  • A-Kinase Anchor Protein 220 KDa 3 4
  • AKAP 220 2 4
  • AKAP-11 3 4
  • PRKA11 3 4
  • Protein Phosphatase 1, Regulatory Subunit 44 3
  • A-Kinase Anchoring Protein, 220kDa 3
  • A Kinase Anchor Protein 220 KDa 3
  • A-Kinase Anchoring Protein 2
  • A-Kinase Anchor Protein 11 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 44 2
  • KIAA0629 4
  • HAKAP220 4
  • PPP1R44 3
  • 220kDa 2

External Ids for AKAP11 Gene

Previous GeneCards Identifiers for AKAP11 Gene

  • GC13P040846
  • GC13P036832
  • GC13P041782
  • GC13P040644
  • GC13P041744
  • GC13P042846
  • GC13P023649

Summaries for AKAP11 Gene

Entrez Gene Summary for AKAP11 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP11 Gene

AKAP11 (A Kinase (PRKA) Anchor Protein 11) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase A binding and protein phosphatase 1 binding. An important paralog of this gene is SPHKAP.

UniProtKB/Swiss-Prot for AKAP11 Gene

  • Binds to type II regulatory subunits of protein kinase A and anchors/targets them

Gene Wiki entry for AKAP11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP11 Gene

Genomics for AKAP11 Gene

Regulatory Elements for AKAP11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AKAP11 Gene

Start:
42,272,125 bp from pter
End:
42,323,267 bp from pter
Size:
51,143 bases
Orientation:
Plus strand

Genomic View for AKAP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP11 Gene

Proteins for AKAP11 Gene

  • Protein details for AKAP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKA4-AKA11_HUMAN
    Recommended name:
    A-kinase anchor protein 11
    Protein Accession:
    Q9UKA4
    Secondary Accessions:
    • O75124
    • Q9NUK7

    Protein attributes for AKAP11 Gene

    Size:
    1901 amino acids
    Molecular mass:
    210512 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92117.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AKAP11 Gene

Proteomics data for AKAP11 Gene at MOPED

Post-translational modifications for AKAP11 Gene

  • Ubiquitination at Lys560
  • Modification sites at PhosphoSitePlus

Other Protein References for AKAP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AKAP11 Gene

Domains for AKAP11 Gene

Gene Families for AKAP11 Gene

HGNC:
  • AKAP :A-kinase anchor proteins
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for AKAP11 Gene

Suggested Antigen Peptide Sequences for AKAP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKA4

UniProtKB/Swiss-Prot:

AKA11_HUMAN :
  • Q9UKA4
Domain:
  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
Family:
  • Belongs to the AKAP110 family.
genes like me logo Genes that share domains with AKAP11: view

Function for AKAP11 Gene

Molecular function for AKAP11 Gene

GENATLAS Biochemistry:
A kinase (PRKA,regulating subunit RIIA) anchor protein 11,expressed in brain,related to rat A kinase anchoring protein AKAP220
UniProtKB/Swiss-Prot Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them

Gene Ontology (GO) - Molecular Function for AKAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008157 protein phosphatase 1 binding TAS 10209101
GO:0051018 protein kinase A binding TAS 10209101
genes like me logo Genes that share ontologies with AKAP11: view

Phenotypes for AKAP11 Gene

GenomeRNAi human phenotypes for AKAP11:
genes like me logo Genes that share phenotypes with AKAP11: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AKAP11 Gene

Localization for AKAP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP11 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP11 Gene COMPARTMENTS Subcellular localization image for AKAP11 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
plasma membrane 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AKAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005777 peroxisome IBA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with AKAP11: view

Pathways for AKAP11 Gene

genes like me logo Genes that share pathways with AKAP11: view

Pathways by source for AKAP11 Gene

1 BioSystems pathway for AKAP11 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP11 Gene

Gene Ontology (GO) - Biological Process for AKAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010738 regulation of protein kinase A signaling IBA --
GO:0035556 intracellular signal transduction TAS 10209101
genes like me logo Genes that share ontologies with AKAP11: view

Transcripts for AKAP11 Gene

mRNA/cDNA for AKAP11 Gene

Unigene Clusters for AKAP11 Gene

A kinase (PRKA) anchor protein 11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:
SP6: - - -
SP7: - -
SP8:
SP9:

Relevant External Links for AKAP11 Gene

GeneLoc Exon Structure for
AKAP11
ECgene alternative splicing isoforms for
AKAP11

Expression for AKAP11 Gene

mRNA expression in normal human tissues for AKAP11 Gene

Protein differential expression in normal tissues for AKAP11 Gene

This gene is overexpressed in Adrenal (18.1), Testis (15.8), Fetal heart (13.4), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP11 Gene

SOURCE GeneReport for Unigene cluster for AKAP11 Gene Hs.105105

mRNA Expression by UniProt/SwissProt for AKAP11 Gene

Q9UKA4-AKA11_HUMAN
Tissue specificity: Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen
genes like me logo Genes that share expressions with AKAP11: view

Expression partners for AKAP11 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKAP11 Gene

Orthologs for AKAP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKAP11 35
  • 84.67 (n)
  • 79.32 (a)
AKAP11 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP11 35
  • 86.92 (n)
  • 82.73 (a)
AKAP11 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap11 35
  • 81.43 (n)
  • 74.48 (a)
Akap11 16
Akap11 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKAP11 35
  • 99.39 (n)
  • 98.74 (a)
AKAP11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap11 35
  • 81.23 (n)
  • 74.87 (a)
oppossum
(Monodelphis domestica)
Mammalia AKAP11 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP11 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKAP11 35
  • 65.78 (n)
  • 55.28 (a)
AKAP11 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP11 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akap11 35
  • 58.47 (n)
  • 48.59 (a)
Str.612 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.30220 35
zebrafish
(Danio rerio)
Actinopterygii akap11 35
  • 55.59 (n)
  • 45.85 (a)
akap11 36
  • 40 (a)
OneToOne
Species with no ortholog for AKAP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP11 Gene

ENSEMBL:
Gene Tree for AKAP11 (if available)
TreeFam:
Gene Tree for AKAP11 (if available)

Paralogs for AKAP11 Gene

Paralogs for AKAP11 Gene

Selected SIMAP similar genes for AKAP11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKAP11: view

Variants for AKAP11 Gene

Sequence variations from dbSNP and Humsavar for AKAP11 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs238313 -- 42,309,037(-) ACCCT(C/T)GCCCC intron-variant
rs238314 -- 42,308,626(-) TTATA(C/T)GCAAA intron-variant
rs238315 -- 42,307,806(-) tcttc(G/T)gatca intron-variant
rs238331 -- 42,287,111(-) GATTA(A/G)CAAAG intron-variant
rs238332 -- 42,282,308(-) GGTGT(A/T)AATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP11 Gene

Variant ID Type Subtype PubMed ID
nsv832590 CNV Gain 17160897
nsv832591 CNV Gain 17160897

Relevant External Links for AKAP11 Gene

HapMap Linkage Disequilibrium report
AKAP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP11 Gene

Disorders for AKAP11 Gene

Relevant External Links for AKAP11

Genetic Association Database (GAD)
AKAP11
Human Genome Epidemiology (HuGE) Navigator
AKAP11

No disorders were found for AKAP11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AKAP11 Gene

Publications for AKAP11 Gene

  1. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. (PMID: 10864471) Reinton N. … Tasken K. (Dev. Biol. 2000) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  5. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. (PMID: 8621616) Lester L.B. … Scott J.D. (J. Biol. Chem. 1996) 2 3

Products for AKAP11 Gene

Sources for AKAP11 Gene

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