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Aliases for AKAP11 Gene

Aliases for AKAP11 Gene

  • A-Kinase Anchoring Protein 11 2 3 5
  • Protein Kinase A Anchoring Protein 11 2 3
  • Protein Kinase A-Anchoring Protein 11 3 4
  • A Kinase (PRKA) Anchor Protein 11 2 3
  • A-Kinase Anchor Protein 220 KDa 3 4
  • AKAP 220 2 4
  • AKAP-11 3 4
  • AKAP220 3 4
  • PRKA11 3 4
  • Protein Phosphatase 1, Regulatory Subunit 44 3
  • A-Kinase Anchoring Protein, 220kDa 3
  • A Kinase Anchor Protein 220 KDa 3
  • A-Kinase Anchoring Protein 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 44 2
  • KIAA0629 4
  • HAKAP220 4
  • PPP1R44 3
  • 220kDa 2

External Ids for AKAP11 Gene

Previous GeneCards Identifiers for AKAP11 Gene

  • GC13P040846
  • GC13P036832
  • GC13P041782
  • GC13P040644
  • GC13P041744
  • GC13P042846
  • GC13P023649

Summaries for AKAP11 Gene

Entrez Gene Summary for AKAP11 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP11 Gene

AKAP11 (A-Kinase Anchoring Protein 11) is a Protein Coding gene. Among its related pathways are G Protein Signaling Pathways and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase A binding and protein phosphatase 1 binding. An important paralog of this gene is SPHKAP.

UniProtKB/Swiss-Prot for AKAP11 Gene

  • Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Gene Wiki entry for AKAP11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP11 Gene

Genomics for AKAP11 Gene

Regulatory Elements for AKAP11 Gene

Promoters for AKAP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AKAP11 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKAP11 Gene

Chromosome:
13
Start:
42,271,481 bp from pter
End:
42,323,267 bp from pter
Size:
51,787 bases
Orientation:
Plus strand

Genomic View for AKAP11 Gene

Genes around AKAP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP11 Gene

Proteins for AKAP11 Gene

  • Protein details for AKAP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKA4-AKA11_HUMAN
    Recommended name:
    A-kinase anchor protein 11
    Protein Accession:
    Q9UKA4
    Secondary Accessions:
    • O75124
    • Q9NUK7

    Protein attributes for AKAP11 Gene

    Size:
    1901 amino acids
    Molecular mass:
    210512 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92117.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AKAP11 Gene

Proteomics data for AKAP11 Gene at MOPED

Post-translational modifications for AKAP11 Gene

  • Ubiquitination at Lys 560
  • Modification sites at PhosphoSitePlus

Other Protein References for AKAP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for AKAP11

No data available for DME Specific Peptides for AKAP11 Gene

Domains & Families for AKAP11 Gene

Protein Domains for AKAP11 Gene

Suggested Antigen Peptide Sequences for AKAP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKA4

UniProtKB/Swiss-Prot:

AKA11_HUMAN :
  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Belongs to the AKAP110 family.
Domain:
  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Family:
  • Belongs to the AKAP110 family.
genes like me logo Genes that share domains with AKAP11: view

Function for AKAP11 Gene

Molecular function for AKAP11 Gene

GENATLAS Biochemistry:
A kinase (PRKA,regulating subunit RIIA) anchor protein 11,expressed in brain,related to rat A kinase anchoring protein AKAP220
UniProtKB/Swiss-Prot Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Gene Ontology (GO) - Molecular Function for AKAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051018 protein kinase A binding TAS 10209101
genes like me logo Genes that share ontologies with AKAP11: view
genes like me logo Genes that share phenotypes with AKAP11: view

Animal Model Products

miRNA for AKAP11 Gene

miRTarBase miRNAs that target AKAP11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP11 Gene

Localization for AKAP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP11 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP11 Gene COMPARTMENTS Subcellular localization image for AKAP11 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3
peroxisome 3
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for AKAP11 Gene

Pathways & Interactions for AKAP11 Gene

genes like me logo Genes that share pathways with AKAP11: view

Pathways by source for AKAP11 Gene

1 BioSystems pathway for AKAP11 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP11 Gene

Gene Ontology (GO) - Biological Process for AKAP11 Gene

None

No data available for SIGNOR curated interactions for AKAP11 Gene

Drugs & Compounds for AKAP11 Gene

No Compound Related Data Available

Transcripts for AKAP11 Gene

mRNA/cDNA for AKAP11 Gene

Unigene Clusters for AKAP11 Gene

A kinase (PRKA) anchor protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:
SP6: - - -
SP7: - -
SP8:
SP9:

Relevant External Links for AKAP11 Gene

GeneLoc Exon Structure for
AKAP11
ECgene alternative splicing isoforms for
AKAP11

Expression for AKAP11 Gene

mRNA expression in normal human tissues for AKAP11 Gene

Protein differential expression in normal tissues from HIPED for AKAP11 Gene

This gene is overexpressed in Adrenal (18.1), Testis (15.8), Fetal heart (13.4), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AKAP11 Gene



SOURCE GeneReport for Unigene cluster for AKAP11 Gene Hs.105105

mRNA Expression by UniProt/SwissProt for AKAP11 Gene

Q9UKA4-AKA11_HUMAN
Tissue specificity: Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.
genes like me logo Genes that share expression patterns with AKAP11: view

Protein tissue co-expression partners for AKAP11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKAP11 Gene

Orthologs for AKAP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP11 35
  • 99.39 (n)
  • 98.74 (a)
AKAP11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKAP11 36
  • 78 (a)
OneToOne
AKAP11 35
  • 84.67 (n)
  • 79.32 (a)
dog
(Canis familiaris)
Mammalia AKAP11 35
  • 86.92 (n)
  • 82.73 (a)
AKAP11 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap11 16
Akap11 36
  • 73 (a)
OneToOne
Akap11 35
  • 81.43 (n)
  • 74.48 (a)
oppossum
(Monodelphis domestica)
Mammalia AKAP11 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP11 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap11 35
  • 81.23 (n)
  • 74.87 (a)
chicken
(Gallus gallus)
Aves AKAP11 36
  • 47 (a)
OneToOne
AKAP11 35
  • 65.78 (n)
  • 55.28 (a)
lizard
(Anolis carolinensis)
Reptilia AKAP11 36
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30220 35
tropical clawed frog
(Silurana tropicalis)
Amphibia akap11 35
  • 58.47 (n)
  • 48.59 (a)
Str.612 35
zebrafish
(Danio rerio)
Actinopterygii akap11 36
  • 40 (a)
OneToOne
akap11 35
  • 55.59 (n)
  • 45.85 (a)
Species with no ortholog for AKAP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP11 Gene

ENSEMBL:
Gene Tree for AKAP11 (if available)
TreeFam:
Gene Tree for AKAP11 (if available)

Paralogs for AKAP11 Gene

Paralogs for AKAP11 Gene

(1) SIMAP similar genes for AKAP11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKAP11: view

Variants for AKAP11 Gene

Sequence variations from dbSNP and Humsavar for AKAP11 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2236364 - 42,300,908(-) CCGTA(C/G)AGACA reference, missense
rs17063163 - 42,301,955(+) TTCAC(A/G)TACTT reference, missense
rs17063167 - 42,302,976(+) CTGTT(A/C)ATGTT reference, missense
rs400288 -- 42,287,636(-) TAAAT(G/T)TAAAG intron-variant
rs401704 -- 42,307,754(-) cctta(A/T)aacat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP11 Gene

Variant ID Type Subtype PubMed ID
nsv832590 CNV Gain 17160897
nsv832591 CNV Gain 17160897

Variation tolerance for AKAP11 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP11 Gene

HapMap Linkage Disequilibrium report
AKAP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP11 Gene

Disorders for AKAP11 Gene

Relevant External Links for AKAP11

Genetic Association Database (GAD)
AKAP11
Human Genome Epidemiology (HuGE) Navigator
AKAP11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP11

No disorders were found for AKAP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP11 Gene

Publications for AKAP11 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. (PMID: 11823486) Schillace R.V. … Carr D.W. (J. Immunol. 2002) 3 23
  3. Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. (PMID: 11152471) Schillace R.V. … Scott J.D. (J. Biol. Chem. 2001) 3 23
  4. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. (PMID: 10864471) Reinton N. … Tasken K. (Dev. Biol. 2000) 3 23
  5. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. (PMID: 8621616) Lester L.B. … Scott J.D. (J. Biol. Chem. 1996) 2 3

Products for AKAP11 Gene

Sources for AKAP11 Gene

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